Pro-inflammatory/anti-inflammatory cytokine imbalance in acute coronary syndromes

Clinical and Experimental Medicine

Volumn 6, Issue 1, 2006, Pages 38-44

  Pasqui, A L ^a,b   Di Renzo, M ^a   Bova, G ^a   Maffei, S ^b   Pompella, G ^a   Auteri, A ^b   Puccetti, L ^b  

^a UNIVERSITY HOSPITAL OF SIENA   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

Author keywords

Acute coronary syndromes (ACS); Cytokines; IFN ; IL10; TNF

Indexed keywords

C REACTIVE PROTEIN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; TUMOR NECROSIS FACTOR ALPHA;

ACUTE CORONARY SYNDROME; ACUTE HEART INFARCTION; ADULT; AGED; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; STATISTICAL SIGNIFICANCE; UNSTABLE ANGINA PECTORIS;

ACUTE DISEASE; AGED; ANGINA, UNSTABLE; C-REACTIVE PROTEIN; CASE-CONTROL STUDIES; FEMALE; HUMANS; INTERFERON TYPE II; INTERLEUKIN-10; MALE; MIDDLE AGED; MONOCYTES; MYOCARDIAL INFARCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33645126333     PISSN: 15918890     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10238-006-0092-9     Document Type: Article

References (38)

