Comparative analysis of growth-phase-dependent gene expression in virulent and avirulent Streptococcus pneumoniae using a high-density DNA microarray

Molecules and Cells

Volumn 21, Issue 1, 2006, Pages 82-88

  Ko, Kwan Soo ^a,b   Park, Sulhee ^a   Oh, Won Sup ^b   Suh, Ji Yoeun ^a   Oh, Tae Jeong ^c   Ahn, Sungwhan ^c   Chun, Jongsik ^d   Song, Jae Hoon ^a,b  

^a Asia Pacific Foundation for Infectious Diseases (APFID)   (South Korea)

^b Sungkyunkwan University School of Medicine   (South Korea)

^c Genomictree Inc   (South Korea)

^d Seoul National University   (South Korea)

Author keywords

Gene expression; Log stat switch; Microarray; Pneumococci; Time course analysis; Virulence

Indexed keywords

BACTERIAL DNA; BACTERIAL POLYSACCHARIDE; BACTERIAL RNA;

ANALYSIS OF VARIANCE; ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM COMPETENCE; DNA MICROARRAY; GENE EXPRESSION REGULATION; GROWTH CURVE; NONHUMAN; RNA ANALYSIS; STRAIN DIFFERENCE; STREPTOCOCCUS PNEUMONIAE; TIME SERIES ANALYSIS; TRANSCRIPTION REGULATION; COMPARATIVE STUDY; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; GENETICS; GROWTH, DEVELOPMENT AND AGING; PATHOGENICITY; TIME; VIRULENCE;

BACTERIA (MICROORGANISMS); STREPTOCOCCUS PNEUMONIAE;

GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, BACTERIAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; STREPTOCOCCUS PNEUMONIAE; TIME FACTORS; TRANSCRIPTION, GENETIC; VIRULENCE;

