p16, retinoblastoma (pRb), and cyclin D1 protein expression in human endometriotic and adenomyotic lesions

Fertility and Sterility

Volumn 85, Issue SUPPL. 1, 2006, Pages 1204-1207

  Goumenou, Anastasia G ^a   Matalliotakis, Ioannis M ^a,b   Tzardi, Maria ^c   Fragouli, Ivoni G ^d   Mahutte, Neal G ^e   Arici, Aydin ^b  

^a UNIVERSITY HOSPITAL OF HERAKLION   (Greece)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CRETE   (Greece)

^d UNIVERSITY OF ATHENS   (Greece)

^e DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

cyclin D1; Endometriosis, adenomyosis; immunohistochemistry; p16; retinoblastoma (pRb)

Indexed keywords

CYCLIN D1; FORMALDEHYDE; ONCOPROTEIN; PARAFFIN; PROTEIN P16; RETINOBLASTOMA PROTEIN;

ADENOMYOSIS; ADULT; ARTICLE; CONTROLLED STUDY; ENDOMETRIUM TUMOR; EVALUATION; FEMALE; GYNECOLOGIC SURGERY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MENSTRUAL CYCLE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; TISSUE SLICE; UNIVERSITY HOSPITAL;

ADENOVIRUS E1A PROTEINS; ADULT; CELL NUCLEUS; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P16; ENDOMETRIOSIS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MIDDLE AGED; NUCLEAR PROTEINS; REPRESSOR PROTEINS; TISSUE DISTRIBUTION;

EID: 33645737066     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2005.11.032     Document Type: Article

References (24)

1. Matalliotakis I.M., Kourtis A.I., and Panidis D.K. Adenomyosis. Obstet Gynecol Clin North Am 30 (2003) 63-82
2. Ferenczy A. Pathophysiology of adenomyosis. Hum Reprod Update 4 (1998) 312-322
3. Varma R., Rollason T., Gupta J.K., and Maher E.R. Endometriosis and the neoplastic process. Reproduction 127 (2004) 293-304
4. Lukas J., Parry D., Aagaard L., Mann D.J., Bartkova J., Strauss M., et al. Retinoblastoma-protein-dependent cell-cycle inhibition by the tumor suppressor p16. Nature 375 (1995) 503-506
5. Shiozawa T., Nikaido T., Shimizu M., Zhai Y., and Fujii S. Immunohistochemical analysis of the expression of CDK4 and p16INK4 in human endometrioid-type endometrial carcinoma. Cancer 80 (1997) 2250-2256
6. Nakashima R., Fujita M., Enomoto T., Haba T., Yoshino K., Wada H., et al. Alteration of p16 and p15 genes in human uterine tumours. Br J Cancer 80 (1999) 458-467
7. Milde-Langosch K., Bamberger A.M., Goemann C., Rossing E., Rieck G., Kelp B., et al. Expression of cell-cycle regulatory proteins in endometrial carcinomas. correlations with hormone receptor status and clinicopathologic parameters. J Cancer Res Clin Oncol 127 (2001) 537-544
8. Tsuda H., Yamamoto K., Inuoe T., Uchiyama I., and Umesaki N. The role of p16-cyclin D/CDK-pRb pathway in the tumorigenesis of endometrioid-type endometrial carcinoma. Br J Cancer 82 (2000) 675-682
9. American Fertility Society. Revised American Fertility Society Classification of Endometriosis. Fertil Steril 43 (1985) 351-355
10. Robinson G., Ellis I.O., and MacLennan K.A. Immunocytochemistry. In: Bancroft J.D., and Stevens A. (Eds). Theory and practice of histological techniques. 3rd ed (1990), Churchill Livingstone, Edinburgh-London 413-436
11. Weinberg R.A. The retinoblastoma protein and cell cycle control. Cell 81 (1995) 323-330
12. Serrano M., Hannon G.J., and Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 366 (1993) 704-707
13. Serrano M., Gomez-Lahoz E., DePinho R.A., Beach D., and Bar-Sagi D. Inhibition of ras-induced proliferation and cellular transformation by p16INK4. Science 267 (1995) 249-252
14. Sherr C.J. Principles of tumor suppression. Cell 116 (2004) 235-246
15. Nielsen G.P., Stemmer-Rachamimov A.O., Shaw J., Roy J.E., Koh j., and Louis D.N. Immunohistochemical surveys of p16INK4A expression in normal human adult and infant tissues. Lab Invest 79 (1999) 1137-1143
16. Semczuk A., and Jakowicki J.A. Alterations of pRb1-cyclin D1-CDK4/6-p16INK4A pathway in endometrial carcinogenesis. Cancer Lett 203 (2004) 1-12
17. Milde-Langosch K., and Riethdorf S. Role of cell-cycle regulatory proteins in gynecological cancer. J Cell Physiol 196 (2003) 224-244
18. Bukovsky A., Caudle M.R., Keenan J.A., Wimalasena J., Foster J.S., Upadhy N.B., and van Meter S.E. Expression of cell cycle regulatory proteins (p53, pRb) in the human female genital tract. J Assist Reprod Genet 12 (1995) 123-131
19. Milde-Langosch K., Riethdorf L., Bamberger A.M., and Loning T. p16/MTS1 and pRB expression in endometrial carcinomas. Virchows Arch 434 (1999) 23-28
20. Bodner-Adler B., Bodner K., Czerwenka K., Kimberger O., Leodolter S., and Mayerhofer K. Expression of p16 protein in patients with uterine smooth muscle tumors. an immunohistochemical analysis. Gynecol Oncol 96 (2005) 62-66
21. Van de Putte G., Holm R., Lie A.K., Trope C.G., and Kristensen G.B. Expression of p27, p21 and p16 protein in early squamous cervical cancer and its relation to prognosis. Gynecol Oncol 89 (2003) 140-147
22. Herman J.G., Merlo A., Mao L., Lapidus R.G., Issa J.-P.J., Davidson N.E., et al. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methlyation in all common human cancers. Cancer Res 55 (1995) 4525-4530
23. Matsumoto Y., Iwasaka T., Yamasaki F., and Sugimuri H. Apoptosis and Ki-67 expression in adenomyotic lesions and in the corresponding ectopic endometrium. Obstet Gynecol 94 (1999) 71-77
24. Jones R.K., Searly R.F., and Bulmer J.N. Apoptosis and Bcl-2 expression in normal human endometrium, endometriosis and adenomyosis. Hum Reprod 13 (1998) 3496-3502