Hodgkin lymphoma, multiple myeloma, soft tissue sarcomas, insect repellents, and phenoxyherbicides

Journal of Occupational and Environmental Medicine

Volumn 48, Issue 3, 2006, Pages 264-274

  Pahwa, Punam ^a   McDuffie, Helen H ^a,f   Dosman, James A ^a   McLaughlin, John R ^b   Spinelli, John J ^c   Robson, Diane ^d   Fincham, Shirley ^e  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

^c BRITISH COLUMBIA CANCER AGENCY   (Canada)

^d SASKATCHEWAN CANCER AGENCY   (Canada)

^e Division of Epidemiology Prevention and Screening   (Canada)

^f ROYAL UNIVERSITY HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DIETHYLTOLUAMIDE; HERBICIDE; INSECT REPELLENT; PHENOXY HERBICIDE; RUBBER; UNCLASSIFIED DRUG;

ARTICLE; CANCER RISK; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; GLOVE; HODGKIN DISEASE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE MYELOMA; POPULATION RESEARCH; PROTECTIVE CLOTHING; SOFT TISSUE SARCOMA; SUNLIGHT;

2,4-DICHLOROPHENOXYACETIC ACID; 2-METHYL-4-CHLOROPHENOXYACETIC ACID; ADULT; AGRICULTURAL WORKERS' DISEASES; CANADA; CASE-CONTROL STUDIES; DEET; DICAMBA; GLOVES, PROTECTIVE; HERBICIDES; HODGKIN DISEASE; HUMANS; INSECT REPELLENTS; MALE; MASKS; MULTIPLE MYELOMA; OCCUPATIONAL EXPOSURE; PROTECTIVE CLOTHING; RISK FACTORS; RUBBER; SARCOMA; SUNLIGHT;

INSECTA;

EID: 33645537420     PISSN: 10762752     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.jom.0000183539.20100.06     Document Type: Article

References (85)

