N-acetylcysteine improves indocyanine green extraction and oxygen transport during hepatic dysfunction

Critical Care Medicine

Volumn 25, Issue 2, 1997, Pages 236-242

  Devlin, John ^a   Ellis, Antony E ^a   McPeake, James ^a   Heaton, Nigel ^a   Wendon, Julia A ^a   Williams, Roger ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

critical illness; disease; hemodynamics; indocyanine green extraction; liver; N acetylcysteine; oxygen consumption; prostacyclin; transplantation

Indexed keywords

ACETYLCYSTEINE; CYCLIC GMP; INDOCYANINE GREEN; PROSTACYCLIN;

ADOLESCENT; ADULT; ARTICLE; ARTIFICIAL VENTILATION; CHRONIC LIVER DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRITICAL ILLNESS; DOSE RESPONSE; FEMALE; HEMODYNAMICS; HUMAN; LIVER CIRCULATION; LIVER FAILURE; LIVER TRANSPLANTATION; MALE; OXYGEN CONSUMPTION; OXYGEN TRANSPORT; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; SPLANCHNIC BLOOD FLOW;

ACETYLCYSTEINE; ADOLESCENT; ADULT; ANTIHYPERTENSIVE AGENTS; EPOPROSTENOL; FEMALE; FREE RADICAL SCAVENGERS; HEMODYNAMIC PROCESSES; HUMANS; INDOCYANINE GREEN; INFUSIONS, INTRAVENOUS; LIVER DISEASES; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; OXYGEN CONSUMPTION;

EID: 0031026805     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199702000-00007     Document Type: Article

References (36)

