Impact of long-term viral suppression in CD4+ recovery of HIV-children on Highly Active Antiretroviral Therapy

BMC Infectious Diseases

Volumn 6, Issue , 2006, Pages

  Resino, Salvador ^a   Resino, Rosa ^a   Leon, Juan A ^b   Bellon, José M ^a   Martin Fontelos, Pablo ^c   Ramos, Jose T ^d   Gurbindo Gutierrez, Dolores ^a   de Jose, Maria I ^c   Ciria, Luis ^e   Muñoz Fernandez, Maria A ^a  

^a HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^b HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

^c HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^d HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^e HOSPITAL INFANTIL UNIVERSITARIO NIÑO JESÚS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMPRENAVIR; ANTIRETROVIRUS AGENT; CD4 ANTIGEN; EFAVIRENZ; INDINAVIR; NELFINAVIR; NEVIRAPINE; PROTEINASE INHIBITOR; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

ARTICLE; CD4+ T LYMPHOCYTE; CHILD; CHILD CARE; CONTROLLED STUDY; DRUG SUBSTITUTION; FEMALE; FOLLOW UP; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; LONG TERM CARE; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; RETROSPECTIVE STUDY; VERTICAL TRANSMISSION; VIRUS LOAD; ADOLESCENT; CD4 LYMPHOCYTE COUNT; DRUG ADMINISTRATION; IMMUNOLOGY; INFANT; PRESCHOOL CHILD;

ADOLESCENT; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4 LYMPHOCYTE COUNT; CHILD; CHILD, PRESCHOOL; DRUG ADMINISTRATION SCHEDULE; FEMALE; HIV INFECTIONS; HUMANS; INFANT; MALE; RETROSPECTIVE STUDIES; VIRAL LOAD;

EID: 33645037828     PISSN: 14712334     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/1471-2334-6-10     Document Type: Article

References (25)

