Pharmacology of botulinum toxin: Differences between type A preparations

European Journal of Neurology

Volumn 13, Issue SUPPL. 1, 2006, Pages 2-10

  Rosales, R L ^a,d   Bigalke, H ^b   Dressler, D ^c  

^a UNIVERSITY OF SANTO TOMAS   (Philippines)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c UNIVERSITY OF ROSTOCK   (Germany)

^d UNIVERSITY OF SANTO TOMAS HOSPITAL   (Philippines)

Author keywords

Botulinum toxin type A; Diffusion; Digit abduction test; Pharmacology; Single fiber electromyography

Indexed keywords

BOTULINUM TOXIN A; BOTULINUM TOXIN B; BOTULINUM TOXIN C1; BOTULINUM TOXIN D; BOTULINUM TOXIN E; BOTULINUM TOXIN F; BOTULINUM TOXIN G; SNARE PROTEIN; UNCLASSIFIED DRUG;

AUTONOMIC NERVE; BLEPHAROSPASM; CHOLINERGIC NERVE; CHOLINERGIC RECEPTOR BLOCKING; CLINICAL TRIAL; CONFERENCE PAPER; DRUG EFFICACY; DRUG FORMULATION; DRUG POTENCY; DRUG SAFETY; DRUG SYNTHESIS; DYSPHAGIA; DYSPHONIA; DYSTONIA; ELECTROMYOGRAM; ESOPHAGUS ACHALASIA; HEMIFACIAL SPASM; HUMAN; MUSCLE ACTION POTENTIAL; MUSCLE EXCITATION; NEUROMUSCULAR SYNAPSE; NONHUMAN; PAIN; PRIORITY JOURNAL; PROTEIN ANALYSIS;

ANIMALS; BOTULINUM TOXIN TYPE A; BOTULINUM TOXINS; CLINICAL TRIALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMPOUNDING; HUMANS; MUSCLE FIBERS; NEUROMUSCULAR AGENTS; NEUROMUSCULAR DISEASES; NEUROMUSCULAR JUNCTION; POISONS;

EID: 33645099746     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2006.01438.x     Document Type: Conference Paper

References (77)