EID: 33645744892     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Berry, A. M. and Paton, J. C. (2000) Additive attenuation of virulence of Streptococcus pneumoniae by mutation of the genes encoding pneumolysin and other putative virulence proteins. Infect. Immun. 68, 133-140.
2. Conway, T. and Scnoolnik G. K. (2003) Microarray expression profiling: capturing a genome-wide portrait of the transcriptome. Mol. Microbiol. 47, 879-889.
3. De Saizieu, A., Gardes, C., Flint, N., Wagner, C., Kamber, M., et al. (2000) Microarray-based identification of a novel Streptococcus pneumoniae regulon controlled by an autoinduced peptide. J. Bacteriol. 182, 4696-4703.
4. Dietrich, G., Kurz. S., Hubner, C., Aepinus, C., Theiss, S., et al. (2003) Transcriptome analysis of Neisseria meningitidis during infection. J. Bacteriol. 185, 155-164.
5. Eriksson, S., Lucchini, S., Thompson, A., Rhen, M., and Hinton, J. C. D. (2003) Unravelling the biology of macrophage infection by gene expression profiling of intracellular Salmonella enterica. Mol. Microbiol. 47, 103-118.
6. Hakenbeck, R., Balmelle, N., Weber, B., Gardes, C., Keck, W., et al. (2001) Mosaic genes and mosaic chromosome: intra- and interspecies genomic variation of Streptococcus pneumoniae. Infect. Immun. 69, 2477-2486.
7. Hava, D. L. and Camilli, A. (2002) Large-scale identification of serotype 4 Streptococcus pneumoniae virulence factors. Mol. Microbiol. 45, 1289-1405.
8. Hava, D. L., LeMieux, J., and Camilli, A. (2003) From nose to lung: the regulation behind Streptococcus pneumoniae virulence factors. Mol. Microbiol. 50, 1103-1110.
9. Hoskins, J., Alborn Jr., W. E., Arnold, J., Blaszczak, L. C., Burgett, S., et al. (2001) Genome of the bacterium Streptococcus pneumoniae strain R6. J. Bacteriol. 183, 5709-5717.
10. Joyce, E. A., Kawale, A., Censini, S., Kim, C. C., Covacci, A., et al. (2004) LuxS is required for persistent pneumococcal carriage and expression of virulence and biosynthesis genes. Infect. Immun. 72, 2964-2975.
11. Kim, J. O. and Weiser, J. N. (1998) Association of intrastrain phase variation in quantity of capsular polysaccharide and teichoic acid with the virulence of Streptococcus pneumoniae. J. Infect. Dis. 177, 368-377.
12. Lau, G. W., Haataja, S., Lonetto, M., Kensit, S. E., Marra, A., et al. (2001) A functional genomic analysis of type 3 Streptococcus pneumoniae virulence. Mol. Microbiol. 40, 555-571.
13. Lee, H., Hur, C. G., Oh, C. J., Kim, H. B., Park, S. Y., et al. (2004) Analysis of the root nodule-enhanced transcriptome in soybean. Mol. Cells 18, 53-62.
14. Liang, F. T., Nelson, F. K., and Fikrig, E. (2002) Molecular adaptation of Borrelia burgdoferi in the murine host. J. Exp. Med. 196, 275-280.
15. Merrell, D. S., Thompson, L. J., Kim, C. C., Mitchell, H., Tompkin, L. S., et al. (2003) Growth phase-dependent response of Helicobacter pylori to iron starvation. Infect. Immun. 71, 6510-6525.
16. Ogunniyi, A. D., Giammarinaro, P., and Paton, J. C. (2002) The genes encoding virulence-associated proteins and the capsule of Streptococcus pneumoniae are upregulated and differentially expressed in vivo. Microbiology 148, 2045-2053.
17. Orihuela, C. J., Radin, J. N., Sublett, J. E., Gao, G., Kaushal, D., et al. (2004a) Microarray analysis of pneumococcal gene expression during invasive disease. Infect. Immun. 72, 5582-5596.
18. Orihuela, C. J., Gao, G., Francis, K. P., Yu, J., and Tuomanen, E. I. (2004b) Tissue-specific contributions of pneumococcal virulence factors to pathogenesis. J. Infect. Dis. 190, 1661-1669.
19. Paton, J. C. (1998) Novel pneumococcal surface proteins: role in virulence and vaccine potential. Trends Microbiol. 6, 85-87.
20. Paustian, M. L., May, B. J., and Kapur, V. (2001) Pasterella multocida gene expression in response to iron limitation. Infect. Immun. 69, 4109-4115.
21. Peterson, S. N., Sung, C. K., Cline, R., Desai, B. V., Snesrud, E., C., et al. (2004) Identification of competence pheromone responsive genes in Streptococcus pneumoniae by use of DNA microarrays. Mol. Microbiol. 52, 1051-1070.
22. Polisi, A., Pontiggia, A., Feger, G., Altieri, M., Mottl, H., et al. (1998) Large-scale identification of virulence genes from Streptococcus pneumoniae. Infect. Immun. 66, 5620-5629.
23. Rimini, R., Jansson, B., Feger, G., Roberts, T. C., de Francesco, M., et al. (2000) Global analysis of transcription kinetic during competence development in Streptococcus pneumoniae using high density DNA arrays. Mol. Microbiol. 36, 1279-1292.
24. Ring, A. and Tuomanen, E. (2000) Host cell invasion by Streptococcus pneumoniae. Subcell. Biochem. 33, 125-135.
25. Robertson, G. T., Ng, W. L., Foley, J., Gilmour, R., and Winkler, M. E. (2002) Global trancriptional analysis of clpP mutations of type2 Streptococcus pneumoniae and their effects on physiology and virulence. J. Bacteriol. 184, 3508-3520.
26. Rosenow, C., Ryan, P., Weiser, J. N., Johnson, S., Fontan, P., et al. (1997) Contribution of novel choline-binding proteins to adherence, colonization and immunogenicity of Streptococcus pneumoniae. Mol. Microbiol. 25, 819-829.
27. Schneider, W. P., Ho, S. K., Christine, J., Yao, M., Marra, A., et al. (2002) Virulence gene identification by differential fluorescence induction analysis of Staphylococcus aureus gene expression during infection-simulating culture. Infect. Immun. 70, 1326-1333.
28. Song, J. H., Ko, K. S., Lee, J. Y., Baek, J. Y., Oh, W. S., et al. (2005) Identification of essential genes in Streptococcus pneumoniae by allelic replacement mutagenesis. Mol. Cells 19, 365-374.
29. Tani, T. H., Khodursky, A., Blumenthal, R. M., Brwon, P. O., and Matthews R. G. (2002) Adaptation to famine: a family of stationary-phase genes revealed by microarray analysis. Proc. Natl. Acad. Sci. USA 99, 13471-13476.
30. Tatusov, R. L., Koonin, E. V., and Lipman, D. J. (1997) A genomic perspective on protein families. Science 278, 631-637.
31. Tettelin, H., Nelson, K. E., Paulsen, I. T., Eisen, J. A., Read, T. D., et al. (2001) Complete genome sequence of a virulent isolate of Streptococcus pneumoniae. Science 293, 498-506.
32. Thompson, L. J., Merrell, D. S., Neilan, B. A., Mitchell, H., Lee, A., et al. (2003) Gene expression profiling of Helicobacter pylori reveals a growth-phase-dependent switch in virulence gene expression. Infect. Immun. 71, 2643-2655.
33. Tuomanen, E. I., Austrian, R., and Masure, A. R. (1995) Pathogenesis of pneumococcal infection. N. Engl. J. Med. 332, 1280-1284.
34. Yother, J. and Briles, D. E. (1992) Structural properties and evolutionary relationships of PspA, a surface protein of Streptococcus pneumoniae, as revealed by sequence analysis. J. Bacteriol. 174, 601-609.