Acetaminophen poisoning

Clinics in Laboratory Medicine

Volumn 26, Issue 1, 2006, Pages 49-65

  Rowden, Adam K ^a   Norvell, Jeffrey ^b   Eldridge, David L ^c   Kirk, Mark A ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b TRUMAN MEDICAL CENTER   (United States)

^c EAST CAROLINA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; ANTIEMETIC AGENT; ANTIHISTAMINIC AGENT; ASPARTATE AMINOTRANSFERASE; CYTOCHROME P450; GLUTATHIONE; ISONIAZID; PARACETAMOL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANAPHYLAXIS; ANGIONEUROTIC EDEMA; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; AUTOPSY; BRONCHOSPASM; DRUG BINDING; DRUG BLOOD LEVEL; DRUG DETOXIFICATION; DRUG INTOXICATION; DRUG MECHANISM; DRUG OVERDOSE; HISTOPATHOLOGY; HUMAN; HYPOTENSION; LIVER BIOPSY; LIVER FAILURE; LIVER TOXICITY; NAUSEA AND VOMITING; NOMOGRAM; NONHUMAN; POISON CENTER; PRIORITY JOURNAL; PROGNOSIS; REVIEW; RISK FACTOR; SKIN MANIFESTATION; TREATMENT DURATION;

ACETAMINOPHEN; ACETYLCYSTEINE; ANALGESICS, NON-NARCOTIC; ANTIDOTES; HUMANS; POISONING;

EID: 33645218422     PISSN: 02722712     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cll.2006.01.004     Document Type: Review

References (100)

1. W.A. Watson, T.L. Litovitz, and W. Klein-Schwartz 2003 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System Am J Emerg Med 22 5 2004 335 404
2. G. Ostapowicz, R.J. Fontana, and F.V. Schiodt Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States Ann Intern Med 137 12 2002 947 954
3. A.J. Singer, T.R. Carracio, and H.C. Mofenson The temporal profile of increased transaminase levels in patients with acetaminophen-induced liver dysfunction Ann Emerg Med 26 1 1995 49 53
4. J.F. Ashbourne, K.R. Olson, and H. Khayam-Bashi Value of rapid screening for acetaminophen in all patients with intentional drug overdose Ann Emerg Med 18 10 1989 1035 1038
5. K.A. Sporer, and H. Khayam-Bashi Acetaminophen and salicylate serum levels in patients with suicidal ingestion or altered mental status Am J Emerg Med 14 5 1996 443 446
6. R.L. Bertholf, L.M. Johannsen, and A. Bazooband False-positive acetaminophen results in a hyperbilirubinemic patient Clin Chem 49 4 2003 695 698
7. M.C. Beuhler, and S.C. Curry False Positive acetaminophen levels associated with hyperbilirubinemia Clin Toxicol (Phila) 43 3 2005 167 170
8. N.J. Baeg, and H.C. Bodenheimer Jr. Long-term sequellae of acetaminophen-associated fulfminant hepatic failure: relevance of early histology Am J Gastroenterol 83 5 1988 569 571
9. K.V. Blake, D. Beiley, and G.M. Zientek Death of a child associated with multiple overdoses of acetaminophen Clin Pharm 7 5 1988 391 397
10. B. McJunkin, K.W. Barwick, and W.C. Little Fatal Massive hepatic necrosis following acetaminophen overdose Jama 236 16 1976 1874 1875
11. J.R. O'Dell, R.K. Zetterman, and D.A. Burnett Centilobular hepatic fibrosis following acetaminophen-induced hepatic necrosis in an alcoholic Jama 255 19 1986 2636 2637
12. K.E. Thummel, J.T. Slattery, and H. Ro Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults Clin Pharmacol Ther 67 6 2000 591 599
13. B.H. Rumack Acetaminophen misconceptions Hepatology 40 1 2004 10 15
14. G.B. Corcoran, J.R. Mitchell, and Y.N. Vaishnav Evidence that acetaminophen and N-hydroxyacetaminophen form a common arylating intermediate, N-acetyl-p-benzoquinoneimine Mol Pharmacol 18 3 1980 536 542
15. J.R. Mitchell, G.B. Corcoran, and C.V. Smith Alkylation and peroxidation injury from chemically reactive metabolites Adv Exp Med Biol 136 Pt A 1981 199 223
