Evaluation of two GnRH-I based vaccine formulations on the testes function of entire Suffolk cross ram lambs

Vaccine

Volumn 24, Issue 16, 2006, Pages 3172-3183

  Earl, Elizabeth R ^a   Waterston, Mary M ^b   Aughey, Elizabeth ^b   Harvey, Michael J A ^b   Matschke, Christian ^c   Colston, Angela ^d   Ferro, Valerie A ^e  

^a Novartis Animal Vaccines Ltd   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c ALTANA PHARMA AG   (Germany)

^d Triveritas Ltd   (United Kingdom)

^e UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Anti fertility; GnRH; Vaccine

Indexed keywords

CYSTEINYLHISTIDYLTRYPTOPHANYLSERYLTYROSYLGLYCYLLEUCYLARGINYLPROLYLGLYCINAMIDE; DIPHTHERIA TOXOID; FOLLITROPIN; GONADORELIN ASSOCIATED PEPTIDE DERIVATIVE; POLYGLACTIN; QUIL A; TESTOSTERONE; TETANUS TOXOID; UNCLASSIFIED DRUG; VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG FORMULATION; HISTOLOGY; LAMB; NONHUMAN; PRIORITY JOURNAL; SCROTUM; SPERMATOGENESIS; TESTIS FUNCTION; VACCINE PRODUCTION; WEIGHT GAIN;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES; CONTRACEPTION, IMMUNOLOGIC; DIPHTHERIA TOXOID; ENZYME-LINKED IMMUNOSORBENT ASSAY; FOLLICLE STIMULATING HORMONE; GONADOTROPIN-RELEASING HORMONE; HISTOCYTOCHEMISTRY; IMMUNIZATION SCHEDULE; LACTIC ACID; MALE; POLYGLYCOLIC ACID; POLYMERS; SAPONINS; SHEEP; SPERMATOGENESIS; TESTICULAR HORMONES; TESTIS; TESTOSTERONE; TETANUS TOXOID; VACCINES, CONJUGATE; VACCINES, CONTRACEPTIVE;

EID: 33645089195     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2006.01.041     Document Type: Article

References (34)

