Effect of sildenafil on gastric emptying in healthy adults

Journal of Gastroenterology and Hepatology (Australia)

Volumn 21, Issue 1 PART2, 2006, Pages 222-226

  Cho, Seung Hyun ^a   Park, Hyojin ^a,c   Kim, Jung Hwan ^a   Ryu, Young Hoon ^a   Lee, Sang In ^a   Conklin, Jeffrey L ^b  

^a Yonsei University College of Medicine   (South Korea)

^b CEDARS SINAI MEDICAL CENTER   (United States)

^c Yonsei University College of Medicine   (South Korea)

Author keywords

Cyclic GMP; Dyspepsia; Gastric emptying; Gastrointestinal motility; Phosphodiesterase inhibitor; Sildenafil

Indexed keywords

PERTECHNETIC ACID TC 99M; PLACEBO; SILDENAFIL;

ADULT; ARTICLE; DRUG EFFECT; DYSPEPSIA; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; STOMACH EMPTYING; STOMACH MOTILITY;

EID: 33645297651     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2006.04113.x     Document Type: Article

References (39)

1. Lucas KA Pitari GM Kazerounian S et al. Guanylate cyclases and signaling by cyclic GMP. Pharmacol. Rev. 2000 52 375 414.
2. Rybalkin SD Yan C Bornfeldt KE Beavo JA. Cyclic GMP phosphodiesterases and regulation of smooth muscle function. Circ. Res. 2003 93 280 92.
3. Haning H Niewohner U Bischoff E. Phosphodiesterase type 5 (PDE5) inhibitors. Prog. Med. Chem. 2003 41 249 306.
4. Sutherland EW Rall TW. The properties of an adenine ribonucleotide produced with cellular particles, ATP, Mg++, and epinephrine or glucagon. J. Am. Chem. Soc. 1957 79 3608 12.
5. Sutherland EW Rall TW. Fractionation and characterization of a cyclic adenine ribonucleotide formed by tissue particles. J. Biol. Chem. 1958 232 1077 91.
6. Soderling SH Beavo JA. Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions. Curr. Opin. Cell. Biol. 2000 12 174 9.
7. Yanaka N Kotera J Ohtsuka A et al. Expression, structure and chromosomal localization of the human cGMP-binding cGMP-specific phosphodiesterase PDE5A gene. Eur. J. Biochem. 1998 255 391 9.
8. Kotera J Fujishige K Akatsuka H Imai Y Yanaka N Omori K. Novel alternative splice variants of cGMP-binding cGMP-specific phosphodiesterase. J. Biol. Chem. 1998 273 26982 90.
9. Lee JI Park H Kim JH Lee SI Conklin JL. The effect of sildenafil on esophageal motor function in healthy subjects and patients with nutcracker esophagus. Neurogastroenterol. Motil. 2003 15 617 24.
10. Park H Clark E Conklin JL. Effects of phosphodiesterase inhibitors on esophageal neuromuscular function. Neurogastroenterol. Motil. 2003 15 625 34.
11. Bortolotti M Mari C Giovannini M Pinna S Miglioli M. Effects of sildenafil on esophageal motility of normal subjects. Dig. Dis. Sci. 2001 46 2301 6.
12. Salonia A Rigatti P Montorsi F. Sildenafil in erectile dysfunction: a critical review. Curr. Med. Res. Opin. 2003 19 241 62.
13. Corbin JD Francis SH Cyclic GMP Phosphodiesterase-5: target of sildenafil. J. Biol. Chem. 1999 274 13729 32.
14. Dundar M Kocak I Dundar SO Erol H. Evaluation of side effects of sildenafil in group of young healthy volunteers. Int. Urol. Nephrol. 2001 32 705 8.
15. Dominguez-Munoz JE. Targeting the abnormalities of gastroduodenal functions in functional dyspepsia. Dig. Dis. 2001 19 195 200.
16. Park HJ Lee JD Jung JK Moon BS Collins P. The functional relationships between hiatal hernia and reflux esophagitis. Yonsei Med. J. 1996 37 278 83.
17. Troncon LEA Bennett RJM Ahluwalia NK Thompson DG. Abnormal intragastric distribution of food during gastric emptying in functional dyspepsia patients. Gut 1994 35 327 32.
18. Park HJ Jung JK Song KS Lee SI Itoh Z Park IS. Effect of erythromycin on gastric emptying in healthy individuals assessed by radio-opaque markers and plasma acetaminophen levels. J. Gastroenterol. 1997 32 734 9.
