Sexual development and the effects of active immunization against GnRH in Chinese Tanyang ram lambs

Animal Reproduction Science

Volumn 77, Issue 3-4, 2003, Pages 129-139

  Cui, S ^a   Chen, Y F ^a   Yue, H N ^b   He, Y Q ^b   McNeilly, A S ^c  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b GANSU AGRICULTURAL UNIVERSITY   (China)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Body weight; GnRH immunization; Sexual development; Sheep male reproduction; Testicular dimension; Testosterone

Indexed keywords

ANIMALIA; OVIS ARIES;

EID: 0038010675     PISSN: 03784320     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4320(03)00043-5     Document Type: Article

References (41)

1. Adam, T.E., Adam, B.M., 1992. Feetlot performance of steers and bulls actively immunized against Gonadotropin-Releasing Hormone. J. Anim. Sci. 70, 1691-1698.
2. Adam, T.E., Daley, C.A., Adam, B.M., Sakeriai, H., 1996. Testes function and feetlot performance of bulls actively immunized against Gonadotropin-Releasing Hormone: Effect of age at immuniation. J. Anim. Sci. 74, 950-954.
3. Ahmad, N., Noakes, D.E., 1996. Sexual maturity in British breeds of goat kids. Br. Vet. J. 152, 93-103.
4. Ahmad, M., Latif, M., Ahmad, M., Qazi, M.H., Sahir, N., Arslan, M., 1984. Age-related changes in body weight, scrotal size and plasma testosterone levels in buffalo bulls (Bubalus bubalis). Theriogenology 22, 651-656.
5. Belibasaki, S., Kouimtzis, S., 2000. Sexual activity and body and testis growth in prepubertal ram lambs of Friesland, Chios, Karagouniki and Serres dairy sheep in Greece. Small Rumin. Res. 37, 109-113.
6. Beverley, J.K., Crighton, D.B., 1984. Reversibility of the effects of active immunization against LH-RH. In: Crighton, D.B. (Ed.), Immunoligical Aspects of Reproduction in Mammals. Butterworths, London, pp. 379-399.
7. Bilaspuri, G.S., Singh, K., 1992. Developmental changes in body weight and testicular titular characteristics in Malabari goat kinds. Theriogenology 37, 507-520.
8. Bongso, T.A., Jainudeen, M.R., Zahrah, A.S., 1982. Relationship of scrotal circumference to age, body weight and onset of spermatogenesis in goat. Theriogenology 18, 513-524.
9. Bonneau, M., Dufour, R., Chouvet, C., Roulet, C., Meadus, W., Squires, E.J., 1994. The effects of immunization against luteinizing hormone-releasing hormone on performance, sexual development, and levels of boar taint-related compounds in intact male pigs. J. Anim. Sci. 72, 14-20.
10. Braun, W.F., Thompson, J.M., Ross, C.V., 1980. Ram scrotal circumference measurements. Theriogenology 13, 221-229.
11. Brown, B.W., Mattner, P.E., Carroll, P.A., Holland, E.J., Paull, D.R., Hoskinson, R.M., Rigby, R.D., 1994. Immunization of sheep against GnRH early in life: effects on reproductive function and hormones in rams. J. Reprod. Fertil. 101, 15-21.
12. Carelli, C., Audibert, F., Gaillard, J., Chedid, L., 1982. Immunological castration of male mice by a totally synthetic vaccine administered in saline. Proc. Natl. Acad. Sci. U.S.A. 79, 5392-5395.
13. Chakraborty, P.K., Stuart, L.D., Brown, J.L., 1989. Puberty in the male Nubian goat: serum concentrations of LH, FSH and testosterone from birth through puberty and semen characteristics at sexual maturity. Anim. Reprod. Sci. 20, 91-101.
14. Clarke, I.J., Brown, B.W., Tran, V.V., Scott, C.J., Fry, R., Millar, R.P., Rao, A., 1998. Neonatal immunization against gonadotropin-releasing hormone (GnRH) results in diminished GnRH secretion in adulthood. Endocrinology 139, 2007-2014.
15. Cook, R.B., Popp, J.D., Kastelic, J.P., Robbins, S., Harland, R., 2000. The effects of active immunization against GnRH on testicular development, feedlot performance, and carcass characteristics of beef bulls. J. Anim. Sci. 8, 2778-2783.
16. D'Occhio, M.J., Aspden, W.J., Trigg, T.E., 2001. Sustained testicular atrophy in bulls actively immunized against GnRH: potential to control carcase characteristics. Anim. Reprod. Sci. 66, 47-58.
17. Fraser, H.M., Gunn, A., Jeffcoate, S.L., Holland, D.T., 1974. Effect of active immunization to luteinizing hormone releasing hormone on serum and pituitary gonadotrophins, testes and accessory sex organs in the male rat. J. Endocrinol. 3, 399-406.
