Alcohol and adult neurogenesis: Roles in Neurodegeneration and recovery in chronic alcoholism

Hippocampus

Volumn 16, Issue 3, 2006, Pages 287-295

  Nixon, Kimberly ^a  

^a University of Kentucky   (United States)

Author keywords

Abstinence; Dentate gyrus; Ethanol; Neural stem cell

Indexed keywords

ALCOHOL;

ADULTHOOD; ALCOHOL ABSTINENCE; ALCOHOL WITHDRAWAL; ALCOHOLISM; CELL PROLIFERATION; CHRONIC TOXICITY; DEGENERATIVE DISEASE; DEMENTIA; DENTATE GYRUS; DEPRESSION; DRUG ABUSE; HIPPOCAMPUS; HUMAN; LEARNING DISORDER; MEMORY DISORDER; MENTAL DISEASE; MOOD DISORDER; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NEUROIMAGING; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; REVIEW; SEIZURE;

ALCOHOL-INDUCED DISORDERS, NERVOUS SYSTEM; ALCOHOLISM; ANIMALS; CELL PROLIFERATION; ETHANOL; HIPPOCAMPUS; HUMANS; NERVE DEGENERATION; NERVE REGENERATION; NEURONAL PLASTICITY; RECOVERY OF FUNCTION; STEM CELLS;

EID: 33645105706     PISSN: 10509631     EISSN: 10981063     Source Type: Journal    
DOI: 10.1002/hipo.20162     Document Type: Review

References (96)