16. B.H. Rumack Acetaminophen hepatotoxicity: the first 35 years J Toxicol Clin Toxicol 40 1 2002 3 20
17. J.M. Tredger, H.M. Smith, and R.B. Read Effects of ethanol ingestion on the metabolism of a hepatotoxic dose of paracetamol in mice Xenobiotica 16 7 1986 661 670
18. L.B. Seeff, B.A. Cuccherini, and H.J. Zimmerman Acetaminophen hepatotoxicity in alcoholics. A therapeutic misadventure Ann Intern Med 104 3 1986 399 404
19. D.C. Whitcomb, and G.D. Block Association of acetaminophen hepatotoxicity with fasting and ethanol use JAMA 272 23 1994 1845 1850
20. B.H. Lauterburg, and M.E. Velez Glutathione deficiency in alcoholics: risk factor for paracetamol hepatotoxicity Gut 29 9 1988 1153 1157
21. F.V. Schiodt, W.M. Lee, and S. Bondesen Influence of acute and chronic alcohol intake on the clinical course and outcome in acetaminophen overdose Aliment Pharmacol Ther 16 4 2002 707 715
22. L.T. Wong, L.W. Whitehouse, and G. Solomonraj Effect of a concomitant single dose of ethanol on the hepatotoxicity and metabolism of acetaminophen in mice Toxicology 17 3 1980 297 309
23. C. Sato, M. Nakano, and C.S. Lieber Prevention of acetaminophen-induced hepatotoxicity by acute ethanol administration in the rat: comparison with carbon tetrachloride-induced hepatoxicity J Pharmacol Exp Ther 218 3 1981 805 810
24. G.P. Bray, P.M. Harrison, and J.G. O'Grady Long-term anticonvulsant therapy worsens outcome in paracetamol-induced fulminant hepatic failure Hum Exp Toxicol 11 4 1992 265 270
25. R. Zand, S.D. Nelson, and J.T. Slattery Inhibition and induction of cytochrome P4502E1-catalyzed oxidation by isoniazid in humans Clin Pharmacol Ther 54 2 1993 142 149
26. R. Murphy, R. Swartz, and P.B. Watkins Severe acetaminophen toxicity in a patient receiving isoniazid Ann Intern Med 113 10 1990 799 800
27. M.M. Epstein, S.D. Nelson, and J.T. Slattery Inhibition of the metabolism of paracetamol by isoniazid Br J Clin Pharmacol 31 2 1991 139 142
28. C.C. Brackett, and J.D. Bloch Phenytoin as a possible cause of acetaminophen hepatotoxicity: case report and review of the literature Pharmacotherapy 20 2 2000 229 233
29. F. Zenger, S. Russmann, and E. Junker Decreased glutathione in patients with anorexia nervosa. Risk factor for toxic liver injury? Eur J Clin Nutr 58 2 2004 238 243
30. F.M. Henretig, S.M. Selbst, and C. Forrest Repeated acetaminophen overdosing. Causing hepatotoxicity in children. Clinical reports and literature review Clin Pediatr (Phila) 28 11 1989 525 528
31. J. Kurtovic, and S.M. Riordan Paracetamol-induced hepatotoxicity at recommended dosage J Intern Med 253 2 2003 240 243
32. B.H. Rumack, and H. Matthew Acetaminophen poisoning and toxicity Pediatrics 55 6 1975 871 876
33. M.J. Smilkstein, G.L. Knapp, and K.W. Kulig Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985) N Engl J Med 319 24 1988 1557 1562
34. L.F. Prescott, R.N. Illingworth, and J.A. Critchley Intravenous N-acetylcysteine: the treatment of choice for paracetamol poisoning BMJ 2 6198 1979 1097 1100
35. R.G. Peterson, and B.H. Rumack Toxicity of acetaminophen overdose JACEP 7 5 1978 202 205
36. L.F. Prescott Treatment of severe acetaminophen poisoning with intravenous acetylcysteine Arch Intern Med 141 3 Spec No 1981 386 389
37. B.H. Rumack, R.C. Peterson, and G.G. Koch Acetaminophen overdose. 662 cases with evaluation of oral acetylcysteine treatment Arch Intern Med 141 3 Spec No 1981 380 385
