Insulin cannot activate extracellular-signal-related kinase due to inability to generate reactive oxygen species in SK-N-BE(2) human neuroblastoma cells

Molecules and Cells

Volumn 20, Issue 2, 2005, Pages 280-287

  Hwang, Jung Jin ^a   Hur, Kyu Chung ^a  

^a Ewha Womans University   (South Korea)

Author keywords

Grb2; Insulin; IRS 1; MAPK ERK; Reactive Oxygen Species

Indexed keywords

ACETYLCYSTEINE; HYDROGEN PEROXIDE; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; MITOGEN ACTIVATED PROTEIN KINASE; PERVANADATE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN GRB2; RAC1 PROTEIN; RAS PROTEIN; REACTIVE OXYGEN METABOLITE; TYROSINE; WORTMANNIN;

ARTICLE; CELL STRAIN; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; INSULIN SENSITIVITY; NEUROBLASTOMA CELL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION;

ANIMALS; CELL LINE, TUMOR; CELLS, CULTURED; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; INSULIN; MAP KINASE SIGNALING SYSTEM; NEUROBLASTOMA; PC12 CELLS; PHOSPHOPROTEINS; PHOSPHORYLATION; RAS PROTEINS; RATS; REACTIVE OXYGEN SPECIES;

EID: 33645224486     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Backer, J. M., Myers, M. G. Jr., Sun, X. J., Chin, D. J., Shoelson, S. E., et al. (1993) Association of IRS-1 with the insulin receptor and the phosphatidylinositol 3′-kinase. Formation of binary and ternary signaling complexes in intact cells. J. Biol. Chem. 268, 8204-8212.
2. Bae, Y. S., Kang, S. W., Seo, M. S., Baines, I. C., Tekle, E., et al. (1997) Epidermal growth factor (EGF)-induced generation of hydrogen peroxide. Role in EGF receptor-mediated tyrosine phosphorylation. J. Biol. Chem. 272, 217-221.
3. 2 production requires the activation of phosphatidylinositol 3-kinase. J. Biol. Chem. 275, 10527-10531.
4. Baltensperger, K., Kozma, L. M., Cherniack, A. D., Klarlund, J. K., Chawla, A., et al. (1993) Binding of the Ras activator son of sevenless to insulin receptor substrate-1 signaling complexes. Science 260, 1950-1952.
5. Banfi, B., Clark, R. A., Steger, K., and Krause, K. (2003) Two novel proteins activate superoxide generation by the NADPH oxidase NOX1. J. Biol. Chem. 278, 3510-3513.
6. Barbior, B. M. (1999) NADPH oxidase: an update. Blood 93, 1464-1476.
7. Bazenet, C. E., Gelderloos, J. A., and Kazlauskas, A. (1996) Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation. Mol. Cell. Biol. 16, 6926-6936.
8. Biedler, J. L., Rofflrt-Tarlov, S., Schachner, M., and Freedman, M. S. (1978) Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones. Cancer Res. 38, 3751-3757.
9. Bokoch, G. M. and Diebold, B. A. (2002) Current molecular models for NADPH oxidase regulation by Rac GTPase. Blood 100, 2692-2696.
10. Buday, L. and Downward, J. (1993) Epidermal growth factor regulates p21 ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor. Cell 73, 611-620.
11. Burdon, R. H. (1995) Superoxide and hydrogen peroxide in relation to mammalian cell proliferation. Free Radic. Biol. Med. 18, 775-794.
12. Claiborne, A., Yeh, J. I., Mallett, T. C., Luba, J., Crane, E. J. 3rd, et al. (1999) Protein-sulfenic acids: diverse roles for an unlikely player in enzyme catalysis and redox regulation. Biochemistry 38, 15407-15416.
13. 2+-dependent thiol activation of fat cell glucose utilization. J. Biol. Chem. 249, 1001-1006.
14. Dugan, L. L., Creedon, D. J., Johnson, E. M., and Holtzman, D. M. (1997) Rapid suppression of free radical formation by nerve growth factor involves the mitogen-activated protein kinase pathway. Proc. Natl. Acad. Sci. USA 94, 4086-4091.
15. Fantl, W. J., Johnson, D. E., and Williams, L. T. (1993) Signalling by receptor tyrosine kinases. Annu. Rev. Biochem. 62, 453-481.
16. Finkel, T. (1998) Oxygen radicals and signaling. Curr. Opin. Cell Biol. 10, 248-253.
17. Heldin, C. H. (1995) Dimerization of cell surface receptors in signal transduction. Cell 80, 213-223.
18. Herrlich, P. and Bohmer, F. D. (2000) Redox regulation of signal transduction in mammalian cells. Biochem. Pharmacol. 59, 35-41.
19. Hunter, T. (2000) Signaling-2000 and beyond. Cell 100, 113-127.
20. Hwang, J. J., Lim, J. H., Kwon, J. H., Lee, K. Y., and Hur, K. C. (1995) Effect of nerve growth factor, insulin, and extracellular matrix proteins on the neurite outgrowth of SK-N-BE(2) human neuroblastoma cells. Mol. Cells 5, 501-507.
