Phenyl phosphoramidate derivatives of stavudine as anti-HIV agents with potent and selective in-vitro antiviral activity against Adenovirus

European Journal of Medicinal Chemistry

Volumn 39, Issue 3, 2004, Pages 225-234

  Uckun, Fatih M ^a   Pendergrass, Sharon ^a   Qazi, Sanjive ^a   Samuel, P ^a   Venkatachalam, T K ^a  

^a PARKER HUGHES INSTITUTE   (United States)

Author keywords

Adenovirus; HIV; Phosphoramidates; Stampidine

Indexed keywords

5' (4 BROMOPHENYLMETHOXYALANYLPHOSPHATE) 2',3' DIDEHYDRO 3' DEOXYTHYMIDINE; 5' (4 CHLOROPHENYLMETHOXYALANYLPHOSPHATE) 2',3' DIDEHYDRO 3' DEOXYTHYMIDINE; 5' (PHENYLMETHOXYALANYLPHOSPHATE) 2',3' DIDEHYDRO 3' DEOXYTHYMIDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BROMINE DERIVATIVE; CHLORIDE; METHYL GROUP; NANOPARTICLE; NITRILE; PHENYL GROUP; PHOSPHORAMIDIC ACID DERIVATIVE; STAVUDINE; UNCLASSIFIED DRUG;

ADENOVIRUS; ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOTOXICITY; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SELECTIVITY; ENTEROVIRUS; EXPERIMENTAL TEST; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; IC 50; MOLECULAR WEIGHT; PLAQUE FORMING CELL; SKIN FIBROBLAST; SUBSTITUTION REACTION; VIRUS INDUCTION; VIRUS INHIBITION; VIRUS PLAQUE;

ADENOVIRIDAE; ADENOVIRIDAE INFECTIONS; AMIDES; ANTI-HIV AGENTS; ANTIVIRAL AGENTS; ENZYME INHIBITORS; HIV INFECTIONS; HIV-1; HUMANS; PHOSPHORIC ACIDS; STAVUDINE; STRUCTURE-ACTIVITY RELATIONSHIP; ZIDOVUDINE;

EID: 1642403276     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejmech.2003.12.002     Document Type: Article

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