1. Barinaga M Secrets of secretion revealed Science 1993 260 487 489
2. Sollner T Rothman JE Neurotransmission: harnessing fusion machinery at the synapse Trends in Neuroscience 1994 17 344 348
3. Blasi J Chapman ER Link E et al. Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25 Nature 1993 365 160 163
4. Schiavo G Benfenati F Poulain B et al. Tetanus and botulinum toxin-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin Nature 1992 359 832 835
5. Schiavo G Rossetto O Catsicas S et al. Identification of the nerve terminal targets of botulinum neurotoxin serotype A, serotype-D, and serotype-E Journal of Biological Chemistry 1993a 68 23784 23787
6. Schiavo G Shone CC Rossetto O Alexander FC Montecucco C Botulinum neurotoxin-F is a zinc endopeptidase specific for VAMP/synaptobrevin Journal of Biological Chemistry 1993b 268 11516 11519
7. Dolly JO Lisk G Foran PG et al. Insights into the extended duration of neuroparalysis by botulinum neurotoxin A relative to the other shorter-acting serotypes: differences between motor nerve terminals and cultured neurons In Jankovic J Hallett M eds Scientific and Therapeutic Aspects of Botulinum Toxin Philadelphia Lippincott, Williams and Wilkins 2002 91 102
8. Mezaki T Kaji R Kohana N Comparison of the genetic efficacies of Type A and F botulinum toxins for blepharospasm: a double-blind, controlled study Neurology 1995 45 506 508
9. Sloop RR Cole BA Escutin RO Human response to botulinum toxin injection. Type B compared with Type A Neurology 1997 49 189 194
10. Eleopora R Tugneli V Rossetto O Different time courses of recovery after poisoning with botulinum neurotoxin serotypes A and E in humans Neuroscience Letters 1998 256 135 138
11. Eleopora R Tugnoli V Quatrale R Rossetto O Montecucco C Different types of botulinum toxin in humans Movement Disorders 2004 19 Suppl. 8 S53 S59
12. Schiavo G Matteoli M Monteccuco C Neurotoxins affecting neuroexocytosis Physiological Reviews 2000 80 717 766
13. Simpson LL Coffield JA Bakry N Chelation of zinc antagonizes the neuromuscular blocking properties of the seven serotypes of botulinum neurotoxin as well as tetanus toxin Journal of Pharmacology and Experimental Therapeutics 1993 267 720 727
14. Simpson LL Maksymowych AB Hao S The role of zinc binding in the biological activity of botulinum toxin Journal of Biological Chemistry 2001 276 27034 27041
15. Kitamura M Binding of botulinum neurotoxin to the synaptosome fraction of the rat brain Naunyn Schmiedeber's Archives of Pharmacology 1976 295 171 175
16. Hagenah R Benecke R Wiegand H Effects of type A botulinum toxin on the cholinergic transmission at spinal Renshaw cells and on the inhibitory action at Ia inhibitory interneurons Naunyn Schmiedeber's Archives of Pharmacology 1977 299 267 272
17. Gundersend CB Howar BD The effects of botulinum toxin on acetylcholine metabolism in mouse brain slices and synaptosomes Journal of Neurochemistry 1978 31 1005 1013
18. Black J Dolly J Selective localization of acceptors for botulinum neurotoxin A in the central and peripheral nervous systems Neuroscience 1987 23 767 779
19. Comella CL Simpson LL Jankovic J Botulinum toxins: transformation of a toxin into a treatment In Waxman S ed From Neuroscience to Neurology Burlington Elsevier 2005 125 139
20. Naumann M Jost W Botulinum toxin treatment of secretory disorders Movement Disorders 2004 19 Suppl. 8 S137 S141
21. Cordivari C Misra P Catania S Lees AJ New therapeutic indications for botulinum toxins Movement Disorders 2004 19 Suppl. 8 S157 S161
22. Koman LA Mooney JF III. Smith B Goodman A Mulvaney T Management of cerebral palsy with botulinum toxin: preliminary investigation Journal of Pediatric Orthopedics 1993 13 489 495
23. Eleopora R Tugnoli V DeGrandis D The variability of the clinical effect induced by botulinum toxin type A: the role of muscle activity in humans Movement Disorders 1997 12 89 94
24. Hesse S Reiter F Konrad M Jahnke MT Botulinum toxin type A and short-term electrical stimulation in the treatment of upper limb flexor spasticity after stroke: a randomized, double-blind, placebo-controlled trial Clinical Rehabilitation 1998 12 381 388
25. Hallett M Effects of botulinum toxin at the neuromuscular junction In Brin MF Jankovic J Hallett M eds Scientific and Therapeutic Aspects of Botulinum Toxin Philadelphia Lippincott Williams & Wilkins 2002 167 171
26. Filippi GM Errico P Santarelli R Bagolini B Manni E Botulinum A toxin effects in rat jaw muscle spindles Acta Otolaryngology 1993 113 400 404
27. Rosales RL Arimura K Takenaga S Osame M Extrafusal and intrafusal muscle effects in experimental botulinum toxin-A injection Muscle and Nerve 1996 19 488 496