1. Bland RD, Shoemaker WC, Abraham E, et al: Hemodynamic and oxygen transport patterns in surviving and nonsurviving postoperative patients. Crit Care Med 1985; 13:85-90
2. Gutierrez G, Paliazas F, Doglio G, et al: Gastric intramucosal pH as a therapeutic index of tissue oxygenation in critically ill patients. Lancet 1992; 339:195-199
3. Gottlieb ME, Stratton HH, Newell JC, et al: Indocyanine green. Its use as an early indicator of hepatic dysfunction following injury in man. Arch Surg 1984; 119:264-268
4. Kholoussy AM, Pollak D, Matsumoto T: Prognostic significance of indocyanine green clearance in critically ill surgical patients. Crit Care Med 1984; 12:115-116
5. Shoemaker WC, Appel PL, Kram HB, et al: Prospective trial of supranormal values of survivors as therapeutic goals in high-risk surgical patients. Chest 1988; 94:1176-1186
6. Ruokonen E, Takala J, Kari A, et al: Regional blood flow and oxygen transport in septic shock. Crit Care Med 1993; 21:1296-1303
7. Giraud GD, MacCannell KL: Decreased nutrient blood flow during dopamine-and epinephrine-induced intestinal vasodilatation. J Pharmacol Exp Ther 1984; 230:214-220
8. Reinhart K, Meier-Hellamnn A, Hannemann L: Regional versus global indicators of tissue oxygenation. In: 1994 Yearbook of Intensive Care and Emergency Medicine. Vincent JL (Ed). Berlin, Springer-Verlag, 1994
9. Wendon J, Alexander GJM, Williams R: Cardiovascular monitoring and local blood flow. In: Acute Liver Failure. Williams R, Hughes RD (Eds). London, Smith Kline and Beecham, 1990, pp 39-42
10. Marik PE, Mohedin M: The contrasting effects of dopamine and norepinephrine on systemic and splanchnic oxygen utilization in hyperdynamic sepsis. JAMA 1994; 272:1354-1357
11. Bihari D, Smithies M, Gimson A, et al: The effects of vasodilatation with prostacyclin on oxygen delivery and uptake in critically ill patients. N Engl J Med 1987; 317:397-403
12. Yamanaka N, Okamoto E, Kato T, et al: Usefulness of monitoring the ICG retention rate as an early indicator of allograft function in liver transplantation. Transplant Proc 1992; 24: 1614-1617
13. Frenette L, Doblar DD, Singer D, et al: Gastric intramural pH as indicator of early allograft viability in orthotopic liver transplantation. Transplantation 1994; 58:292-297
14. Oellerich M, Burdeleski M, Lautz H, et al: Predictors of one-year pretransplant survival in patients with cirrhosis. Hepatology 1991; 14:1029-1034
15. Harrison PM, Wendon JA, Gimson AES, et al: Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure. N Engl J Med 1991; 324:1852-1857
16. Harrison PM, Keays R, Bray GP, et al: Improved outcome in paracetamol-induced fulminant hepatic failure following late administration of acetylcysteine. Lancet 1990; 335: 1572-1573
17. Spies CD, Reinhart K, Witt I, et al: Influence of N-acetylcysteine on indirect indicators of tissue oxygenation in septic shock patients: Results from a prospective, randomized, double-blind study. Crit Care Med 1994; 22: 1738-1746
18. Zhang H, Spapen H, Nguyen DN, et al: Protective effects of N-acetylcysteine in endotoxaemia. Am J Physiol 1994; 26615:H1746-H1754
19. Bakker J, Zhang H, depierreux M, et al: Effects of N-acetylcysteine in endotoxic shock. J Crit Care 1994; 9:236-243
20. Lewis FR, Pfeiffer UJ (Eds): Practical Applications of Fibreoptics in Critical Care Monitoring. Berlin, Springer-Verlag, 1990
21. De Backer D, Berre J, Zhang H, et al: Relationship between oxygen uptake and oxygen delivery in septic patients: Effects of prostacyclin versus dobutamine. Crit Care Med 1993; 21: 1658-1664
22. Wendon JA, Harrison PM, Keays R, et al: Cerebral blood flow and metabolism in fulminant liver failure. Hepatology 1994; 19:1407-1413
23. Dantzker DR: The gastrointestinal tract: The canary of the body? JAMA 1993; 270:1247-1248
24. Harrison PM, Wendon JA, Williams R: Increase in plasma cyclic 3′,5′-guanosine monophosphate but not atrial natriuretic factor in response to N-acetylcysteine infusion in fulminant hepatic failure. Abstr. J Vasc Res 1992; 29:129
25. Payen D, Kubes P: Nitric oxide donors reduce the rise in reperfusion-induced intestinal permeability. Am J Physiol 1993; 265:G189-G195
26. Meyer J, Stothert JC, Pollard V, et al: Increased organ blood flow in sepsis and its reversal with the nitric oxide synthesis inhibitor L-NAME. Abstr. Crit Care Med 1993; 21:8280
27. G-monomethyl L-arginine (NMA) restores arterial blood pressure but reduces cardiac output in a canine model of endotoxic shock. Biochem Biophys Res Commun 1991; 178:1135-1140
28. G-monomethyl L-arginine inhibits endotoxin-induced nitrate/nitrite biosynthesis while promoting hepatic damage. J Leukoc Biol 1990; 48:565-569
29. Hutcheson IR, Whittle BJR, Boughton-Smith NK: Role of nitric oxide in maintaining vascular integrity in endotoxin-induced acute intestinal damage in the rat. Br J Pharmacol 1990; 101:815-820
30. Clements MG, Bauer M, Pannen BHJ: Heterogeneity of hepatic perfusion in shock. In: 1995 Yearbook of Intensive Care and Emergency Medicine. Vincent JL (Ed). Berlin, Springer-Verlag, 1995
31. Radermacher P, Buhl R, Kemnitz J, et al: Prostacyclin improves gastric intramucosal pH in patients with septic shock. Abstr. Clin Intensive Care 1994; 4(Suppl):9
32. 2) increases apparent liver blood flow in man. Prostaglandins Leukot Med 1983; 10:449-454
33. Radermacher P, Santak B, Wust HJ, et al: Prostacyclin for the treatment of pulmonary hypertension in the adult respiratory syndrome: Effects on pulmonary capillary pressure and ventilation-perfusion distributions. Anaesthesiology 1990; 72:238-244
34. Rodman T, Sobel M, Close HP: Arterial oxygen unsaturation and the ventilation perfusion defect of Laennec's cirrhosis. N Engl J Med 1960; 263:73-76
35. Devlin J, Page AC, O'Grady J, et al: Angiographically determined arteriopathy in liver graft dysfunction and survival. J Hepatol 1993; 18:68-73
36. Jalan R, Plevris JN, Jalan AR, et al: A pilot study of indocyanine green clearance as a predictor of graft function. Transplantation 1994; 58:196-200