Aberrant stalk development and breakdown of tip dominance in Dictyostelium cell lines with RNAi-silenced expression of calcineurin B

BMC Developmental Biology

Volumn 6, Issue , 2006, Pages

  Boeckeler, Katrina ^a,b   Tischendorf, Gilbert ^a   Mutzel, Rupert ^a   Weissenmayer, Barbara ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CALCINEURIN B; PROTEIN SUBUNIT; REGULATOR PROTEIN; UNCLASSIFIED DRUG; CALCINEURIN INHIBITOR; PROTOZOAL PROTEIN;

ARTICLE; CELL DIFFERENTIATION; CELL LINE; CELL VACUOLE; CHIMERA; CONTROLLED STUDY; CORRELATION ANALYSIS; DEVELOPMENTAL DISORDER; DICTYOSTELIUM; GENE EXPRESSION; GENE SILENCING; NONHUMAN; PARASITE DEVELOPMENT; PROTOZOAN SPORE; RNA INTERFERENCE; WILD TYPE; ANIMAL; ANTAGONISTS AND INHIBITORS; CYTOLOGY; DOWN REGULATION; ENZYMOLOGY; GENETICS; GROWTH, DEVELOPMENT AND AGING; MUTATION; PHYSIOLOGY; TRANSGENE; ULTRASTRUCTURE;

DICTYOSTELIUM; DICTYOSTELIUM DISCOIDEUM; EUKARYOTA; PROTOZOA;

ANIMALS; CALCINEURIN; CALCINEURIN INHIBITORS; CELL LINE; DICTYOSTELIUM; DOWN-REGULATION; MUTATION; PROTOZOAN PROTEINS; RNA INTERFERENCE; SPORES, PROTOZOAN; TRANSGENES;

EID: 33645582003     PISSN: 1471213X     EISSN: 1471213X     Source Type: Journal    
DOI: 10.1186/1471-213X-6-12     Document Type: Article

References (37)

