Regulation of adiponectin in adipocytes upon exposure to HIV-1

HIV Medicine

Volumn 7, Issue 4, 2006, Pages 268-274

  Sankale J L G ^a   Tong, Q ^b,d   Hadigan, C M ^c   Tan, G ^b   Grinspoon, S K ^c   Kanki, P J ^a   Hotamisligil, G S ^b  

^a Harvard AIDS Institute   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Adipocyte; Adiponectin; HAART; HIV; Insulin resistance; Lipodystrophy

Indexed keywords

ADIPONECTIN; ANTIRETROVIRUS AGENT; CD4 ANTIGEN;

ADIPOCYTE; ANTIGEN EXPRESSION; ARTICLE; BIOASSAY; CELL LYSATE; CONTROLLED STUDY; DATA ANALYSIS; EXPOSURE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IN VITRO STUDY; MEASUREMENT; MOLECULAR MECHANICS; MONONUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; REGULATORY MECHANISM; SUBCUTANEOUS TISSUE; SUPERNATANT; T LYMPHOCYTE ACTIVATION;

ADIPOCYTES; ADIPOGENESIS; ADIPONECTIN; ADIPOSE TISSUE; ANIMALS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4-POSITIVE T-LYMPHOCYTES; HIV INFECTIONS; HIV-1; HIV-ASSOCIATED LIPODYSTROPHY SYNDROME; HUMANS; INTERLEUKIN-2; INTERLEUKIN-6; LEUKOCYTES, MONONUCLEAR; MICE; RECEPTORS, HIV; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33645463033     PISSN: 14642662     EISSN: 14681293     Source Type: Journal    
DOI: 10.1111/j.1468-1293.2006.00372.x     Document Type: Article

References (28)