1. Sudakin DL, Trevathan WR. DEET: a review and update of safety and risk in the general population. J Toxicol. 2003;41:831-839.
2. Fradin MS, Day JF. Comparative efficacy of insect repellents against mosquito bites. N Engl J Med. 2002;347:13-18.
3. McGready R, Hamilton KA, Simpson JA, et al. Safety of the insect repellent N, N-diethyl-M-toluamide (DEET) in pregnancy. Am J Trop Med Hyg. 2001;65:285-289.
4. Robbins PJ, Cherniack MG. Review of the codistribution and toxicity of the insect repellent N, N-diethyl-m-toluamide (DEET). J Toxicol Environ Health. 1986;18:503-525.
5. Health Canada Pest Management Regulatory Agency. Personal insect repellents containing DEET (N-N-diethyl-m-toluamide and related compounds). Re-evaluation decision document RRD2002-01, 2002:1-40.
6. Harvard Health Letter. DEET is hard to beat. Harvard Medical School, 2003;28(9):1-3.
7. Nentwig G. Use of repellents as prophylactic agents. Parasitol Res. 2003;90:S40-S48.
8. Artsob H. Arthropod-borne disease in Canada: a clinician's perspective from the 'cold zone.' Paediatr Child Health. 2000;5:206-213.
9. Abou-Donia MB, Wilmarth KR, Abdel-Rahman AA, Jensen KF, Oehme FW, Kurt TL. Increased neurotoxicity following concurrent exposure to pyridostgmine bromide, DEET, and chlorpyrifos. Fundamental Appl Toxicol. 1996;34:201-222A.
10. Abou-Donia MB, Wilmarth KR. Neurotoxicity resulting from coexposure to pyridostigmine bromide, DEET, and permethrin: implications of Gulf war chemical exposures. J Toxicol Environ Health. 1996;48:35-56B.
11. Haley RW, Kurt TL. Self-reported exposure to neurotoxic chemical combinations in the Gulf war. JAMA. 1997;277:231-237.
12. Thompson HM. Interactions between pesticides: a review of reported effects and their implications for wildlife risk assessment. Ecotoxicol. 1996;5:59-81.
13. Pont AR, Charron AR, Brand RM. Active ingredients in sunscreens act as topical penetration enhancers for the herbicide 2,4-dichlorophenoxyacetic acid. Toxicol Appl Pharmacol. 2004;195:348-354.
14. Frances SP, Auliff AM, Edstein MD, Cooper RD. Survey of personal protection measures against mosquitoes among Australian Defense Force personnel deployed to East Timor. Mil Med. 2003;168:227-230.
15. Riviere JE, Baynes RE, Brooks JD, Yeatts JL, Monteiro-Riviere A. Percutaneous absorption of topical N, N-diethyl-m-toluamide (DEET): effects of exposure variables and coadministered toxicants. J Toxicol Environ Health Part A. 2003;66:133-151.
16. Hardell L, Eriksson M, Lenner P, Lundgren E. Malignant lymphoma and exposure to chemicals especially organic solvents, chlorophenol and phenoxy acids: a case-control study. Br J Cancer. 1981;43:169-176.
17. Ogiso T, Iwaki M, Paku T. Effect of various enhancers on transdermal penetration of indomethacin and urea, and relationship between penetration parameters and enhancement factors. J Pharmacol Sci. 1995;84:482-488.
18. Balarajan R, Acheson ED. Soft tissue sarcomas in agriculture and forestry workers. J Epidemiol Community Health. 1984;38:113-116.
19. Brownson RC, Reif JS. A cancer registry-based study of occupational risk for lymphoma, multiple myeloma and leukaemia. Int J Epidemiol. 1988;17:27-32.
20. Pearce NE, Smith AH, Fisher DO. Malignant lymphoma and multiple myeloma linked with agricultural occupations in a New Zealand cancer registry-based study. Am J Epidemiol. 1985;121:225-235.
21. Cantor KP, Blair A. Farming and mortality from multiple myeloma: a case-control study with the use of death certificates. J Natl Cancer Inst. 1984;72:251-255.
22. Burmeister LF, Everett GD, Van Lier SF, Isacson P. Selected cancer mortality and farm practices in Iowa. Am J Epidemiol. 1983;118:72-77.
23. Cuzick J, De Stavola B. Multiple myeloma - a case-control study. Br J Cancer. 1988;57:516-520.
24. Cerhan JR, Cantor KP, Williamson K, Lynch CF, Torner JC, Burmeister LF. Cancer mortality among Iowa farmers: recent results, time trends, and lifestyle factors (United States). Cancer Causes Control. 1998;9:311-319.
25. Demers PA, Vaughan TL, Koepsell TD, et al. A case-control study of multiple myeloma and occupation. Am J Ind Med. 1993;23:629-639.
26. Khuder SA, Mutgi AB. Meta-analyses of multiple myeloma and farming. Am J Ind Med. 1997;32:510-516.
27. Herrinton LJ, Demers PA, Koepsell TD, et al. Epidemiology of the M-component immunoglobulin types of multiple myeloma. Cancer Causes Control. 1993;4:83-92.
28. Boffeta P, Stellman SD, Garfinkel L. A case-control study of multiple myeloma nested in the American Cancer Society Prospective Study. Int J Cancer. 1989;43:554-559.
