Ghrelin reverses molecular, structural and hemodynamic alterations of the right ventricle in pulmonary hypertension;A grelina reverte as alterações moleculares, estruturais e hemodinâmicas ventriculares direitas presentes na hipertensão pulmonar

Revista Portuguesa de Cardiologia

Volumn 25, Issue 1, 2006, Pages 55-63

  Henriques Coelho, Tiaco ^b   Roncon Albuquerque Jr , Roberto ^b   Lourenço, André P ^b   Baptista, Maria J ^b   Oliveira, Sílvia M ^b   Brandão Nogueira, Ana ^b   Correia Pinto, Jorge ^b   Leite Moreira, Adelino F ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b NONE

Author keywords

Neurohumoral; Right ventricular function; Vascular remodeling

Indexed keywords

DRUG VEHICLE; ENDOTHELIN 1; GHRELIN; MESSENGER RNA; MONOCROTALINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HEART MUSCLE; HEART RIGHT VENTRICLE; HEART RIGHT VENTRICLE PRESSURE; HEART VENTRICLE ENDDIASTOLIC PRESSURE; HEMODYNAMIC PARAMETERS; LUNG BLOOD VESSEL; MALE; MORPHOLOGY; MORPHOMETRICS; MUSCLE CELL; NONHUMAN; PULMONARY HYPERTENSION; RAT; SYSTOLIC BLOOD PRESSURE;

ANIMALS; CALCIUM-TRANSPORTING ATPASES; ENDOTHELIN-1; GROWTH HORMONE; HEMODYNAMIC PROCESSES; HYPERTENSION, PULMONARY; MALE; MYOCARDIUM; PEPTIDE HORMONES; RATS; RATS, WISTAR; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; VENTRICULAR DYSFUNCTION, RIGHT;

EID: 33645471370     PISSN: 08702551     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Tajima M, Weinberg EO, Bartunek J, et al. Treatment with growth hormone enhances contractile reserve and intracellular calcium transients in myocytes from rats with postinfarction heart failure. Circulation 1999;129:127-34.
2. Nagaya N, Uematsu M, Kojima M, et al. Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure. Circulation 2001;104:1430-5.
3. Nagaya N, Kojima M, Uematsu M, et al. Hemodynamic and hormonal effects of human ghrelin in healthy volunteers. Am J Physiol Regulatory Integrative Comp Physiol 2001;280: R1483-R1487.
4. Wiley KE, Davenport AP. Comparison of vasodilators in human internal mammary artery: ghrelin is a potent physiological antagonist of endothelin-1. Br J Pharmacol 2002;136: 1146-52.
5. Henriques-Coelho T, Correia-Pinto J, Roncon-Albuquerque R Jr., et al. Endogenous production of ghrelin and beneficial effects of its exogenous administration in monocrotaline-induced pulmonary hypertension. Am J Physiol Heart Circ Physiol 2004;287:H2885-H2890.
6. Chen SJ, Chen YF, Meng QC, et al. Endothelin-receptor antagonist bosentan prevents and reverses hypoxic pulmonary hypertension in rats. J Appl Physiol 1995;79:2122-31.
7. Correia-Pinto J, Henriques-Coelho T, Oliveira SM, Leite-Moreira AF. Evaluation of biventricular function in the rat: a new experimental model. Rev Port Cardiol. 2002;21:1295-1302.
8. Leite-Moreira AF, Correia-Pinto J. Load as an acute determinant of end-diastolic pressure-volume relation. Am J Physiol Heart Circ Physiol 2001;280:H51-H59.
9. Volante M, Fulcheri E, Allia E, Cerrato M, Pucci A, Papotti M. Ghrelin expression in fetal, infant and adult human lung. J Histochem Cytochem 2002;50:1013-21.
10. Shimizu Y, Nagaya N, Teranishi Y, et al. Ghrelin improves endothelial dysfunction through growth hormone-independent mechanisms in rats. Biochem Biophys Res Commun 2003;310:830-5.