Alloimmune and autoimmune background in recurrent pregnancy loss - Successful immunotherapy by intravenous immunoglobulin

American Journal of Reproductive Immunology

Volumn 55, Issue 5, 2006, Pages 331-340

  Kotlan, Beatrix ^a   Padanyi, Agnes ^a   Batorfi, Jozsef ^a   Fulop, Vilmos ^a   Szigetvari, Ivan ^a   Rajczy, Katalin ^a   Penzes, Maria ^a   Gyodi, Eva ^a   Reti, Marienne ^a   Petranyi, Gyozo ^a  

^a NATIONAL MEDICAL CENTER   (Hungary)

Author keywords

Cytotoxic T lymphocyte; Immunological assay; Spontaneous abortion

Indexed keywords

ANTINUCLEAR ANTIBODY; CARDIOLIPIN ANTIBODY; DOUBLE STRANDED DNA ANTIBODY; ERYTHROCYTE ANTIBODY; FC RECEPTOR; HLA A ANTIGEN; HLA B ANTIGEN; HLA C ANTIGEN; HLA DQ ANTIGEN; HUMAGLOBIN; IMMUNOGLOBULIN; PHOSPHOLIPID ANTIBODY;

ADULT; ALLOIMMUNITY; ARTICLE; AUTOIMMUNITY; CELL ACTIVITY; CELL MEDIATED CYTOTOXICITY; CELL MEDIATED LYMPHOLYSIS; CHILDBIRTH; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HLA TYPING; HUMAN; IMMUNOASSAY; IMMUNOFLUORESCENCE TEST; IMMUNOTHERAPY; MEDICAL ASSESSMENT; NATURAL KILLER CELL; PATIENT SELECTION; PREGNANCY OUTCOME; PRIORITY JOURNAL; PROLYMPHOCYTE; RECURRENT ABORTION; TREATMENT FAILURE; TREATMENT INDICATION; TREATMENT OUTCOME;

ABORTION, HABITUAL; ADULT; AUTOANTIBODIES; AUTOIMMUNITY; CASE-CONTROL STUDIES; FEMALE; HUMANS; IMMUNITY, CELLULAR; IMMUNOGLOBULINS, INTRAVENOUS; ISOANTIBODIES; KILLER CELLS, NATURAL; PREGNANCY; T-LYMPHOCYTES, CYTOTOXIC;

EID: 33645462091     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/j.1600-0897.2006.00368.x     Document Type: Article

References (45)

