CLLU1 expression levels predict time to initiation of therapy and overall survival in chronic lymphocytic leukemia

European Journal of Haematology

Volumn 76, Issue 6, 2006, Pages 455-464

  Buhl, Anne Mette ^a   Jurlander, Jesper ^a   Geisler, Christian Hartmann ^a   Pedersen, Lone Bredo ^a   Andersen, Mette Klarskov ^a   Josefsson, Pär ^a   Petersen, Jørgen Holm ^a,b   Leffers, Henrik ^a  

^a Rigshospitalet   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Chronic lymphocytic leukemia; Chronic lymphocytic leukemia upregulated gene1; Outcome; Prognostic factor

Indexed keywords

CD38 ANTIGEN; COMPLEMENTARY DNA; GENE PRODUCT; IMMUNOGLOBULIN SUBCLASS; IMMUNOGLOBULIN VH; MESSENGER RNA; PROTEIN CLLU1; PROTEIN KINASE ZAP 70; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER SURVIVAL; CHROMOSOME ABERRATION; CHRONIC LYMPHATIC LEUKEMIA; CYTOGENETICS; DISEASE COURSE; DISEASE MARKER; DOSE TIME EFFECT RELATION; FEMALE; GENE IDENTIFICATION; GENE ISOLATION; GENE MUTATION; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RISK ASSESSMENT; STATISTICAL SIGNIFICANCE; TRANSCRIPTION REGULATION;

AGED; AGED, 80 AND OVER; ANTIGENS, CD38; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 12; COHORT STUDIES; DENMARK; DNA, COMPLEMENTARY; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; LEUKEMIA, LYMPHOCYTIC, CHRONIC; LIFE TABLES; MALE; MIDDLE AGED; NEOPLASM PROTEINS; ORGAN SPECIFICITY; POLYMERASE CHAIN REACTION; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RNA, MESSENGER; RNA, NEOPLASM; SURVIVAL ANALYSIS; TIME FACTORS; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 33645513159     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/j.0902-4441.2005.t01-1-EJH2530.x     Document Type: Article

References (45)

