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Volumn 343, Issue 1, 2006, Pages 110-116

Transient stability of the helical pattern of region F19-L22 of the N-terminal domain of p53: A molecular dynamics simulation study

Author keywords

Folding; Molecular dynamics simulations; N terminal domain; p53; p53 MDM2 interaction

Indexed keywords

PROTEIN MDM2; PROTEIN P53;

EID: 33645095919     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.02.129     Document Type: Article
Times cited : (17)

References (38)
  • 1
    • 0027109075 scopus 로고
    • Cancer. P53, guardian of the genome
    • D.P. Lane Cancer. P53, guardian of the genome Nature 358 1992 15 16
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 2
    • 0030941458 scopus 로고    scopus 로고
    • P53, the cellular gatekeeper for the growth and division
    • A.J. Levine p53, the cellular gatekeeper for the growth and division Cell 88 1997 323 331
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 4
    • 0028222124 scopus 로고
    • P53 and E2F-1 cooperate to mediate apoptosis
    • X. Wu, and A.J. Levine p53 and E2F-1 cooperate to mediate apoptosis Proc. Natl. Acad. Sci. USA 91 1994 3602 3606
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 3602-3606
    • Wu, X.1    Levine, A.J.2
  • 5
    • 0028171968 scopus 로고
    • Mediation of c-Myc-induced apoptosis by p53
    • H. Hermeking, and D. Eick Mediation of c-Myc-induced apoptosis by p53 Science 265 1994 2091 2093
    • (1994) Science , vol.265 , pp. 2091-2093
    • Hermeking, H.1    Eick, D.2
  • 6
    • 0025024469 scopus 로고
    • Presence of a potent transcription activating sequence in the p53 protein
    • S. Fields, and S.K. Jang Presence of a potent transcription activating sequence in the p53 protein Science 249 1990 1046 1049
    • (1990) Science , vol.249 , pp. 1046-1049
    • Fields, S.1    Jang, S.K.2
  • 7
    • 0025193635 scopus 로고
    • Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene
    • L. Raycroft, H.Y. Wu, and G. Lozano Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene Science 249 1990 1049 1051
    • (1990) Science , vol.249 , pp. 1049-1051
    • Raycroft, L.1    Wu, H.Y.2    Lozano, G.3
  • 9
    • 0026637484 scopus 로고
    • A C-terminal alpha-helix plus basic region motif is the major structural determinant of p53 tetramerization
    • H.W. Sturzbecher, R. Brain, C. Addison, K. Rudge, M. Remm, M. Grimaldi, E. Keenan, and J.R. Jenkins A C-terminal alpha-helix plus basic region motif is the major structural determinant of p53 tetramerization Oncogene 7 1992 1513 1523
    • (1992) Oncogene , vol.7 , pp. 1513-1523
    • Sturzbecher, H.W.1    Brain, R.2    Addison, C.3    Rudge, K.4    Remm, M.5    Grimaldi, M.6    Keenan, E.7    Jenkins, J.R.8
  • 10
    • 0027174586 scopus 로고
    • Use of the two-hybrid system to identify the domain of p53 involved in oligomerization
    • K. Iwabuchi, B. Li, P. Bartel, and S. Fields Use of the two-hybrid system to identify the domain of p53 involved in oligomerization Oncogene 8 1993 1693 1696
    • (1993) Oncogene , vol.8 , pp. 1693-1696
    • Iwabuchi, K.1    Li, B.2    Bartel, P.3    Fields, S.4
  • 11
    • 0033945124 scopus 로고    scopus 로고
    • Structure of the negative regulatory domain of p53 bound to S100B(ββ)
    • R.R. Rustandi, D.M. Baldisseri, and D.J. Weber Structure of the negative regulatory domain of p53 bound to S100B(ββ) Nat. Struct. Biol. 7 2000 570 574
    • (2000) Nat. Struct. Biol. , vol.7 , pp. 570-574
    • Rustandi, R.R.1    Baldisseri, D.M.2    Weber, D.J.3
  • 12
    • 0034862475 scopus 로고    scopus 로고
    • The C-terminus of p53: The more you learn the less you know
    • J. Ahn, and C. Prives The C-terminus of p53: the more you learn the less you know Nat. Struct. Biol. 8 2001 730 732
    • (2001) Nat. Struct. Biol. , vol.8 , pp. 730-732
    • Ahn, J.1    Prives, C.2
  • 13
    • 0027983669 scopus 로고
    • Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations
    • Y. Cho, S. Gorina, P.D. Jeffrey, and N.P. Pavletich Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations Science 265 1994 346 355
    • (1994) Science , vol.265 , pp. 346-355
    • Cho, Y.1    Gorina, S.2    Jeffrey, P.D.3    Pavletich, N.P.4
  • 15
    • 0037418548 scopus 로고    scopus 로고
    • Structure, function, and aggregation of the zinc-free form of the p53 DNA binding domain
    • J.S. Butler, and S.N. Loh Structure, function, and aggregation of the zinc-free form of the p53 DNA binding domain Biochemistry 42 2003 2396 2403
    • (2003) Biochemistry , vol.42 , pp. 2396-2403
    • Butler, J.S.1    Loh, S.N.2
  • 16
    • 0028952841 scopus 로고
    • Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms
    • P.D. Jeffrey, S. Gorina, and N.P. Pavletich Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms Science 267 1995 1498 1502
    • (1995) Science , vol.267 , pp. 1498-1502
    • Jeffrey, P.D.1    Gorina, S.2    Pavletich, N.P.3
  • 17