1. Ross R (1999) Atherosclerosis - an inflammatory disease. N Engl J Med 340:115-126
2. Hansson GK (2001) Immune mechanisms in atherosclerosis. Arterioscler Thromb Vasc Biol 21:1876-1890
3. Libby P, Ridker PM, Maseri A (2002) Inflammation and atherosclerosis. Circulation 105:1135-1143
4. Selwyn AP, Kinlay S, Ganz P (1997) Atherogenesis and ischaemic heart disease. Am J Cardiol 80:3H-7H
5. Mulvihill NT, Foley JB (2002) Inflammation in acute coronary syndromes. Heart 87:201-204
6. Libby P, Clinton SK (1993) The role of macrophages in atherogenesis. Curr Opin Lipidol 4:355-363
7. Moreno PR, Falk E, Palacios IS, Newell JB, Fuster V, Fallon JT (1994) Macrophage infiltration in acute coronary syndromes: implication for plaque rupture. Circulation 90:775-778
8. Kishikawa H, Shimokama T, Watanabe T (1993) Localization of T lymphocytes and macrophages expressing IL-1, IL-2 receptor, IL-6 and TNF in human aortic intima: role of cell mediated immunity in human atherogenesis. Virchows Arch A Pathol Anat 423:433-442
9. + T cells in atherosclerosis. Biomed Pharmacother 57:287-291
10. Kato K, Matsubara T, Iida K, Suzuki O, Sato Y (1999) Elevated levels of pro-inflammatory cytokines in coronary artery thrombi. Int J Cardiol 70:267-273
11. Mazzone A, De Servi S, Vezzoli M, Fossati G, Mazzucchelli I, Gritti D, Ottini E, Mussini A, Specchia G (1999) Plasma levels of interleukin-2, -6,-10 and phenotypic characterization of circulating T-lymphocytes in ischemic heart disease. Atherosclerosis 145:369-734
12. de Vries JE (1995) Immunosuppressive and anti-inflammatory properties of interleukin 10. Ann Med 27:537-541
13. de Waal Malefyt R, Abrams RJ, Bennett B, Figdor CG, de Vries JE (1991) Interleukin (IL)-10 inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 174:1209-1220
14. Uyemura K, Demer LL, Castie SC, Jullien D, Berliner JA, Gately MK, Warrier RR, Pham N, Fogelman AM, Modlin RL (1996) Cross-regulatory roles of interleukin (IL)-12 and IL-10 in atherosclerosis. J Clin Invest 97:2130-2138
15. Waehre T, Halversen B, Damas JK, Yndestad A, Brosstad F, Gullestad L, Kjekshus J, Froland SS, Aukrust P (2002) Inflammatory imbalance between IL10 and TNFalfa in unstable angina potential plaque stabilizing effects of IL10. Eur J Clin Invest 32:803-810
16. Yeh ET, Anderson HV, Pasceri V, Willerson JT (2001) C-reactive protein: linking inflammation to cardiovascular complications. Circulation 104:974-975
17. Blake GJ, Ridker PM (2001) High sensitivity C-reactive protein for predicting cardiovascular disease: an inflammatory hypothesis. Eur Heart J 22:349-352
18. Yamashita H, Shimada K, Seki E, Mokuno H, Daida H (2003) Concentrations of interleukins, interferon and C-reactive protein in stable and unstable angina pectoris. Am J Cardiol 91:133-136
19. Ridker PM (2001) High sensitivity C-reactive protein: potential adjunct for global risk assessment in the primary prevention of cardiovascular disease. Circulation 103:1813-1818
20. Hansson GK, Jonasson L, Holm L, Clowes MM, Clowes AW (1988) Gamma-interferon regulates vascular smooth muscle cells proliferation and Ia antigen expression in vivo and in vitro. Circ Res 63:712-719
21. Warner SJC, Friedman GB, Libby P (1989) Immune interferon inhibits proliferation and induces 2′-5′ oligoadenylate synthetase gene expression in human vascular smooth muscle cells. J Clin Invest 83:1174-1182
22. Farb A, Burke A, Tang A, Liang TY, Mannan P, Smialek J, Virmani R (1996) Coronary plaque erosion without rupture into a lipid core. A frequent cause of coronary thrombosis in sudden coronary death. Circulation 93:1354-1363
23. Stemme S, Faber B, Holm J, Wiklund O, Witzum JL, Hansson GK (1995) T lymphocytes from human atherosclerotic plaques recognize oxidised low-density lipoprotein. Proc Natl Acad Sci USA 92:3893-3897
24. Davies M, Richardson P, Woolf N, Katz DR, Mann J (1993) Risk of thrombosis in human atherosclerotic plaques: role of extracellular lipid, macrophage and smooth muscle cell content. Br Heart J 69:377-381
25. Hansson GK (2001) Regulation of immune mechanisms in atherosclerosis. Ann N Y Acad Sci 947:157-165
26. Caligiuri G, Paulsson G, Nicoletti A, Maseri A, Hansson GR (2000) Evidence for antigen-driven T-cell response in unstable angina. Circulation 102:1114-1119
27. Weyand CM, Goronzy JJ, Liuzzo G, Kopecky SL, Holmes DR Jr, Frye RL (2001) T-cell immunity in acute coronary syndromes. Mayo Clin Proc 76:1011-1020
28. Alam SE, Nasser SS, Fernainy KE, Habib AA, Badr KF (2004) Cytokine imbalance in acute coronary syndrome. Curr Opin Pharmacol 4:166-170
29. Smith DA, Irving SD, Sheldon J, Cole D, Kaski JC (2001) Serum levels of the anti-inflammatory cytokine IL-10 are decreased in patients with unstable angina. Circulation 104:746-749
30. Tziakas DN, Chalikias GK, Hatzinikolaou HI, Parissis JT, Papadopoulos ED, Trypsianis GA, Papadopoulo E, Tentes IK, Karas SM, Hatseras DI (2003) Anti-inflammatory cytokine profile in acute coronary syndromes: behaviour of interleukin-10 in association with serum metalloproteinases and proinflammatory cytokines. Int J Cardiol 92:169-175
31. Wang P, Wu P, Siegel MI, Egan RW, Billah MM (1995) Interleukin(IL)-10 inhibits nuclear factor kB (NF-kB) activation in human monocytes: IL-10 and IL-4 suppress cytokine synthesis by different mechanisms. J Biol Chem 270:9558-9563
32. Lacraz S, Nicod LP, Chicheportiche R, Welgus HG, Dayer JM (1995) IL-10 inhibits metalloproteinase and stimulates TIMP-1 production in human mononuclear phagocytes. J Clin Invest 96:2304-2310
33. Lindmark E, Tenno T, Chen J, Siegbahn A (1998) IL-10 inhibits LPS-induced human monocyte tissue factor expression in whole blood. Br J Haematol 102:597-604
34. Mertz PM, Dewitt DL, Stetler-Stevenson WG, Wahl LM (1994) Interleukin-10 suppression of monocyte prostaglandin H syntase-2: mechanism of prostaglandin dependent matrix metalloproteinase production. J Biol Chem 269:21322-21329
35. Cohen SB, Crawley JB, Kahan MC, Feldmann M, Foxwell BM (1997) Interleukin-10 rescues T cells from apoptotic cell death: association with an upregulation of Bcl-2. Immunology 92:1-5
36. Yang Z, Zingarelli B, Szabo C (2000) Crucial role of endogenous interleukin-10 production in myocardial ischaemia/reperfusion injury. Circulation 101:1019-1026
37. Mallat Z, Besnard S, Duriez M, Deleuze V, Emmanuel F, Bureau MF, Soubrier F, Esposito B, Duez H, Fievet C, Staels B, Duverger N, Scherman D, Tedgui A (1999) Protective role of interleukin-10 in atherosclerosis. Circ Res 85:e17-e24
38. Pinderski Oslund LJ, Hedrick CC, Olvera T, Hagenbaugh A, Territo M, Berliner JA, Fyfe AI (1999) Interleukin-10 blocks atherosclerotic events in vitro and in vivo. Arterioscler Thromb Vasc Biol 19:2847-2853