19. Anvari M Paterson CA Daniel EE. Role of nitric oxide mechanisms in control of pyloric motility and transpyloric flow of liquids in conscious dogs. Dig. Dis. Sci. 1998 43 506 12.
20. Orihata M Sarna SK. Nitric oxide mediates mechano- and chemoreceptor-activated intestinal feedback control of gastric emptying. Dig. Dis. Sci. 1996 41 1303 9.
21. Orihata M Sarna SK. Inhibition of nitric oxide synthase delays gastric emptying of solid meals. J. Pharmacol. Exp. Therap. 1994 271 660 70.
22. Plourde V Quintero E Suto G Coimbra C Tache Y. Delayed gastric emptying by inhibitors of nitric oxide synthase in rats. Eur. J. Pharmacol. 1994 256 125 9.
23. Tomita R Tqanjoh K Fujisaki S Fukuzawa M. The role of nitric oxide (NO) in human pyloric sphincter. Hepatogastroenterology 1999 46 2999 3003.
24. Schurrkes JA Meulemans AL. Nitric oxide and gastric relaxation. Dig. Dis. Sci. 1994 39 79S 81S.
25. Tack J Demedts I Meulemans AL Schurrkes JA Janssens J. Role of nitric oxide in the gastric accommodation reflex and meal induced satiety in humans. Gut 2002 51 219 24.
26. Kuiken SD Vergeer M Heisterkamp SH Tytgat GN Boeckxstaens GE. Role of nitric oxide in gastric motor and sensory functions in healthy subjects. Gut 2002 51 212 18.
27. Barbier AJ Lefebvre RA. Relaxant influence of phosphodiesterase inhibitors in the cat gastric fundus. Eur. J. Pharmacol. 1995 276 41 7.
28. Sun WM Doran S Jones KL et al. Effects of nitroglycerin on liquid gastric emptying and antropyloroduodenal motility. Am. J. Physiol. 1998 275 G1173 8.
29. Konturek JW Thor P Domschke W. Effects of nitric oxide on antral motility and gastric emptying in humans. Eur. J. Gastroenterol. Hepatol. 1995 7 97 102.
30. Williams SJ Parsons ME. Nitric oxide an enteric nonadrenergic- noncholinergic relaxant transmitter: evidence using phosphodiesterase V and nitric oxide synthase inhibition. Br. J. Pharmacol. 1995 116 1789 96.
31. de Rosalmeida MC Saraiva LD da Graca JR et al. Sildenafil, a phosphodiesterase-5 inhibitor, delays gastric emptying and gastrointestinal transit of liquid in awake rats. Dig. Dis Sci. 2003 48 2064 8.
32. Watkins CC Sawa A Jaffrey S et al. Insulin restores neuronal nitric oxide synthase expression and function that is lost in diabetic gastropathy. J. Clin. Invest. 2000 106 373 84.
33. Gilja OH Hausken T Odegaard S Berstad A. Three-dimensional ultrasonography of the gastric antrum in patients with functional dyspepsia. Scand. J. Gastroenterol. 1996 31 847 55.
34. Scott AM Kellow JE Shuter B et al. Intragastric distribution and gastric emptying of solids and liquids in functional dyspepsia. Lack of influence of symptom subgroups and H. pylori associated gastritis. Dig. Dis. Sci. 1993 38 2247 54.
35. Piessevaux H Tack J Walrand S Pauwels S Geubel A. Intragastric distribution of standard meal in health and functional dyspepsia: correlation with specific symptoms. Neurogastroenterol. Motil. 2003 15 447 55.
36. Maczka M Thor P Lorens K Konturek SJ. Nitric oxide inhibits the myoelectrical activity of small intestine in dogs. J. Physiol. Pharmacol. 1993 44 31 42.
37. Russo A Fraser R Adachi K Horowitz M Boeckxstaens G. Evidence that nitric oxide mechanisms regulate small intestine motility in humans. Gut 1999 44 72 6.
38. Rodriguez-Membrilla A Martinez V Jimenez M Gonalons E Vergara P. Is nitric oxide the final mediator regulating the migrating myoelectric complex cycle? Am. J. Physiol. 1995 268 G207 14.
39. Sarna SK Otterson MF Ryan RP Cowles VE. Nitric oxide regulates migrating motor complex cycling and its postprandial disruption. Am. J. Physiol. 1993 265 G749 66.