38. R. Keays, P.M. Harrison, and J.A. Wendon Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial BMJ 303 6809 1991 1026 1029
39. P.M. Harrison, R. Keays, and G.P. Bray Improved outcome of paracetamol-induced fulminant hepatic failure by late administration of acetylcysteine Lancet 335 8705 1990 1572 1573
40. E.W. Cetaruk, R.C. Dart, and R.S. Horowitz Extended-release acetaminophen overdose JAMA 275 9 1996 686
41. A.R. Temple Dear Doctor, Tylenol ER letter [product insert] 1995 McNeil Consumer Products Company Fort Washington (PA)
42. S. Vassallo, A.N.G.A. Khan, and M.A. Howland Use of the Rumack-Matthew nomogram in cases of extended-release acetaminophen toxicity Ann Intern Med 125 11 1996 940
43. E.W. Cetaruk, R.C. Dart, and K.M. Hurlbut Tylenol Extended Relief overdose Ann Emerg Med 30 1 1997 104 108
44. K.E. Bizovi, S.E. Aks, and F. Paloucek Late increase in acetaminophen concentration after overdose of Tylenol Extended Relief Ann Emerg Med 28 5 1996 549 551
45. D.R. Douglas, J.B. Sholar, and M.J. Smilkstein A pharmacokinetic comparison of acetaminophen products (Tylenol Extended Relief vs regular Tylenol) Acad Emerg Med 3 8 1996 740 744
46. R.D. Mathis, J.S. Walker, and D.W. Kuhns Subacute acetaminophen overdose after incremental dosing J Emerg Med 6 1 1988 37 40
47. E. Kozer, J. Barr, and M. Bulkowstein A prospective study of multiple supratherapeutic acetaminophen doses in febrile children Vet Hum Toxicol 44 2 2002 106 109
48. F.F. Daly, G.F. O'Malley, and K. Heard Prospective evaluation of repeated supratherapeutic acetaminophen (paracetamol) ingestion Ann Emerg Med 44 4 2004 393 398
49. E.K. Kuffner, R.C. Dart, and G.M. Bogdan Effect of maximal daily doses of acetaminophen on the liver of alcoholic patients: a randomized, double-blind, placebo-controlled trial Arch Intern Med 161 18 2001 2247 2252
50. L.F. Prescott, R.N. Illingworth, and J.A. Critchley Intravenous N-acetylcysteine: still the treatment of choice for paracetamol poisoning BMJ 280 6206 1980 46 47
51. R.G. Peterson, and B.H. Rumack N-acetylcysteine for acetaminophen overdosage (cont.) N Engl J Med 296 9 1977 515
52. B.H. Lauterburg, G.B. Corcoran, and J.R. Mitchell Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo J Clin Invest 71 4 1983 980 991
53. J.R. Mitchell, S.S. Thorgeirsson, and W.Z. Potter Acetaminophen-induced hepatic injury: protective role of glutathione in man and rationale for therapy Clin Pharmacol Ther 16 4 1974 676 684
54. A.R. Buckpitt, D.E. Rollins, and J.R. Mitchell Varying effects of sulfhydryl nucleophiles on acetaminophen oxidation and sulfhydryl adduct formation Biochem Pharmacol 28 19 1979 2941 2946
55. J.T. Slattery, J.M. Wilson, and T.F. Kalhorn Dose-dependent pharmacokinetics of acetaminophen: evidence of glutathione depletion in humans Clin Pharmacol Ther 41 4 1987 413 418
56. C.D. Spies, K. Reinhart, and I. Witt Influence of N-acetylcysteine on indirect indicators of tissue oxygenation in septic shock patients: results from a prospective, randomized, double-blind study Crit Care Med 22 11 1994 1738 1746
57. P.M. Harrison, J.A. Wendon, and A.E. Gimson Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure N Engl J Med 324 26 1991 1852 1857
58. J. Devlin, A.E. Ellis, and J. McPeake N-acetylcysteine improves indocyanine green extraction and oxygen transport during hepatic dysfunction Crit Care Med 25 2 1997 236 242
59. T.S. Walsh, P. Hopton, and B.J. Philips The effect of N-acetylcysteine on oxygen transport and uptake in patients with fulminant hepatic failure Hepatology 27 5 1998 1332 1340