1. Aanson LC, Chen PE, Wyllie DJA, Colquhoun D, Schoepfer R. 1998. Identification of amino acid residues of the NR2A subunit that control glutamate potency in recombinant NR1/NR2A NMDA receptors. J Neurosci 18:581-589.
2. Abrous DN, Adriani W, Montaron MF, Aurousseau C, Rougon G, Le Moal M, Piazza PV. 2002. Nicotine self-administration impairs hippocampal plasticity. J Neurosci 22:3656-3662.
3. Abrous DN, Koehl M, Le Moal M. 2005. Adult neurogenesis: from precursors to network and physiology. Physiol Rev 85:523-569.
4. Adickes ED, Mollner TJ, Lockwood SK. 1990. Ethanol induced morphologic alterations during growth and maturation of cardiac myocytes. Alcohol Clin Exp Res 14:827-831.
5. Agartz I, Momenan R, Rawlings RR, Kerich MJ, Hommer DW. 1999. Hippocampal volume in patients with alcohol dependence. Arch Gen Psychiatry 56:356-363.
6. Ahluwalia BS, Westney LS, Rajguru SU. 1995. Alcohol inhibits cell mitosis in G2-M phase in cell cycle in a human lymphocytes in vitro study. Alcohol 12:589-592.
7. Altman J. 1969. Autoradiographic and histological studies of postnatal neurogenesis. 3. Dating the time of production and onset of differentiation of cerebellar microneurons in rats. J Comp Neurol 136: 269-293.
8. Arendt T, Allen Y, Marchbanks RM, Schugens MM, Sinden J, Lantos PL, Gray JA. 1989. Cholinergic system and memory in the rat: Effects of chronic ethanol, embryonic basal forebrain projection system. Neuroscience 33:435-462.
9. Armstrong RJ, Barker RA. 2001. Neurodegeneration: a failure of neuroregeneration? Lancet 358:1174-1176.
10. Bengochea O, Gonzalo LM. 1990. Effect of chronic alcoholism on the human hippocampus. Histol Histopathol 5:349-357.
11. Bleich S, Sperling W, Degner D, Graesel E, Bleich K, Wilhelm J, Havemann-Reinecke U, Javaheripour K, Kornhuber J. 2003. Lack of association between hippocampal volume reduction and first-onset alcohol withdrawal seizure. A volumetric magneticresonanceimaging (MRI) study. Alcohol Alcohol 38:40-44.
12. Bond NW, Di Giusto EL. 1976. Impairment of Hebb-Williams maze performance following prolonged alcohol consumption in rats. Pharmacol Biochem Behav 5:85-86.
13. Brady KT, Sonne SC. 1999. The role of stress in alcohol use, alcoholism treatment, and relapse. Alcohol Res Health 23:263-271.
14. Brandt J, Butters N, Ryan C, Bayog R. 1983. Cognitive loss and recovery in long-term alcohol abusers. Arch Gen Psychiatry 40: 435-442.
15. Brezun JM, Daszuta A. 1999. Depletion in serotonin decreases neurogenesis in the dentate gyrus and the subventricular zone of adult rats. Neuroscience 89:999-1002.
16. Brezun JM, Daszuta A. 2000. Serotonin may stimulate granule cell proliferation in the adult hippocampus, as observed in rats grafted with foetal raphe neurons. Eur J Neurosci 12:391-396.
17. Cameron HA, McKay RD. 2001. Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus. J Comp Neurol 435:406-417.
18. Carlen PL, Wortzman G, Holgate RC, Wilkinson DA, Rankin JC. 1978. Reversible cerebral atrophy in recently abstinent chronic alcoholics measured by computed tomography scans. Science 200: 1076-1078.
19. Chen WA, Maier SE, West JR. 1996. Toxic effects of ethanol on the fetal brain. In: Dietrich RA, Erwin VG, editors. Pharmacological effects of ethanol on the nervous system. Boca Raton: CRC Press p 343-361.
20. Collins MA, Corse TD, Neafsey EJ. 1996. Neuronal degeneration in rat cerebrocortical and olfactory regions during subchronic "binge" intoxication with ethanol: possible explanation for olfactory deficits in alcoholics. Alcohol Clin Exp Res 20:284-292.
21. Cook RT, Keiner JA. 1991. Ethanol-induced growth inhibition of erythroleukemia stem cells. Cell cycle effects. Acta Haematol 86:6-13.
22. Cook RT, Keiner JA, Yen A. 1990. Ethanol causes accelerated G1 arrest in differentiating HL-60 cells. Alcohol Clin Exp Res 14:695-703.
23. Crews FT, Nixon K. 2003. Alcohol, neural stem cells, and adult neurogenesis. Alcohol Res Health 27:197-204.