1. Resino S, Bellón JM, Gurbindo D, Ramos JT, León JA, Mellado MJ, Muñoz-Fernández MA: Viral Load and CD4+ T-Cells Response to HAART in HIV-Infected Children: a Observational Study. Clin Infect Dis 2003, 37:1216-1225.
2. Borkowsky W, Stanley K, Douglas SD, Lee S, Wiznia A, Pelton S, Yogev R, McIntosh K, Nachman S: Immunologic response to combination nucleoside analogue plus protease inhibitor therapy in stable antiretroviral therapy-experienced human immunodeficiency virus-infected children. J Infect Dis 2000, 182:96-103.
3. Resino S, Bellón JM, Resino R, Navarro ML, Ramos JT, Mellado MJ, de Jose MI, Muñoz-Fernández MA: Extensive implementation of highly active antiretroviral therapy shows great effectiveness on the survival and surrogate markers in vertically HIV-infected children. Clin Infect Dis 2004, 38:1605-1612.
4. Wiznia A, Stanley K, Krogstad P, Johnson G, Lee S, McNamara J, Moye J, Jackson JB, Mendez H, Aguayo R, Dieudonne A, Kovacs A, Bamji M, Abrams E, Rana S, Sever J, Nachman S: Combination nucleoside analog reverse transcriptase inhibitor(s) plus nevirapine, nelfinavir, or ritonavir in stable antiretroviral therapy-experienced HIV-infected children: week 24 results of a randomized controlled trial - PACTG 377. Pediatric AIDS Clinical Trials Group 377 Study Team. AIDS Res Hum Retroviruses 2000, 16:1113-1121.
5. van Rossum AM, Geelen SP, Hartwig NG, Wolfs TF, Weemaes CM, Scherpbier HJ, van Lochem EG, Hop WC, Schutten M, Osterhaus AD, Burger DM, de Groot R: Results of 2 years of treatment with protease-inhibitor - containing antiretroviral therapy in dutch children infected with human immunodeficiency virus type 1. Clin Infect Dis 2002, 34:1008-1016.
6. Soh CH, Oleske JM, Brady MT, Spector SA, Borkowsky W, Burchett SK, Foca MD, Handelsman E, Jimenez E, Dankner WM, Hughes MD: Long-term effects of protease-inhibitor-based combination therapy on CD4 T-cell recovery in HIV-I-infected children and adolescents. Lancet 2003, 362:2045-2051.
7. Holmberg SD, Hamburger ME, Moorman AC, Wood KC, Palella FJJ: Factors associated with maintenance of long-term plasma human immunodeficiency virus RNA suppression. Clin Infect Dis 2003, 37:702-707.
8. Resino S, Galan I, Perez A, Leon JA, Seoane E, Gurbindo D, Muñoz-Fernández MA: HIV-infected children with moderate-severe immune-suppression: changes in the immune system after highly active antiretroviral therapy. Clin Exp Immunol 2004, 137:570-577.
9. Douek DC, Picker LJ, Koup RA: T cell dynamics in HIV-I infection. Annu Rev Immunol 2003, 21:265-304.
10. Chiappini E, Galli L, Zazzi M, de Martino M: Immunological recovery despite virological failure is independent of human immunodeficiency virus-type 1 resistant mutants in children receiving highly active antiretroviral therapy. J Med Virol 2003, 70:506-512.
11. Peruzzi M, Azzari C, Galli L, Vierucci A, De Martino M: Highly active antiretroviral therapy restores in vitro mitogen and antigen-specific T-lymphocyte responses in HIV-I perinatally infected children despite virological failure. Clin Exp Immunol 2002, 128:365-371.
12. Melvin AJ, Rodrigo AG, Mohan KM, Lewis PA, Manns-Arcuino L, Coombs RW, Mullins JI, Frenkel LM: HIV-I dynamics in children. J Acquir Immune Defic Syndr Hum Retrovirol 1999, 20:508-513.
13. Deeks SG, Barbour JD, Grant RM, Martin JN: Duration and predictors of CD4 T-cell gains in patients who continue combination therapy despite detectable plasma viremia. AIDS 2002, 16:201-207.
14. Resino S, Bellón JM, Ramos JT, Gonzalez-Rivera M, de José MI, González MI, Gurbindo D, Mellado MJ, Cabrero E, Muñoz-Fernández MA: Positive virologic outcome after lopinavir/ritonavir salvage therapy in protease inhibitor-experienced HIV-I-infected children. A prospective cohort study. J Antimicrob Chemother 2004, 54:921-931.
15. Paul ME, Mao C, Charurat M, Serchuck L, Foca M, Hayani K, Handelsman EL, Diaz C, McIntosh K, Shearer WT: Predictors of immunologic long-term nonprogression in HIV-infected children: Implications for initiating therapy. J Allergy Clin Immunol 2005, 115:848-855.
16. Koletar SL, Williams PL, Wu J, McCutchan JA, Cohn SE, Murphy RL, Lederman HM, Currier JS: Long-term follow-up of HIV-infected individuals who have significant increases in CD4+ cell counts during antiretroviral therapy. Clin Infect Dis 2004, 39:1500-1506.
17. Deeks SG, Barbour JD, Martin JN, Swanson MS, Grant RM: Sustained CD4+ T cell response after virologic failure of protease inhibitor-based regimens in patients with human immunodeficiency virus infection. J Infect Dis 2000, 181:946-953.
18. Kaufmann GR, Bloch M, Finlayson R, Zaunders J, Smith D, Cooper DA: The extent of HIV-I-related immunodeficiency and age predict the long- term CD4 T lymphocyte response to potent antiretroviral therapy. Aids 2002, 16:359-367.
19. Tarwater PM, Margolick JB, Jin J, Phair JP, Detels R, Rinaldo C, Giorgi J, Munoz A: Increase and plateau of CD4 T-cell counts in the 3(1/2) years after initiation of potent antiretroviral therapy. J Acquir Immune Defic Syndr 2001, 27:168-175.
20. Hunt PW, Deeks SG, Rodriguez B, Valdez H, Shade SB, Abrams DI, Kitahata MM, Krone M, Neilands TB, Brand RJ, Lederman MM, Martin JN: Continued CD4 cell count increases in HIV-infected adults experiencing 4 years of viral suppression on antiretroviral therapy. Aids 2003, 17:1907-1915.
21. Franco JM, Leon-Leal JA, Leal M, Cano-Rodriguez A, Pineda JA, Macias J, Rubio A, Rey C, Sanchez B, Lissen E: CD4+ and CD8+ T lymphocyte regeneration after anti-retroviral therapy in HIV-I-infected children and adult patients. Clin Exp Immunol 2000, 119:493-498.
22. Jimenez JL, Resino S, Martinez-Colom A, Bellon JM, Munoz-Fernandez MA: Mutations at codons 54 and 82 of HIV protease predict virological response of HIV-infected children on salvage lopinavir/ritonavir therapy. J Antimicrob Chemother 2005 in press.
23. Harrigan PR, Hogg RS, Dong WW, Yip B, Wynhoven B, Woodward J, Brumme CJ, Brumme ZL, Mo T, Alexander CS, Montaner JS: Predictors of HIV drug-resistance mutations in a large antiretroviral-naive cohort initiating triple antiretroviral therapy. J Infect Dis 2005, 191:339-347.
24. Watson DC, Farley JJ: Efficacy of and adherence to highly active antiretroviral therapy in children infected with human immunodeficiency virus type 1. Pediatr Infect Dis J 1999, 18:682-689.
25. Reddington C, Cohen J, Baldillo A, Toye M, Smith D, Kneut C, Demaria A, Bertolli J, Hsu HW: Adherence to medication regimens among children with human immunodeficiency virus infection. Pediatr Infect Dis J 2000, 19:1148-1153.