Interferon-γ increases neuronal death in response to amyloid-β1-42

Journal of Neuroinflammation

Volumn 3, Issue , 2006, Pages

  Bate, Clive ^a   Kempster, Sarah ^a   Last, Victoria ^a   Williams, Alun ^a  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; CASPASE 3; GAMMA INTERFERON; HYDROGEN PEROXIDE; INTERLEUKIN 1BETA; INTERLEUKIN 6; PHOSPHOLIPASE A2; PHOSPHOLIPASE C GAMMA1; PROSTAGLANDIN E2; STAUROSPORINE; TUMOR NECROSIS FACTOR ALPHA;

ALZHEIMER DISEASE; ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN NERVE CELL; CELL SURVIVAL; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; MOUSE; NERVE CELL DEGENERATION; NERVE CELL GROWTH; NERVE CELL NECROSIS; NEUROBLASTOMA CELL; NEUROTOXICITY; NONHUMAN; PATHOGENESIS; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; SENSITIZATION;

EID: 33645806720     PISSN: 17422094     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-3-7     Document Type: Article

References (21)

1. Hardy J, Selkoe DJ: The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002, 297:353-356.
2. Esler WP, Wolfe MS: A portrait of Alzheimer secretases - new features and familiar faces. Science 2001, 293:1449-1454.
3. Selkoe DJ: Translating cell biology into therapeutic advances in Alzheimer's disease. Nature 1999, 399:A23-A31.
4. Yankner BA, Dawes LR, Fisher S, Villa-Komaroff L, Oster-Granite ML, Neve RL: Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. Science 1989, 245:417-420.
5. Forloni G, Chiesa R, Smiroldo S, Verga L, Salmona. M, Tagliavini F, Angeretti N: Apoptosis mediated neurotoxicity induced by chronic application of beta amyloid fragment 25-35. Neuroreport 1993, 4:523-526.
6. Akiyama H, Arai T, Kondo H, Tanno E, Haga C, Ikeda K: Cell mediators of inflammation in the Alzheimer disease brain. Alzheimer Dis Assoc Disord 2000, 14(Suppl 1):S47-S53.
7. Papassotiropoulos A, Bagli M, Jessen F, Bayer TA, Maier W, Rao ML, Heun RA: A genetic variation of the inflammatory cytokine interleukin-6 delays the initial onset and reduces the risk for sporadic Alzheimer's disease. Ann Neurol 1999, 45:666-668.
8. Bate C, Salmona M, Williams A: The role of platelet activating factor in prion and amyloid-β neurotoxicity. Neuroreport 2004, 15:509-513.
9. Bate C, Reid S, Williams A: Killing of prion-damaged neurones by microglia. Neuroreport 2001, 12:2589-2594.
10. Salmona M, Morbin M, Massignan T, Colombo L, Mazzoleni G, Capobianco R, Diomede L, Thaler F, Mollica L, Musco G, Kourie D, Bugiani O, Sharma D, Inouye H, Kirschner DA, Forloni G, Tagliavini F: Structural properties of Gerstmann-Straussler-Scheinker disease amyloid protein. J Biol Chem 2003, 278:48146-48153.
11. Wiesner DA, Dawson G: Staurosporine induces programmed cell death in embryonic neurons and activation of the ceramide pathway. J Neurochem 1996, 66:1418-1425.
12. Cohen GM: Caspases: the executioners of apoptosis. Biochem J 1997, 326(Pt 1): 1-16.
13. Kriem B, Sponne I, Fifre A, Malaplate-Armand C, Lozac'h-Pillot K, Koziel V, Yen-Potin FT, Bihain B, Oster T, Olivier JL, Pillot T: Cytosolic phospholipase A2 mediates neuronal apoptosis induced by soluble oligomers of the amyloid-β peptide. The FASEB Journal 2004:04-1807fje.
14. Abbas N, Bednar I, Mix E, Marie S, Paterson D, Ljungberg A, Morris C, Winblad B, Nordberg A, Zhu J: Up-regulation of the inflammatory cytokines IFN-gamma and IL-12 and down-regulation of IL-4 in cerebral cortex regions of APP(SWE) transgenic mice. J Neuroimmunol 2002, 126:50-57.
15. Lehtonen JY, Holopainen JM, Kinnunen PK: Activation of phospholipase A2 by amyloid beta-peptides in vitro. Biochemistry 1996, 35:9407-9414.
16. Bate C, Reid S, Williams A: Phospholipase A2 inhibitors or platelet activating factor antagonists prevent prion replication. J Biol Chem 2004, 279:36405-36411.
17. Lindbom J, Ljungman AG, Lindahl M, Tagesson C: Increased gene expression of novel cytosolic and secretory phospholipase A(2) types in human airway epithelial cells induced by tumor necrosis factor-alpha and IFN-gamma. J Interferon Cytokine Res 2002, 22:947-955.
18. Blasko I, Stampfer-Kountchev M, Robatscher P, Veerhuis R, Eikelenboom P, Grubeck-Loebenstein B: How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: the role of microglia and astrocytes. Aging Cell 2004, 3:169-176.
19. Baker CA, Lu ZY, Manuelidis L: Early induction of interferon-responsive mRNAs in Creutzfeldt-Jakob disease. J Neurovirol 2004, 10:29-40.
20. Neumann H, Schmidt H, Wilharm E, Behrens L, Wekerle H: Interferon gamma gene expression in sensory neurons: evidence for autocrine gene regulation. J Exp Med 1997, 186:2023-2031.
21. Allen LB, Cochran KW: Acceleration of scrapie in mice by target-organ treatment with interferon inducers. Ann N Y Acad Sci 1977, 284:676-680.