Prodrug of proline analogue reduces hypoxic pulmonary hypertension in rats

Pulmonary Pharmacology and Therapeutics

Volumn 19, Issue 4, 2006, Pages 242-250

  Simon, Paul M ^a,d   Pachence, James ^a   Belinka, Benjamin ^a   Poiani, George J ^b,e   Lu, Shou En ^c   Tozzi, Carol A ^b,f   Riley, David J ^b  

^a VectraMed Inc   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c RUTGERS SCHOOL OF PUBLIC HEALTH   (United States)

^d Morphotek Inc   (United States)

^e RY34 B364 ^*  (United States)

^f MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antihypertensive agents; Collagen; Drug delivery systems; Fibrosis; Hypertension; Pulmonary

Indexed keywords

4 HYDROXY PROLINE POLY(ETHYLENE GLYCOL) LYSINE; COLLAGEN; PRODRUG; PROLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG EFFICACY; DRUG FORMULATION; DRUG POTENTIATION; DRUG SAFETY; DRUG SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; HEART VENTRICLE PRESSURE; HYPOXIA; MALE; NONHUMAN; OSMOTIC MINIPUMP; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RAT;

ANIMALS; ANOXIA; BLOOD PRESSURE; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROXYPROLINE; HYPERTENSION, PULMONARY; INFUSION PUMPS; INJECTIONS, INTRAVENOUS; INJECTIONS, SPINAL; INJECTIONS, SUBCUTANEOUS; LYSINE; MALE; POLYETHYLENE GLYCOLS; PRODRUGS; PROLINE; PULMONARY ARTERY; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; TREATMENT OUTCOME;

EID: 33645230243     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2005.07.001     Document Type: Article

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