DNA vaccines based on genetically detoxified derivatives of pneumolysin fail to protect mice against challenge with Streptococcus pneumoniae

FEMS Immunology and Medical Microbiology

Volumn 46, Issue 2, 2006, Pages 291-297

  Ferreira, Daniela M ^a   Arêas, Ana Paula M ^a   Darrieux, Michelle ^a   Leite, Luciana C C ^a   Miyaji, Eliane N ^a  

^a INSTITUTO BUTANTAN   (Brazil)

Author keywords

DNA vaccine; Pneumolysin; Streptococcus pneumoniae

Indexed keywords

DNA VACCINE; IMMUNOGLOBULIN G ANTIBODY; PNEUMOCOCCUS VACCINE; PNEUMOLYSIN; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIBODY TITER; ANTIGEN EXPRESSION; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; COMPLEMENT ACTIVATION; CONTROLLED STUDY; CYTOLYSIS; DETOXIFICATION; DNA VECTOR; EXPERIMENTAL INFECTION; FEMALE; GENE MUTATION; IMMUNE RESPONSE; IMMUNIZATION; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; STREPTOCOCCUS INFECTION; STREPTOCOCCUS PNEUMONIAE;

ANIMALS; ANTIBODIES, BACTERIAL; BACTERIAL PROTEINS; CELL LINE; CRICETINAE; HUMANS; MICE; MICE, INBRED BALB C; PNEUMOCOCCAL INFECTIONS; PNEUMOCOCCAL VACCINES; RECOMBINANT PROTEINS; STREPTOCOCCUS PNEUMONIAE; STREPTOLYSINS; VACCINES, CONJUGATE; VACCINES, DNA;

EID: 33645075710     PISSN: 09288244     EISSN: 1574695X     Source Type: Journal    
DOI: 10.1111/j.1574-695X.2006.00040.x     Document Type: Article

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