24. Crews FT, Steck JC, Chandler LJ, Yu CJ, Day A. 1998. Ethanol, stroke, brain damage, and excitotoxicity. Pharmacol Biochem Behav 59:981-991.
25. Crews FT, Miller MW, Ma W, Nixon K, Zawada S. 2003. Neural stem cells and alcohol. Alcohol Clin Exp Res 27:324-335.
26. Crews FT, Collins MA, Dlugos C, Littleton J, Wilkins L, Neafsey EJ, Pentney R, Snell LD, Tabakoff B, Zou J. 2004. Alcohol-induced neurodegeneration: when, where and why? Alcohol Clin Exp Res 28: 350-364.
27. Crews FT, Mdzinarishvili A, Kim DH, He J, Nixon K. Neurogenesis in adolescent brain is potently inhibited by ethanol. Neuroscience, in press.
28. De Witte P, Pinto E, Ansseau M, Verbanck P. 2003. Alcohol and withdrawal: from animal research to clinical issues. Neurosci Biobehav Rev 27:189-197.
29. Driessen M, Veltrup C, Wetterling T, John U, Dilling H. 1998. Axis I, axis II comorbidity in alcohol dependence and the two types of alcoholism. Alcohol Clin Exp Res 22:77-86.
30. Duman RS, Heninger GR, Nestler EJ. 1997. A molecular and cellular theory of depression. Arch Gen Psychiatry 54:597-606.
31. Eckardt MJ, Martin PR. 1986. Clinical assessment of cognition in alcoholism. Alcohol Clin Exp Res 10:123-127.
32. Eisch AJ. 2002. Adult neurogenesis: implications for psychiatry. Prog Brain Res 138:315-342.
33. Eisch AJ, Mandyam CD. 2004. Drug dependence and addiction, II: Adult neurogenesis and drug abuse. Am J Psychiatry 161:426
34. Eriksson PS, Perfilieva E, Bjork-Eriksson T, Alborn AM, Nordborg C, Peterson DA, Gage FH. 1998. Neurogenesis in the adult human hippocampus. Nat Med 4:1313-1317.
35. Franke H, Kittner H, Berger P, Wirkner K, Schramek J. 1997. The reaction of astrocytes and neurons in the hippocampus of adult rats during chronic ethanol treatment and correlations to behavioral impairments. Alcohol 14:445-454.
36. Friday KE, Howard GA. 1991. Ethanol inhibits human bone cell proliferation and function in vitro. Metabolism 40:562-565.
37. Goodlett CR, Horn KH, Zhou FC. 2005. Alcohol teratogenesis: mechanisms of damage and strategies for intervention. Exp Biol Med (Maywood) 230:394-406.
38. Gould E, Tanapat P. 1997. Lesion-induced proliferation of neuronal progenitors in the dentate gyrus of the adult rat. Neuroscience 80:427-436.
39. Gould E, Beylin A, Tanapat P, Reeves A, Shors TJ. 1999. Learning enhances adult neurogenesis in the hippocampal formation. Nat Neurosci 2:260-265.
40. Grant BF, Dawson DA, Stinson FS, Chou SP, Dufour MC, Pickering RP. 2004. The 12-month prevalence and trends in DSM-IV alcohol abuse and dependence: United States, 1991-1992 and 2001-2002. Drug Alcohol Depend 74:223-234.
41. Hall W, Zador D. 1997. The alcohol withdrawal syndrome. Lancet 349:1897-1900.
42. Hamelink C, Hampson A, Wink DA, Eiden LE, Eskay RL. 2005. Comparison of cannabidiol, antioxidants, and diuretics in reversing binge ethanol-induced neurotoxicity. J Pharmacol Exp Ther 314: 780-788.
43. Harding AJ, Wong A, Svoboda M, Kril JJ, Halliday GM. 1997. Chronic alcohol consumption does not cause hippocampal neuron loss in humans. Hippocampus 7:78-87.
44. Harper C. 1998. The neuropathology of alcohol-specific brain damage, or does alcohol damage the brain? J Neuropathol Exp Neurol 57:101-110.
45. He J, Nixon K, Shetty AK, Crews FT. 2005. Chronic alcohol exposure reduces hippocampal neurogenesis and dendritic growth of newborn neurons. Eur J Neurosci 21:2711-2720.
46. Heinz H, Mann K, Weinberger DR, Goldman D. 2001. Serotonergic dysfunction, negative mood states, and response to alcohol. Alcohol Clin Exp Res 25:487-495.
47. Herrera DG, Yague AG, Johnsen-Soriano S, Bosch-Morell F, Collado-Morente L, Muriach M, Romero FJ, Garcia-Verdugo JM. 2003. Selective impairment of hippocampal neurogenesis by chronic alcoholism: protective effects of an antioxidant. Proc Natl Acad Sci USA 100:7919-7924.
48. Hillman JRS, Schroeder JP, Nixon K, Crews FT, Hodge CW. 2005. Cessation of chronic alcohol drinking: effects on depression-like behavior and neurogenesis in mice. Alcohol Clin Exp Res 29:15A.
