HIV Protease Inhibitors Increase Adiponectin Levels in HIV-Negative Men [4]

Journal of Acquired Immune Deficiency Syndromes

Volumn 36, Issue 1, 2004, Pages 645-647

  Lee, Grace A ^b,c   Mafong, Derek D ^d   Noor, Mustafa A ^a,b,c   Lo, Joan C ^c,e   Mulligan, Kathleen ^c,e   Schwarz, Jean Marc ^b,e,f   Schambelan, Morris ^c,e   Grunfeld, Carl ^b,c  

^a BRISTOL MYERS SQUIBB   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^e SAN FRANCISCO GENERAL HOSPITAL   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ADIPONECTIN; GLUCOSE; INDINAVIR; INSULIN; LOPINAVIR; NELFINAVIR; PROTEINASE INHIBITOR; RITONAVIR; SAQUINAVIR; STAVUDINE; ZIDOVUDINE;

ADIPOSE TISSUE; DRUG MECHANISM; FATTY ACID METABOLISM; GLUCOSE METABOLISM; HUMAN; HUMAN EXPERIMENT; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INSULIN RESISTANCE; LETTER; LIPID BLOOD LEVEL; LIPOATROPHY; LIPOHYPERTROPHY; MALE; NORMAL HUMAN; PRIORITY JOURNAL; VIRUS INHIBITION;

ADIPONECTIN; DRUG COMBINATIONS; HIV PROTEASE INHIBITORS; HIV SERONEGATIVITY; HUMANS; INDINAVIR; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; PYRIMIDINONES; RITONAVIR;

EID: 2142813985     PISSN: 15254135     EISSN: None     Source Type: Journal    
DOI: 10.1097/00126334-200405010-00017     Document Type: Letter

References (12)

1. Staiger H, Tschritter O, Machann J, et al. Relationship of serum adiponectin and leptin concentrations with body fat distribution in humans. Obes Res. 2003;11:368-372.
2. Stefan N, Stumvoll M. Adiponectin: its role in metabolism and beyond. Horm Metab Res. 2002;34:469-474.
3. Berg AH, Combs TP, Du X, et al. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med. 2001;7:947-953.
4. Yamauchi T, Kamon J, Waki H, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med. 2001;7:941-946.
5. Addy CL, Gavrila A, Tsiodras S, et al. Hypoadiponectinemia is associated with insulin resistance, hypertriglyceridemia, and fat redistribution in human immunodeficiency virus-infected patients treated with highly active antiretroviral therapy. J Clin Endocrinol Metab. 2003;88:627-636.
6. Jones S, Janneh O, Waitte C, Back D, et al. Altered adipocytokine gene expression in murine 3T3-F442A adipocytes treated with PIs and NRTIs. Paper presented at: 5th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV; 2003; Paris, France.
7. Shankar SS, Degawa-Yamauchi M, Considine RV, Dube MP, et al. Indinavir increases serum adiponectin in healthy HIV-negative men. Paper presented at: 63rd Scientific Sessions of the American Diabetes Association; 2003; New Orleans, LA.
8. Shankar SS D-YM, Considine RV, Steinberg HO, et al. Indinavir-associated endothelial dysfunction is associated with increased plasma adiponectin levels. Paper presented at: 5th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV; 2003; Paris, France.
9. Noor MA, Lo JC, Mulligan K, et al. Metabolic effects of indinavir in healthy HIV-seronegative men. AIDS. 2001;15:F11-F18.
10. Lee G, Seneviratne T, Noor M, Lo J, et al. The metabolic effects of lopinavir/ritonavir in HIV-negative men. AIDS. In press.
11. Mulligan K, Grunfeld C, Tai VW, et al. Hyperlipidemia and insulin resistance are induced by protease inhibitors independent of changes in body composition in patients with HIV infection. J Acquir Immune Defic Syndr. 2000;23: 35-43.
12. Hadigan C, Yawetz S, Thomas A, Havers F, et al. A randomized, double-blind, placebo-controlled study of rosiglitazone for patients with HIV lipodystrophy. Paper presented at: 5th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV; 2003; Paris, France.