18. Fraser, H.M., Gunn, A., Jeffcoate, S.L., Holland, D.T., 1977. Preparation of antisera to luteinizing hormone releasing hormone. J. Endocrinol. 61, ix-x.
19. Glass, A.R., Anderson, J., Herbert, D., Vigersky, R.A., 1984. Relationship between pubertal timing and body size in underfed male rats. Endocrinology 115, 19-24.
20. Hinojosa, A.M., Bloeser, J.R., Thomson, S.R.M., Watson, E.D., 2001. The effect of a GnRH antagonist on endocrine and seminal parameters in stallions. Theriogenology 56, 903-912.
21. Hohl, M.C.K., Waidelich, S., Drochner, W., Claus, R., 2002. Active immunization of boars against GnRH at an early age: consequences for testicular function, boar taint accumulation and N-retention. Livestock Reprod. Sci. 74, 147-157.
22. Hosie, B.D., Carruthers, J., Sheppard, B.W., 1996. Bloodless castration of lambs: results of a questionnaire. Br. Vet. J. 152, 47-55.
23. Hotzel, M.J., Caraty, A., Martin, G.B., 1997. Effects of nutrition on testicular growth in mature Merino rams actively immunized against GnRH. J. Reprod. Fertil. 110, 307-313.
24. Huxsoll, C.C., Price, E.O., Adam, T.E., 1998. Testis function, carcase traits, and aggressive behavior of beef bulls actively immunized against gonadotrophin-releasing hormone. J. Anim. Sci. 76, 1760-1766.
25. Kiyma, Z., Adams, T.E., Hess, B.W., Riley, M.L., Murdoch, W.J., Moss, G.E., 2000. Gonadal function, sexual behavior, feedlot performance, and carcass traits of ram lambs actively immunized against GnRH. J. Anim. Sci. 78, 2237-2243.
26. Madani, M.O.K., Rahal, M.S., Eawia, M.T., Eluwhaishi, B.A., 1989. Puberty and early sexual development in Libian fat-tailed ram lambs. Br. Vet. J. 145, 276-288.
27. Malmgren, L., Andresen, O., Dalin, A.M., 2001. Effect of GnRH immunization on hormonal levels, sexual behaviour, semen quality and testicular morphology in mature stallions. Equine Vet. J. 33, 75-83.
28. McNeilly, J.R., Fordyce, M., Land, R.B., Lee, G.J., Webb, R., 1986. Endocrine differences in ram after genetic selection for testis size. J. Reprod. Fertil. 76, 131-140.
29. Olster, D.H., Foster, D.L., 1988. Control of gonadotrophin secretion during the pubertal and seasonal transitions in male sheep. J. Reprod. Fertil. 82, 179-191.
30. Otts, R.S., Menon, M.A., 1980. Breeding soundness examination of rams and bucks, a review. Theriogenology 13, 155-164.
31. Rabb, M.H., Thompson Jr., D.L., Barry, B.E., Colborn, D.R., Hehnke, K.E., Garza Jr., F., 1990. Effects of active immunization against GnRH on LH, FSH and prolactin storage, secretion and response to their secretagogues in pony geldings. J. Anim. Sci. 68, 3322-3329.
32. Robertson, I.S., Wilson, J.C., Fraser, H.M., 1979. Immunological castration in male cattle. Vet. Rec. 105, 556-557.
33. Robertson, I.S., Fraser, H.M., Innes, G.M., Jones, A.S., 1982. Effect of immunological castration on sexual and production characteristics in male cattle. Vet. Rec. 111, 529-531.
34. Salhab, S.A., Zarkawi, M., Wardeh, M.F., Al-Masri, M.R., Kassem, R., 2001. Development of testicular dimensions and size, and their relationship to age, body weight and parental size in growing Awassi ram lambs. Small Rumin. Res. 40, 187-191.
35. Schanbacher, B.D., 1982. Responses of ram lambs to active immunization against testosterone and luteinizing hormone-releasing hormone. Am. J. Physiol. 242, E201-E205.
36. Schanbacher, B.D., 1984. Active immunization against LH-RH in the male. In: Crighton, D.B. (Ed.), Immunoligical Aspects of Reproduction in Mammals. Butterworths, London, pp. 345-362.
37. Thompson Jr., D.L., 2000. Immunization against GnRH in male species (comparative aspects). Anim. Reprod. Sci. 60-61, 459-469.
38. Tilbrook, A.J., Galloway, D.B., Williams, A.H., Clarke, I.J., 1993. Treatment of young rams with an agonist of GnRH delays reproductive development. Horm. Behav. 27, 5-28.
39. Winter, A.C., 1996. Castration-kinder cut. Br. Vet. J. 152, 7-8.
40. Zeng, X.Y., Turkstra, J.A., Meloen, R.H., Liu, X.Y., Chen, F.Q., Schaaper, W.M.M., Oonk, H.B., Guo, D.Z., van de Wiel, D.F.M., 2002. Active immunization against gonadotrophin-releasing hormone in Chinese male pigs: effects of dose on antibody titer, hormone levels and sexual development. Anim. Reprod. Sci. 70, 223-233.
41. Zhao, Y.Z., 2000. Sheep Production, China Agricultural Press, Beijing, pp.79-89.