Alanyl-glutamine dipeptide inhibits hepatic ischemia-reperfusion injury in rats

World Journal of Gastroenterology

Volumn 12, Issue 9, 2006, Pages 1373-1378

  Jia, Chang Jun ^a   Dai, Chao Liu ^a   Zhang, Xu ^a   Cui, Kai ^a   Xu, Feng ^a   Xu, Yong Qing ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Alanyl glutamine dipeptide; Bax; Bcl 2; Glutathione; Hepatic ischemia reperfusion injury

Indexed keywords

ALANINE AMINOTRANSFERASE; ALANYLGLUTAMINE; DIPEPTIDE; GLUTATHIONE; LACTATE DEHYDROGENASE; LIVER ENZYME; PROTEIN BAX; PROTEIN BCL 2; SODIUM CHLORIDE; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; CENTRAL VENOUS CATHETER; CHEMICAL PARAMETERS; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; HISTOPATHOLOGY; LIVER ISCHEMIA; LIVER PROTECTION; MALE; MICROMORPHOLOGY; NONHUMAN; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; REPERFUSION INJURY; STATISTICAL SIGNIFICANCE; ULTRASTRUCTURE;

EID: 33645515861     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v12.i9.1373     Document Type: Article

References (37)

1. Arii S, Teramoto K, Kawamura T. Current progress in the understanding of and therapeutic strategies for ischemia and reperfusion injury of the liver. J Hepatobiliary Pancreat Surg 2003; 10: 189-194
2. Melis GC, ter Wengel N, Boelens PG, van Leeuwen PA. Glutamine: recent developments in research on the clinical significance of glutamine. Curr Opin Clin Nutr Metab Care 2004; 7: 59-70
3. Gianotti L, Alexander JW, Gennari R, Pyles T, Babcock GF. Oral glutamine decreases bacterial translocation and improves survival in experimental gut-origin sepsis. JPEN J Parenter Enteral Nutr 1995; 19: 69-74
4. Houdijk AP, Rijnsburger ER, Jansen J, Wesdorp RI, Weiss JK, McCamish MA, Teerlink T, Meuwissen SG, Haarman HJ, Thijs LG, van Leeuwen PA. Randomised trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma. Lancet 1998; 352: 772-776
5. Harward TR, Coe D, Souba WW, Klingman N, Seeger JM. Glutamine preserves gut glutathione levels during intestinal ischemia/reperfusion. J Surg Res 1994; 56: 351-355
6. Wischmeyer PE, Jayakar D, Williams U, Singleton KD, Riehm J, Bacha EA, Jeevanandam V, Christians U, Serkova N. Single dose of glutamine enhances myocardial tissue metabolism, glutathione content, and improves myocardial function after ischemia-reperfusion injury. JPEN J Parenter Enteral Nutr 2003; 27: 396-403
7. Prem JT, Eppinger M, Lemmon G, Miller S, Nolan D, Peoples J. The role of glutamine in skeletal muscle ischemia/reperfusion injury in the rat hind limb model. Am J Surg 1999; 178:147-150
8. Sun K, Liu ZS, Sun Q. Role of mitochondria in cell apoptosis during hepatic ischemia-reperfusion injury and protective effect of ischemic postconditioning. World J Gastroenterol 2004; 10: 1934-1938
9. Oltvai ZN, Milliman CL, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993; 74: 609-619
10. Celli A, Que FG, Gores GJ, LaRusso NF. Glutathione depletion is associated with decreased Bcl-2 expression and increased apoptosis in cholangiocytes. Am J Physiol 1998; 275: G749- G757
11. Bilbao G, Contreras JL, Eckhoff DE, Mikheeva G, Krasnykh V, Douglas JT, Thomas FT, Thomas JM, Curiel DT. Reduction of ischemia-reperfusion injury of the liver by in vivo adenovirus-mediated gene transfer of the antiapoptotic Bcl-2 gene. Ann Surg 1999; 230: 185-193
12. Griffiths RD, Jones C, Palmer TE. Six-month outcome of critically ill patients given glutamine-supplemented parenteral nutrition. Nutrition 1997; 13: 295-302
13. Schauer RJ, Kalmuk S, Gerbes AL, Leiderer R, Meissner H, Schildberg FW, Messmer K, Bilzer M. Intravenous administration of glutathione protects parenchymal and non-parenchymal liver cells against reperfusion injury following rat liver transplantation. World J Gastroenterol 2004; 10: 864-870
14. Armeni T, Ghiselli R, Balercia G, Goffi L, Jassem W, Saba V, Principato G. Glutathione and ultrastructural changes in inflow occlusion of rat liver. J Surg Res 2000; 88:207-214
15. Hong RW, Rounds JD, Helton WS, Robinson MK, Wilmore DW. Glutamine preserves liver glutathione after lethal hepatic injury. Ann Surg 1992; 215: 114-119
