Knockdown of CD146 reduces the migration and proliferation of human endothelial cells

Cell Research

Volumn 16, Issue 3, 2006, Pages 313-318

  Kang, Yanyong ^a,c   Wang, Fengcai ^a,b   Feng, Jing ^a   Yang, Dongling ^a   Yang, Xu ^c   Yan, Xiyun ^a  

^a INSTITUTE OF BIOPHYSICS   (China)

^b ANYANG NORMAL UNIVERSITY   (China)

^c CENTRAL CHINA NORMAL UNIVERSITY   (China)

Author keywords

Adhesion molecule CD146; Small interfering RNA; Vascular endothelial cell

Indexed keywords

CD146 ANTIGEN; MESSENGER RNA; SMALL INTERFERING RNA;

ANGIOGENESIS; ARTICLE; CELL ADHESION; CELL CULTURE; CELL MOTION; CELL PROLIFERATION; CYTOLOGY; DRUG EFFECT; ENDOTHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; HUMAN; PHYSIOLOGY; VASCULAR ENDOTHELIUM; WOUND HEALING;

ANTIGENS, CD146; CELL ADHESION; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; HUMANS; NEOVASCULARIZATION, PHYSIOLOGIC; RNA, MESSENGER; RNA, SMALL INTERFERING; WOUND HEALING;

EID: 33645063715     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/sj.cr.7310039     Document Type: Article

References (22)

1. Carmeliet P. Angiogenesis in health and disease. Nat Med 2003; 9:653-660.
2. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other diseases. Nat Med 1995; 1:27-31
3. Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature 2000; 14:249-257.
4. Zetter BR. Angiogenesis and tumor metastasis. Annu Rev Med 1998; 49:407-424.
5. Nelson NJ. Angiogenesis research is on fast forward. J Natl Cancer Inst 1999; 91:820-822.
6. Ferrara N, Hillan KJ, Gerber HP, et al. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov 2004; 3:391-400.
7. Tournaire R, Simon MP, le Noble F, et al. A short synthetic peptide inhibits signal transduction, migration and angiogenesis mediated by Tie2 receptor. EMBO Rep 2004; 5:262-267.
8. Brooks, PC, Clark RA, Cheresh DA. Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science 1994; 264:569-571.
9. Lehmann JM, Riethmuler G, Johnson JP. MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily. Proc Natl Acad Sci U S A. 1989; 86:9891-9895.
10. Shih IM, Elder DE, Speicher D, et al. Isolation and functional characterization of the A32 melanoma associated antigens. Cancer Res. 1994; 54:2514-2520.
11. Bardin N, Frances V, Lesaule G, et al. Identification of the S-Endol endothelial-associated antigen. Biochem Biophys Res Commun. 1996; 218:210-216.
12. Mills L, Tellez C, Huang S, et al. Fully Human Antibodies to MCAM/MUC18 inhibit tumor growth and metastasis of human melanoma. Cancer Res 2002; 62:5106-5114.
13. Yan X, Lin Y, Yang D, et al. A novel anti-CD 146 monoclonal antibody, AA98, inhibits angiogenesis and tumor growth. Blood 2003; 102:184-191.
14. Elbashir SM, Harborth J, Lendeckel W, et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001; 411:494-498.
15. Caplen NJ, Parrish S, Imani F. Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems. Proc Natl Acad Sci U S A 2001; 98:9742-9747.
16. Fire A, Xu S, Montgomery MK, et al. Potent and specific genetic interference by double-stranded RNA in caenorhabditis elegans. Nature 1998; 391:806-811.
17. Guan H, Zhou Z, Wang H, et al. A small interfering RNA targeting vascular endothelial growth factor inhibits Ewing's sarcoma growth in a xenograft mouse model. Clin Cancer Res 2005; 11:2662-2669.
18. Kim B, Tang Q, Biswas PS, et al. Inhibition of ocular angiogenesis by siRNA targeting vascular endothelial growth factor-pathway genes; therapeutic strategy for herpetic stromal keratitis. Am J Pathol. 2004; 165:2177-2185
19. Zhang G, Gurtu V, Kain SR, et al. Early detection of apoptosis using a fluorescent conjugate of annexin V. Biotechniques 1997; 23:525-531.
20. Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971; 285:1182-1186.
21. Solovey AN, Gui L, Chang L, et al. Identification and function assessment of endothelial P1H12. J Lab Clin Med 2001; 138:322-331.
22. Joyce B. Cell adhesion and angiogenesis. J Clin Invest 1997; 99:373-376.