Localized internal radiotherapy with y particles embedded in a new thermosetting alginate gel: a feasibility study in pigs

Nuclear Medicine Communications

Volumn 27, Issue 2, 2006, Pages 185-190

  Holte, Øyvind ^a   Skretting, Arne ^b   Bach Gansmo, Tore ^b   Hol, Per Kristian ^b   Johnsrud, Kjersti ^b   Tønnesen, Hanne Hjorth ^b   Karlsen, Jan ^b  

^a UNIVERSITY OF OSLO   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Alginate; Animal experiments; Gels; Injectables; Localized radiation therapy; Yttrium 90 silicate

Indexed keywords

ALGINIC ACID; DRUG CARRIER; LIPOSOME; YTTRIUM; YTTRIUM 90;

ANIMAL; ANTIBODY SPECIFICITY; ARTICLE; CHEMISTRY; FEASIBILITY STUDY; GEL; INTRAMUSCULAR DRUG ADMINISTRATION; PARTICLE SIZE; SWINE; TEMPERATURE; TISSUE DISTRIBUTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; BONE MARROW; CONTROLLED STUDY; DRUG UPTAKE; FEMALE; LIVER; LUNG; NONHUMAN; RADIATION ABSORPTION; RADIOACTIVITY;

ALGINATES; ANIMALS; DRUG CARRIERS; FEASIBILITY STUDIES; GELS; INJECTIONS, INTRAMUSCULAR; LIPOSOMES; ORGAN SPECIFICITY; PARTICLE SIZE; SWINE; TEMPERATURE; TISSUE DISTRIBUTION; YTTRIUM RADIOISOTOPES;

EID: 33645240443     PISSN: 01433636     EISSN: 14735628     Source Type: Journal    
DOI: 10.1097/01.mnm.0000194398.97195.d9     Document Type: Article

References (33)