16. Ahmad S, White CW, Chang LY, Schneider BK, Allen CB. Glutamine protects mitochondrial structure and function in oxygen toxicity. Am J Physiol Lung Cell Mol Physiol 2001; 280:L779-L791
17. Wang Y, Tian Fz, Tang LJ, Huang DR, Li XJ, Yin ZL. Effects of glycogen on rabbit donor liver during ischemia-reperfusion. Shijie Huaren Xiaohua Zazhi 2001; 9: 255-259
18. Xia JZ, Wu ZH. Metabolism of glutamine-dipeptide supplemented TPN decreasing injuries of liver and intestine in intraperitoneal chemotherapy rats. Parenteral Enteral Nutrition 1997; 4: 78-82
19. Dai CL, Xia ZL, Kume M, Yamamoto Y, Yamagami K, Ozaki N, Yamaoka Y. Heat shock protein 72 normothermic ischemia, and the impact of congested portal blood reperfusion on rat liver. World J Gastroenterol 2001; 7: 415-418
20. Ferri M, Gabriel S, Gavelli A, Franconeri P, Huguet C. Bacterial translocation during portal clamping for liver resection. A clinical study. Arch Surg 1997; 132: 162-165
21. van Leeuwen PA, Hong RW, Rounds JD, Rodrick ML, Wilmore D. Hepatic failure and coma after liver resection is reversed by manipulation of gut contents: the role of endotoxin. Surgery 1991; 110:169-174. discussion 174-175
22. Wang XD, Parsson H, Andersson R, Soltesz V, Johansson K, Bengmark S. Bacterial translocation, intestinal ultrastructure and cell membrane permeability early after major liver resection in the rat. Br J Surg 1994; 81: 579-584
23. Colletti LM, Remick DG, Burtch GD, Kunkel SL, Strieter RM, Campbell DA Jr. Role of tumor necrosis factor-alpha in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat. J Clin Invest 1990; 85: 1936-1943
24. van As AB, Lotz Z, Tyler M, Kahn D. Reperfusion injury associated with portal venous and hepatic arterial perfusion in liver transplantation. Transplantation 2002; 74: 158-163
25. Liu DL, Jeppsson B, Hakansson CH, Odselius R. Multiple-system organ damage resulting from prolonged hepatic inflow interruption. Arch Surg 1996; 131: 442-447
26. Wang X, Andersson R, Soltesz V, Bengmark S. Bacterial translocation after major hepatectomy in patients and rats. Arch Surg 1992; 127: 1101-1106
27. Scheppach W, Loges C, Bartram P, Christl SU, Richter F, Dusel G, Stehle P, Fuerst P, Kasper H. Effect of free glutamine and alanyl-glutamine dipeptide on mucosal proliferation of the human ileum and colon. Gastroenterology 1994; 107: 429-434
28. Li J, Langkamp-Henken B, Suzuki K, Stahlgren LH. Glutamine prevents parenteral nutrition-induced increases in intestinal permeability. JPEN J Parenter Enteral Nutr 1994; 18: 303-307
29. Yasuhara M. L-glutamine-induced heme oxygenase-1 protects small intestine from warm ischemia and reperfusion injury in the rat. Hokkaido Igaku Zasshi 2001; 76: 21-34
30. Blikslager AT, Rhoads JM, Bristol DG, Roberts MC, Argenzio RA. Glutamine and transforming growth factor-alpha stimulate extracellular regulated kinases and enhance recovery of villous surface area in porcine ischemic-injured intestine. Surgery 1999; 125: 186-194
31. Ikeda S, Kudsk KA, Le T, Zarzaur BL, Johnson CD. Glutamine improves impaired cellular exudation and polymorphonuclear neutrophil phagocytosis induced by total parenteral nutrition after glycogen-induced murine peritonitis. Shock 2003; 19: 50-54
32. Manhart N, Vierlinger K, Spittler A, Bergmeister H, Sautner T, Roth E. Oral feeding with glutamine prevents lymphocyte and glutathione depletion of Peyer's patches in endotoxemic mice. Ann Surg 2001; 234: 92-97
33. Sarantos P, Ockert K, Souba WW. Endotoxin stimulates lymphocyte glutaminase expression. Arch Surg 1993; 128: 920-924
34. Alverdy JA, Aoys E, Weiss-Carrington P, Burke DA. The effect of glutamine-enriched TPN on gut immune cellularity. J Surg Res 1992; 52: 34-38
35. Oshimi Y, Miyazaki S. Fas antigen-mediated DNA fragmentation and apoptotic morphologic changes are regulated by elevated cytosolic Ca2+ level. J Immunol 1995; 54: 599-609
36. Gantner F, Leist M, Jilg S, Germann PG, Freudenberg MA, Tiegs G. Tumor necrosis factor-induced hepatic DNA fragmentation as an early marker of T cell-dependent liver injury in mice. Gastroenterology 1995; 109: 166-176
37. Bartling B, Holtz J, Darmer D. Contribution of myocyte apoptosis to myocardial infarction? Basic Res Cardiol 1998; 93: 71-84