Conditional (loxP-flanked) allele for the gene encoding the retinoic acid-synthesizing enzyme retinaldehyde dehydrogenase 2 (RALDH2)

Genesis (United States)

Volumn 44, Issue 3, 2006, Pages 155-158

  Vermot, Julien ^a,f   Garnier, Jean Marie ^a   Dierich, Andrée ^a,b   Niederreither, Karen ^c   Harvey, Richard P ^d,e   Chambon, Pierre ^a,b   Dollé, Pascal ^a,b  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b INSTITUT CLINIQUE DE LA SOURIS   (France)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d ST VINCENT S HOSPITAL   (Australia)

^e UNIVERSITY OF NEW SOUTH WALES   (Australia)

^f CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Aldehyde dehydrogenases; Conditional mutagenesis; Cre recombinase; Gene targeting; Mouse development; Retinoids

Indexed keywords

RETINAL DEHYDROGENASE; RETINAL DEHYDROGENASE 2; RETINOIC ACID; UNCLASSIFIED DRUG;

ALLELE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DEVELOPMENT; DNA FLANKING REGION; EMBRYO; GENE INACTIVATION; GENE MUTATION; GENETIC ANALYSIS; GENETIC CODE; MOUSE; MUTANT; NONHUMAN; PHENOTYPE; PLEIOTROPY; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ANIMALIA; CUCUMBER MOSAIC VIRUS; MUS MUSCULUS; VERTEBRATA;

EID: 33645759515     PISSN: 1526954X     EISSN: 1526968X     Source Type: Journal    
DOI: 10.1002/gene.20195     Document Type: Article

References (31)