    • 0030575866 scopus 로고    scopus 로고
    • Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2
    • S. Gorina, and N.P. Pavletich Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2 Science 274 1996 1001 1005
    • (1996) Science , vol.274 , pp. 1001-1005
    • Gorina, S.1    Pavletich, N.P.2
  • 18
    • 0031303353 scopus 로고    scopus 로고
    • Solution conformation of an essential region of the p53 transactivation domain
    • M.V. Botuyan, J. Momand, and Y. Chen Solution conformation of an essential region of the p53 transactivation domain Fold. Des. 2 1997 331 342
    • (1997) Fold. Des. , vol.2 , pp. 331-342
    • Botuyan, M.V.1    Momand, J.2    Chen, Y.3
  • 20
    • 0036415663 scopus 로고    scopus 로고
    • P53 contains large unstructured regions in its native state
    • S. Bell, C. Klein, L. Muller, S. Hansen, and J. Buchner p53 contains large unstructured regions in its native state J. Mol. Biol. 322 2002 917 927
    • (2002) J. Mol. Biol. , vol.322 , pp. 917-927
    • Bell, S.1    Klein, C.2    Muller, L.3    Hansen, S.4    Buchner, J.5
  • 22
    • 18344377030 scopus 로고    scopus 로고
    • The p53 pathway: Positive and negative feedback loops
    • S.L. Harris, and A.J. Levine The p53 pathway: positive and negative feedback loops Oncogene 24 2005 2899 2908
    • (2005) Oncogene , vol.24 , pp. 2899-2908
    • Harris, S.L.1    Levine, A.J.2
  • 24
    • 0036803243 scopus 로고    scopus 로고
    • Intrinsically unstructured proteins
    • P. Tompa Intrinsically unstructured proteins Trends Biochem. Sci. 27 2002 527 533
    • (2002) Trends Biochem. Sci. , vol.27 , pp. 527-533
    • Tompa, P.1
  • 28
    • 0343005873 scopus 로고    scopus 로고
    • Molecular dynamics simulations of a polyalanine octapeptide under Ewald boundary conditions: Influence of artificial periodicity on peptide conformation
    • W. Weber, P.H. Hünenberger, and J.A. McCammon Molecular dynamics simulations of a polyalanine octapeptide under Ewald boundary conditions: influence of artificial periodicity on peptide conformation J. Phys. Chem. B 104 2000 3668 3675
    • (2000) J. Phys. Chem. B , vol.104 , pp. 3668-3675
    • Weber, W.1    Hünenberger, P.H.2    McCammon, J.A.3
  • 30
    • 33846823909 scopus 로고
    • Particle mesh Ewald: An N•log(N) method for Ewald sums in large systems
    • T. Darden, D. York, and L. Pedersen Particle mesh Ewald: an N•log(N) method for Ewald sums in large systems J. Chem. Phys. 98 1993 10089 10092
    • (1993) J. Chem. Phys. , vol.98 , pp. 10089-10092
    • Darden, T.1    York, D.2    Pedersen, L.3
  • 31
    • 84946450438 scopus 로고
    • Algorithms for macromolecular dynamics and constraint dynamics
    • W.F. van Gunsteren, and H.J.C. Berendsen Algorithms for macromolecular dynamics and constraint dynamics Mol. Phys. 34 1977 1311 1327
    • (1977) Mol. Phys. , vol.34 , pp. 1311-1327
    • Van Gunsteren, W.F.1    Berendsen, H.J.C.2
  • 33
    • 0029619259 scopus 로고
    • Knowledge-based protein secondary structure assignment
    • D. Frishman, and P. Argos Knowledge-based protein secondary structure assignment Proteins 23 1995 566 579
    • (1995) Proteins , vol.23 , pp. 566-579
    • Frishman, D.1    Argos, P.2
  • 34
    • 0027222956 scopus 로고
    • Mapping of the p53 and mdm-2 interaction domains
    • J. Chen, V. Marechal, and A.J. Levine Mapping of the p53 and mdm-2 interaction domains Mol. Cell. Biol. 13 1993 4107 4114
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 4107-4114
    • Chen, J.1    Marechal, V.2    Levine, A.J.3
  • 35
    • 0027964904 scopus 로고
    • Immunochemical analysis of the interaction of p53 with MDM2;-fine mapping of the MDM2 binding site on p53 using synthetic peptides
    • S.M. Picksley, B. Vojtesek, A. Sparks, and D.P. Lane Immunochemical analysis of the interaction of p53 with MDM2;-fine mapping of the MDM2 binding site on p53 using synthetic peptides Oncogene 9 1994 2523 2529
    • (1994) Oncogene , vol.9 , pp. 2523-2529
    • Picksley, S.M.1    Vojtesek, B.2    Sparks, A.3    Lane, D.P.4
  • 36
    • 10844238962 scopus 로고    scopus 로고
    • Computational studies and peptidomimetic design for the human p53-MDM2 complex
    • H. Zhong, and H.A. Carlson Computational studies and peptidomimetic design for the human p53-MDM2 complex Proteins 58 2005 222 234
    • (2005) Proteins , vol.58 , pp. 222-234
    • Zhong, H.1    Carlson, H.A.2
  • 37
    • 0029062595 scopus 로고
    • Two critical hydrophobic amino acids in the N-terminal domain of the p53 protein are required for the gain of function phenotypes of human p53 mutants
    • J. Lin, A.K. Teresky, and A.J. Levine Two critical hydrophobic amino acids in the N-terminal domain of the p53 protein are required for the gain of function phenotypes of human p53 mutants Oncogene 10 1995 2387 2390
    • (1995) Oncogene , vol.10 , pp. 2387-2390
    • Lin, J.1    Teresky, A.K.2    Levine, A.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.