Intranasal continuous combined 17β-estradiol/norethisterone therapy improves the lipid profile in healthy postmenopausal women

Fertility and Sterility

Volumn 85, Issue 4, 2006, Pages 979-988

  Hemelaar, Majoie ^a   Kenemans, Peter ^a   De Bie, Lut ^b   Van De Weijer, Peter H M ^c   Van Der Mooren, Marius J ^a,d  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Diagnostic Centre Eindhoven   (Netherlands)

^c GELRE HOSPITALS   (Netherlands)

^d VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Estradiol; Intranasal; Lipids; Lipoproteins; Norethisterone; oral

Indexed keywords

APOLIPOPROTEIN A1; CHOLESTEROL; ESTRADIOL; HIGH DENSITY LIPOPROTEIN; LIPID; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; NORETHISTERONE; TRIACYLGLYCEROL;

ADULT; ARTICLE; ATHEROGENESIS; CLIMACTERIUM; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; LIPID METABOLISM; MAJOR CLINICAL STUDY; POSTMENOPAUSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STATISTICAL ANALYSIS; SYMPTOMATOLOGY; UNSPECIFIED SIDE EFFECT;

ADMINISTRATION, INTRANASAL; ADMINISTRATION, ORAL; AEROSOLS; CHOLESTEROL; DOUBLE-BLIND METHOD; DRUG COMBINATIONS; ESTRADIOL; FEMALE; HUMANS; INTERNATIONALITY; LIPIDS; MIDDLE AGED; NORETHINDRONE; POSTMENOPAUSE; TIME FACTORS;

EID: 33645380356     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2005.09.036     Document Type: Article

References (34)