1. Stirrat GM: Recurrent spontaneous abortion. In Immunological Obstetrics, CB Coulam, WP Faulk, JA McIntyre (eds). New York, Norton Medical Books, 1992, pp 357-376.
2. Hill JA: Immunologic factors in spontaneous abortion. In Reproductive Immunology, RA Bronson, NJ Alexander, DJ Anderson, DW Branch, WH Kutteh (eds). Paris, Blackwell Science, 1996, pp 433-442.
3. Porter TF, Scott JR: Evidence-based care of recurrent miscarriage. Best Pract Res Clin Obstet Gynaecol 2005; 19: 85-101.
4. Matalon ST, Blank M, Levy Y, Carp HJ, Arad A, Burek L, Grunebaum E, Sherer Y, Ornoy A, Refetoff S, Weiss RE, Rose NR, Shoenfeld Y: The pathogenic role of anti-thyroglobulin antibody on pregnancy: Evidence from an active immunization model in mice. Hum Reprod 2003; 18: 1094-1099.
5. Von Landenberg P, Matthias T, Zaech J, Schultz M, Lorber M, Blank M, Shoenfeld Y: Antiprothrombin antibodies are associated with pregnancy loss in patients with the antiphospholipid syndrome. Am J Reprod Immunol 2003; 49: 51-56.
6. Coulam C, Rukavina R: Immunomodulatory analogies between trophoblastic and cancer cells and their hosts. In Cancer and Pregnancy, ER Barnea, E Jauniaux, PE Schwartz (eds). London, Springer, 2001, pp 190-208.
7. Barnea ER, Levine SP: Maternal immune response to trophoblast, GTD and cancer. In Cancer and Autoimmunity, Y Shoenfeld, ME Gershwin (eds). Amsterdam, Elsevier Science Publishers, 2000, pp 343-349.
8. Bermas BL, Hill JA: Proliferative responses to Recall antigens are associated with pregnancy outcome in women with a history of recurrent spontaneous abortion. J Clin Invest 1997; 100: 1330-1334.
9. Szekeres-Bartho J, Bakonyi A, Polgar B, Par G, Faust Z, Palkovics T, Szereday L: The role of gamma/delta T cells in progesterone-mediated immunomodulation during pregnancy: A review. Am J Reprod Immunol 1999; 42: 44-48.
10. Check JH, Arwitz M, Gross J, Szekeres-Bartho J, Wu CH: Evidence that the expression of progesterone-induced blocking factor by maternal T-lymphocytes is positively correlated with conception. Am J Reprod Immunol 1997; 38: 6-8.
11. Wegman TG, Lin H, Guilbert L, Mosmann TR: Bidirectional cytokine interactions in the maternal-fetal relationship: Is successful pregnancy a TH2 phenomenon ? Immunol Today 1993; 14: 353-356.
12. Pfeiffer KA, Fimmers R, Engels G, van der Ven H, van der Ven K: The HLA-genotype is potentially associated with idiopathic recurrent spontaneous abortion. Mol Hum Reprod 2002; 7: 373-378.
13. Aoki K, Kajiura S, Matsumoto Y, Ogasawara M, Okada S, Yagami Y, Gleicher N: Preconceptional natural-killer-cell activity as a predictor of miscarriage. Lancet 1995; 345: 1340-1342.
14. Manyonda IT, Pereipa RS, Pearce JM, Sharrock CEM: Limiting dilution analysis of the allo-MHC anti-paternal cytotoxic T cell response II: recurrent spontaneous abortion and the effect of immunotherapy. Clin Exp Immunol 1993; 93: 132-137.
15. Le Bouteiller P: Regulation of the expression of HLA class I genes in human trophoblasts. Pathol Biol 1995; 43: 628-635.
16. Rouas-Freiss N, Paul P, Dausset J, Carosella ED: HLA-G promotes immune tolerance. J Biol Regul Homeost Agents 2000; 14: 93-98.
17. Chaouat G, Ledee-bataill N, Dubanchet S: Is there a place for immunomodulation in assisted reproduction techniques? J Reprod Immunol 2004; 62: 29-39.
18. Kotlan B, Fulop V, Padanyi A, Szigetvari I, Reti M, Gyodi E, Feher E, Petranyi G: High partner antigen specific cytotoxic T lymphocyte precursor frequencies in women with unexplained recurrent spontaneous abortions. Human Reprod 2001; 16: 1278-1285.
19. Coulam CB, Krysa L, Stern JJ, Bustillo M: Intravenous immunoglobulin for treatment of recurrent pregnancy loss. Am J Reprod Immunol 1995; 34: 333-337.
20. Coulam CB, Stephenson M, Stern JJ, Clark DA: Immunotherapy for recurrent pregnancy loss: Analysis of results from clinical trials. Am J Reprod Immunol 1996; 35: 352-359.
21. Clark DA, Coulam CB, Daya S, Chaouat G: Unexplained sporadic and recurrent miscarriage in the new millennium: A critical analysis of immune mechanisms and treatments. Hum Reprod Update 2001; 7: 501-511.
22. Takakuwa K, Kanazawa K, Takeuchi S: Production of blocking antibodies by vaccination with husband's lymphocytes in unexplained recurrent aborters: The role in successful pregnancy. Am J Reprod Immunol 1986; 10: 1-9.
23. Beer AE, Shekar SS, Quebbeman JF, Zhu X: Paternal and non-paternal leukocyte immunization in women with recurrent spontaneous abortions: immune responses and subsequent pregnancy outcome. Reprod Immunol Materno-fetal Relationship 1987; 154: 161-178.