28. Kaji R Muscle afferent block for dystonia: implications for the physiologic mechanism of action of botulinum toxin In Brin MF Jankovic J Hallett M eds Scientific and Therapeutic Aspects of Botulinum Toxin Philadelphia Lippincott, Williams & Wilkins 2002 455 459
29. Rosales RL Delgado M Botulinum toxin A and muscle afferent block in X-linked dystonia-parkinsonism of Panay Movement Disorders 2004 18 Suppl. 9 S19 (Abstract)
30. Boroff DA Chen GS On the question of permeability of the blood-brain barrier to BoNT International Archives of Allergy and Applied Immunology 1975 48 495 504
31. Curra A Trompetto C Abbruzzese G Berardelli A Central effects of Botulinum toxin A. Evidence and supposition Movement Disorders 2004 19 Suppl. 8 S60 S64
32. Wiegand H Erdmann G Wellhoner HH 125I-labelled botulinum a neurotoxin: pharmacokinetics in cats after neuromuscular injection Naunyn Schmiedeberg's Archives of Pharmacology 1976 292 161 165
33. Moreno-Lopez B Pastor AM De la Cruz RR Delgado-Garcia JM Dose- dependent central effects of botulinum neurotoxin type A: a pilot study in the alert behaving cat Neurology 1977 48 456 464
34. Berardelli A Gilio F Curra A Effects of botulinum toxin type A on central nervous system function In Brin M Jankovic J Hallett M eds Scientific and Therapeutic Aspects of Botulinum Toxin Philadelphia Lippincott, Williams and Wilkins 2002 171 177
35. Sampaio C Costa J Ferreira JJ Clinical comparability of marketed formulations of botulinum toxin Movement Disorders 2004 19 Suppl. 8 S129 S136
36. Quinn N Hallett M Dose standardization of botulinum toxin Lancet 1989 1 964
37. Nussgens Z Roggenkaemper P Comparison of two botulinum toxin preparations in the treatment of essential blepharospasm Graefe's Archives of Clinical and Experimental Ophthalmology 1997 235 197 199
38. Sampaio C Ferreira JJ Simoes F et al. DYSBOT: a single-blind, randomized, parallel study to determine whether any differences can be detected in the efficacy and tolerability of two formulations of botulinum toxin type A-Dysport® and Botox®- assuming a ratio of 4:1 Mov Disord 1997 12 1013 1018
39. Whurr R Brookes G Barnes C Comparison of dosage effects between the American and British botulinum toxin A product in treatment of spasmodic dysphonia Movement Disorders 1995 10 56
40. Odergren T Hjaltason H Kaakkola S et al. A double blind, randomized, parallel group study to investigate the dose equivalence of Dysport® and Botox® in the treatment of cervical dystonia Journal of Neurology Neurosurgery and Psychiatry 1998 64 6 12
41. Ranoux D Gury C Fondarai J Mas JL Zuber M Respective potencies of Botox® and Dysport®: a double blind, randomized, crossover study in cervical dystonia Journal of Neurology Neurosurgery and Psychiatry 2002 72 459 462
42. Dressler D Dysport® produces intrinsically more swallowing problems than Botox®: unexpected results from a conversion factor study in cervical dystonia Journal of Neurology Neurosurgery and Psychiatry 2002 73 604
43. Dressler D Benecke R Autonomic side-effects of botulinum toxin type B treatment of cervical dystonia and hyperhidrosis European Journal of Neurology 2003 49 34 38
44. Shaari CM Sanders I Assessment of the biological activity of botulinum toxin In Jankovic J Hallett M eds Therapeutic with Botulinum Toxin New York Marcel Dekker Inc. 1994 159 170
45. Borodic GE Ferrante RJ Pearce LB Alderson K Pharmacology and histology of therapeutic application of botulinum toxin In Jankovic J Hallett M eds Therapy with Botulinum Toxin New York Marcel Dekker Inc. 1994 119 157
46. English AW Weeks OI Compartmentalization of single muscle units in cat lateral gastrocnemius Experimental Brain Research 1984 56 361 368
47. Schieber MH Chua M Petit J Hunt CC Tension distribution of single motor units in multi-tendoned muscles: comparison of a homologous digit muscle in cats and monkeys Journal of Neuroscience 1997 17 1734 1747
48. Wohlfarth K Goschel H Frevert J Dengler R Bigalke H Botulinum A toxins: units versus units Naunyn Schmiedeberg's Archives of Pharmacology 1997 355 335 340
49. Wohlfarth K Kampe K Bigalke H Pharmacokinetic properties of different formulations of botulinum neurotoxin type A Movement Disorders 2004 19 Suppl. 8 S65 S67
50. Sugiyama H Brenner SL DasGupta BR Detection of clostridium botulinum toxin by local paralysis elicited with intramuscular challenge Applied Microbiology 1975 30 420 423
51. Aoki R Preclinical update on Botox® (botulinum toxin type A)-purified neurotoxin complex relative to other botulinum neurotoxin preparations European Journal of Neurology 1999 6 Suppl. 4 S3 S10
52. Aoki R A comparison of the safety margins of botulinum neurotoxin serotypes A, B and F in mice Toxicon 2001 39 1815 1820
53. Aoki R Botulinum neurotoxin serotypes A and B preparations have different safety margins in preclinical models of muscle weakening efficacy and systemic safety Toxicon 2002 40 923 928