1. Baldini A. 2004. DiGeorge syndrome: an update. Curr Opin Cardiol. 19:201-204.
2. Chambon P. 1996. A decade of molecular biology of retinoic acid receptors. FASEB J 10:940-954.
3. Chen TH, Chang TC, Kang JO, Choudhary B, Makita T, Tran CM, Burch JB, Eid H, Sucov HM. 2002. Epicardial induction of fetal cardiomyocyte proliferation via a retinoic acid-inducible trophic factor. Dev Biol 250:198-207.
4. Cosgrove D, Gray D, Dierich A, Kaufman J, Lemeur M, Benoist C, Mathis D. 1991. Mice lacking MHC class II molecules. Cell 66:1051-1066.
5. Duester G. 2000. Families of retinoid dehydrogenases regulating vitamin A function: production of visual pigment and retinoic acid. Eur J Biochem 267:4315-4324.
6. Dupé V, Davenne M, Brocard J, Dollé P, Mark M, Dierich A, Chambon P, Rijli FM. 1997. In vivo functional analysis of the Hoxa-1 3′ retinoic acid response element (3′RARE). Development 124:399-410.
7. Gu H, Zou YR, Rajewsky K. 1993. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell 18:1155-1164.
8. Hochgreb T, Linhares VL, Menezes DC, Sampaio AC, Yan CY, Cardoso WV, Rosenthal N, Xavier-Neto J. 2003. A caudorostral wave of RALDH2 conveys anteroposterior information to the cardiac field. Development 130:5363-5374.
9. Hsu LC, Chang WC, Yoshida A. 2000. Mouse type-2 retinaldehyde dehydrogenase (RALDH2): genomic organization, tissue-dependent expression, chromosome assignment and comparison to other types. Biochim Biophys Acta 1492:289-293.
10. Kido T, Lau YF. 2005. A Cre gene directed by a human TSPY promoter is specific for germ cells and neurons. genesis 42:263-275.
11. Li XH, Kakkad B, Ong DE. 2004. Estrogen directly induces expression of retinoic acid biosynthetic enzymes, compartmentalized between the epithelium and underlying stromal cells in rat uterus. Endocrinology 145:4756-4762.
12. Lin M, Zhang M, Abraham M, Smith SM, Napoli JL. 2003. Mouse retinal dehydrogenase 4 (RALDH4), molecular cloning, cellular expression, and activity in 9-cis-retinoic acid biosynthesis in intact cells. J Biol Chem 278:9856-9861.
13. Mark M, Chambon P. 2003. Functions of RARs and RXRs in vivo: genetic dissection of the retinoid signaling pathway. Pure Appl Chem 75:1709-1732.
14. Martin M, Gallego-Llamas J, Ribes V, Kedinger M, Niederreither K, Chambon P, Dollé P, Gradwohl G. 2005. Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice. Dev Biol 284:399-411.
15. Metzger D, Indra AK, Li M, Chapellier B, Calleja C, Ghyselinck NB, Chambon P. 2003. Targeted conditional somatic mutagenesis in the mouse: temporally-controlled knock out of retinoid receptors in epidermal keratinocytes. Methods Enzymol 364:379-408.
16. Mic FA, Haselbeck RJ, Cuenca AE, Duester G. 2002. Novel retinoic acid generating activities in the neural tube and heart identified by conditional rescue of Raldh2 null mutant mice. Development 129:2271-2282.
17. Mic FA, Sirbu IO, Duester G. 2004. Retinoic acid synthesis controlled by Raldh2 is required early for limb bud initiation and then later as a proximodistal signal during apical ectodermal ridge formation. J Biol Chem 279:26698-26706.
18. Moon AM, Boulet AM, Capecchi MR. 2000. Normal limb development in conditional mutants of Fgf4. Development 127:989-996.
19. Moss JB, Xavier-Neto J, Shapiro MD, Nayeem SM, McCaffery P, Dräger UC, Rosenthal N. 1998. Dynamic patterns of retinoic acid synthesis and response in the developing mammalian heart. Dev Biol 199:55-71.
20. Niederreither K, McCaffery P, Dräger UC, Chambon P, Dollé P. 1997. Restricted expression and retinoic acid-induced downregulation of the retinaldehyde dehydrogenase type 2 (RALDH-2) gene during mouse development. Mech Dev 62:67-78.
21. Niederreither K, Subbarayan V, Dollé P, Chambon P. 1999. Embryonic retinoic acid synthesis is essential for early mouse post-implantation development. Nat Genet 21:444-448.
22. Niederreither K, Vermot J, Messaddeq N, Schuhbaur B, Chambon P, Dollé P. 2001. Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse. Development 128:1019-1031.
23. Niederreither K, Vermot J, Schuhbaur B, Chambon P, Dollé P. 2002. Embryonic retinoic acid synthesis is required for forelimb growth and anteroposterior patterning in the mouse. Development 129:3563-3574.
24. Rühl R, Fritzsche B, Vermot J, Niederreither K, Neumann U, Fritzemeier K, Schweigert FJ, Dollé P. 2006. Regulation of expression of the retinoic acid synthesizing enzymes retinaldehyde dehydrogenases in uteri of ovariectomized mice after treatment with estrogen, gestagen and their combination. Reprod Fertil Dev (in press).
25. Stanley EG, Biben C, Elefanty A, Barnett L, Koentgen F, Robb L, Harvey RP. 2002. Efficient Cre-mediated deletion in cardiac progenitor cells conferred by a 3′UTR-ires-Cre allele of the homeobox gene Nkx2-5. Int J Dev Biol 46:431-439.
26. Vermot J, Fraulob V, Dollé P, Niederreither K. 2000. Expression of enzymes synthesizing (aldehyde dehydrogenase 1 and retinaldehyde dehydrogenase 2) and metabolizing (Cyp26) retinoic acid in the mouse female reproductive system. Endocrinology 141:3638-3645.
27. Vermot J, Niederreither K, Garnier JM, Chambon P, Dollé P. 2003. Decreased embryonic retinoic acid synthesis results in a DiGeorge syndrome phenotype in newborn mice. Proc Natl Acad Sci U S A 100:1763-1768.
28. Vermot J, Schuhbaur B, Le Mouellic H, McCaffery P, Gamier JM, Hentsch D, Brulet P, Niederreither K, Chambon P, Dollé P, Le Roux I. 2005. Retinaldehyde dehydrogenase 2 and Hoxc8 are required in the murine brachial spinal cord for the specification of Lim1+ motoneurons and the correct distribution of Islet1+ motoneurons. Development 132:1611-1621.
29. Vitelli F, Baldini A. 2003. Generating and modifying DiGeorge syndrome-like phenotypes in model organisms: is there a common genetic pathway? Trends Genet 19:588-593.
30. Wilson JG, Roth CB, Warkany J. 1953. An analysis of the syndrome of malformations induced by maternal vitamin A deficiency. Effects of restoration of vitamin A at various times during gestation. Am J Anat 92:189-217.
31. Zhai Y, Sperkova Z, Napoli JL. 2001. Cellular expression of retinal dehydrogenase types 1 and 2: effects of vitamin A status on testis mRNA. J Cell Physiol 186:220-232.