Fatal HHV-6 associated encephalitis in an HIV-1 infected patient treated with cidofovir

Journal of Infection

Volumn 52, Issue 4, 2006, Pages 237-242

  Astriti, Myrto ^a,b   Zeller, Valérie ^a   Boutolleau, David ^a   Gautheret Dejean, Agnès ^a,c   Allen, George ^a   Seilhean, Danielle ^c   Agut, Henri ^a   Bricaire, François ^a   Katlama, Christine ^a   Bossi, Philippe ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b Hellenic Centre for Infectious Diseases Control   (Greece)

^c Faculty of Pharmacy   (France)

Author keywords

Cidofovir therapy; HHV 6 encephalitis; HIV 1 infected patient; PCR HHV 6

Indexed keywords

ACICLOVIR; CIDOFOVIR; GANCICLOVIR; LAMIVUDINE; RITONAVIR; SAQUINAVIR; VALACICLOVIR; VIRUS DNA; ZIDOVUDINE;

ADULT; ARTICLE; ATAXIA; BRAIN BIOPSY; CASE REPORT; CEREBROSPINAL FLUID ANALYSIS; COGNITIVE DEFECT; DEATH; DRUG WITHDRAWAL; EARLY DIAGNOSIS; ELECTROENCEPHALOGRAM; EPILEPTIC STATE; FANCONI RENOTUBULAR SYNDROME; FATALITY; FEMALE; FOLLOW UP; GRAND MAL SEIZURE; HEADACHE; HUMAN; HUMAN HERPESVIRUS 6; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MEMORY DISORDER; NUCLEAR MAGNETIC RESONANCE IMAGING; PARESTHESIA; PSYCHOMOTOR RETARDATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TONIC CLONIC SEIZURE; TREATMENT FAILURE; TREMOR; VIRUS ENCEPHALITIS;

ANTIVIRAL AGENTS; BIOPSY; BRAIN; CYTOSINE; ENCEPHALITIS, VIRAL; FATAL OUTCOME; FEMALE; HERPESVIRUS 6, HUMAN; HIV INFECTIONS; HIV-1; HUMANS; MAGNETIC RESONANCE IMAGING; MIDDLE AGED; PHOSPHONIC ACIDS; POLYMERASE CHAIN REACTION; ROSEOLOVIRUS INFECTIONS; VIRAL LOAD;

EID: 33645282498     PISSN: 01634453     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinf.2005.07.006     Document Type: Article

References (24)