29. Gallagher RP, Spinelli JJ, Elwood JM, Skippen DH. Allergies and agricultural exposure as risk factors for multiple myeloma. Br J Cancer. 1983;48:853-857.
30. Eriksson M, Karlsson M. Occupational and other environmental factors and multiple myeloma: a population based case-control study. Br J Ind Med. 1992;49:95-103.
31. Franceschi S, Serraino D, La Vecchia C, Bidoli E, Tirelli U. Occupation and risk of Hodgkin's disease in North-East Italy. Int J Cancer. 1991;48:831-835.
32. Wiklund K, Lindefors B-M, Holm L-E. Risk of malignant lymphoma in Swedish agricultural and forestry workers. Br J Ind Med. 1988;45:19-24.
33. Pearce NE, Smith AH, Howard JK, Sheppard RA, Giles HJ, Teague CA. Case-control study of multiple myeloma and farming. Br J Cancer. 1986;54:493-500.
34. Steineck G, Wiklund K. Multiple myeloma in Swedish agricultural workers. Int J Epidemiol. 1986;15:321-325.
35. Lee WJ, Hoppin JA, Blair A, et al. Cancer incidence among pesticide applicators exposed to alachlor in the Agricultural Health Study. Am J Epidemiol. 2004;159:373-380.
36. Kogevinas M, Kauppinen T, Winkelmann, et al. Soft tissue sarcoma and non-Hodgkin's lymphoma in workers exposed to phenoxy herbicides, chlorophenols, and dioxins: two nested case-control studies. Epidemiology. 1995;6:396-402.
37. Lynge E. Cancer in phenoxy herbicide manufacturing workers in Denmark, 1947-87 - an update. Cancer Causes Control. 1993;4:261-272.
38. Hansen ES, Hasle H, Lander F. A cohort study on cancer incidence among Danish gardeners. Am J Ind Med. 1992;21:651-660.
39. Hardell L, Eriksson M, The association between soft tissue sarcomas and exposure to phenoxyacetic acids. Cancer. 1988;62:652-656.
40. Swaen GMH, van Vliet C, Slangen JJM, Sturmans F. Cancer mortality among licensed herbicide applicators. Scand J Work Environ Health. 1992;18:201-204.
41. Morris PD, Koepsell TD, Daling JR, et al. Toxic substance exposure and multiple myeloma: a case-control study. J Natl Cancer Inst. 1986;76:987-994.
42. Eriksson M, Hardell L, Berg NO, Moller T, Axelson O. Soft-tissue sarcomas and exposure to chemical substances: a case-referent study. Br J Ind Med. 1981;38:27-33.
43. Hardell L, Sandstrom A. Case-control study: soft-tissue sarcomas and exposure to phenoxyacetic acids or chlorophenols. Br J Cancer. 1979;39:711-717.
44. Nanni O, Falcini F, Buiatti E, et al. Multiple myeloma and work in agriculture: results of a case-control study in Forli, Italy. Cancer Causes Control. 1998;9:277-283.
45. Zahm SH, Blair A, Holmes FF, Boysen CD, Robel RJ. A case-referent study of soft-tissue sarcoma and Hodgkin's disease. Scand J Work Environ Health. 1988;14:224-230.
46. Swaen GMH, van Amelsvoort LGPM, Slangen JJM, Mohren DCL. Cancer mortality in a cohort of licensed herbicide applicators. Int Arch Occup Environ Health. 2004;77:293-295.
47. Pahwa P, McDuffie HH, Dosman JA, et al. Exposure to animals and selected risk factors among Canadian farm residents with Hodgkin's disease, multiple myeloma, or soft tissue sarcoma. J Occup Environ Med. 2003;45:857-868.
48. Cantor KP, Silberman W. Mortality among aerial pesticide applicators and flight instructors: follow-up from 1965-1988. Am J Ind Med. 1999;36:239-247.
49. McCunney RJ. Hodgkin's disease, work, and the environment: a review. J Occup Environ Med. 1999;41:36-46.
50. Masala G, Di Lollo S, Picoco C, et al. Incidence rates of leukemias, lymphomas and myelomas in Italy: geographic distribution and NHL histotypes. Int J Cancer. 1996;68:156-159.
51. Semenciw RM, Morrison HI, Riedel D, Wilkins K, Ritter L, Mao Y. Multiple myeloma mortality and agricultural practices in the prairie provinces of Canada. J Occup Med. 1993;35:357-361.
52. Serraino D, Franceschi S, La Vecchia C, Carbone A. Occupation and soft-tissue sarcoma in northeastern Italy. Cancer Causes Control. 1992;3:25-30.
53. Ronco G, Costa G, Lynge E. Cancer risk among Danish and Italian farmers. Br J Ind Med. 1992;49:220-225.
54. Heineman EF, Olsen JH, Pottern LM, Gomez M, Raffn E, Blair A. Occupational risk factors for multiple myeloma among Danish men. Cancer Causes Control. 1992;3:555-568.
55. Pottern LM, Heineman EF, Olsen JH, Raffn E, Blair A. Multiple myeloma among Danish women: employment history and workplace exposures. Cancer Causes Control. 1992;3:427-432.
56. Johnson CC, Feingold M, Tilley B. A meta-analysis of exposure to phenoxy acid herbicides and chlorophenols in relation to risk of soft tissue sarcoma. Int Arch Occup Environ Health. 1990;62:513-520.
57. Wiklund K, Dich J, Holm L-E. Soft tissue sarcoma risk in Swedish licensed pesticide applicators. J Occup Med. 1988B;30:801-804.