49. Hunt WA. 1993. Are binge drinkers more at risk of developing brain damage? Alcohol 10:559-561.
50. Jang MH, Shin MC, Chung JH, Shin HD, Kim Y, Kim EH, Kim CJ. 2002a. Effects of Puerariae radix on cell proliferation and nitric oxide synthase expression in dentate gyrus of alcohol-intoxicated Sprague-Dawley rats. Jpn J Pharmacol 88:355-358.
51. Jang MH, Shin MC, Jung SB, Lee TH, Bahn GH, Kwon YK, Kim EH, Kim CJ. 2002b. Alcohol and nicotine reduce cell proliferation and enhance apoptosis in dentate gyrus. Neuroreport 13:1509-1513.
52. Jang MH, Shin MC, Kim EH, Kim CJ. 2002c. Acute alcohol intoxication decreases cell proliferation and nitric oxide synthase expression in dentate gyrus of rats. Toxicol Lett 133:255-262.
53. Jin K, Minami M, Lan JQ, Mao XO, Batteur S, Simon RP, Greenberg DA. 2001. Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat. Proc Natl Acad Sci USA 98:4710-4715.
54. Johnson BA. 2004. Role of the serotonergic system in the neurobiology of alcoholism: implications for treatment. CNS Drugs 18:1105-1118.
55. Kempermann G, Wiskott L, Gage FH. 2004. Functional significance of adult neurogenesis. Curr Opin Neurobiol 14:186-191.
56. Kozorovitskiy Y, Gould E. 2003. Adult neurogenesis: a mechanism for brain repair? J Clin Exp Neuropsychol 25:721-732.
57. Kuhn HG, Palmer TD, Fuchs E. 2001. Adult neurogenesis: a compensatory mechanism for neuronal damage. Eur Arch Psychiatry Clin Neurosci 251:152-158.
58. Laakso MP, Vaurio O, Savolainen L, Repo E, Soininen H, Aronen HJ, Tiihonen J. 2000. A volumetric MRI study of the hippocampus in type 1 and 2 alcoholism. Behav Brain Res 109:177-186.
59. Liu J, Solway K, Messing RO, Sharp FR. 1998. Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils. J Neurosci 18:7768-7778.
60. Lukoyanov NV. 1999. Behavioral and neuroanatomical consequences of chronic ethanol intake and withdrawal. Physiol Behav 66:337-346.
61. Malberg JE, Duman RS. 2003. Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. Neuropsychopharmacology 28:1562-1571.
62. Malberg JE, Fisch AJ, Nestler EJ, Duman RS. 2000. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci 20:9104-9110.
63. Matthews DB, Morrow AL. 2000. Effects of acute and chronic ethanol exposure on spatial cognitive processing and hippocampal function in the rat. Hippocampus 10:122-130.
64. Miller MW. 1995. Generation of neurons in the rat dentate gyrus and hippocampus: Effects of perinatal and postnatal treatment with ethanol. Alcohol Clin Exp Res 17:304-314.
65. Naranjo CA, Knoke DM. 2001. The role of selective serotonin reuptake inhibitors in reducing alcohol consumption. J Clin Psychiatry 62:18-25.
66. National Institute on Alcohol Abuse and Alcoholism (NIAAA). 2000. Tenth special report to the U.S. congress on alcohol and health. Bethesda, MD: NIAAA.
67. Newman JP, Terris DJ, Moore M. 1995. Trends in the management of alcohol withdrawal syndrome. Laryngoscope 105:1-7.
68. Nixon K, Crews FT. 2002. Binge ethanol exposure decreases neurogenesis in adult rat hippocampus. J Neurochem 83:1087-1093.
69. Nixon K, Crews FT. 2004. Temporally specific burst in cell proliferation increases hippocampal neurogenesis in protracted abstinence from alcohol. J Neurosci 24:9714-9722.
70. Obernier JA, Bouldin TW, Crews FT. 2002a. Binge ethanol exposure in adult rats causes necrotic cell death. Alcohol Clin Exp Res 26:547-557.
71. Obernier JA, White AM, Swartzwelder HS, Crews FT. 2002b. Cognitive deficits and CNS damage after a 4-day binge ethanol exposure in rats. Pharmacol Biochem Behav 72:521-532.
72. Palmer TD, Takahashi J, Gage FH. 1997. The adult rat hippocampus contains primordial neural stem cells. Mol Cell Neurosci 8:389-404.
73. Parent JM. 2002. The role of seizure-induced neurogenesis in epileptogenesis and brain repair. Epilepsy Res 50:179-189.
74. Parent JM, Yu TW, Leibowitz RT, Geschwind DH, Sloviter RS, Lowenstein DH. 1997. Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus. J Neurosci 17:3727-3738.