24. Stephenson MD, Dreher K, Houlihan E: Prevention of unexplained recurrent spontaneous abortion using intravenous immunoglobulin: A prospective, randomized, double-blinded, placebo-controlled trial. Am J Reprod Immunol 1998; 39: 82-88.
25. Sticker RB, Steinleitner A, Bookoff CN: Successful treatment of immunologic abortion with low-dose intravenous immunoglobulin. Fertil Steril 2000; 73: 536-540.
26. Christiansen OB, Nielsen HS, Pedersen B: Active or passive immunization in unexplained recurrent miscarriage. J Reprod Immunol 2004; 62: 41-52.
27. Wallington T: New uses for immunoglobulin therapies. Vox Sang 2004; 87: 155-157.
28. Omwandho CO, Gruessner SE, Roberts TK, Tinneberg HR: Intravenous immunoglobulin (IVIG): Modes of action in the clinical management of recurrent pregnancy loss (RPL) and selected autoimmune disorders. Clin Chem Lab Med 2004; 42: 359-370.
29. Fischer P, Jendreyko N, Hoffmann M, Lerch H, Uttenreuther-Fischer MM, Chen PP, Gaedicke G: Platelet-reactive IgG antibodies cloned by phage display and panning with IVIG from three patients with autoimmune thrombocytopenia. Br J Haematol 1999; 195: 626-640.
30. Levy Y, Sherer Y, Mathieu A, Cauli A, Passiu G, Sanna G, Janackovic Z, Blank M, Shoenfeld Y: Anti-cardiolipin antibody from a patient with antiphospholipid syndrome (APS) recognizes only an epitope expressed by cardiolipin/beta 2-glycoprotein-I (beta 2GPI) complex and induces APS. Clin Exp Rheumatol 2000; 18: 479-484.
31. Ganong WF: Physiology of reproduction. In Current Obstetric and Gynecologic Diagnosis and Treatment, 6th edn, ML Pernoll, RC Benson (eds). Norwalk, CT, Appleton and Lange, 1987,pp 109-126.
32. Ray JG: NIH Lymphocyte Microcytotoxicity Technique. NIAID Manual of Tissue Typing Techniques 1979-80. Bethesda, MD, NIH publication No. 80-545, 1979, 39 pp.
33. van Rood JJ, van Leeuwen A, Keuning JJ, Blusse van Oud Alblas AA: The serological recognition of the human MLC determinants using a modified cytotoxicity technique. Tissue Antigens 1975; 5: 73-79.
34. Padanyi A, Gyodi E, Sarmay G, Reti M, Mayer K, Kassai M, Petranyi GyG: Functional and immunogenetic characterization of FcR-blocking antibody. Immnol Lett 1990; 26: 131-138.
35. Krause I, Uziel Y, Guedj D, Mukamel M, Molad Y, Amit M, Weinberger A: Mode of presentation and multisystem involvement in Behcet's disease: the influence of sex and age of disease onset. J Rheumatol 1998; 25: 1566-1569.
36. Chou MJ, Lee SL, Chen TY, Tsay GJ: Specificity of antinuclear antibodies in primary biliary cirrhosis. Ann Rheum Dis 1995; 54: 148-151.
37. Wang EC, Lehner PJ, Graham S, Borysiewicz LK: CD8 high (CD57+) T cells in normal, healthy individuals specifically suppress the generation of cytotoxic T lymphocytes to Epstein-Barr virus-transformed B cell lines. Eur J Immunol 1994; 24: 2903-2909.
38. Strijbosch LWG, Buurman WA, Does RJNH: Limiting dilution assays; experimental design and statistical analysis. J Immunol Methods 1987; 97: 133-140.
39. Mueller-Eckhardt G: Alternative treatment to lymphocyte immunization for treatment of recurrent spontaneous abortion: Immunotherapy with intravenous immunoglobulin for prevention of recurrent pregnancy loss: European experience. Am J Reprod Immunol 1994; 32: 281-285.
40. Kotlan B, Gyodi E, Szabo T, Takacs K, Troppmair J, Petri I, Padanyi A, Kaiser G, Kassai M, Huber C: Comparative study of alloimmune reactions induced by leukocyte and platelet transfusions in humans: Characteristic changes of activation markers, gamma interferon, and FcR blocking antibody production. Hum Immunol 1988; 22: 19-29.
41. Malinowski A: Recurrent spontaneous abortion of alloimmunologic etiology -diagnosis and immunotherapy. Gynecol Pol 2001; 72: 885-898 (review).
42. Vaquero E, Lazzarin N, Valensise H, Menghini S, Di Pierro G, Cesa F, Romanini C: Pregnancy outcome in recurrent spontaneous abortion associated with antiphospholipid antibodies: A comparative study of intravenous immunoglobulin versus prednisone plus low-dose aspirin. Am J Reprod Immunol 2001; 45: 174-179.
43. Carp HJ, Toder V, Gazit E, Ahiron R, Torchinski A, Masiach S, Shoenfeld Y: Further experience with intravenous immunoglobulin in women with recurrent miscarriage and a poor prognosis. Am J Reprod Immunol 2001; 46: 268-273.
44. Gleicher N, Vidali A, Karande V: The immunological 'Wars of the Roses': disagreements amongst reproductive immunologists. Hum Reprod 2002; 17: 539-542.
45. Christiansen OB, Nielsen HS, Pedersen B: Active or passive immunization in unexplained recurrent miscarriage. J Reprod Immunol 2004; 62: 41-52.