Oligopyrrole carboxamides linked with a nucleobase as potential DNA minor groove binding ligands: Synthesis, DNA binding and biological evaluation

Pharmazie

Volumn 61, Issue 4, 2006, Pages 261-268

  Keuser, C ^a   Pindur, Ulf ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; AMIDE; CONGOCIDINE; DISTAMYCIN A; DNA TOPOISOMERASE; N2 [5 [[[3 (DIMETHYLAMINO)PROPYL]AMINO]CARBONYL] 1 METHYL 1H 3 PYRROLYL] 1 METHYL 4 [[3 (2,4 DIOXO 1,2,3,4 TETRAHYDRO 1 PYRIMIDINYL)PROPANOYL]AMINO] 1H 2 PYRROLE CARBOXAMIDE; N2 [5 [[[3 (DIMETHYLAMINO)PROPYL]AMINO]CARBONYL] 1 METHYL 1H 3 PYRROLYL] 1 METHYL 4 [[4 (2,4 DIOXO 1,2,3,4 TETRAHYDRO 1 PYRIMIDINYL)BUTANOYL]AMINO] 1H 2 PYRROLE CARBOXAMIDE; N2 [5 [[[3 (DIMETHYLAMINO)PROPYL]AMINO]CARBONYL] 1 METHYL 1H 3 PYRROLYL] 1 METHYL 4 [[4 (5 METHYL 2,4 DIOXO 1,2,3,4 TETRAHYDRO 1 PYRIMIDINYL)BUTANOYL]AMINO] 1H 2 PYRROLE CARBOXAMIDE; N2 [5 [[[3 (DIMETHYLAMINO)PROPYL]AMINO]CARBONYL] 1 METHYL 1H 3 PYRROLYL] 4 [[4 (6 AMINO 9H 9 PYRINYL)BUTANOYL]AMINO] 1 METHYL 1H 2 PYRROLE CARBOXAMIDE; OLIGOPYRROLE CARBOXAMIDE DERIVATIVE; THYMINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CARBOXY TERMINAL SEQUENCE; CELL STRAIN MCF 7; CONTROLLED STUDY; DNA BINDING; DNA SYNTHESIS; DRUG CYTOTOXICITY; DRUG MECHANISM; ENZYME INHIBITION; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DNA; DNA TOPOISOMERASES, TYPE I; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; INDICATORS AND REAGENTS; LIGANDS; NUCLEOTIDES; PYRROLES;

EID: 33645763240     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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