75. Parent JM, Vexler ZS, Gong C, Derugin N, Ferriero DM. 2002. Rat forebrain neurogenesis and striatal neuron replacement after focal stroke. Ann Neurol 52:802-813.
76. Parsons OA. 1993. Impaired neuropsychological cognitive functioning in sober alcoholics. In: Hunt WA, Nixon SJ, editors. Alcohol-induced brain damage (NIAAA Research Monograph No. 22). Rockville, MD: National Institutes of Health. p 173-194.
77. Pawlak R, Skrzypiec A, Sulkowski S, Buczko W. 2002. Ethanol-induced neurotoxicity is counterbalanced by increased cell proliferation in mouse dentate gyrus. Neurosci Lett 327:83-86.
78. Penick EC, Powell BJ, Nickel EJ, Bingham SF, Riesenmy KR, Read MR, Campbell J. 1994. Co-morbidity of lifetime psychiatric disorder among male alcoholic patients. Alcohol Clin Exp Res 18: 1289-1293.
79. Pfefferbaum A, Kim KO, Zipursky RB, Mathalon DH, Lane B, Ha CN, Rosenbloom MJ, Sullivan EV. 1992. Brain gray and white matter volume loss accelerates with aging in chronic alcoholics: A quantitative MRI study. Alcohol Clin Exp Res 16:1078-1089.
80. Pfefferbaum A, Sullivan EV, Mathalon DH, Lim KO. 1997. Frontal lobe volume loss observed with magnetic resonance imaging in older chronic alcoholics. Alcohol Clin Exp Res 21:521-529.
81. Pfefferbaum A, Sullivan EV, Mathalon DH, Shear PK, Rosenbloom MJ, Lim KO. 1995. Longitudinal changes in magnetic resonance imaging brain volumes in abstinent and relapsed alcoholics. Alcohol Clin Exp Res 19:1177-1191.
82. Rice AC, Bullock MR, Shelton KL. 2004. Chronic ethanol consumption transiently reduces adult neural progenitor cell proliferation. Brain Res 1011:94-98.
83. Riley JN, Walker DW. 1978. Morphological alterations in hippocampus after long-term alcohol consumption in mice. Science 201:646-648.
84. Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, Weisstaub N, Lee J, Duman R, Arancio O, et al. 2003. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301:805-809.
85. Sapolsky RM. 2003. Stress and plasticity in the limbic system. Neurochem Res 28:1735-1742.
86. Schuckit MA, Monteiro MG. 1988. Alcoholism, anxiety and depression. Br J Addict 83:1373-1380.
87. Shors TJ, Miesegaes G, Beylin A, Zhao M, Rydel T, Gould E. 2001. Neurogenesis in the adult is involved in the formation of trace memories. Nature 410:372-376.
88. Sullivan EV, Pfefferbaum A. 2005. Neurocircuitry in alcoholism: a substrate of disruption and repair. Psychopharmacology 180:583-594.
89. Sullivan EV, Marsh L, Mathalon DH, Lim KO, Pfefferbaum A. 1995. Anterior hippocampal volume deficits in nonamnesic, aging chronic alcoholics. Alcohol Clin Exp Res 19:110-122.
90. Sullivan EV, Rosenbloom MJ, Lim KO, Pfefferbaum A. 2000a. Longitudinal changes in cognition, gait, and balance in abstinent and relapsed alcoholic men: relationships to changes in brain structure. Neuropsychology 14:178-188.
91. Sullivan EV, Rosenbloom MJ, Pfefferbaum A. 2000b. Pattern of motor and cognitive deficits in detoxified alcoholic men. Alcohol Clin Exp Res 24:611-621.
92. Valdez GR, Koob GF. 2004. Allostasis and dysregulation of corticotropin-releasing factor and neuropeptide Y systems: implications for the development of alcoholism. Pharmacol Biochem Behav 79: 671-689.
93. van Praag H, Christie BR, Sejnowski TJ, Gage FH. 1999. Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc Natl Acad Sci USA 96:13427-13431.
94. Walker DW, Barnes DE, Zornetzer SF, Hunter BE, Kubanis P. 1980. Neuronal loss in hippocampus induced by prolonged ethanol consumption in rats. Science 209:711-713.
95. Zimmerman BT, Crawford GD, Dahl R, Simon FR, Mapoles JE. 1995. Mechanisms of acetaldehyde-mediated growth inhibition: delayed cell cycle progression and induction of apoptosis. Alcohol Clin Exp Res 19:434-440.
96. Zou JY, Nixon K, Kim DH, Joseph J, Crews FT. 2004. Effects of antioxidants on binge drinking neurodegeneration and neurogenesis. Alcohol Clin Exp Res 28(Suppl):119A.