1. S. Lofthouse, and J. Kemp Manipulating the immune response; applications in livestock breeding J Reprod Immunol 57 1/2 2002 239 253
2. D.L. Thompson Immunization against GnRH in male species (comparative aspects) Anim Reprod Sci 60/61 2000 459 469
3. V.A. Ferro Current advances in anti-fertility vaccines for fertility control and non-contraceptive applications Expert Rev Vaccines 1 4 2002 443 452
4. Z. Kiyma, T.E. Adams, B.W. Hess, M.L. Riley, W.J. Murdoch, and G.E. Moss Gonadal function, sexual behavior, feedlot performance, and carcass traits of ram lambs actively immunized against GnRH J Anim Sci 78 9 2000 2237 2243
5. F.R. Dunshea, C. Colantoni, K. Howard, I. McCauley, P. Jackson, and K.A. Long Vaccination of boars with a GnRH vaccine (Improvac) eliminates boar taint and increases growth performance J Anim Sci 79 10 2001 2524 2535
6. V.A. Ferro, R. Costa, K.C. Carter, M.J.A. Harvey, M.M. Waterston, and A.B. Mullen Immune responses to a GnRH-based anti-fertility immunogen, induced by different adjuvants and subsequent effects on vaccine efficacy Vaccine 22 2004 1024 1031
7. V.A. Ferro, M.A. Khan, E.R. Earl, M.J. Harvey, A. Colston, and W.H. Stimson Influence of carrier protein conjugation site and terminal modification of a GnRH-I peptide sequence in the development of a highly specific anti-fertility vaccine. Part I Am J Reprod Immunol 48 6 2003 361 371
8. S. Sad, H.M. Gupta, G.P. Talwar, and R. Raghupathy Carrier-induced suppression of the antibody response to a 'self' hapten Immunology 74 2 1991 223 227
9. G.P. Talwar, O. Singh, R. Pal, N. Chatterjee, P. Sahai, and K. Dhall A vaccine that prevents pregnancy in women Proc Natl Acad Sci USA 91 18 1994 8532 8536
10. V.A. Ferro, M.A. Khan, D. McAdam, A. Colston, E. Aughey, and A.B. Mullen Efficacy of an anti-fertility vaccine based on mammalian gonadotrophin releasing hormone (GnRH-I) - a histological comparison in male animals Vet Immunol Immunopathol 101 1/2 2004 73 86
11. R.M. Hoskinson, R.D. Rigby, P.E. Mattner, V.L. Huynh, M. D'Occhio, and A. Neish Vaxstrate: an anti-reproductive vaccine for cattle Aust J Biotechnol 4 3 1990 166 170 176
12. V.A. Ferro, M.A. Khan, V.S. Latimer, D. Brown, H.F. Urbanski, and W.H. Stimson Immunoneutralisation of GnRH-I, without cross-reactivity to GnRH-II, in the development of a highly specific anti-fertility vaccine for clinical and veterinary use J Reprod Immunol 51 2 2001 109 129
13. V.A. Ferro, and W.H. Stimson Effects of adjuvant, dose and carrier pre-sensitisation on the immunisation efficacy of a GnRH analogue Drug Des Discov 14 3 1996 179 195
14. V.A. Ferro, and W.H. Stimson Investigation into suitable carrier molecules for use in an anti-gonadotrophin releasing hormone vaccine Vaccine 16 11/12 1998 1095 1102
15. S. Sad, G.P. Talwar, and R. Raghupathy Influence of the genetic background and carrier protein on the antibody response to GnRH J Reprod Immunol 19 2 1991 197 207
16. S. Sad, H.M. Gupta, G.P. Talwar, and R. Raghupathy Hyporesponsiveness to a GnRH vaccine in a non-responder mouse strain is T-cell mediated J Reprod Immunol 20 2 1991 189 194
17. G.J. Fernando, T.J. Stewart, R.W. Tindle, and I.H. Frazer Vaccine-induced Th1-type responses are dominant over Th2-type responses in the short term whereas pre-existing Th2 responses are dominant in the longer term Scand J Immunol 47 5 1998 459 465
18. S. Shirodkar, R.L. Hutchinson, D.L. Perry, J.L. White, and S.L. Hem Aluminum compounds used as adjuvants in vaccines Pharm Res 7 12 1990 1282 1288
19. F. Janett, U. Lanker, H. Jorg, M. Hassig, and R. Thun The castration of male lambs by immunization against GnRH Schweiz Arch Tierheilkd 145 6 2003 291 299
20. M. Bonneau, R. Dufour, C. Chouvet, C. Roulet, W. Meadus, and E.J. Squires The effects of immunization against luteinizing hormone-releasing hormone on performance, sexual development, and levels of boar taint-related compounds in intact male pigs J Anim Sci 72 1 1994 14 20
21. S. Cui, Y.F. Chen, H.N. Yue, Y.Q. He, and A.S. McNeilly Sexual development and the effects of active immunization against GnRH in Chinese Tanyang ram lambs Anim Reprod Sci 77 3/4 2003 129 139
22. D. Aissat, J.M. Sosa, D.M. de Avila, K.P. Bertrand, and J.J. Reeves Endocrine, growth, and carcass characteristics of bulls immunized against luteinizing hormone-releasing hormone fusion proteins J Anim Sci 80 9 2002 2209 2213
23. J.M. Sosa, Y. Zhang, D.M. de Avila, K.P. Bertrand, and J.J. Reeves Technical note: recombinant LHRH fusion protein suppresses estrus in heifers J Anim Sci 78 5 2000 1310 1312
24. M.J. Jung, Y.C. Moon, I.H. Cho, J.Y. Yeh, S.E. Kim, and W.S. Chang Induction of castration by immunization of male dogs with recombinant gonadotropin-releasing hormone (GnRH)-canine distemper virus (CDV) T helper cell epitope p35 J Vet Sci 6 1 2005 21 24
25. J.A. Turkstra, X.Y. Zengt, J.T. van Diepent, A.W. Jongbloed, H.B. Oonk, and D.F. van de Wielt Performance of male pigs immunized against GnRH is related to the time of onset of biological response J Anim Sci 80 11 2002 2953 2959
26. N.J. Beekman, W.M. Schaaper, J.A. Turkstra, and R.H. Meloen Highly immunogenic and fully synthetic peptide-carrier constructs targetting GnRH Vaccine 17 15/16 1999 2043 2050
27. D.J. Prendiville, W.J. Enright, M.A. Crowe, L. Vaughan, and J.F. Roche Immunization of prepubertal beef heifers against gonadotropin-releasing hormone: immune, estrus, ovarian, and growth responses J Anim Sci 73 10 1995 3030 3037
28. D.J. Prendiville, W.J. Enright, M.A. Crowe, M. Finnerty, N. Hynes, and J.F. Roche Immunization of heifers against gonadotropin-releasing hormone: antibody titers, ovarian function, body growth, and carcass characteristics J Anim Sci 73 8 1995 2382 2389
29. X.Y. Zeng, J.A. Turkstra, R.H. Meloen, X.Y. Liu, F.Q. Chen, and W.M. Schaaper Active immunization against gonadotrophin-releasing hormone in Chinese male pigs: effects of dose on antibody titer, hormone levels and sexual development Anim Reprod Sci 70 3/4 2002 223 233
30. X.Y. Zeng, J.A. Turkstra, D.F. van de Wiel, D.Z. Guo, X.Y. Liu, and R.H. Meloen Active immunization against gonadotrophin-releasing hormone in Chinese male pigs Reprod Domest Anim 36 2 2001 101 105
31. J.A. Turkstra, F.J. van der Meer, J. Knaap, P.J. Rottier, K.J. Teerds, and B. Colenbrander Effects of GnRH immunization in sexually mature pony stallions Anim Reprod Sci 86 3/4 2005 247 259
32. J.G. Jago, N.R. Cox, J.J. Bass, and L.R. Matthews The effect of prepubertal immunization against gonadotropin-releasing hormone on the development of sexual and social behavior of bulls J Anim Sci 75 10 1997 2609 2619
33. I.J. Clarke, B.W. Brown, V.V. Tran, C.J. Scott, R. Fry, and R.P. Millar Neonatal immunization against gonadotropin-releasing hormone (GnRH) results in diminished GnRH secretion in adulthood Endocrinology 139 4 1998 2007 2014
34. W.T. Oliver, I. McCauley, R.J. Harrell, D. Suster, D.J. Kerton, and F.R. Dunshea A gonadotropin-releasing factor vaccine (Improvac) and porcine somatotropin have synergistic and additive effects on growth performance in group-housed boars and gilts J Anim Sci 81 8 2003 1959 1966