Characterization of pegylated copolymeric micelles and in vivo pharmacokinetics and biodistribution studies

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 77, Issue 1, 2006, Pages 188-194

  Lin, Wen Jen ^a   Chen, Yi Chen ^a   Lin, Chi Chang ^a   Chen, Chau Fong ^a   Chen, Ji Wang ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Biodistribution; Micelles; Pharmacokinetics; Poly(ethylene glycol); Poly(lactone)

Indexed keywords

COPOLYMERIZATION; COPOLYMERS; MONOMERS; PHARMACOKINETICS; TOXICITY;

BIODISTRIBUTION; POLY(ETHYLENE GLYCOL); POLY(LACTONE); POLYDISPERSITIES;

MICELLES;

COPOLYMER; DELTA VALEROLACTONE; EPSILON CAPROLACTONE; INDOMETACIN; LACTONE; LACTONE DERIVATIVE; MACROGOL; PEGYLATED COPOLYMER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CYTOTOXICITY; DIALYSIS; DRUG DISTRIBUTION; DRUG RETENTION; DRUG UPTAKE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MICELLE; NONHUMAN; PARTICLE SIZE; POLYMERIZATION; RAT; RING OPENING; SUSTAINED RELEASE PREPARATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIOCOMPATIBLE MATERIALS; CELL SURVIVAL; CELLS, CULTURED; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; FIBROBLASTS; HEXANOIC ACIDS; HUMANS; INDOMETHACIN; LACTONES; MALE; MATERIALS TESTING; MICELLES; PARTICLE SIZE; POLYETHYLENE GLYCOLS; RATS; RATS, WISTAR; TISSUE DISTRIBUTION;

EID: 33645410046     PISSN: 00219304     EISSN: 15524981     Source Type: Journal    
DOI: 10.1002/jbm.b.30418     Document Type: Article

References (21)

1. Kwon GS, Okano T. Polymeric micelles as new drug carriers. Adv Drug Deliv Rev 1996;21:107-116.
2. Liu H, Farrell S, Uhrich K. Drug release characteristics of unimolecular polymeric micelles. J Control Release 2000;68: 167-174.
3. Yokoyama M, Miyauchi M, Yamada N, Okano T, Sakurai Y, Kataoka K, Inoue S. Characterization and anticancer activity of the micelle-forming polymeric anticancer drug adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer. Cancer Res 1990;50:1693-1700.
4. Yokoyama M, Okano T, Sakurai Y, Ekimoto H, Shibazaki C, Kataoka K. Toxicity and antitumor activity against solid tumors of micelle-forming polymeric anticancer drug and its extremely long circulation in blood. Cancer Res 1991;51:3229-3236.
5. Matsumura Y, Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res 1986;46:6387-6392.
6. Maeda H, Matsumura Y. Tumoritropic and lymphotropic principles of macromolecular drugs. Crit Rev Ther Drug Carrier Syst 1989;6:193-210.
7. Matsumura Y, Maruo K, Kimura M, Yamamoto T, Konno T, Maeda H. Kinin-generating cascade in advanced cancer patients and in vitro study. Jpn J Cancer Res 1991;82:732-741.
8. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1995;1:27-31.
9. Dvorak HF, Nagy JA, Dvorak JT, Dvorak AM. Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules. Am J Pathol 1988;133: 95-109.
10. Gaur U, Sahoo SK, De TK, Ghosh PC, Maitra A, Ghosh PK. Biodistribution of fluoresceinated dextran using novel nanoparticles evading reticuloendothelial system. Int J Pharm 2000;202: 1-10.
11. Laus M, Sparnacci K, Ensoli B, Butto BO, Caputo A, Mantovani I, Zuccheri G, Samori B, Tondelli L. Complex associates of plasmid DNA and a novel class of block copolymers with PEG and cationic segments as new vectors for gene delivery. J Biomater Sci Polym Ed 2001;12:209-228.
12. Cerrai P, Tricoli M, Andruzzi F. Polyether-polyester block copolymers by non-catalyzed polymerization of e-caprolactone with polyethylene glycol). Polymer 1989;30:338-343.
13. Kim SY, Ha JC, Lee YM. Poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide)/poly(ε-caprolactone) thermo-responsive drug release behaviors. J Control Release 2000;65: 345-358.
14. Lin WJ, Juang LW, Lin CC. Stability and release performance of a series of pegylated copolymeric micelles. Pharm Res 2003; 20:668-673.
15. Li SM, Chen XH, Gross RA, McCarthy SP. Hydrolytic degradation of PCL/PEO copolymers in alkaline media. J Mater Sci Mater Med 2000;11:227-233.
16. Ge H, Hu Y, Jiang X, Cheng D, Yuan Y, Bi H, Yang C. Preparation, characterization, and drug release behaviors of drug nimodipine-loaded poly(e-caprolactone)-poly(ethylene oxide)-poly(ε-caprolactone) amphiphilic triblock copolymer micelles. J Pharm Sci 2002;91:1463-1473.
17. Maiti S, Chatterji PR. Comparison of the aggregation behavior of di- and triblock nonionic amphiphilies with linear and cyclic hydrophobic tails. Langmuir 1997;13:5011-5015.
18. 1H NMR spectroscopy. Biomaterials 1997;18:27-30.
19. Allen C, Maysinger D, Eisenberg A. Nano-engineering block copolymer aggregates for drug delivery. Colloids Surf B Biointerfaces 1999;16:1-35.
20. Varadaraj R, Bock J, Valint P, Zushma S, Thomas R. Fundamental interfacial properties of alkyl-branched sulfate and ethoxy sulfate surfactants derived from Guerbet alcohols. 1. Surface and instantaneous interfacial tensions. J Phys Chem 1991;95:1671-1676.
21. Saez A, Guzman M, Molpeceres J, Aberturas MR. Freeze-drying of polycaprolactone and poly(D,L-lactic-glycolic) nanoparticles induce minor particle size changes affecting the oral pharmacokinetics of loaded drugs. Eur J Pharm Biopharm 2000; 50:379-387.