21. Imbert, V., Rupec, R. A., Livolsi, A., Pahl, H. L., Traenckner, E. B., et al. (1996) Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha. Cell 86, 787-798.
22. Jaiswal, R. K., Moodie, S. A., Wolfman, A., and Landreth, G. E. (1994) The mitogen-activated protein kinase cascade is activated by B-Raf in response to nerve growth factor through interaction with p21ras. Mol. Cell. Biol. 14, 6944-6953.
23. 2+ signaling followed by phospholipase-A2 activation and potentiated by an adenosine derivative. Endocrinology 136, 116-123.
24. 2 generation in 3T3 L1-cells. Biochem. J. 307, 549-556.
25. 2 generation in human adipocyte plasma membranes is mediated by Galphai2. J. Biol. Chem. 272, 10135-10143.
26. Kuhne, M. R., Pawson, T., Lienhard, G. E., and Feng, G. S. (1993) The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp. J. Biol. Chem. 268, 11479-11481.
27. Kypta, R. M., Goldberg, Y., Ulug, E. T., and Courtneidge, S. A. (1990) Association between the PDGF receptor and members of the src family of tyrosine kinases. Cell 62, 481-492.
28. Leevers, S. J., Paterson, H. F., and Marshall, C. J. (1994) Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane. Nature 369, 411-414.
29. Li, N., Batzer, A., Daly, R., Yajnik, V., Skolnik, E., et al. (1993) Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling. Nature 363, 85-88.
30. Lo, Y. Y. and Cruz, T. F. (1995) Involvement of reactive oxygen species in cytokine and growth factor induction of c-fos expression in chondrocytes. J. Biol. Chem. 270, 11727-11730.
31. Macdonald, S. G., Crews, C. M., Wu, L., Driller, J., Clark, R., et al. (1993) Reconstitution of the Raf-1-MEK-ERK signal transduction pathway in vitro. Mol. Cell. Biol. 13, 6615-6620.
32. Mahadev, K., Zilbering, A., Zhu, L., and Goldstein, B. J. (2001a) Insulin-stimulated hydrogen peroxide reversibly inhibits protein-tyrosine phosphatase 1b in vivo and enhances the early insulin action cascade. J. Biol. Chem. 276, 21938-21942.
33. Mahadev, K., Wu, X., Zilbering, A., Zhu, L., Lawrence, J. T., et al. (2001b) Hydrogen peroxide generated during cellular insulin stimulation is integral to activation of the distal insulin signaling cascade in 3T3-L1 adipocytes. J. Biol. Chem. 276, 48662-48669.
34. Meier, B., Cross, A. R., Hancock, J. T., Kamp, F., and Jones, O. T. G. (1991) Identification of a superoxide generating NADPH-oxidase system in human fibroblasts. Biochem. J. 275, 241-245.
35. Ohba, M., Shibanuma, M., Kuroki, T., and Nose, K. (1994) Production of hydrogen peroxide by transforming growth factor-beta 1 and its involvement in induction of egr-1 in mouse osteoblastic cells. J. Cell Biol. 126, 1079-1088.
36. phox may participate in forming this oxidase in vitro and in vivo. J. Biol. Chem. 274, 19814-19822.
37. Rozakis-Adcock, M., Fernley, R., Wade, J., Pawson, T., and Bowtell, D. (1993) The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1. Nature 363, 83-85.
38. Sattler, M., Winkler, T., Verma, S., Byrne, C. H., Shrikhande, G., et al. (1999) Hematopoietic growth factors signal through the formation of reactive oxygen species. Blood 93, 2928-2935.
39. Seo, J. H., Ahn, Y., Lee, S., Yeo, C. Y., and Hur, K. C. (2005) The major target of the endogenously generated reactive oxygen species in response to insulin stimulation is phosphatase and tensin homolog and not phosphoinositide-3 kinase (PI-3 kinase) in the PI-3 kinase/Akt pathway. Mol. Biol. Cell 16, 348-357.
40. Songyang, Z., Shoelson, S. E., Chaudhuri, M., Gish, G., Pawson, T., et al. (1993) SH2 domains recognize specific phosphopeptide sequences. Cell 72, 767-778.
41. 2 for platelet-derived growth factor signal transduction. Science 270, 296-299.
42. Sundaresan, M., Yu, Z. X., Ferrans, V. J., Sulciner, D. J., Gutkind, J. S., et al. (1996) Regulation of reactive-oxygen-species generation in fibroblasts by Rac1. Biochem. J. 318, 379-382.
43. Szatrowski, T. P. and Nathan, C. F. (1991) Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res. 51, 794-798.
44. White, M. F. (1998) The IRS-signalling system: a network of docking proteins that mediate insulin action. Mol. Cell. Biochem. 182, 3-11.
45. White, M. F. and Kahn, C. R. (1994) The insulin signaling system. J. Biol. Chem. 269, 1-4.
46. Zhang, Z. Y. (1998) Protein-tyrosine phosphatases: biological function, structural characteristics, and mechanism of catalysis. Crit. Rev. Biochem. Mol. Biol. 33, 1-52.