Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat

Liver Transplantation

Volumn 12, Issue 4, 2006, Pages 550-559

  Lehmann, Thorsten G ^a   Luedde, Tom ^b   Schwabe, Robert F ^c   Bunzendahl, Hartwig ^a   Samulski, R Jude ^a   Lemasters, John J ^b   Brenner, David A ^c  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BETA GALACTOSIDASE; BILIRUBIN; CYCLIN D1; OXYGEN RADICAL; PROTEIN P21; SUPEROXIDE DISMUTASE;

ADENOVIRUS VECTOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME RELEASE; FEMALE; GENE OVEREXPRESSION; GENE THERAPY; GRAFT SURVIVAL; HISTOPATHOLOGY; HYPOTHESIS; LIVER INJURY; LIVER NECROSIS; LIVER REGENERATION; LIVER SIZE; LIVER TRANSPLANTATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SURGICAL TECHNIQUE; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; ANIMALS; BETA-GALACTOSIDASE; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; GENETIC VECTORS; LIVER REGENERATION; LIVER TRANSPLANTATION; MODELS, ANIMAL; ORGAN SIZE; OXIDATIVE STRESS; PORTAL SYSTEM; RATS; SUPEROXIDE DISMUTASE; TRANSFECTION; TREATMENT OUTCOME;

EID: 33645554179     PISSN: 15276465     EISSN: 15276473     Source Type: Journal    
DOI: 10.1002/lt.20632     Document Type: Article

References (52)