1. Weiner RE, Spencer RP. Microspheres, Microcapsules & Liposomes. Vol. 3. Radionuclide Therapy with Radiolabelled Particulates. Arshady R (editor). London: Citus Books; 2001, pp. 321-360.
2. 90Y radiocolloids. Br J Radiol 1975; 48:377-381.
3. Oka M, Rekonen A, Ruotsi A, Seppala O. Intra-articular injection of Y-90 resin colloid in the treatment of rheumatoid knee joint effusions. Acta Rheumatol Scand 1971; 17:148-159.
4. Rodriguez-Merchan EC, Wiedel JD. General principles and indications of synoviorthesis (medical synovectomy) in haemophilia. Haemophilia 2001; 7(Suppl 2):6-10.
5. Powell JL, Burrell MO, Kirchner AB. Intraperitoneal radioactive chromic phosphate P 32 in the treatment of ovarian cancer. South Med J 1987; 80:1513-1517.
6. 18F-FDG uptake and tumour size on PET/CT. Eur J Nucl Med Mol Imaging 2005; 32:778-787.
7. Gray B, Van Hazel G, Hope M, Burton M, Moroz P, Anderson J, Gebski V. Randomised trial of SIR-spheres plus chemotherapy vs. chemotherapy alone for treating patients with liver metastases from primary large bowel cancer. Ann Oncol 2001; 12:1711-1720.
8. 90yttrium microspheres for extensive colorectal liver metastases. J Gastrointest Surg 2001; 5:294-302.
9. Campbell AM, Bailey IH, Burton MA. Analysis of the distribution of intra-arterial microspheres in human liver following hepatic yttrium-90 microsphere therapy. Phys Med Biol 2000; 45:1023-1033.
10. Shepherd FA, Rotstein LE, Houle S, Yip TC, Paul K, Sniderman KW. A phase I dose escalation trial of yttrium-90 microspheres in the treatment of primary hepatocellular carcinoma. Cancer 1992; 70:2250-2254.
11. Nijsen F, Rook D, Brandt C, Meijer R, Dullens H, Zonnenberg B, et al. Targeting of liver tumor in rats by selective delivery of holmium-166 loaded microspheres: a biodistribution study. Eur J Nucl Med 2001; 28:743-749.
12. Nakakuma K, Tashiro S, Hiraoka T, Uemura K, Konno T, Miyauchi Y, Yokoyama I. Studies on anticancer treatment with an oily anticancer drug injected into the ligated feeding hepatic artery for liver cancer. Cancer 1983; 52:2193-2200.
13. Lau WY, Leung TWT, Ho SKW, Chan M, Machin D, Lau J, et al. Adjuvant intra-arterial iodine-131-labeled lipiodol for resectable hepatocellular carcinoma: a prospective randomized trial. Lancet 1999; 353:797-801.
14. Okayasu I, Hatakeyama S, Yoshida T, Yoshimatsu S, Tsuruta K, Miyamoto H, Kimula Y. Selective and persistent deposition and gradual drainage of iodized oil. Lipiodol in the hepatocellular carcinoma after injection into the feeding hepatic artery. Am J Clin Pathol 1988; 90:536-544.
15. 153Sm-chitosan complex for radiation synovectomy. Nucl Med Biol 2001; 28:719-725.
16. Song J, Suh CH, Park YB, Lee SH, Yoo NC, Lee JD, et al. A phase I/IIa study on intra-articular injection of holmium-166-chitosan complex for the treatment of knee synovitis of rheumatoid arthritis. Eur J Nucl Med 2001; 28:489-497.
17. 166Ho-chitosan complex (DW-166HC) into the prostate of rat. Eur J Nucl Med Mol Imaging 2005; 32:911-917.
18. Suzuki YS, Momose Y, Higashi N, Shigematsu A, Park KB, Kim YM, et al. Biodistribution and kinetics of holmium-166 chitosan complex (DW-166HC) in rats and mice. J Nucl Med 1998; 39:2161-2166.
19. Holte O, Skretting A, Tønnesen HH, Karlsen J. Preparation of radionuclide/gel formulation for localised radiotherapy to a wide range of organs and tissues. Pharmazie 2005; (in press).
20. Smidsrød O, Draget KI. Chemistry and physical properties of alginates. Carbohydr Europe 1996; 14:6-13.
21. Smidsrød O, Skjåk-Bræk G. Alginate as immobilization matrix for cells. Trends Biotechnol 1990; 8:71-78.
22. Skjåk-Bræk G, Espevik T. Application of alginate gels in biotechnology and biomedicine. Carbohydr Europe 1996; 14:19-25.
23. Skaugrud Ø, Hagen A, Borgersen B, Dornish M. Biomedical and pharmaceutical applications of alginate. Biotechnol Genet Eng Rev 1999; 16:23-39.
24. Simpkin DJ. Radiation interactions and internal dosimetry in nuclear medicine. Radiographics 1999; 19:155-167.
25. Stabin MG, Tagesson M, Thomas SR, Ljungberg M, Strand SE. Radiation dosimetry in nuclear medicine. Appl Radiat Isotopes 1999; 50:73-87.
26. Betageri GV, Kulkarni AR. Microspheres, Microcapsules Liposomes. Vol. 1: Preparation of Liposomes. Arshady R (editor): London: Citus Books; 1999, pp. 498-499.
27. Rouser G, Fleisner S, Yamamoto A. Two dimensional thin layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots. Lipids 1970; 5:494-496.
28. Ruotsalainen U, Raitakari M, Nuutila P, Oikonen V, Sipila H, Teras M, et al. Quantitative blood flow measurement of skeletal muscle using oxygen-15-water and PET. J Nucl Med 1997; 38:314-319.
29. Oddy VH, Brown BW, Jones AW. Measurement of organ blood flow using tritiated water. I. Hind limb muscle blood flow in conscious ewes. Aust J Biol Sci 1981; 34:419-425.
30. Drescher W, Schneider T, Becker C, Hobolth J, Rüther W, Hansen ES, Bünger C. Selective reduction of bone blood flow by short-term treatment with high-dose methylprednisolone. An experimental study in pigs. J Bone Joint Surg Br 2001; 83:274-277.
31. Drescher W, Weigert KP, Bunger MH, Ingerslev J, Bunger C, Hansen ES. Femoral head blood flow reduction and hypercoagulability under 24 h megadose steroid treatment in pigs. J Orthop Res 2004; 22:501-508.
32. Schneider T, Drescher W, Becker C, Sangill R, Stodkilde-Jorgensen H, Heydthausen M, et al. Dynamic gadolinium-enhanced MRI evaluation of porcine femoral head ischemia and reperfusion. Skeletal Radiol 2003; 32:59-65.
33. Østensen J, Hede R, Myreng Y, Ege T, Holtz E. Intravenous injection of Albunex® microspheres causes thromboxane mediated pulmonary hypertension in pigs, but not in monkeys or rabbits. Acta Physiol Scand 1992; 144:307-315.