Effects of adjuvant, dose and carrier pre-sensitisation on the immunisation efficacy of a GnRH analogue

Drug Design and Discovery

Volumn 14, Issue 3, 1996, Pages 179-195

  Ferro, V A ^a   Stimson, W H ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Drug dose; Epitope suppression; Gonadotrophin releasing hormone; Immunisation; Testosterone suppression; Tetanus toxoid pre sensitisation

Indexed keywords

ADJUVANT; CONTRACEPTIVE AGENT; GONADORELIN DERIVATIVE; TESTOSTERONE; TETANUS TOXOID; VACCINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; MALE; NONHUMAN; RAT; SENSITIZATION; TESTOSTERONE BLOOD LEVEL;

ADJUVANTS, IMMUNOLOGIC; ALUMINUM HYDROXIDE; ANIMALS; ANTIBODY FORMATION; ATROPHY; CARRIER PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITOPES; FEMALE; GONADOTROPIN-RELEASING HORMONE; IMMUNIZATION; MALE; RATS; RATS, SPRAGUE-DAWLEY; TESTIS; TESTOSTERONE; TETANUS TOXOID;

EID: 0030455130     PISSN: 10559612     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Dimhofer, S., Wick, G. and Berger, P. (1994) The suitability of hCG-based birth-control vaccines. Immunology Today, 15, 469-474.
2. Scaramuzzi, R.J., Campbell, B.K. and Martin, G.B. (1993) Immunological approaches to fertility regulation in domestic livestock. Immunology and Cell Biology, 71, 489-499.
3. Giri, D.K., Jayaraman, S., Neelram, G.S., Jayashankar, R. and Talwar, G.P. (1991) Prostatic hypoplasia in Bonner monkeys following active immunisation with semisynthetic anti-LHRH vaccine. Exp. Mol. Path., 54, 255-264.
4. West, C.P. (1988) LHRH analogues in the management of uterine fibroids, PMS and breast malignancies. Ballieres Clinical Obstetrics and Gynaecology, 2, 689-710.
5. Furr, B.J.A. and Nicholson, R.I. (1982) Use of analogues of luteinizing hormone-releasing hormone for the treatment of cancer. J. Reprod. Fert., 64, 529-540.
6. Morrison, C.A. Fishleigh, R.V. Ward, D.J. and Robson, B. (1987) Computer aided design and physiological testing of a LHRH analogue for "adjuvant-free" immunocastration. FEBS Lett., 214, 65-73.
7. Ferro, V.A., O'Grady, J.E., Notman, J. and Stimson, W.H. (1996) A comparison of adjuvants used to investigate the immunogenicity of a GnRH analogue in male rats. Vaccine. 14, 451-457.
8. Ferro, V.A., O'Grady, I.E., Notman, J. and Stimson, W.H. (1996) Development of a hormone neutralising vaccine, using GnRH-glycys-PPD, for use in the treatment of oestrogen-dependent disorders. Therapeutic Immunology, in press.
9. Ferro, V.A., Horton, W.A. and Stimson, W.H. (1994) Immunisation with LHRH for the treatment of hormone-dependent tumours. Second Conference on Industrial Immunology ISBN 0 85295 335 6, p40-42.
10. Ferro, V.A., O'Grady, J.E., Notman, J. and Stimson, W.H. (1995) Immunological castration using a GnRH analogue conjugated to PPD. Food and Agricultural Immunology, 7, 259-272.
11. Bomford, B. (1980) The comparative selectivity of adjuvants for humoral and cell mediated immunity. Clin. Exp. Immunol., 39, 435-441.
12. Lussow, A.R., Giudice, G.D., Renia, L., Mazier, D., Verhave, J.P., Verdini, A.S., Pessi, A., Loius, J.A. and Lambert, P.H. (1990) Use of a tuberculin purified protein derivative-asn-ala-asn-pro conjugate in bacillus Calmette-Guerin primed mice overcomes H-2 restriction of the antibody response and avoids the need for adjuvants. Proc Nat. Acad. Sci., 87, 2960-2964.
