The physical stability of thermally-stressed phospholipid-based emulsions containing methyl, propyl and heptyl parabens as model drugs

International Journal of Pharmaceutics

Volumn 265, Issue 1-2, 2003, Pages 133-140

  Zhang, Xiaoguang ^a,b   Kirsch, Lee E ^a  

^a UNIVERSITY OF IOWA   (United States)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Anisotropy; Coalescence; Emulsion stability; Fluorescence polarization; Molecular diffusion; Ostwalt ripening; Paraben; Phospholipids; Photon correlation spectroscopy

Indexed keywords

1,6 PHENYL 1,3,5 HEXATRIENE; 4 HYDROXYBENZOIC ACID ESTER; ALKENE DERIVATIVE; HEPTYL PARABEN; METHYL PARABEN; PROPYL PARABEN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANISOTROPY; AQUEOUS SOLUTION; ARTICLE; CALCULATION; CONCENTRATION RESPONSE; CORRELATION ANALYSIS; DISSOLUTION; DRUG SOLUBILITY; EMULSION; GROWTH INHIBITION; GROWTH RATE; LIPOPHILICITY; PHOTON; PRIORITY JOURNAL; RIGIDITY; THEORETICAL STUDY; THERMOSTABILITY; VISCOSITY;

EID: 0141533084     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2003.07.007     Document Type: Article

References (31)

