Transdermal delivery of amino acids and antioxidants enhance collagen synthesis: In vivo and in vitro studies

Connective Tissue Research

Volumn 46, Issue 4-5, 2005, Pages 251-257

  Han, Bo ^a   Nimni, Marcel E ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Aging; Antioxidants; Skin collagen; Sulfur

Indexed keywords

AMINO ACID; ANTIOXIDANT; BENZYL ALCOHOL; GROWTH FACTOR; METHIONINE; PLATELET DERIVED GROWTH FACTOR; PROANTHOCYANIDIN; SULFUR; THIOCTIC ACID; TRANSFORMING GROWTH FACTOR BETA;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL PROLIFERATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; CUTANEOUS PARAMETERS; DERMIS; DOSE RESPONSE; DRUG ADMINISTRATION ROUTE; DRUG DESIGN; DRUG FORMULATION; DRUG MECHANISM; EPIDERMIS; FIBROBLAST; HISTOLOGY; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; RAT;

ADMINISTRATION, CUTANEOUS; AMINO ACIDS; ANIMALS; ANTIOXIDANTS; CELL PROLIFERATION; CELLS, CULTURED; COLLAGEN; DERMIS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPIDERMIS; FEMALE; METHIONINE; PROANTHOCYANIDINS; RATS; REGENERATION; SKIN; SKIN AGING; THIOCTIC ACID; THYMIDINE; TREATMENT OUTCOME;

ANIMALIA;

EID: 33645131812     PISSN: 03008207     EISSN: 16078438     Source Type: Journal    
DOI: 10.1080/03008200500416716     Document Type: Article

References (34)

