Distinct binding of cholesterol and 5β-cholestane-3α,7α, 12α-triol to cytochrome P450 27A1: Evidence from modeling and site-directed mutagenesis studies

Biochemistry

Volumn 45, Issue 14, 2006, Pages 4396-4404

  Mast, Natalia ^a   Murtazina, Dilyara ^a   Liu, Hong ^a   Graham, Sandra E ^b   Bjorkhem, Ingemar ^c   Halpert, James R ^a   Peterson, Julian ^b   Pikuleva, Irina A ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; ENZYME KINETICS; HYDROXYLATION; MATHEMATICAL MODELS; MUTAGENESIS; VITAMINS;

CEREBROTENDINOUS XANTHOMATOSIS; CYTOCHROME P450 27A1 ENZYME; REGIOSELECTIVE HYDROXYLATION;

CHOLESTEROL;

5BETA CHOLESTANE 3ALPHA,7ALPHA,12ALPHA TRIOL; CHOLESTEROL; COLECALCIFEROL; CYTOCHROME P450; CYTOCHROME P450 27A1; STEROID; UNCLASSIFIED DRUG;

ARTICLE; CEREBROTENDINOUS XANTHOMATOSIS; COMPUTER MODEL; CYTOCHROME P450 27A1 DEFICIENCY; DISEASE ASSOCIATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME DEFICIENCY; HYDROXYLATION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; BINDING SITES; CHOLESTANOLS; CHOLESTEROL; COMPUTER SIMULATION; CYTOCHROME P-450 CYP27A1; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; SEQUENCE ALIGNMENT; STEROID HYDROXYLASES;

EID: 33645686660     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi052654w     Document Type: Article

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