Cytomorphological study on human submandibular gland following treatment with secretagogue drugs

Cell and Tissue Research

Volumn 324, Issue 2, 2006, Pages 347-352

  Testa Riva, Francesca ^a   Puxeddu, Roberto ^a   Loy, Francesco ^a   Conti, Gabriele ^a   Riva, Alessandro ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Clozapine; Exocytosis; Human; Salivary glands; Scanning electron microscopy; Transmission electron microscopy

Indexed keywords

ADRENERGIC RECEPTOR BLOCKING AGENT; CARBACHOL; CLOZAPINE; MUSCARINIC AGENT; MUSCARINIC RECEPTOR BLOCKING AGENT;

ARTICLE; CALCULATION; CELL SECRETION; CELL STRUCTURE; CYTOPLASM; HUMAN; HUMAN TISSUE; HYPERSALIVATION; MICROVILLUS; PRIORITY JOURNAL; SALIVATION; SCANNING ELECTRON MICROSCOPY; SUBMANDIBULAR GLAND; TRANSMISSION ELECTRON MICROSCOPY;

ADULT; AGED; ANTIPSYCHOTIC AGENTS; CARBACHOL; CLOZAPINE; EXOCYTOSIS; FEMALE; HUMANS; MALE; MICROSCOPY, ELECTRON; MICROVILLI; MIDDLE AGED; SALIVATION; SECRETORY VESICLES; SUBMANDIBULAR GLAND;

EID: 33645806763     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00441-005-0149-1     Document Type: Article

References (25)

1. 1 agonism a pre-requisite for mimicking clozapine's actions? Psychopharmacology 178:451-460
2. Davydov L, Botts SR (2000) Clozapine-induced hypersalivation. Ann Pharmacother 34:662-665
3. Ekström J (1987) Neuropeptides and secretion. J Dent Res 66:524-530
4. Ekström J (2001) Gustatory-salivary reflexes induce non-adrenergic, non-cholinergic acinar degranulation in the rat parotid gland. Exp Physiol 86:475-480
5. Ekström J, Ekström PF (2001) Acinar degranulation in the rat parotid gland induced by neuropeptides. Exp Physiol 86:733-738
6. Ekström J, Asztély A, Tobin G (1996) Non-adrenergic, non-cholinergic influences on parotid acinar degranulation in response to stimulation of the parasympathetic innervation in the anaesthetized rat. Exp Physiol 81:935-942
7. Ekström J, Asztély A, Tobin G (1998) Parasympathetic non-adrenergic, non-cholinergic mechanisms in salivary glands and their role in reflex secretion. Eur J Morphol 36 (Suppl):208-212
8. Ekström J, Helander HF, Tobin G (1993) Parasympathetic non-adrenergic non-cholinergic mechanisms in reflex secretion of parotid acinar granules in conscious rat. J Physiol (Lond) 472:233-244
9. Fife RS, Chase WF, Dore RK, Wiesenhutter CW, Lockhart PB, Tindall E, Suen JY (2002) Cevimeline for the treatment of xerostomia in patients with Sjögren syndrome: a randomized trial. Arch Intern Med 162:1293-1300
10. Giraldo E, Martos F, Gomez A, Garcia A, Vigano MA, Ladinsky H, Sanchez de La Cuesta F (1988) Characterization of muscarinic receptor subtypes in human tissues. Life Sci 43:1507-1515
11. Ishikawa Y, Skowronski MT, Ishida H (2000) Persistent increase in the amount of aquaporin-5 in the apical plasma membrane of rat parotid acinar cells induced by a muscarinic agonist SNI-2011. FEBS Lett 477:253-257
12. 4 subtypes of muscarinic receptors. Eur J Pharmacol 376:119-125
13. Olianas MC, Maullu C, Onali P (1997) Effects of clozapine on rat striatal muscarinic receptors coupled to inhibition of adenylyl cyclase activity and on the human cloned m4 receptor. Br J Pharmacol 122:401-408
14. Olianas MC, Maullu C, Onali P (1999) Mixed agonist-antagonist properties of clozapine at different human cloned muscarinic receptor subtypes expressed in Chinese hamster ovary cells. Neuropsychopharmacology 20:263-270
15. Pepeu G (1996) Trasmissione colinergica. In: Clementi F, Fumagalli G (eds) Trattato di Farmacologia, vol 1. UTET, Torino, pp 229-244
16. Pochet S, Garcia-Marcos M, Fernandez M, Marino A, Dehaye JP (2003) Regulation by clozapine of calcium handling by rat submandibular acinar cells. Cell Calcium 34:465-475
17. Riva A, Loffredo F, Segawa A, Congiu T, Testa Riva F (1998) Human salivary glands parenchymal cells seen by SEM from the cytoplasmic side using a new osmium maceration method. Eur J Morphol 36 (Suppl):35-40
18. 4 maceration method for the visualization of internal structures and surfaces by high resolution scanning electron microscopy. Scanning Microscopy 13:111-122
19. Riva A, Puxeddu R, Loy F, Testa Riva F (2002) Morphofunctional studies on human labial salivary glands. Eur J Morphol 40:227-233
20. Riva A, Puxeddu R, Loy F, Isola M, Cabras T, Testa Riva F (2003) Serous and mucous cells of human submandibular salivary gland stimulated in vitro by isoproterenol, carbachol and clozapine: an LM, TEM, and HRSEM study. Eur J Morphol 41:83-87
21. Segawa A, Riva A (1996) Dynamics of salivary secretion studied by confocal laser and scanning electron microscopy. Eur J Morphol 34:215-219
22. Segawa A, Loffredo F, Puxeddu R, Yamashina S, Testa Riva F, Riva A (1998) Exocytosis in human salivary glands visualized by high-resolution scanning electron microscopy. Cell Tissue Res 291:325-336
23. Tanaka K, Mitsushima A (1984) A preparation method for observing intracellular structures by scanning electron microscopy. J Microsc 133:213-222
24. Washio T, Kohsaka K, Arisawa H, Masunaga H, Nagatsuka S, Satoh Y (2003) Pharmacokinetics and metabolism of radiolabelled SNI-2011, a novel muscarinic receptor agonist, in healthy volunteers. Arznei Forschung 53:80-86
25. 4 receptor agonist. Eur J Pharmacol 269:R1-R2