1. Lo JC, Mulligan K, Tai VW, Algren H, Schambelan M. 'Buffalo hump' in men with HIV-1 infection. Lancet 1998; 351: 867-870.
2. Miller KD, Jones E, Yanovski JA, Shankar R, Feuerstein I, Falloon J. Visceral abdominal-fat accumulation associated with use of indinavir. Lancet 1998; 351: 871-875.
3. Carr A, Samaras K, Chisholm DJ, Cooper DA. Abnormal fat distribution and use of protease inhibitors. Lancet 1998; 351: 1736.
4. Gan SK, Samaras K, Carr A, Chisholm D. Anti-retroviral therapy, insulin resistance and lipodystrophy. Diabetes Obes Metab 2001; 3: 67-71.
5. Jain RG, Furfine ES, Pedneault L, White AJ, Lenhard JM. Metabolic complications associated with antiretroviral therapy. Antiviral Res 2001; 51: 151-177.
6. Mallon PW, Cooper DA, Carr A. HIV-associated lipodystrophy. HIV Med 2001; 2: 166-173.
7. Dowell P, Flexner C, Kwiterovich PO, Lane MD. Suppression of preadipocyte differentiation and promotion of adipocyte death by HIV protease inhibitors. J Biol Chem 2000; 275: 41325-41332.
8. Nguyen AT, Gagnon A, Angel JB, Sorisky A. Ritonavir increases the level of active ADD-1/SREBP-1 protein during adipogenesis. AIDS 2000; 14: 2467-2473.
9. Caron M, Auclair M, Vigouroux C, Glorian M, Forest C, Capeau J. The HIV protease inhibitor indinavir impairs sterol regulatory element-binding protein-1 intranuclear localization, inhibits preadipocyte differentiation, and induces insulin resistance. Diabetes 2001; 50: 1378-1388.
10. Noor MA, Lo JC, Mulligan K et al. Metabolic effects of indinavir in healthy HIV-seronegative men. AIDS 2001; 15: F11-F18.
11. Noor MA, Seneviratne T, Aweeka FT et al. Indinavir acutely inhibits insulin-stimulated glucose disposal in humans: A randomized, placebo-controlled study. AIDS 2002; 16: F1-F8.
12. Purnell JQ, Zambon A, Knopp RH et al. Effect of ritonavir on lipids and post-heparin lipase activities in normal subjects. AIDS 2000; 14: 51-57.
13. Murata H, Hruz PW, Mueckler M. The mechanism of insulin resistance caused by HIV protease inhibitor therapy. J Biol Chem 2000; 275: 20251-20254.
14. Rudich A, Vanounou S, Riesenberg K et al. The HIV protease inhibitor nelfinavir induces insulin resistance and increases basal lipolysis in 3T3-L1 adipocytes. Diabetes 2001; 50: 1425-1431.
15. Liang JS, Distler O, Cooper DA et al. HIV protease inhibitors protect apolipoprotein B from degradation by the proteasome: A potential mechanism for protease inhibitor-induced hyperlipidemia. Nat Med 2001; 12: 1327-1331.
16. Tong Q, Sankale JL, Hadigan CM et al. Regulation of adiponectin in human immunodeficiency virus-infected patients: Relationship to body composition and metabolic indices. J Clin Endocrinol Metab 2003; 88: 1559-1564.
17. Addy CL, Gavrila A, Tsiodras S, Brodovicz K, Karchmer AW, Mantzoros CS. Hypoadiponectinemia is associated with insulin resistance, hypertriglyceridemia, and fat redistribution in human immunodeficiency virus-infected patients treated with highly active antiretroviral therapy. J Clin Endocrinol Metab 2003; 88: 627-636.
18. Sutinen J, Korsheninnikova E, Funahashi T, Matsuzawa Y, Nyman T, Yki-Jarvinen H. Circulating concentration of adiponectin and its expression in subcutaneous adipose tissue in patients with highly active antiretroviral therapy-associated lipodystrophy. J Clin Endocrinol Metab 2003; 88: 1907 -1910.
19. Vigouroux C, Maachi M, Nguyen TH et al. Serum adipocytokines are related to lipodystrophy and metabolic disorders in HIV-infected men under antiretroviral therapy. AIDS 2003; 17: 1503-1511.
20. Mynarcik DC, Combs T, McNurlan MA, Scherer PE, Komaroff E, Gelato MC. Adiponectin and leptin levels in HIV-infected subjects with insulin resistance and body fat redistribution. J Acquir Immune Defic Syndr 2002; 31: 514-520.
21. Hazan U, Romero IA, Cancello R et al. Human adipose cells express CD4, CXCR4, and CCR5 [corrected] receptors: A new target cell type for the immunodeficiency virus-1? FASEB J 2002; 16: 1254-1256.
22. Kokkotou EG, Sankale JL, Mani I et al. In vitro correlates of HIV-2-mediated HIV-1 protection. Proc Natl Acad Sci USA 2000; 97: 6797-6802.
23. Sankale JL, Hamel D, Woolsey A et al. Molecular evolution of human immunodeficiency virus type 1 subtype A in Senegal: 1988-97. J Hum Virol 2000; 3: 157-164.
24. Gerhardt CC, Romero IA, Cancello R, Camoin L, Strosberg AD. Chemokines control fat accumulation and leptin secretion by cultured human adipocytes. Mol Cell Endocrinol 2001; 175: 81-92.
25. Munier S, Borjabad A, Lemaire M, Mariot V, Hazan U. In vitro infection of human primary adipose cells with HIV-1: A reassessment. AIDS 2003; 17: 2537-2539.
26. Dupin N, Buffet M, Marcelin AG et al. HIV and antiretroviral drug distribution in plasma and fat tissue of HIV-infected patients with lipodystrophy. AIDS 2002; 16: 2419-2424.
27. Lee GA, Mafong DD, Noor MA et al. HIV protease inhibitors increase adiponectin levels in HIV-negative men. J Acquir Immune Defic Syndr 2004; 36: 645-647.
28. Lee GA, Seneviratne T, Noor MA et al. The metabolic effects of lopinavir/ritonavir in HIV-negative men. AIDS 2004; 18: 641-649.