1. Wight C, Cohen B. Shortage of organs for transplantation [editorial]. Br Med J 1996;312:989-990.
2. Broelsch CE, Emond JC, Thistlethwaite JR, Rouch DA, Whitington PF, Lichtor JL. Liver transplantation with reduced-size donor organs. Transplantation 1988;45:519-524.
3. Emond JC, Whitington PF, Thistlethwaite JR, Cherqui D, Alonso EA, Woodle IS, et al. Transplantation of two patients with one liver. Analysis of a preliminary experience with "split-liver" grafting. Ann Surg 1990;212:14-22.
4. Rogiers X, Malago M, Gawad K, Jauch KW, Olausson M, Knoefel WT, et al. In situ splitting of cadaveric livers: the ultimate expansion of a limited donor pool. Ann Surg 1996;224:331-339.
5. Marcos A. Fisher RA, Ham JM, Olzinski AT, Shifiman ML, Sanyal AJ, et al. Selection and outcome of living donors for adult to adult right lobe transplantation. Transplantation 2000;69:2410-2415.
6. Sugawara Y, Makuuchi M. Technical advances in living-related liver transplantation. J Hepatobiliary Pancreat Surg 1999;6:245-253.
7. Beavers KL, Sandler RS. Fair JH, Johnson MW, Shrestha R. The living donor experience: donor health assessment and outcomes after living donor liver transplantation. Liver Transpl 2001;7:943-947.
8. Renz JF, Busuttil RW. Adult-to-adult living-donor liver transplantation: a critical analysis. Semin Liver Dis 2000; 20:411-424.
9. Lemasters JJ, Thurman RG. Reperfusion injury after liver preservation for transplantation. Annu Rev Pharmacol Toxicol 1997;37:327-338.
10. Connor HD, Gao W, Nukina S, Lemasters JJ, Mason RP, Thurman RG. Evidence that free radicals are involved in graft failure following orthotopic liver transplantation in the rat: an electron paramagnetic resonance spin trapping study. Transplantation 1992;54:199-204.
11. Lemasters JJ, Caldwell-Kenkel JC, Currin RT, Tanaka Y, Thurman RG. Activation of Kupffer cells following reperfusion of rat liver stored in Euro-Collins solution. Hepatology 1988;18:8.
12. McCord JM, Fridovich I. The reduction of cytochrome C by milk xanthine oxidase. J Biol Chem 1968;243:5753-5760.
13. Mizoe A, Kondo S, Azuma T, Fujioka H, Tanaka K, Hashida M, et al. Preventive effects of superoxide dismutase derivatives modified with monosaccharides on reperfusion injury in rat liver transplantation. J Surg Res 1997;73:160-165.
14. Prince HM. Gene transfer: a review of methods and applications. Pathology 1998;30:335-347.
15. Jaffe HA, Danel C, Longenecher G, Metzger M, Setoguchi Y, Rosenfeld MA, et al. Adenovirus-mediated in vivo gene transfer and expression in normal rat liver. Nat Genet 1992;1:372-378.
16. Bilbao G, Contreras JL, Gomez-Navarro J, Eckhoff DE, Mikheeva G, Krasnykh V, et al. Genetic modification of liver grafts with an adenoviral vector encoding the BCL-2 gene improves organ preservation. Transplantation 1999; 67:775-783.
17. Lehmann TG, Wheeler MD. Schoonhoven P, Bunzendahl H, Samulski RJ, Thurman RG. Delivery of Cu/Zn-super-oxide dismutase genes with a viral vector minimizes liver injury and improves survival after liver transplantation in the rat. Transplantation 2000;69:1051-1057.
18. Lehmann TG, Wheeler MD, Schwabe RF, Connor HD, Schoonhoven R, Bunzendahl H, et al. Gene delivery of Cu/Zn-superoxide dismutase improves graft function after transplantation of fatty livers in the rat. Hepatology 2000;32:1255-1264.
19. Lehmann TG, Wheeler MD, Froh M, Schwabe RF, Bunzendahl H, Samulski RJ et al. Effects of three superoxide dismutase genes delivered with an adenovirus on grafts function after transplantationof fatty livers in the rat. Transplantation 2003;76:28-37.
20. Sugawara Y, Makuuchi M. Small-for-size graft problems in adult-to-adult living-donor liver transplantation. Transplantation 2003;75:S20-S22.
21. Rigby PW. Cloning vectors derived from animal viruses. J Gen Virol 1983;64:255-266.
22. Rosenfeld MA, Siegfried W, Yoshimura K, Yoneyama K, Fukayama M, Stier LE et aL Adenovirus-mediated transfer of a recombinant alpha 1-antitrypsin gene to the lung epithelium in vivo. Science 1991;252:431-434.
23. Zimmermann FA, Butcher GW, Davies HS, Brons G, Kamada N, Türel O. Techniques of orthotopic liver transplantation in the rat and some studies of the immunologic response to fully allogenic liver grafts. Transplant Proc 1979;1:571-577.
24. Gao W, Lemasters JJ, Thurman RG. Development of a new method for hepatic rearterialization in rat orthotopic liver transplantation: reduction of liver injury and improvement of surgical outcome by arterialization. Transplantation 1993;56:19-24.
25. Zhong Z, Qu W, Connor HD, Thurman RG. Inactivation of Kupffer cells minimizes reperfusion injury in fat-loaded livers from ethanol-treated rats. Transplant Proc 1995;27: 528-530.