1. S.Z. Salahuddin D.V. Ablashi P.D. Markham S.F. Josephs S. Sturzenegger M. Kaplan et. al. Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders Science 234 1986 596-601
2. J.T. Aubin H. Collandre D. Candotti D. Ingrand C. Rouzioux M. Burgard et. al. Several groups among human herpesvirus 6 strains can be distinguished by southern blotting and polymerase chain reaction J Clin Microbiol 29 1991 367-372
3. J.A. Levy F. Ferro D. Greenspan E.T. Lennette Frequent isolation of HHV-6 from saliva and high seroprevalence of the virus in the population Lancet 335 1990 1047-1050
4. K. Yamanishi T. Okuno K. Shiraki M. Takahashi T. Kondo Y. Asano et. al. Identification of human herpesvirus-6 as a causal agent for exanthem subitum Lancet 1 1988 1065-1067
5. W.R. Drobyski W.M. Dunne E. Burd K.K. Knox R.C. Ash M.M. Horowitz et. al. Human herpesvirus-6 (HHV-6) infection in allogeneic bone marrow transplant recipients: Evidence of a marrow-suppressive role for HHV-6 in vivo J Infect Dis 167 1993 735-739
6. W.R. Drobyski K.K. Knox D. Majewski D.R. Carrigan Brief report: Fatal encephalitis due to variant B human herpesvirus-6 infection in a bone marrow-transplant recipient N Engl J Med 330 1994 1356-1360
7. K.K. Knox D.R. Carrigan Active human herpesvirus (HHV-6) infection of the central nervous system in patients with AIDS J Acquir Immune Defic Syndr Hum Retrovirol 9 1995 69-73
8. M. Ito J. Baker D. Mock et. al. Human herpesvirus 6-meningoencephalitis in an HIV patient with progressive multifocal leukoencephalopathy Acta Neuropathol 100 2000 337-341
9. K.K. Knox D.P. Harrington D.R. Carrigan Fulminant human herpesvirus six encephalitis in a human immunodeficiency virus-infected infant J Med Virol 45 1995 288-292
10. J.T. Aubin L. Poirel C. Robert J.M. Huraux H. Agut Identification of human herpesvirus 6 variants A and B by amplimer hybridization with variant-specific oligonucleotides and amplification with variant-specific primers J Clin Microbiol 32 1994 2434-2440
11. A. Gautheret-Dejean C. Manichanh F. Thien-Ah-Koon A.M. Fillet N. Mangeney M. Vidaud et. al. Development of a real-time polymerase chain reaction assay for the diagnosis of human herpesvirus-6 infection and application to bone marrow transplant patients J Virol Methods 100 2002 27-35
12. M. Segondy J. Astruc N. Atoui B. Echenne C. Robert H. Agut Herpesvirus 6 infection in young children N Engl J Med 327 1992 1099-1100
13. N. Ishiguro S. Yamada T. Takahashi Y. Takahashi T. Togashi T. Okuno et. al. Meningo-encephalitis associated with HHV-6 related exanthem subitum Acta Paediatr Scand 79 1990 987-989
14. S. Kawaguchi S. Suga T. Kozawa T. Nakashima T. Yoshikawa Y. Asano Fatal encephalitis/encephalopathy in primary human herpesvirus-6 infection Arch Dis Child 67 1992 1484-1485
15. M.T. Caserta C.B. Hall K. Schnabel K. McIntyre C. Long M. Costanzo et. al. Neuroinvasion and persistence of human herpesvirus 6 in children J Infect Dis 170 1994 1586-1589
16. M. Luppi P. Barozzi A. Maiorana R. Marasca G. Torelli Human herpesvirus 6 infection in normal human brain tissue J Infect Dis 169 1994 943-944
17. P.K. Chan H.K. Ng A.F. Cheng Detection of human herpesviruses 6 and 7 genomic sequences in brain tumours J Clin Pathol 52 1999 620-623
18. S. Bossolasco R. Marenzi H. Dahl L. Vago M.R. Terreni F. Broccolo L. Vago M.R. Terreni F. Broccolo et. al. Human herpesvirus 6 in cerebrospinal fluid of patients infected with HIV: Frequency and clinical significance J Neurol Neurosurg Psychiatry 67 1999 789-792
19. P. Cinque L. Vago H. Dahl L. Vago M.R. Terreni F. Broccolo et. al. Polymerase chain reaction on cerebrospinal fluid for diagnosis of virus-associated opportunistic diseases of the central nervous system in HIV-infected patients AIDS 10 1996 951-958
20. C. Manichanh C. Olivier-Aubron J.P. Lagarde J.T. Aubin P. Bossi A. Gautheret-Dejean et. al. Selection of the same mutation in the U69 protein kinase gene of human herpesvirus-6 after prolonged exposure to ganciclovir in vitro and in vivo J General Virol 82 2001 2767-2776
21. S. Dewhurst K. McIntyre K. Schnabel C.B. Hall Human herpesvirus 6 (HHV-6) variant B accounts for the majority of symptomatic primary HHV-6 infections in a population of U.S. infants J Clin Microbiol 31 1993 416-418
22. C.B. Hall M.T. Caserta K.C. Schnabel C. Long L.G. Epstein R.A. Insel et. al. Persistence of human herpesvirus 6 according to site and variant: Possible greater neurotropism of variant A Clin Infect Dis 26 1998 132-137
23. C. Rieux A. Gautheret-Dejean D. Challine-Lehmann C. Kirch H. Agut J.P. Vernant Human herpesvirus-6 meningoencephalitis in a recipient of an unrelated allogeneic bone marrow transplantation Transplantation 65 1998 1408-1411
24. J. Gausnault M. Kahraman M.G. de Goër de Herve D. Durali J.F. Delfraissy Y. Taoufik Critical role of JC virus-specific CD4 T-cell responses in preventing progressive multifocal leukoencephalopathy AIDS 17 2003 1443-1449