1. Hogan PG, Chen L, Nardone J, Rao A: Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev 2003, 17:2205-2232.
2. Crabtree GR: Calcium, calcineurin, and the control of transcription. J Biol Chem 2001, 276:2313-2316.
3. Rusnak F, Mertz P: Calcineurin: form and function. Physiol Rev 2000, 80:1483-1521.
4. Aichem A, Mutzel R: Unconventional mRNA processing in the expression of two calcineurin B isoforms in Dictyostelium. J Mol Biol 2001, 308:873-882.
5. Dammann H, Hellstern S, Husain Q, Mutzel R: Primary structure, expression and developmental regulation of a Dictyostelium calcineurin A homologue. Eur J Biochem 1996, 238:391-399.
6. Weissenmayer B, Boeckeler K, Lahrz A, Mutzel R: The calcineurin inhibitor gossypol impairs growth, cell signalling and development in Dictyostelium discoideum. FEMS Microbiol Lett 2005, 242:19-25.
7. Moniakis J, Coukell MB, Janiec A: Involvement of the Ca2+-ATPase PAT1 and the contractile vacuole in calcium regulation in Dictyostelium discoideum. J Cell Sci 1999, 112:405-414.
8. Coukell B, Li Y, Moniakis J, Cameron A: The Ca2+/calcineurin-regulated cup gene family in Dictyostelium discoideum and its possible involvement in development. Eukaryot Cell 2004, 3:61-71.
9. Horn F, Gross J: A role for calcineurin in Dictyostelium discoideum development. Differentiation 1996, 60:269-275.
10. Azhar M, Kennady PK, Pande G, Espiritu M, Holloman W, Brazill D, Gomer RH, Nanjundiah V: Cell cycle phase, cellular Ca2+ and development in Dictyostelium discoideum. Int J Dev Biol 2001, 45:405-414.
11. Schlatterer C, Walther P, Muller M, Mendgen K, Zierold K, Knoll G: Calcium stores in differentiated Dictyostelium discoideum: prespore cells sequester calcium more efficiently than pre-stalk cells. Cell Calcium 2001, 29:171-182.
12. Schaap P, Nebl T, Fisher PR: A slow sustained increase in cytosolic Ca2+ levels mediates stalk gene induction by differentiation inducing factor in Dictyostelium. EMBO J 1996, 15:5177-5183.
13. Martens H, Novotny J, Oberstrass J, Steck TL, Postlethwait P, Nellen W: RNAi in Dictyostelium: the role of RNA-directed RNA polymerases and double-stranded RNase. Mol Biol Cell 2002, 13:445-453.
14. Hannon GJ: RNA interference. Nature 2002, 418:244-251.
15. Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC: Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998, 391:806-811.
16. Eichinger L, Pachebat JA, Glockner G, Rajandream MA, Sucgang R, Berriman M, Song J, Olsen R, Szafranski K, Xu Q, Tunggal B, Kummerfeld S, Madera M, Konfortov BA, Rivero F, Bankier AT, Lehmann R, Hamlin N, Davies R, Gaudet P, Fey P, Pilcher K, Chen G, Saunders D, Sodergren E, Davis P, Kerhornou A, Nie X, Hall N, Anjard C, Hemphill L, Bason N, Farbrother P, Desany B, Just E, Morio T, Rost R, Churcher C, Cooper J, Haydock S, vanDriessche N, Cronin A, Goodhead I, Muzny D, Mourier T, Pain A, Lu M, Harper D, Lindsay R, al : The genome of the social amoeba Dictyostelium discoideum. Nature 2005, 435:43-57.
17. Kessin RH: Dictyostelium - Evolution, cell biology, and the development of multicellularity. Cambridge, UK, Cambridge Univ. Press; 2001:xiv + 294.
18. Harwood AJ, Plyte SE, Woodgett J, Strutt H, Kay RR: Glycogen synthase kinase 3 regulates cell fate in Dictyostelium. Cell 1995, 80:139-148.
19. Chisholm RL, Firtel RA: Insights into morphogenesis from a simple developmental system. Nat Rev Mol Cell Biol 2004, 5:531-541.
20. Ginsburg GT, Kimmel AR: Autonomous and nonautonomous regulation of axis formation by antagonistic signaling via 7-span cAMP receptors and GSK3 in Dictyostelium. Genes Devel 1997, 11:2112-2123.
21. Kim L, Harwood A, Kimmel AR: Receptor-dependent and tyrosine phosphatase-mediated inhibition of GSK3 regulates cell fate choice. Dev Cell 2002, 3:523-532.
22. Neal JW, Clipstone NA: Glycogen Synthase Kinase-3 Inhibits the DNA Binding Activity of NFATc. J Biol Chem 2001, 276:3666-3673.
23. Diehn M, Alizadeh AA, Rando OJ, Liu CL, Stankunas K, Botstein D, Crabtree GR, Brown PO: Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation. Proc Natl Acad Sci U S A 2002, 99:11796-11801.
24. Coates JC, Grimson MJ, Williams RS, Bergman W, Blanton RL, Harwood AJ: Loss of the beta-catenin homologue aardvark causes ectopic stalk formation in Dictyostelium. Mech Dev 2002, 116:117-127.
25. Grimson MJ, Coates JC, Reynolds JP, Shipman M, Blanton RL, Harwood AJ: Adherens junctions and beta-catenin-mediated cell signalling in a non-metazoan organism. Nature 2000, 408:727-731.
26. Saneyoshi T, Kume S, Amasaki Y, Mikoshiba K: The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos. Nature 2002, 417:295-299.
27. Huelsken J, Behrens J: The Wnt signalling pathway. J Cell Sci 2002, 115:3977-3978.
28. Albrecht V, Weinl S, Blazevic D, D'Angelo C, Batistic O, Kolukisaoglu U, Bock R, Schulz B, Harter K, Kudla J: The calcium sensor CBL1 integrates plant responses to abiotic stresses. Plant J 2003, 36:457-470.
29. Jeromin A, Muralidhar D, Parameswaran MN, Roder J, Fairwell T, Scarlata S, Dowal L, Mustafi SM, Chary KV, Sharma Y: N-terminal myristoylation regulates calcium-induced conformational changes in neuronal calcium sensor-1. J Biol Chem 2004, 279:27158-27167.
30. Watts DJ, Ashworth JM: Growth of myxamoebae of the cellular slime mould Dictyostelium discoideum in axenic culture. Biochem J 1970, 119:171-174.
31. Schlatterer C, Knoll G, Malchow D: Intracellular calcium during chemotaxis of Dictyostelium discoideum - a new fura-2 derivative avoids sequestration of the indicator and allows long-term calcium measurements. Eur J Cell Biol 1992, 58:172-181.
32. Pang KM, Lynes MA, Knecht DA: Variables controlling the expression level of exogenous genes in Dictyostelium. Plasmid 1999, 41:187-197.
33. Yanisch-Perron C, Vieira J, Messing J: Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. Gene 1985, 33:103-119.
34. Witke W, Nellen W, Noegel A: Homologous recombination in the Dictyostelium alpha-actinin gene leads to an altered mRNA and lack of the protein. EMBO J 1987, 6:4143-4148.
35. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685.
36. Spurr AR: A low-viscosity epoxy resin embedding medium for electron microscopy. J Ultrastruct Res 1969, 26:31-43.
37. Richardson KC, Jarett L, Finke EH: Embedding in epoxy resins for ultrathin sectioning in electron microscopy. Stain Technol 1960, 35:313-323.