Replicated linkage for eye color on 15q using comparative ratings of sibling pairs

Behavior Genetics

Volumn 36, Issue 1, 2006, Pages 12-17

  Posthuma, Danielle ^a   Visscher, Peter M ^b   Willemsen, Gonneke ^a   Zhu, Gu ^b   Martin, Nicholas G ^b   Slagboom, P Eline ^c   De Geus, Eco J C ^a   Boomsma, Dorret I ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Comparative phenotypes; Eye color; Regression based linkage

Indexed keywords

ARTICLE; CALCULATION; CHROMOSOME 15Q; COMPARATIVE STUDY; CONTROLLED STUDY; DIZYGOTIC TWINS; EYE COLOR; FATHER; GENE REPLICATION; GENETIC LINKAGE; GENETIC TRAIT; GENETICS; GENOMICS; HERITABILITY; HUMAN; LINKAGE ANALYSIS; MONOZYGOTIC TWINS; MOTHER; PROBABILITY; REGRESSION ANALYSIS; SIBLING;

ADOLESCENT; ADULT; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 15; EYE COLOR; HUMANS; PROBABILITY; SIBLINGS; TWINS, DIZYGOTIC; TWINS, MONOZYGOTIC;

EID: 33645790126     PISSN: 00018244     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10519-005-9007-x     Document Type: Article

References (24)

1. Abecasis, G. R., Cherny, S. S., Cookson, W. O., and Cardon, L. R. (2002). Merlin-rapid analysis of dense genetic maps using sparse gene flow trees. Nat. Genet. 30:97-101.
2. Abecasis, G. R., Cherny, S. S., Cookson, W. O., and Cardon, L. R. (2001). GRR: graphical representation of relationship errors. Bioinformatics 17:742-743.
3. Badano, J. L., and Katsanis, N. (2002). Beyond Mendel: an evolving view of human genetic disease transmission. Nat. Rev. Genet. 3:779-789.
4. Boissy, R. E. (1998). Extracutaneous Melanocytes. In J.J. Nordlund et al. (eds.), The Pigmentary System - Physiology and Pathophysiology, Oxford University Press, pp. 59-72
5. Boomsma, D. I., Vink, J. M., van Beijsterveldt, T. C., de Geus, E. J., Beem, A. L., Mulder, E. J. C. M., Derks, E. M., Riese, H., Willemsen, G. A., Bartels, M., van den Berg, M., Kupper, N. H., Polderman, T. J., Posthuma, D., Rietveld, M. J., Stubbe, J. H., Knol, L. I., Street, T., and van Baal, G. C. M. (2002). Netherlands TwinRegister: a focus on longitudinal research. Twin Res. 5:401-406.
6. Christensen, K., Frederiksen, H., Vaupel, J. W., and McGue, M. (2003). Age trajectories of genetic variance in physical functioning: a longitudinal study of Danish twins aged 70 years and older. Behav. Genet. 33:125-136.
7. Davenport, G. C., and Davenport, C. B. (1907). Heredity of eyecolor in man. Science 26:590-592.
8. Eaves, L. J., Neale, M. C., and Meyer, J. M. (1991). A model for comparative ratings in studies of within-family differences. Behav. Genet. 21:531-536.
9. Frudakis, T., Thomas, M., Gaskin, Z., Venkateswarlu, K., Chandra, K. S., Ginjupalli, S., Gunturi, S., Natrajan, S., Ponnuswamy, V. K., and Ponnuswamy, K. N. (2003). Sequences associated with human iris pigmentation. Genetics 165:2071-2083.
10. Haseman, J. K., and Elston, R. C. (1972). The investigation of linkage between a quantitative trait and a marker locus. Behav. Genet. 2:3-19.
11. Heijmans, B. T., Beekman, M., Putter, H., Lakenberg, N., van der Wijk, H. J., Whitfield, J. B., Posthuma, D., Pedersen, N. L., Martin, N. G., Boomsma, D. I., and Slagboom, P. E. (2005). Meta-analysis of four new genome scans for lipid parameters and analysis of positional candidates in positive linkage regions. Eur. J. Hum. Genet. advance online publication, July 13, 2005; doi:10.1038/sj.ejhg.5201466
12. Hudziak, J. J., van Beijsterveldt, C. E., Bartels, M., Rietveld, M. J., Rettew, D. C., Derks, E. M., and Boomsma, D. I. (2003). Individual differences in aggression: genetic analyses by age, gender, and informant in 3-, 7-, and 10-year-old Dutch twins. Behav. Genet. 33:575-589.
13. Imesch, P. D., Wallow, I. H., and Albert, D. M. (1997). The color of the human eye: a review of morphologic correlates and of some conditions that affect iridial pigmentation. Surv. Ophthalmol. 41(Suppl. 2):S117-S123.
14. Kirk, K. M., Eaves, L. J., Meyer, J. M., Saul, A., and Martin, N. G. (2000). Twin study of adolescent genetic susceptibility to mosquito bites using ordinal and comparative rating data. Genet. Epidemiol. 19:178-190.
15. Kong, A., Gudbjartsson, D. F., Sainz, J., Jonsdottir, G. M., Gudjonsson, S. A., Richardsson, B., Sigurdardottir, S., Barnard, J., Hallbeck, B., Masson, G., Shlien, A., Palsson, S. T., Frigge, M. L., Thorgeirsson, T. E., Gulcher, J. R., and Stefansson, K. (2002). A high-resolution recombination map of the human genome. Nat. Genet. 31:241-247.
16. Kong, X., Murphy, K., Raj, T., He, C., White, P. S., and Matise, T. C. (2004). A combined linkage-physical map of the human genome. Am. J. Hum. Genet. 75:1143-1148.
17. Oetting, W. S., and King, R. A. (1993). Molecular basis of type I (tyrosinase-related) oculocutaneous albinism: mutations and polymorphisms of the human tyrosinase gene. Hum. Mutat. 2:1-6.
18. Penrose, L. S. (1937). Genetic Linkage in graded Human Characters. Ann. Eugen. 8:233-237.
19. Prota, G., Hu, D. N., Vincensi, M. R., McCormick, S. A., and Napolitano, A. (1998). Characterization of melanins in human irides and cultured uveal melanocytes from eyes of different colors. Exp. Eye Res. 67:293-299.
20. Sturm, R. A., and Frudakis, T. N. (2004). Eye colour: portals into pigmentation genes and ancestry. Trends Genet. 8:327-332.
21. Sturm, R. A., Teasdale, R. D., and Box, N. F. (2001). Human pigmentation genes: identification, structure and consequences of polymorphic variation. Gene 277:49-62.
22. Swerdlow, A. J., De Stavola, B. L., Floderus, B., Holm, N. V., Kaprio, J., Verkasalo, P. K., and Mack, T. (2002). Risk factors for breast cancer at young ages in twins: an international population-based study. J. Natl. Cancer. Inst. 94:1238-1246.
23. Visscher, P. M., and Hopper, J. L. (2001). Power of regression and maximum likelihood methods to map QTL from sib-pair and DZ twin data. Ann. Hum. Genet. 65:583-601.
24. Zhu, G., Evans, D. M., Duffy, D. L., Montgomery, G. W., Medland, S. E., Gillespie, N. A., Ewen, K. R., Jewell, M., Liew, Y. W., Hayward, N. K., Sturm, R. A., Trent, J. M., and Martin, N. G. (2004). A genome scan for eye color in 502 twin families: most variation is due to a QTL on chromosome 15q. Twin Res. 7:197-210.