1. Buscall R., Davis S.S., Potts D.C. The effect of long-chain alkanes on the stability of oil-in-water emulsions. The significance of Ostwald ripening. Colloid Polym. Sci. 257:1979;636-644.
2. Davis S.S., Round H.P., Purewal T.S. Ostwald ripening and the stability of emulsion systems: an explanation for the effect of an added third component. J. Colloid Interface Sci. 80:1981;508-511.
3. Deniz K.U., Panicker L., Parvathanathan P.S., Datta F., Vivekanandan S., Ramanathan K.V., Khetrapal C.L. Drug-lipid interaction in model membrane DPPC-water: a DSC and proton NMR study. Mol. Cryst. Liq. Cryst. 288:1996;237-247.
4. Dickinson E., Murray B.S., Stainsby G. Coalescence stability of emulsion-sized droplets at a planar oil-water interface and the relationship to protein film surface rheology. J. Chem. Soc., Faraday Trans. 1. 84:1988;871-883.
5. Fridberg, S.E., Quencer, L.F., Hilton, M.L., 1996. Theory of emulsions. In: Lieberman, H.A., Rieger, M.M., Banker, G.S., (Eds.), Pharmaceutical Dosage Forms: Disperse Systems, 2nd ed. vol. 1. Marcel Dekker Inc., New York, pp. 53-90.
6. Han S.K., Kim J.S., Lee Y.S., Kim M. Effect of drug substances on the microviscosity of lipid bilayer of liposomal membranes. Arch. Pharm. Res. 13:1990;192-197.
7. Higuchi W.I., Misra J. Physical degradation of emulsions via the molecular diffusion route and the possible prevention thereof. J. Pharm. Sci. 51:1962;459-466.
8. Ivanov I.B. Effect of surface mobility on the dynamic behavior of thin liquid films. Pure Appl. Chem. 52:1980;1241-1262.
9. Ivanov, I.B., Jain, R.K., Somasundara, P., Traykov, T.T., 1979. The role of surfactants on the coalescences of emulsion droplets. In: Mittal, K.L. (Ed.), Chemistry of Surfactants, vol. 2. Plenum Press, New York, pp. 817-840.
10. Jones A.F., Wilson S.D.R. The film dranage problem in droplet coalescence. J. Fluid Mech. 87:1978;263-288.
11. Kabalnov A.S., Shchukin E.D. Ostwald ripening theory: application to fluorocarbon emulsion stability. Adv. Colloid Interface Sci. 38:1992;69-97.
12. Kabalnov A.S., Pertzov A.V., Shchukin E.D. Ostwald ripening in emulsions 1. Direct observations of Ostwald ripening in emulsions. J. Colloid Interface Sci. 118:1987a;590-597.
13. Kabalnov A.S., Pertzov A.V., Shchukin E.D. Ostwald ripening in two-component disperse phase systems: application to emulsion stability. Colloids Surf. 24:1987b;19-32.
14. Kabalnov A.S., Makarov K.N., Pertzov A.V., Shcherbakova O.V. Solubility of fluorocarbons in water as a key parameter determining fluorocarbon emulsion stability. J. Fluorine Chem. 50:1990;271-284.
15. Lawrence A.S.C., Mills O.S. Kinetics of the coagulation of emulsions. Faraday Discuss. Chem. Soc. 18:1954;98-104.
16. Lee G.W.J., Tadros T.F. Formation and stability of emulsions produced by dilution of emulsifiable concentrates. Part II. The influence of surfactant concentration on stability of oil-in-water emulsions. Colloid Surf. 5:1982a;117-127.
17. Lee G.W.J., Tadros T.F. Formation and stability of emulsions produced by dilution of emulsifiable concentrates. Part III. The coalescence of oil droplets at a planar oil-water interface. Colloid Surf. 5:1982b;129-135.
18. Levy M.Y., Benita S. Design and characterization of submicronized o/w emulsion of diazepam for parenteral use. Int. J. Pharm. 54:1989;103-112.
19. Levy M.Y., Benita S. Short- and long-term stability assessment of a new injectable diazepam submicron emulsion. J. Parenter. Sci. Technol. 45:1991;101-107.
20. Lifshitz I.M., Slyozov V.V. The kinetics of precipitation from supersaturated solid solutions. J. Phys. Chem. Solids. 19:1961;35-50.
21. Prankerd R.J., Frank S.G., Stella V. Preliminary development and evaluation of a parenteral formulation of penclomedine (NSC-338720; 3,5-dichloro-2,4-dimethoxy-6-trichloromethylpyridine): a novel, practically water insoluble cytotoxic agent. J. Parenteral Sci. Tech. 42:1988;76-81.
22. Simamora P., Dannenfelser R.M., Tabibi S.E., Yalkowsky S.H. Emulsion formulations for intravenous administration of paclitaxell. PDA J. Pharm. Sci. Tech. 52:1998;170-172.
23. Stella V.J., Umprayn K., Waugh W.N. Development of parenteral formulations of experimental cytotoxic agents. I. Rhizoxin (NSC-332598). Int. J. Pharm. 43:1988;191-199.
24. Tadros, T.F., Vincent, B., 1983. Emulsion stability. In: Becher, P. (Ed.), Encyclopedia of Emulsion Technology. Marcel Dekker, New York, vol. 1. pp. 130-278.
25. Wagner C. Theorie der alterrung von niederschlagen durch umlosen. Zeit. Elektrochem. 65:1961;581-591.
26. Walstra, P, 1996. Emulsion stability. In: Becher, P. (Ed.), Encyclopedia of Emulsion Technology, vol. 4. Marcel Dekker, New York, pp. 1-61.
27. Yamaguchi T., Nishizaki K., Itai S., Hayashi H., Ohshima H. Physicochemical characterization of parenteral lipid emulsion: determination of Hamaker constants and activation energy of coalescence. Pharm. Res. 12:1995a;342-347.
28. Yamaguchi T., Nishizaki K., Itai S., Hayashi H., Ohshima H. Physicochemical characterization of parenteral lipid emulsion: influence of cosurfactants on flocculation and coalescence. Pharm. Res. 12:1995b;1273-1278.
29. Yamamura K., Nakao M., Yano K., Miyamoto K., Yotsuyanagi T. Stability of forskolin in lipid emulsions and oil/water partition coefficients. Chem. Pharm. Bull. 39:1991;1032-1034.
30. Zhang X., Kirsch L.E. An Assessment of techniques for evaluating the physical stability of parenteral emulsions. PDA J. Pharm. Sci. Tech. 57:2003;83-92.
31. Zhang, X., Kirsch, L.E., 2003. Correlation of the thermal stability of phopholipid-based emulsions and microviscosity measurements using fluorescence polarization. Pharm. Dev. Tech., in press.