60. J.A. Wendon, P.M. Harrison, and R. Keays Cerebral blood flow and metabolism in fulminant liver failure Hepatology 19 6 1994 1407 1413
61. M.K. Bruno, S.D. Cohen, and E.A. Khairallah Antidotal effectiveness of N-acetylcysteine in reversing acetaminophen-induced hepatotoxicity. Enhancement of the proteolysis of arylated proteins Biochem Pharmacol 37 22 1988 4319 4325
62. S. Cuzzocrea, G. Costantino, and E. Mazzon Protective effect of N-acetylcysteine on multiple organ failure induced by zymosan in the rat Crit Care Med 27 8 1999 1524 1532
63. M.L. Bajt, T.R. Knight, and J.J. Lemasters Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: protection by N-acetyl cysteine Toxicol Sci 80 2 2004 343 349
64. V. Lewerenz, S. Hanelt, and C. Nastevska Antioxidants protect primary rat hepatocyte cultures against acetaminophen-induced DNA strand breaks but not against acetaminophen-induced cytotoxicity Toxicology 191 2-3 2003 179 187
65. J.A. Brent, and B.H. Rumack Role of free radicals in toxic hepatic injury. II. Are free radicals the cause of toxin-induced liver injury? J Toxicol Clin Toxicol 31 1 1993 173 196
66. T.R. Knight, M.W. Fariss, and A. Farhood Role of lipid peroxidation as a mechanism of liver injury after acetaminophen overdose in mice Toxicol Sci 76 1 2003 229 236
67. Acetadote package insert 2004 Cumberland Pharmaceuticals Nashville (TN)
68. L.F. Miller, and B.H. Rumack Clinical safety of high oral doses of acetylcysteine Semin Oncol 10 1 Suppl 1 1983 76 85
69. M.J. Smilkstein, A.C. Bronstein, and C. Linden Acetaminophen overdose: a 48-hour intravenous N-acetylcysteine treatment protocol Ann Emerg Med 20 10 1991 1058 1063
70. O.F. Woo, P.D. Mueller, and K.R. Olson Shorter duration of oral N-acetylcysteine therapy for acute acetaminophen overdose Ann Emerg Med 35 4 2000 363 368
71. N.A. Buckley, I.M. Whyte, and D.L. O'Connell Oral or intravenous N-acetylcysteine: which is the treatment of choice for acetaminophen (paracetamol) poisoning? J Toxicol Clin Toxicol 37 6 1999 759 767
72. S.E. Taylor Acetaminophen intoxication and length of treatment: how long is long enough? - A comment Pharmacotherapy 24 5 2004 694 696 [discussion: 696]
73. T.G. Mant, J.H. Tempowski, and G.N. Volans Adverse reactions to acetylcysteine and effects of overdose Br Med J (Clin Res Ed) 289 6439 1984 217 219
74. L. Yip, R.C. Dart, and K.M. Hurlbut Intravenous administration of oral N-acetylcysteine Crit Care Med 26 1 1998 40 43
75. B. Bailey, D.K. Amre, and P. Gaudreault Fulminant hepatic failure secondary to acetaminophen poisoning: a systematic review and meta-analysis of prognostic criteria determining the need for liver transplantation Crit Care Med 31 1 2003 299 305
76. R.M. Lynch, and R. Robertson Anaphylactoid reactions to intravenous N-acetylcysteine: a prospective case controlled study Accid Emerg Nurs 12 1 2004 10 15
77. M.E. Mullins, R.U. Schmidt Jr., and T.B. Jang What is the rate of adverse events with intravenous versus oral N-acetylcysteine in pediatric patients? Ann Emerg Med 44 5 2004 547 549
78. L.W. Kao, M.A. Kirk, and R.B. Furbee What is the rate of adverse events after oral N-acetylcysteine administered by the intravenous route to patients with suspected acetaminophen poisoning? Ann Emerg Med 42 6 2003 741 750
79. B. Bailey, and M.A. McGuigan Management of anaphylactoid reactions to intravenous N-acetylcysteine Ann Emerg Med 31 6 1998 710 715
80. A.V. Appelboam, P.I. Dargan, and J. Knighton Fatal anaphylactoid reaction to N-acetylcysteine: caution in patients with asthma Emerg Med J 19 6 2002 594 595