13. Ferro, V.A. and Stimson, W.H. (1996) Examination of various carrier molecules for use in the construction of an effective anti-GnRH vaccine. Bioconjugate Chemistry, in press.
14. Adams, T.E. and Adams, B.M. (1990) Reproductive function and feedlot performance of beef heifers actively immunised against GnRH. J. Animal Sci., 68. 2793-2805.
15. Tiong, G.K.L., Gill, H.S., Lofthouse, S. and Puri, N.K. (1993) Comparison of conventional adjuvants and "adjuvant-free" monoclonal antibody targeting for stimulating antibody responses against a conjugate of Iuteinizing hormone releasing hormone and avidin. Vaccine, 11, 425-444.
16. Talwar, G.P., Singh, O., Pal, R. and Chatterjee, N. (1992) Vaccines for control of fertility and hormone dependent cancers. Int. J. Pharmac., 14, 511-514.
17. Singh, M., Singh, A. and Talwar, G.P. (1991) Controlled delivery of diphtheria toxoid using biodegradable poly(D,L-lactide) microcapsules. Pharm. Res., 8, 958-961.
18. Pierre, P., Denis, O., Bazin, H., Mbella, E.M. and Vaerman, J.-P. (1992) Modulation of oral tolerance to ovalbumin by cholera toxin and its B subunit. Eur. J. Immunol., 22, 3179-3182.
19. Herzenberg, L.A., Tokuhisa, T. and Hayakawa, K. (1983). Epitope-specific regulation. A. Rev. Immun., 1, 609-632.
20. Sad, S., Gupta, H.M., Talwar, G.P. and Raghupathy, R. (1991) Carrier-induced suppression of the antibody response to a "self" hapten. Immunology, 72, 223-227.
21. Sad, S., Chauhan, V.S., Arunan, K. and Raghupathy, R. (1993) Synthetic gonadotrophin-releasing hormone (GnRH) vaccines incorporating GnRH and synthetic T-helper epitopes. Vaccine, 11, 1145-1156.
22. Schutze, M.P., Deriaud, E., Przewlocki, G. and LeClerc, C. (1989) Carrier-induced epitopic suppression is initiated through clonal dominance. J. Immunol., 142, 2635-2640
23. Etlinger, H.M., Felix, A.M., Gillissen, D., Heimer, E.P., Just, M., Pink, J.R., Sinigaglia, F., Strurchler, D., Takacs, B., Trzeciak, A. and Matile, H. (1988) Assessment in humans of a synthetic peptide-based vaccine against the sporozite stage of the human malarial parasite, Plasmodium falciparum. J. Immunol., 140, 626-633.
24. Thau, R. (1992) Anti-LHRH and anti-pituitary gonadotropin vaccines: their development and clinical applications. Stand J. Immunol , 11, 127-130.
25. Gaur, A., Arunan, K., Singh, O. and Talwar, G.P. (1990) Bypass by an alternate carrier of acquired unresponsiveness to hCG upon repeated immunization with tetanus conjugated vaccine. Int. Immunol., 2, 151-155.
26. Meloen, R.H. (1995) Basic aspects of immunomodulation through active immunisation. Livestock Production Science, 42, 135-145.
27. Stevens, V. (1993) Vaccine delivery systems: Potential methods for use in antifertility vaccines. Am. J. Reprod. Immunol, 29, 176-188.
28. Schally, A. V. and Schally, A.M. (1987) Male contraception involving testosterone supplementation: possible increased risks of prostate cancer? Lancet, 1, 448-450.
29. Hirabayashi, Y., Tamura, S.I., Suzuki, Y., Nagamine, T., Aizawa, C., Shimada, K. and Kurata, T. (1991). H-2-unrestricted adjuvant effect of cholera toxin B subunit on murine antibody responses to influenza virus haemagglutinin. Immunology, 72, 329-335.