CuI/proline-catalyzed N-arylation of nitrogen heterocycles

Chinese Chemical Letters

Volumn 17, Issue 3, 2006, Pages 313-316

  Deng, Wei ^a   Wang, Ye Feng ^a   Zhang, Chen ^a   Liu, Lei ^a   Guo, Qing Xiang ^a  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

Author keywords

Cross coupling reaction; CuI; N arylation; Nitrogen heterocycle; Proline

Indexed keywords

EID: 33645336033     PISSN: 10018417     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

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21. 4 (12.5 mmol), CuI (0.25 mmol), and L-proline (1.0 mmol) in 10 mL of dioxane was heated at 100 °C under nitrogen atmosphere for 24 h. The resulting suspension was cooled to room temperature and filtered through a 2-3 cm pad of silica gel with 100 mL of EtOAc. The filtrate was concentrated and the residue was purified by chromatography to afford the pure product.
22. 4 (12.5 mmol), CuI (1.0 mmol), and L-proline (1.0 mmol) in 10 mL of DMF was heated at 140 °C under nitrogen atmosphere for 48 h. The resulting suspension was cooled to room temperature and filtered through a 2-3 cm pad of silica gel with 100 mL of EtOAc. The filtrate was concentrated and the residue was purified by chromatography to afford the pure product.