81. W.H. Dribben, S.M. Porto, and B.K. Jeffords Stability and microbiology of inhalant N-acetylcysteine used as an intravenous solution for the treatment of acetaminophen poisoning Ann Emerg Med 42 1 2003 9 13
82. J.G. O'Grady, G.J. Alexander, and K.M. Hayllar Early indicators of prognosis in fulminant hepatic failure Gastroenterology 97 2 1989 439 445
83. D.J. Mutimer, R.C. Ayres, and J.M. Neuberger Serious paracetamol poisoning and the results of liver transplantation Gut 35 6 1994 809 814
84. A.J. Makin, J. Wendon, and R. Williams A 7-year experience of severe acetaminophen-induced hepatotoxicity (1987-1993) Gastroenterology 109 6 1995 1907 1916
85. A.C. Anand, P. Nightingale, and J.M. Neuberger Early indicators of prognosis in fulminant hepatic failure: an assessment of the King's criteria J Hepatol 26 1 1997 62 68
86. P.M. Harrison, J.G. O'Grady, and R.T. Keays Serial prothrombin time as prognostic indicator in paracetamol induced fulminant hepatic failure BMJ 301 6758 1990 964 966
87. C. Payen, A. Dachraoui, and C. Pulce Prothrombin time prolongation in paracetamol poisoning: a relevant marker of hepatic failure? Hum Exp Toxicol 22 11 2003 617 621
88. I.M. Whyte, N.A. Buckley, and D.M. Reith Acetaminophen causes an increased International Normalized Ratio by reducing functional factor VII Ther Drug Monit 22 6 2000 742 748
89. L.E. Schmidt, T.T. Knudsen, and K.P. Dalhoff [Effect of N-acetylcysteine on prothrombin index in patients with uncomplicated paracetamol poisoning.] Ugeskr Laeger 166 40 2004 3502 3504
90. L.E. Schmidt, T.T. Knudsen, and K. Dalhoff Effect of acetylcysteine on prothrombin index in paracetamol poisoning without hepatocellular injury Lancet 360 9340 2002 1151 1152
91. L.M. Pereira, P.G. Langley, and K.M. Hayllar Coagulation factor V and VIII/V ratio as predictors of outcome in paracetamol induced fulminant hepatic failure: relation to other prognostic indicators Gut 33 1 1992 98 102
92. B.G. Gazzard, J.M. Henderson, and R. Williams Early changes in coagulation following a paracetamol overdose and a controlled trial of fresh frozen plasma therapy Gut 16 8 1975 617 620
93. I. Mitchell, D. Bihari, and R. Chang Earlier identification of patients at risk from acetaminophen-induced acute liver failure Crit Care Med 26 2 1998 279 284
94. L.E. Schmidt, and K. Dalhoff Serum phosphate is an early predictor of outcome in severe acetaminophen-induced hepatotoxicity Hepatology 36 3 2002 659 665
95. P.Y. Chung, M.D. Sitrin, and H.S. Te Serum phosphorus levels predict clinical outcome in fulminant hepatic failure Liver Transpl 9 3 2003 248 253
96. K.L. Ng, J.S. Davidson, and A.J. Bathgate Serum phosphate is not a reliable early predictor of outcome in paracetamol induced hepatotoxicity Liver Transpl 10 1 2004 158 159
97. W. Bernal, N. Donaldson, and D. Wyncoll Blood lactate as an early predictor of outcome in paracetamol-induced acute liver failure: a cohort study Lancet 359 9306 2002 558 563
98. L.E. Schmidt, and K. Dalhoff Hyperamylasaemia and acute pancreatitis in paracetamol poisoning Aliment Pharmacol Ther 20 2 2004 173 179
99. F.V. Schiodt, S. Bondesen, and N. Tygstrup Prediction of hepatic encephalopathy in paracetamol overdose: a prospective and validated study Scand J Gastroenterol 34 7 1999 723 728
100. L.E. Schmidt, and K. Dalhoff Alpha-fetoprotein is a predictor of outcome in acetaminophen-induced liver injury Hepatology 41 1 2004 26 31