1. C aligaris -C appio F H amblin TJ B-cell chronic lymphocytic leukemia: a bird of a different feather J Clin Oncol 1999 17 399 408
2. C hiorazzi N R ai KR F errarini M Chronic lymphocytic leukemia N Engl J Med 2005 352 804 815
3. R ai KR S awitsky A C ronkite EP C hanana AD L evy RN P asternack BS Clinical staging of chronic lymphocytic leukemia Blood 1975 46 219 234
4. B inet JL A uquier A D ighiero G et al. A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis Cancer 1981 48 198 206
5. S arfati M C hevret S C hastang C et al. Prognostic importance of serum soluble CD23 level in chronic lymphocytic leukemia Blood 1996 88 4259 4264
6. H allek M W anders L O stwald M et al. Serum beta(2)-microglobulin and serum thymidine kinase are independent predictors of progression-free survival in chronic lymphocytic leukemia and immunocytoma Leuk Lymphoma 1996 22 439 447
7. K allander CF S imonsson B H agberg H G ronowitz JS Serum deoxythymidine kinase gives prognostic information in chronic lymphocytic leukemia Cancer 1984 54 2450 2455
8. J uliusson G O scier DG F itchett M et al. Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities N Engl J Med 1990 323 720 724
9. D ohner H S tilgenbauer S B enner A et al. Genomic aberrations and survival in chronic lymphocytic leukemia N Engl J Med 2000 343 1910 1916
10. D amle RN W asil T F ais F et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia Blood 1999 94 1840 1847
11. H amblin TJ D avis Z G ardiner A O scier DG S tevenson FK Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia Blood 1999 94 1848 1854
12. I brahim S K eating M D o KA et al. CD38 expression as an important prognostic factor in B-cell chronic lymphocytic leukemia Blood 2001 98 181 186
13. G hia P G uida G S tella S et al. The pattern of CD38 expression defines a distinct subset of chronic lymphocytic leukemia (CLL) patients at risk of disease progression Blood 2003 101 1262 1269
14. H amblin TJ O rchard JA I bbotson RE et al. CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease Blood 2002 99 1023 1029
15. Z upo S I snardi L M egna M et al. CD38 expression distinguishes two groups of B-cell chronic lymphocytic leukemias with different responses to anti-IgM antibodies and propensity to apoptosis Blood 1996 88 1365 1374
16. K lein U T u Y S tolovitzky GA et al. Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells J Exp Med 2001 194 1625 1638
17. R osenwald A A lizadeh AA W idhopf G et al. Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia J Exp Med 2001 194 1639 1647
18. O rchard JA I bbotson RE D avis Z et al. ZAP-70 expression and prognosis in chronic lymphocytic leukaemia Lancet 2004 363 105 111
19. R assenti LZ H uynh L T oy TL et al. ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia N Engl J Med 2004 351 893 901
20. S up SJ D omiati -S aad R K elley TW S teinle R Z hao X H si ED ZAP-70 expression in B-cell hematologic malignancy is not limited to CLL/SLL Am J Clin Pathol 2004 122 582 587
21. S chweighoffer E V anes L M athiot A N akamura T T ybulewicz VL Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion Immunity 2003 18 523 533
22. S tratowa C L offler G L ichter P et al. CDNA microarray gene expression analysis of B-cell chronic lymphocytic leukemia proposes potential new prognostic markers involved in lymphocyte trafficking Int J Cancer 2001 91 474 480
23. H aslinger C S chweifer N S tilgenbauer S et al. Microarray gene expression profiling of B-cell chronic lymphocytic leukemia subgroups defined by genomic aberrations and VH mutation status J Clin Oncol 2004 22 3937 3949
24. B uhl AM J urlander J J orgensen FS et al. Identification of a gene on chromosome 12q22 uniquely overexpressed in chronic lymphocytic leukemia Blood 2006 107 in press
25. C heson BD B ennett JM G rever M et al. National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment Blood 1996 87 4990 4997
26. Comparative CT method of relative quantification In ABI Prism 7900HT Sequence Detection System User Guide p E11 E13
27. C ampbell MJ Z elenetz AD L evy S L evy R Use of family specific leader region primers for PCR amplification of the human heavy chain variable region gene repertoire Mol Immunol 1992 29 193 203
28. B illadeau D A hmann G G reipp P V an Ness B The bone marrow of multiple myeloma patients contains B cell populations at different stages of differentiation that are clonally related to the malignant plasma cell J Exp Med 1993 178 1023 1031
29. B illadeau D Q uam L T homas W et al. Detection and quantitation of malignant cells in the peripheral blood of multiple myeloma patients Blood 1992 80 1818 1824
30. T omlinson I W illiams S C orbett S C ox J W inter G V-BASE Sequence Directory. MRC Centre for Protein Engineering Cambridge United Kingdom 1996
31. C respo M B osch F V illamor N et al. ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia N Engl J Med 2003 348 1764 1775
32. D urig J N uckel H C remer M et al. ZAP-70 expression is a prognostic factor in chronic lymphocytic leukemia Leukemia 2003 17 2426 2434
33. C ox D Partial likelihood Biometrika 1975 62 269 276
34. V asconcelos Y D avi F L evy V et al. Binet's staging system and VH genes are independent but complementary prognostic indicators in chronic lymphocytic leukemia J Clin Oncol 2003 21 3928 3932
35. V andesompele J D e Preter K P attyn F et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes Genome Biol 2002 3 0034.1 0034.11
36. W iestner A R osenwald A B arry TS et al. ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile Blood 2003 101 4944 4951
37. K rober A S eiler T B enner A et al. V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia Blood 2002 100 1410 1416
38. K im SZ C how KU K ukoc -Z ivojnov N et al. Expression of ZAP-70 protein correlates with disease stage in chronic lymphocytic leukemia and is associated with, but not generally restricted to, non-mutated Ig VH status Leuk Lymphoma 2004 45 2037 2045
39. H eintel D K ienle D S hehata M et al. High expression of lipoprotein lipase in poor risk B-cell chronic lymphocytic leukemia Leukemia 2005 19 1216 1223
40. O ppezzo P V asconcelos Y S ettegrana C et al. The LPL/ADAM29 expression ratio is a novel prognosis indicator in chronic lymphocytic leukemia Blood 2005 106 650 657
41. R aval A L ucas DM M atkovic JJ et al. TWIST2 Demonstrates differential methylation in immunoglobulin variable heavy chain mutated and unmutated chronic lymphocytic leukemia J Clin Oncol 2005 23 3877 3885
42. S cielzo C G hia P C onti A et al. HS1 protein is differentially expressed in chronic lymphocytic leukemia patient subsets with good or poor prognoses J Clin Invest 2005 115 1644 1650
43. C hen L W idhopf G H uynh L et al. Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia Blood 2002 100 4609 4614
44. C hen L A pgar J H uynh L et al. ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia Blood 2004 105 2036 2041
45. D eaglio S V aisitti T B ergui L et al. CD38 and CD100 lead a network of surface receptors relaying positive signals for B-CLL growth and survival Blood 2005 105 3042 3050