1. Montagna, W. (1965) Advances in Biology of Skin Skin. New York: Pergamon Press.
2. Nimni, M. (1983) Collagen: Structure, function, and metabolism in normal and fibrotic tissues Semin. Arthritis Rheum., 13(1), pp. 1-86. [PUBMED] [INFOTRIEVE] [CSA]
3. Yamauchi, M. and Woodley, D. and Mechanic, G. (1988) Aging and cross-linking of skin collagen Biochem. Biophys. Res. Commun., 152(2), pp. 898-903. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
4. Yamauchi, M. (1991) Collagen cross-linking in sun-exposed and unexposed sites of aged human skin J. Invest. Dermatol., 97(5), pp. 938-941. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
5. Podda, M. and Grundmann-Kollmann, M. (2001) Low molecular weight antioxidants and their role in skin ageing Clin. Exp. Dermatol., 26(7), pp. 578-582. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
6. Packer, L. and Roy, S. and Sen, C. (1997) Alpha-lipoic acid: A metabolic antioxidant and potential redox modulator of transcription Adv. Pharmacol., 38, pp. 79-101. [PUBMED] [INFOTRIEVE] [CSA]
7. Teichert, J. (1998) Investigations on the pharmacokinetics of alpha-lipoic acid in healthy volunteers Int. J. Clin. Pharmacol. Ther., 36(12), pp. 625-628. [PUBMED] [INFOTRIEVE] [CSA]
8. Biewenga, G. and Haenen, G. and Bast, A. (1997) The pharmacology of the antioxidant lipoic acid Gen. Pharmacol., 29(3), pp. 315-331. [PUBMED] [INFOTRIEVE] [CSA]
9. Packer, L. (1994) Antioxidant properties of lipoic acid and its therapeutic effects in prevention of diabetes complications and cataracts Ann. NY. Acad. Sci., 738, pp. 257-264. [PUBMED] [INFOTRIEVE] [CSA]
10. Podda, M. (1996) Kinetic study of cutaneous and subcutaneous distribution following topical application of [7,8-14C]rac-alpha-lipoic acid onto hairless mice Biochem. Pharmacol., 52(4), pp. 627-633. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
11. Davies, K. (1999) The broad spectrum of responses to oxidants in proliferating cells: A new paradigm for oxidative stress IUBMB Life, 48(1), pp. 41-47. [PUBMED] [INFOTRIEVE] [CSA]
12. Han, B. (2003) Proanthocyanidin: A natural crosslinking reagent for stabilizing collagen matrices J. Biomed. Mater. Res. A., 65(1), pp. 118-124. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
13. Bravo, L. (1998) Polyphenols: Chemistry, dietary sources, metabolism, and nutritional significance Nutr. Rev., 56(11), pp. 317-333. [PUBMED] [INFOTRIEVE] [CSA]
14. Teixeira, S. (2002) Bioflavonoids: Proanthocyanidins and quercetin and their potential roles in treating musculoskeletal conditions J. Orthop. Sports Phys. Ther., 2(7), pp. 357-363. [CSA]
15. Rao, C. and Rao, V. and Steinmann, B. (1983) Bioflavonoid-mediated stabilization of collagen in adjuvant-induced arthritis Scand. J. Rheumatol., 12(1), pp. 39-42. [PUBMED] [INFOTRIEVE] [CSA]
16. Cordoba, F. and Nimni, M. (2003) Chondroitin sulfate and other sulfate containing chondroprotective agents may exhibit their effects by overcoming a deficiency of sulfur amino acids Osteoarthr. Cart., 11(3), pp. 228-230. [CSA] [CROSSREF]
17. Nimni, M. and Cordoba, F and Strates, B and Han, B.Chondroitin sulfate and sulfur containing condroprotective agents: Is there a basis for their Pharmacological action? Curr. Rheum. Rev. In press [CSA]
18. Cheung, H. (1980) In vitro synthesis of normal bone (Type I) collagen by bones of Paget's disease patients Proc. Soc. Exp. Biol. Med., 163(4), pp. 547-552. [PUBMED] [INFOTRIEVE] [CSA]
19. Rosenblat, G. (1998) Acylated ascorbate stimulates collagen synthesis in cultured human foreskin fibroblasts at lower doses than does ascorbic acid Connect. Tissue Res., 37(3-4), pp. 303-311. [PUBMED] [INFOTRIEVE] [CSA]
20. Nimni, M. and Ertl, D. and Oakes, R. (1990) Distribution of griseofulvin in the rat: Comparison of the oral and topical route of administration J. Pharm. Pharmacol., 42(10), pp. 729-731. [PUBMED] [INFOTRIEVE] [CSA]
21. Peng, L. and Nimni, M. (1999) Delivery of erythromycin to subcutaneous tissues in rats by means of a trans-phase delivery system J. Pharm. Pharmacol., 51(10), pp. 1135-1141. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
22. Katiyar, S. and Ahmad, N. and Mukhtar, N. (2000) Green tea and skin Arch. Dermatol., 136(8), pp. 989-994. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
23. Greul, A. (2002) Photoprotection of UV-irradiated human skin: An antioxidative combination of vitamins E and C, carotenoids, selenium and proanthocyanidins Skin Pharmacol. Appl. Skin. Physiol., 15(5), pp. 307-315. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
24. Han, D. and Tritschler, H. and Packer, L. (1995) Alpha-lipoic acid increases intracellular glutathione in a human T-lymphocyte Jurkat cell line Biochem. Biophys. Res. Commun., 207(1), pp. 258-264. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
25. Suh, J. (2004) (R)-alpha-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: Evidence for increased cysteine requirement for GSH synthesis Arch. Biochem. Biophys., 423(1), pp. 126-135. [CSA] [CROSSREF]
26. Fang, Y. and Yang, S. and Wu, G. (2002) Free radicals, antioxidants, and nutrition Nutrition, 18(10), pp. 872-879. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
27. Lin, J. (2004) Alpha-lipoic acid is ineffective as a topical antioxidant for photoprotection of skin J. Invest. Dermatol., 123(5), pp. 996-998. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
28. Beitner, H. (2003) Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoageing of facial skin Br. J. Dermatol., 149(4), pp. 841-849. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
29. Moini, H. and Packer, L. and Saris, N. (2002) Antioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acid Toxicol. Appl. Pharmacol., 182(1), pp. 84-90. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
30. Mikulak, S. and Vangsness, C. and Nimni, M. (1998) Transdermal delivery and accumulation of indomethacin in subcutaneous tissues in rats J. Pharm. Pharmacol., 50(2), pp. 153-158. [PUBMED] [INFOTRIEVE] [CSA]
31. Ballmer, P. and Studer, H. (1994) The effect of prednisolone and a protein-deficient diet on plasma albumin and fibrinogen in a turpentine-induced acute-phase reaction in rats J. Lab. Clin. Med., 123(1), pp. 117-125. [PUBMED] [INFOTRIEVE] [CSA]
32. Liu, J. and Killilea, D. and Ames, B. (2002) Age-associated mitochondrial oxidative decay: Improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L-carnitine and/or R-alpha-lipoic acid Proc. Natl. Acad. Sci. USA, 99(4), pp. 1876-1881. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
33. Wu, G. (2004) Glutathione metabolism and its implications for health J. Nutr., 134(3), pp. 489-492. [PUBMED] [INFOTRIEVE] [CSA]
34. Ames, B. (2004) Supplements and tuning up metabolism J. Nutr., 34(11), pp. 3164S-3168S. [CSA]