High epidermal growth factor receptor amplification rate but low mutation frequency in Middle East lung cancer population

Human Pathology

Volumn 37, Issue 4, 2006, Pages 453-457

  Al Kuraya, Khawla ^a   Siraj, Abdul K ^a   Bavi, Prashant ^a   Al Jommah, Naif ^a   Ezzat, Adnan ^a   Sheikh, Salwa ^a   Amr, Samir ^a   Al Dayel, Fouad ^a   Simon, Ronald ^b   Guido, Sauter ^b  

^a KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Amplification; EGFR; Epidermal growth factor receptor; Gefitinib; Lung cancer; Middle East; Mutation

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEFITINIB;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; ETHNIC DIFFERENCE; ETHNIC GROUP; EXON; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; IMMUNOHISTOCHEMISTRY; LUNG CANCER; MALE; MIDDLE EAST; MUTATIONAL ANALYSIS; PROTEIN EXPRESSION; SAUDI ARABIA;

ADENOCARCINOMA; ADULT; AGED; ANTINEOPLASTIC AGENTS; CARCINOMA, SQUAMOUS CELL; COHORT STUDIES; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; FEMALE; GENE AMPLIFICATION; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; LUNG NEOPLASMS; MALE; MIDDLE AGED; MUTATION; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; SAUDI ARABIA; TISSUE ARRAY ANALYSIS;

EID: 33645123418     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2005.12.004     Document Type: Article

References (21)

1. S.M. Thomas, and J.R. Grandis Pharmacokinetic and pharmacodynamic properties of EGFR inhibitors under clinical investigation Cancer Treat Rev 30 2004 255 268
2. E. Razis, D. Skarlos, and E. Briasoulis Treatment of non-small cell lung cancer with gefitinib ("Iressa", ZD1839): the Greek experience with a compassionate-use program Anticancer Drugs 16 2005 191 198
3. J. Amann, S. Kalyankrishna, and P.P. Massion Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer Cancer Res 65 2005 226 235
4. R.S. Herbst, G. Giaccone, and J.H. Schiller Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial-INTACT 2 J Clin Oncol 22 2004 785 794
5. J.G. Paez, P.A. Janne, and J.C. Lee EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy Science 304 2004 1497 1500
6. A. Marchetti, C. Martella, and L. Felicioni EGFR mutations in non-small-cell lung cancer: analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment J Clin Oncol 23 2005 857 865
7. H. Shigematsu, L. Lin, and T. Takahashi Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers J Natl Cancer Inst 97 2005 339 346
8. K. Al-Kuraya, P. Schraml, and S. Sheikh Predominance of high-grade pathway in breast cancer development of Middle East women Mod Pathol 18 2005 891 897
9. H. Buerger, J. Packeisen, and A. Boecker Allelic length of a CA dinucleotide repeat in the egfr gene correlates with the frequency of amplifications of this sequence-first results of an inter-ethnic breast cancer study J Pathol 203 2004 545 550
10. A.K. Joe, L. Memeo, and J. McKoy Cyclin D1 overexpression is associated with estrogen receptor expression in Caucasian but not African-American breast cancer Anticancer Res 25 2005 273 281
11. A.D. Santin, S. Bellone, and E.R. Siegel Racial differences in the overexpression of epidermal growth factor type II receptor (HER2/neu): a major prognostic indicator in uterine serous papillary cancer Am J Obstet Gynecol 192 2005 813 818
12. World Health Organization Pathology and genetics of tumours of the lung, thymus and heart 2004 Oxford University Press Lyon (Oxford)
13. J. Kononen, L. Bubendorf, and A. Kallioniemi Tissue microarrays for high-throughput molecular profiling of tumor specimens Nat Med 4 1998 844 847
14. T.J. Lynch, D.W. Bell, and R. Sordella Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib N Engl J Med 350 2004 2129 2139
15. P. Schraml, J. Kononen, and L. Bubendorf Tissue microarrays for gene amplification surveys in many different tumor types Clin Cancer Res 5 1999 1966 1975
16. S.W. Han, T.Y. Kim, and P.G. Hwang Predictive and prognostic impact of epidermal growth factor receptor mutation in non-small-cell lung cancer patients treated with gefitinib J Clin Oncol 23 2005 2493 2501
17. F.R. Hirsch, M. Varella-Garcia, and P.A. Bunn Jr Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis J Clin Oncol 21 2003 3798 3807
18. P.T. Reissmann, H. Koga, R.A. Figlin, E.C. Holmes, and D.J. Slamon Amplification and overexpression of the cyclin D1 and epidermal growth factor receptor genes in non-small-cell lung cancer. Lung Cancer Study Group J Cancer Res Clin Oncol 125 1999 61 70
19. D.N. Ionescu, E. Sasatomi, K. Cieply, M. Nola, and S. Dacic Protein expression and gene amplification of epidermal growth factor receptor in thymomas Cancer 103 2005 630 636
20. F.R. Hirsch, G.V. Scagliotti, C.J. Langer, M. Varella-Garcia, and W.A. Franklin Epidermal growth factor family of receptors in preneoplasia and lung cancer: perspectives for targeted therapies Lung Cancer 41 Suppl 1 2003 S29 S42
21. S. Suzuki, Y. Dobashi, H. Sakurai, K. Nishikawa, M. Hanawa, and A. Ooi Protein overexpression and gene amplification of epidermal growth factor receptor in nonsmall cell lung carcinomas. An immunohistochemical and fluorescence in situ hybridization study Cancer 103 2005 1265 1273