1. M.J. Van der Mooren, P. Kenemans Postmenopausal hormone therapy impact on menopause-related symptoms, chronic disease and quality of life Drugs 64 2004 821 836
2. I.F. Godsland Effects of postmenopausal hormone replacement therapy on lipid, lipoprotein, and apolipoprotein (a) concentrations analysis of studies published from 1974-2000 Fertil Steril 75 2001 898 915
3. R. Sitruk-Ware Progestins and cardiovascular risk markers Steroids 65 2000 651 658
4. B. De Lignieres, A. Basdevant, G. Thomas, J.C. Thalabard, C. Mercier-Bodard, J. Conard Biological effects of estradiol-17 beta in postmenopausal women oral versus percutaneous administration J Clin Endocrinol Metab 62 1986 536 541
5. P.Y. Scarabin, E. Oger Plu-Bureau Differential association of oral and transdermal oestrogen-replacement therapy with venous thromboembolism risk Lancet 362 2003 428 432
6. J. Studd, B. Pornel, I. Marton, J. Bringer, C. Varin, Y. Tsouderos Aerodiol Study Group Efficacy and acceptability of intranasal 17 beta-oestradiol for menopausal symptoms randomised dose-response study Lancet 353 1999 1574 1578
7. L.A. Mattsson, C. Christiansen, J.C. Colau, S. Palacios, P. Kenemans, C. Bergeron Clinical equivalence of intranasal and oral 17beta-estradiol for postmenopausal symptoms Am J Obstet Gynecol 182 2000 545 552
8. P. Lopes, H.M. Merkus, J. Nauman, F. Bruschi, J.M. Foidart, J. Calaf Randomized comparison of intranasal and transdermal estradiol Obstet Gynecol 96 2000 906 912
9. W.T. Friedewald, R.I. Levy, D.S. Fredrickson Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge Clin Chem 18 1972 499 502
10. K. Widhalm, R. Pakosta Precipitation with polyethylene glycol and density-gradient ultracentrifugation compared for determining high-density lipoprotein subclasses HDL2 and HDL3 Clin Chem 37 1991 238 240
11. J. Carlstedt-Duke Cellular estrogen activity implications for pulsed estrogen therapy Maturitas 38 Suppl 1 2001 S7 S13
12. P. Kenemans, A.R. Genazzani, S. Palacios, H.P. Schneider Pulsed estrogen exposure selectively modulates tissue response a hypothesis Gynecol Endocrinol 18 2004 159 164
13. J.P. Devissaguet, N. Brion, O. Lhote, P. Deloffre Pulsed estrogen therapy pharmacokinetics of intranasal 17-beta-estradiol (S21400) in postmenopausal women and comparison with oral and transdermal formulations Eur J Drug Metab Pharmacokinet 24 1999 265 271
14. E. Farish, K. Spowart, J.F. Barnes, C.D. Fletcher, A. Calder, A. Brown Effects of postmenopausal hormone replacement therapy on lipoproteins including lipoprotein(a) and LDL subfractions Atherosclerosis 126 1996 77 84
15. J.C. Stevenson, A. Oladipo, N. Manassiev, M.I. Whitehead, S. Guilford, A.J. Proudler Randomized trial of effect of transdermal continuous combined hormone replacement therapy on cardiovascular risk markers Br J Haematol 124 2004 802 808
16. B.W. Walsh, I. Schiff, B. Rosner, L. Greenberg, V. Ravnikar, F.M. Sacks Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins N Engl J Med 325 1991 1196 1204
17. C.D. Gardner, S.P. Fortmann, R.M. Krauss Association of small low-density lipoprotein particles with the incidence of coronary artery disease in men and women JAMA 276 1996 875 881
18. M.J. Van der Mooren, J. de Graaf, P.N. Demacker, A.F. de Haan, R. Rolland Changes in the low-density lipoprotein profile during 17 beta-estradiol- dydrogesterone therapy in postmenopausal women Metabolism 43 1994 799 802
19. H. Campos, B.W. Walsh, H. Judge, F.M. Sacks Effect of estrogen on very low density lipoprotein and low density lipoprotein subclass metabolism in postmenopausal women J Clin Endocrinol Metab 82 1997 3955 3963
20. E.J. Schaefer, S. Lamon-Fava, J.L. Jenner, J.R. McNamara, J.M. Ordovas, C.E. Davis Lipoprotein(a) levels and risk of coronary heart disease in men. The Lipid Research Clinics Coronary Primary Prevention Trial JAMA 271 1994 999 1003
21. A.D. MBewu, P.N. Durrington Lipoprotein (a) structure, properties and possible involvement in thrombogenesis and atherogenesis Atherosclerosis 85 1990 1 14
22. W. Su, H. Campos, H. Judge, B.W. Walsh, F.M. Sacks Metabolism of Apo(a) and ApoB100 of lipoprotein(a) in women effect of postmenopausal estrogen replacement J Clin Endocrinol Metab 83 1998 3267 3276
23. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease the Scandinavian Simvastatin Survival Study (4S) Lancet 344 1994 1383 1389
24. J.R. Downs, M. Clearfield, S. Weis, E. Whitney, D.R. Shapiro, P.A. Beere Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study JAMA 279 1998 1615 1622
25. F. Grodstein, M.J. Stampfer, J.E. Manson, G.A. Colditz, W.C. Willett, B. Rosner Postmenopausal estrogen and progestin use and the risk of cardiovascular disease N Engl J Med 335 1996 453 461
26. S. Hulley, D. Grady, T. Bush, C. Furberg, D. Herrington, B. Riggs Heart and Estrogen/progestin Replacement Study (HERS) Research Group Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women JAMA 280 1998 605 613
27. J.E. Manson, J. Hsia, K.C. Johnson, J.E. Rossouw, A.R. Assaf, N.L. Lasser Estrogen plus progestin and the risk of coronary heart disease N Engl J Med 349 2003 523 534
28. T.B. Clarkson The new conundrum do estrogens have any cardiovascular benefits? Int J Fertil Womens Med 47 2002 61 68
29. G.L. Anderson, M. Limacher, A.R. Assaf, T. Bassford, S.A. Beresford, H. Black Effects of conjugated equine estrogen in postmenopausal women with hysterectomy the Women's Health Initiative randomized controlled trial JAMA 291 2004 1701 1712
30. W.M. Van Baal, J.J. Emeis, M.J. van der Mooren, H. Kessel, P. Kenemans, C.D. Stehouwer Impaired procoagulant-anticoagulant balance during hormone replacement therapy? A randomised, placebo-controlled 12-week study Thromb Haemost 83 2000 29 34
31. W.M. Van Baal, P. Kenemans, M.J. van der Mooren, H. Kessel, J.J. Emeis, C.D. Stehouwer Increased C-reactive protein levels during short-term hormone replacement therapy in healthy postmenopausal women Thromb Haemost 81 1999 925 928
32. M.S. Post, M.J. van der Mooren, C.D.A. Stehouwer, W.M. van Baal, V. Mijatovic, C.G. Schalkwijk Effects of transdermal and oral oestrogen replacement therapy on C-reactive protein levels in postmenopausal women a randomised, placebo-controlled trial Thromb Haemost 88 2002 605 610
33. M.S. Post, M.J. van der Mooren, W.M. van Baal, M.A. Blankenstein, H.M. Merkus, M.V.A.M. Kroeks Effects of low-dose oral and transdermal estrogen replacement therapy on hemostatic factors in healthy postmenopausal women a randomized placebo-controlled study Am J Obstet Gynecol 189 2003 1221 1227
34. K.K. Koh, M.S. Shin, I. Sakuma, J.Y. Ahn, D.K. Jin, H.S. Kim Effects of conventional or lower doses of hormone replacement therapy in postmenopausal women Arterioscler Thromb Vasc Biol 24 2004 1516 1521