Hypersensitivity of prediabetic JCR:LA-cp rats to fine airborne combustion particle-induced direct and noradrenergic-mediated vascular contraction

Toxicological Sciences

Volumn 90, Issue 2, 2006, Pages 385-391

  Proctor, Spencer D ^a   Dreher, Kevin L ^b   Kelly, Sandra E ^a   Russell, James C ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Cardiovascular disease; Fine particulate air pollution; Insulin resistance; JCR:LA cp rat; Type 2 diabetes; Vasculopathy; Vasospasm

Indexed keywords

ACETYLCHOLINE; INSULIN; N(G) NITROARGININE METHYL ESTER; PHENYLEPHRINE;

AIR POLLUTION; AIRBORNE PARTICLE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; CARDIOVASCULAR DISEASE; COMBUSTION; CONTROLLED STUDY; ENDOTHELIUM; ENVIRONMENTAL IMPACT; EXPOSURE; FLY ASH; IMPAIRED GLUCOSE TOLERANCE; IN VITRO STUDY; INSULIN RESISTANCE; LEACHING; MALE; NONHUMAN; OBESITY; PARTICULATE MATTER; PATHOPHYSIOLOGY; RAT; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE RELAXATION; VASOCONSTRICTION;

AIR POLLUTANTS; ANIMALS; AORTA, THORACIC; ATHEROSCLEROSIS; CARBON; DIABETES MELLITUS, TYPE 2; INSULIN RESISTANCE; MALE; PARTICULATE MATTER; PHENYLEPHRINE; RATS; RATS, INBRED STRAINS; VASOCONSTRICTION;

ANIMALIA;

EID: 33645115354     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfj100     Document Type: Article

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