26. McCord JM, Fridovich I. The utility of superoxide dismutase in studying free radical reactions. II. The mechanism of the mediation of cytochrome c reduction by a variety of electron carriers. J Biol Chem 1970:245:1374-1377.
27. Thurman RG, Marzi I, Seitz G, Thies J, Lemasters JJ, Zimmermann FA. Hepatic reperfusion injury following orthotopic liver transplantation in the rat. Transplantation 1988;46:502-506.
28. Bergmeyer HU. Methods of enzymatic analysis. New York: Academic Press, 1988.
29. Savier E, Lemasters JJ, Thurman RG. Kupfier cells participate in rejection following liver transplantation in the rat. Transpl Int 1994:7:S183-S186.
30. Iimuro Y, Nishiura T, Hellerbrand C, Behrns HE, Schoon-hoven R, Grisham. JW et al. NFkappaB prevents apoptosis and liver dysfunction during liver regeneration. J Clin Invest 1998:101:802-811.
31. Becker F. Restoration of liver mass following partial hepatectomy: "Surgical hepatrophy". Am J Pathol 1963:43: 497-507.
32. Ludde T, Kubicka S, Plumpe J, Liedtke C, Manns MP, Trautwein C. Ras adenoviruses modulate cyclin E protein expression and DNA synthesis after partial hepatectomy. Oncogene 2001;20:5264-5278.
33. Jaeschke H, Bautista AP, Spolarics Z, Spitzer JJ. Super-oxide generation by Kupffer cells and priming of neutrophils during reperfusion after hepatic ischemia. Free Rad Res Comms 1991:277-284.
34. Gores GJ, Flarsheirn CE, Dawson TL, Nieminen A-L, Herman B, Lemasters JJ. Swelling reductive stress and cell death during chemical hypoxia in hepatocytes. Am J Physiol 1989;257:C347-C354.
35. Manna SK, Zhang HJ, Yan T, Oberley LW, Aggarwal BB. Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappaB and activated protein-1. J Biol Chem 1998;273:13245-13254.
36. Diehl AM, Hock JB. Mitochondrial uncoupling: role of uncoupling protein anion carriers and relationship to thermogenesis and weight control "the benefits of losing control". J Bioenerg Biomembr 1999;31:493-506.
37. Lee FY, Li Y, Zhu H, Yang S, Lin HZ, Trush M, et al. Tumor necrosis factor increases mitochondrial oxidant production and induces expression of uncoupling protein-2 in the regenerating mice [correction of rat] liver. Hepatology 1999:29: 677-687.
38. Imberti R, Nieminen A, Herman B, Lemasters JJ. Mitochondrial and glycolytic disfunction in lethal injury to hepatocytes by t-Buthylhydroperoidde: protection by fructose, cyclosporin A and trifluoperazine. The Journal of Pharmacological and Experimental Therapeutics 1993:265:392-400.
39. Breen AP, Murphy JA. Reactions of oxyl radicals with DNA. Free Radic Biol Med 1995; 18:1033-1077.
40. Jaeschke H, Farhood A. Smith CW. Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo. FASEB J 1990;4:3355-3359.
41. Oberley LW, Buettner GR. Role of superoxide dismutase in cancer: a review. Cancer Res 1979;39:1141-1149.
42. Bolitho G, Engelbrecht G, Lotz Z, Tyler M. McLeod H, Jaskiewicz K, et al. Liver regeneration after hepatic ischemia and reduced liver autotransplantation in the rat. Hepatology 1993; 17:273-279.
43. Foschi D, Castoldi L, Lesma A, Musazzi M, Benevento A, Trabuccht E. Effects of ischernia and reperfusion injury on liver regeneration in rats. Eur J Surg 1993; 159:393-398.
44. Selzner N. Selzner M, Tian Y, Kadry Z, Clavien P-A. Cold ischemia decreases liver regeneration after partial liver transplantation in the rat: a TNF-alpha/IL-6-dependent mechanism. Hepatology 2002;36:812-818.
45. Fredericks WM, Marx F, Chamuleau RA, van Noorden CJ, James J. Immunocytochemical determination of ploidy class-dependent bromodeoxyuridine incorporation in rat liver parenchymal cells after partial hepatectomy. Histochemistry 1990,93:627-630.
46. Michalopoulos GK, DeFrances MC. Liver regeneration. Science 1997;276:60-66.
47. Nelsen CJ, Rickheim DG, Timchenko NA, Stanley MW, Albrecht JH. Transient expression of cychn D1 is sufficient to promote hepatocyte replication and liver growth in vivo. Cancer Res 2004;61:8564-8568.
48. Schwabe RF, Bradham CA, Uehara T, Hatano, E, Bennett BL, Schoonhoven R et al. c-Jun-N-terminal kinase drives cychn D1 expression and proliferation during liver regeneration. Hepatology 2003:37:824-832.
49. Morgan DO. Principles of CDK regulation. Nature 1995; 374:131-134.
50. Rickheim DG, Nelsen CJ, Fassett JT, Timchenko NA, Hansen LK, Albrecht JH. Differential regulation of cyclins D1 and D3 in hepatocyte proliferation. Hepatology 2002;36: 30-38.
51. Renz JF, Roberts JP. Long-term complications of living donor liver transplantation. Liver Transpl 2000;6:S73-S76.
52. Marshall E. Gene therapy death prompts review of adenovirus vector [news]. Science 1999;286:2244-2245.