58. Woods JA, Poilissar L, Severson RK, Heuser LS, Kulander BG. Soft tissue sarcoma and non-Hodgkin's lymphoma in relation to phenoxyherbicide and chlorinated phenol exposure in Western Washington. J Natl Cancer Inst. 1987;78:899-910.
59. Hoar SK, Blair A, Holmes F, et al. Agricultural herbicide use and risk of lymphoma and soft tissue sarcoma. JAMA. 1986;256:1141-1147.
60. Wiklund K, Holm L-E. Soft tissue sarcoma risk in Swedish agricultural and forestry workers. J Natl Cancer Inst. 1986;76:229-234.
61. Kang H, Enziger F, Breslin P, Feil M, Lee Y, Shepard B. Soft tissue sarcoma and military service in Vietnam: a case-control study. J Natl Cancer Inst. 1987;79:693-699.
62. Smith AH, Pearce NE, Fisher DO, Giles HJ, Teague CA, Howard JK. Soft tissue sarcoma and exposure to phenoxyherbicides and chlorophenols in New Zealand. J Natl Cancer Inst. 1984;73:1111-1117.
63. Smith AH, Fisher DO, Giles HJ, Pearce N. The New Zealand soft tissue sarcoma case-control study: interview findings concerning phenoxyacetic acid exposure. Chemosphere. 1983;12:565-571.
64. Smith AH, Pearce NE. Update on soft tissue sarcoma and phenoxyherbicides in New Zealand. Chemosphere. 1986;15:1795-1798.
65. Monographs on the Evaluation of Carcinogenic Risks to Humans. Occupational Exposures in Insecticide Application and Some Pesticides, vol 53. Lyon, France: IARC; 1991.
66. McDuffie HH, Pahwa P, McLaughlin JR, et al. Non-Hodgkin's lymphoma (NHL) and specific pesticide exposures in men: Cross Canada Study of Pesticides and Health. Cancer Epidemiol Biomarkers Prev. 2001;10:1155-1163.
67. Hayes WJ, Laws ER. Handbook of Pesticide Toxicology. San Diego: Academic Press, Inc; 1991.
68. Moody RP, Nadeau B. Effect of the mosquito repellent DEET and long-wave ultraviolet radiation on permeation of the herbicide 2,4-D and the insecticide DDT in natural rubber gloves. Am Ind Hyg Assc J. 1992;53:436-441.
69. Tos-Luty S, Latuszynska J, Halliop J, et al. Skin penetration of selected pesticides. Ann Agric Environ Med. 1994;1:57-67.
70. McDuffie HH, Pahwa P, Robson D, et al. Insect repellents, phenoxyherbicide exposure and non-Hodgkin's lymphoma. J Occup Environ Med. 2005;47:806-816.
71. SPSS-Data Entry II Statistical Packages for the Social Sciences: Statistical Data Analysis. Chicago: SPSS Inc; 1998.
72. Breslow NE, Day NE. Statistical Methods in Cancer Research, vol 1: The Analysis of Case-Control Studies. IARC Scientific publication no 32, Lyon, France: IARC; 1980.
73. SAS Institute Inc, version 8.2. Cary, NC: SAS Institute Inc; 1999-2001.
74. Grover R, Cessna AJ, Muir NI, Riedel D, Franklin CA, Yoshida K. Factors affecting the exposure of ground-rig applicators to 2,4-D dimethylamine salt. Arch Environ Contam Toxicol. 1986;15:677-686.
75. Grover R, Franklin CA, Muir NI, Cessna AJ, Riedel D. Dermal exposure and urinary metabolite excretion in farmers repeatedly exposed to 2,4-D amine. Toxicol Letters. 1986;33:73-83.
76. Semchuk KM, McDuffie HH, Senthilselvan A, Dosman JA, Cessna AJ, Irvine DG. Factors associated with detection of bromoxynil in a sample of rural residents. J Toxicol Environ Health Part A. 2003;66:103-132.
77. Selim S, Hartnagel RE Jr, Osimitz TG, Gabriel KL, Schoenig GP. Absorption, metabolism, and excretion of N, N-Diethyl-m-toluamide following dermal application to human volunteers. Fundam Appl Toxicol. 1995;25:95-100.
78. Windheuser JJ, Haslam JL, Caldwell L, Shaffer R. The use of N, N-Diethyl-m-toluamide to enhance dermal and transdermal delivery of drugs. J Pharm Sci. 1982;71:1211-1213.
79. Tisch M, Schmezer P, Faulde M, Groh A, Mayer AGH. Genotoxicity studies on permethrin, DEET and diazinon in primary human nasal mucosal cells. Eur Arch Otorhinolaryngol. 2002;259:150-153.
80. Hardell L, Nasman A, Ohlson C-G, Fredrikson M. Case-control study on risk factors for testicular cancer. Int J Oncol. 1998;13:1299-1303.
81. Wiklund K, Dich J, Holm L-E. Risk of malignant lymphoma in Swedish pesticide appliers. Br J Cancer. 1987;56:505-508.
82. Becher H, Flesch-Janys D, Kauppinen T, et al. Cancer mortality in German male workers exposed to phenoxy herbicides and dioxins. Cancer Causes Control. 1996;7:312-321.
83. Kogevinas M, Becher H, Benn T, et al. Cancer mortality in workers exposed to phenoxy herbicides, chlorophenols, and dioxins. Am J Epidemiol. 1997;145:1061-1075.
84. Brown LM, Burmeister LF, Everett GD, Blair A. Pesticide exposure and multiple myeloma in Iowa men. Cancer Causes Control. 1993;4:153-156.
85. Wingren G, Fredrikson M, Brage HN, Nordenskjold B, Axelson O. Soft tissue sarcoma and occupational exposures. Cancer. 1990;66:806-811.