Effects of levetiracetam on nocturnal sleep and daytime vigilance in healthy volunteers

Epilepsia

Volumn 47, Issue 1, 2006, Pages 82-85

  Cicolin, Alessandro ^a,b,c   Magliola, Umberto ^a   Giordano, Alessandra ^a   Terreni, Anna ^a   Bucca, Caterina ^a   Mutani, Roberto ^a,b  

^a UNIVERSITY OF TURIN   (Italy)

^b ISTITUTO AUXOLOGICO ITALIANO   (Italy)

^c Dipartimento di Neuroscienze   (Italy)

Author keywords

Antiepileptic drugs; Daytime sleepiness; Levetiracetam; Polysomnography; Sleep architecture

Indexed keywords

ETIRACETAM; PLACEBO;

ADULT; ALERTNESS; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; EPILEPSY; EPWORTH SLEEPINESS SCALE; FEMALE; HUMAN; MALE; NIGHT SLEEP; NONREM SLEEP; NORMAL HUMAN; POLYSOMNOGRAPHY; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; SLEEP; SLEEP DISORDER; SLEEP TIME; SLEEP WAKING CYCLE; SOMNOLENCE; STATISTICAL SIGNIFICANCE;

ADULT; ANTICONVULSANTS; AROUSAL; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; EPILEPSY; FEMALE; HUMANS; MALE; PIRACETAM; PLACEBOS; POLYSOMNOGRAPHY; SLEEP; SLEEP DISORDERS; TREATMENT OUTCOME;

EID: 33645026102     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2006.00376.x     Document Type: Article

References (20)

1. Bazil CW Epilepsy and sleep disturbance Epilepsy Behav 2003 4 39 45
2. Placidi F Scalise A Marciani MG et al. Effect of antiepileptic drugs on sleep Clin Neurophysiol 2000 111 suppl 2 S115 S119
3. Sammaritano MR Sherwin AL Effects of anticonvulsants on sleep Neurology 2000 54 suppl 1 S16 S24
4. Mendez M Radtke RA Interactions between sleep and epilepsy J Clin Neurophysiol 2001 18 106 127
5. Legros B Bazil CW Effects of antiepileptic drugs on sleep architecture: a pilot study Sleep Med 2003 4 51 55
6. Sadek A French JA Levetiracetam In Shorvon S Perucca E Fish D et al. eds The Treatment of Epilepsy Malden Mass Blackwell Science 2004 187
7. Bell C Vanderlinden H Hiersemenzel R et al. The effects of levetiracetam on objective and subjective sleep parameters in healthy volunteers and patients with partial epilepsy J Sleep Res 2002 11 255 263
8. Khatami R Siegel AM Bassetti CL Hypersomnia in an epilepsy patient treated with levetiracetam Epilepsia 2005 46 588 589
9. Johns MW Reliability and factor analysis of the Epworth Sleepiness Scale Sleep 1992 15 376 381
10. Carskadon MA Dement WC Mitler MM et al. Guidelines for the multiple sleep latency test (MSLT): a standard measure of sleepiness Sleep 1986 9 519 524
11. Rechtschaffen A Kales A A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects Washington DC US Government Printing Office 1968
12. American Sleep Disorders Association EEG arousals: scoring rules and examples: a preliminary report from the Sleep Disorders Atlas Task Force of the American Sleep Disorders Association Sleep 1992 15 173 184
13. Mathias S Wetter TC Steiger A et al. The GABA uptake inhibitor tiagabine promotes slow wave sleep in normal elderly subjects Neurobiol Aging 2001 22 247 253
14. A agonist THIP produces slow wave sleep and reduces spindling activity in NREM sleep in humans Psychopharmacology 1997 130 285 291
15. Mendelson WB Hypnotic medications: mechanisms of action and pharmacologic effects In Kryger MH Roth T Dement WC eds Principles and Practice of Sleep Medicine Philadelphia Elsevier Saunders 2005 444
16. Foldvary-Schaefer N De Leon Sanchez I et al. Gabapentin increases slow-wave sleep in normal adults Epilepsia 2002 43 1493 1497
17. st Annual meeting; 2001 December 8-12 San Juan Puerto Rico
18. Walker MC Fisher A Mechanisms of antiepileptic drug action In Shorvon S Perucca E Fish D et al. eds The Treatment of Epilepsy Malden Mass Blackwell Science 2004 96
19. Lynch BA Lambeng N Nocka K et al. The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam Proc Natl Acad Sci U S A 2004 101 9861 9866
20. Bazil CW Effects of antiepileptic drugs on sleep structure: are all drugs equal? CNS Drugs 2003 17 719 728