54. Arezzo J Litwak MS Caputo FA Meyer KE Shopp GM Spread of paralysis to nearby and distant noninjected muscles in a monkey hand model: comparison of BoNTB and BoNTA In Brin M Jankovic J Hallett M eds Scientific and Therapeutic Aspects of Botulinum Toxin Philadelphia Lippincott, Williams and Wilkins 2002 123 133
55. Diaz JB Rosales RL Gumangan MC Comparative rat muscle diffusion study between two botulinum toxin type A preparations using digit abduction and thigh movement scales Philippine Journal of Neurology 2004 8 61 (Abstract)
56. Ampil E Rosales RL Effects of simvastatin and gemfibrozil in the skeletal muscles of normal and diabetic rats Philippine Journal of Neurology 2003 7 25 30
57. Rosales RL Arimura K Gamez G Osame M X-linked dystonia-parkinsonism: botulinum toxin therapy and stimulation single-fiber electromyography Electroencephalography and Clinical Neurophysiology (Section of Electromyography and Motor Control) 1995 97 Suppl. S234 S235
58. Ma J Smith BP Smith TL Walker FO Rosencrance EV Koman LA Juvenile and adult rat neuromuscular junctions: density, distribution and morphology Muscle Nerve 2002 26 804 809
59. Whelchel DD Brehmer TM Brooks PM Darragh N Coffield JA Molecular targets of botulinum toxin at mammalian neuromuscular junction Movement Disorders 2004 19 Suppl. 8 S7 S16
60. de Paiva A Meunier FA Molgo J Aoki KR Dolly JO Functional repair of motor endplates after botulinum neurotoxin type A poisoning: biphasic switch of synaptic activity between nerve sprouts and their parent terminals Proceedings of the National Academy of Sciences (USA) 1999 96 3200 3205
61. Rosales RL Osame M Kouka M Arimura K Nakashima H Navarro JC Clinical and morphometric analysis of biopsied biceps brachii muscles in adult onset chronic proximal spinal muscular atrophy Brain 1988 11 859 875
62. Billante CR Zealear DL Billante M et al. Comparison of neuromuscular blockade and recovery with botulinum toxins A and F Muscle and Nerve 2002 26 395 403
63. Goldman D Staple J Spatial and temporal expression of acetylcholine receptor RNAs in innervated and denervated rat soleus muscle Neuron 1989 3 218 228
64. Duchen LW Changes in motor innervations and cholinesterase localization induced by botulinum toxin in skeletal muscle of the mouse: differences between fast and slow muscles Journal of Neurology Neurosurgery and Psychiatry 1970 33 40 54
65. Inagi K Muscle fiber-type changes induced by botulinum toxin injection in the rat larynx Otolaryngology Head and Neck Surgery 1999 120 876 883
66. Ansved T Odergren T Borg K Muscle fiber atrophy in leg muscles after botulinum toxin type A treatment of cervical dystonia Neurology 1997 48 1440 1442
67. Hudlicka O The response of muscle to enhanced and reduced activity Clinics in Endocrinology and Metabolism 1990 4 417 439
68. Goldspink G Changes in muscle mass and phenotype and the expression of autocrine and systemic growth factors by muscle in response to stretch and overload Journal of Anatomy 1999 194 323 334
69. Blakemore SJ Rickhuss PK Watt PW Rennie MJ Hundal HS Effects of limb immobilization on cytochrome c oxidase activity and GLUT4 and GLUT5 protein expression in human skeletal muscle Clinical Science 1996 91 591 599
70. Sanders D Massey E Buckley E Botulinum toxin for blepharospasm: single fiber EMG studies Neurology 1986 36 545 547
71. Olney R Aminoff M Gelb D Lowenstein D Neuromuscular effects distant from the site of botulinum neurotoxin injection Neurology 1988 38 1780 1783
72. Lange DJ Rubin M Greene PE et al. Distant effects of locally injected botulinum toxin: a double-blind study of single fiber EMG changes Muscle Nerve 1991 14 672 675
73. Girlanda P Vita G Nicolosi C Milone S Messina C Botulinum toxin therapy: distant effects on neuromuscular transmission and autonomic nervous system Journal of Neurology Neurosurgery and Psychiatry 1992 55 844 845
74. Eleopora R Tugnoli V Caniatti L De Grandis D Botulinum toxin treatment in the facial muscles of humans: evidence of an action in untreated near muscles by peripheral diffusion Neurology 1996 46 1158 1160
75. Raciborska DA Trimble WS Charlton MP Presynaptic protein interactions in vivo: evidence from botulinum A, C, D, and E at the frog neuromuscular junction European Journal of Neuroscience 1998 10 2617 2628
76. Jurasinski CV Lieth E Dang Do AN Schengrund CL Correlation of cleavage of SNAP-25 with muscle function in a rat model of botulinum neurotoxin type A induced paralysis Toxicon 2001 39 1309 1315
77. Kalandakanond S Coffield JA Cleavage of intracellular substrates of botulinum toxins A, C and D in a mammalian target tissue Journal of Pharmacology and Experimental Therapeutics 2001 296 749 755