Optimization of radiotherapy dose-time fractionation with consideration of tumor specific biology

Medical Physics

Volumn 32, Issue 12, 2005, Pages 3666-3677

  Yang, Yong ^a   Xing, Lei ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Biological model; Fractionation; Linear quadratic model; NTCP; Optimization; Radiobiology; TCP

Indexed keywords

BIOPHYSICS; FRACTIONATION; HISTOLOGY; OPTIMIZATION; RADIATION EFFECTS; RADIOACTIVITY; RADIOTHERAPY;

BIOLOGICAL MODELING; BIOLOGICALLY EFFECTIVE DOSE; EXTERNAL BEAM RADIOTHERAPY; LINEAR-QUADRATIC MODELS; NTCP; OVERALL TREATMENT TIME; RADIATION THERAPY TREATMENT; RADIOBIOLOGY;

TUMORS;

ARTICLE; CANCER CONTROL; CANCER RADIOTHERAPY; CLINICAL PROTOCOL; PRIORITY JOURNAL; RADIATION BEAM; RADIATION DOSE FRACTIONATION; REOXYGENATION; SENSITIZATION; STATISTICAL MODEL; TECHNIQUE; BIOLOGICAL MODEL; BIOPHYSICS; COMPUTER ASSISTED RADIOTHERAPY; HUMAN; NEOPLASM; PATHOLOGY; RADIOBIOLOGY; STATISTICS; TIME;

BIOPHYSICS; DOSE FRACTIONATION; HUMANS; MODELS, BIOLOGICAL; NEOPLASMS; RADIOBIOLOGY; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED; TIME FACTORS;

EID: 33645014060     PISSN: 00942405     EISSN: None     Source Type: Journal    
DOI: 10.1118/1.2126167     Document Type: Article

References (43)

1. A. Brahme, " Individualizing cancer treatment: biological optimization models in treatment planning and delivery, " Int. J. Radiat. Oncol., Biol., Phys. 49, 327-337 (2001).
2. C. Burman et al., " Planning, delivery, and quality assurance of intensity-modulated radiotherapy using dynamic multileaf collimator: a strategy for large-scale implementation for the treatment of carcinoma of the prostate, " Int. J. Radiat. Oncol., Biol., Phys. 39, 863-873 (1997).
3. A. Eisbruch, " Intensity-modulated radiotherapy of head-and-neck cancer: encouraging early results, " Int. J. Radiat. Oncol., Biol., Phys. 53, 1-3 (2002).
4. T. R. Mackie and A. R. Smith, " Intensity-modulated conformal radiation therapy and 3-dimensional treatment planning will significantly reduce the need for therapeutic approaches with particles such as protons, " Med. Phys. 26, 1185-1187 (1999).
5. Y. Yang and L. Xing, " Clinical knowledge-based inverse treatment planning, " Phys. Med. Biol. 49, 5101-5117 (2004).
6. J. G. Rosenman, J. S. Halle, M. A. Socinski, K. Deschesne, D. T. Moore, H. Johnson, R. Fraser, and D. E. Morris, " High-dose conformal radiotherapy for treatment of stage IIIA/IIIB non-small-cell lung cancer: technical issues and results of a phase I/II trial, " Int. J. Radiat. Oncol., Biol., Phys. 54, 348-356 (2002).
7. H.J. Thames HD. Fractionation in Radiotherapy (Taylor & Francis, London, 1987).
8. H. R. Withers, " Biologic basis for altered fractionation schemes, " Cancer 55, 2086-2095 (1985).
9. D. J. Brenner, E. J. Hall, Y. Huang, and R. K. Sachs, " Optimizing the time course of brachytherapy and other accelerated radiotherapeutic protocols, " Int. J. Radiat. Oncol., Biol., Phys. 29, 893-901 (1994).
10. J. F. Fowler, " Biological factors influencing optimum fractionation in radiation therapy, " Acta Oncol. 40, 712-717 (2001).
11. S. D. Young and R. P. Hill, " Effects of reoxygenation on cells from hypoxic regions of solid tumors: analysis of transplanted murine tumors for evidence of DNA overreplication, " Cancer Res. 50, 5031-5038 (1990).
12. D. J. Lee et al., " Results of an RTOG phase III trial (RTOG 85-27) comparing radiotherapy plus etanidazole with radiotherapy alone for locally advanced head and neck carcinomas, " Int. J. Radiat. Oncol., Biol., Phys. 32, 567-576 (1995).
13. G. J. Peters, C. L. van der Wilt, F. Gyergyay, J. A. van Laar, M. Treskes, W. J. van der Vijgh, and H. M. Pinedo, " Protection by WR-2721 of the toxicity induced by the combination of cisplatin and 5-fluorouracil, " Int. J. Radiat. Oncol., Biol., Phys. 22, 785-789 (1992).
14. J. F. Weiss, K. S. Kumar, T. L. Walden, R. Neta, M. R. Landauer, and E. P. Clark, " Advances in radioprotection through the use of combined agent regimens, " Int. J. Radiat. Biol. 57, 709-722 (1990).
15. H. D. Thames, Jr., H. R. Withers, L. J. Peters, and G. H. Fletcher, " Changes in early and late radiation responses with altered dose fractionation: implications for dose-survival relationships, " Int. J. Radiat. Oncol., Biol., Phys. 8, 219-226 (1982).
16. J. S. Cooper, " Will altered fraction schemes alter the future?, " Int. J. Radiat. Oncol., Biol., Phys. 19, 1621-1622 (1990).
17. B. Jones, R. G. Dale, P. Finst, and S. J. Khaksar, " Biological equivalent dose assessment of the consequences of hypofractionated radiotherapy, " Int. J. Radiat. Oncol., Biol., Phys. 47, 1379-1384 (2000).
18. R. Mohan, Q. Wu, M. Manning, and R. Schmidt-Ullrich, " Radiobiological considerations in the design of fractionation strategies for intensity-modulated radiation therapy of head and neck cancers, " Int. J. Radiat. Oncol., Biol., Phys. 46, 619-630 (2000).
19. C. R. King, T. A. DiPetrillo, and D. E. Wazer, " Optimal radiotherapy for prostate cancer: predictions for conventional external beam, IMRT, and brachytherapy from radiobiologic models, " Int. J. Radiat. Oncol., Biol., Phys. 46, 165-172 (2000).
20. J. F. Fowler, W. A. Tome, J. D. Fenwick, and M. P. Mehta, " A challenge to traditional radiation oncology, " Int. J. Radiat. Oncol., Biol., Phys. 60, 1241-1256 (2004).
21. H. R. Withers, " Biological basis of radiation therapy for cancer, " Lancet 339, 156-159 (1992).
22. J. F. Fowler, " The linear-quadratic formula and progress in fractionated radiotherapy, " Br. J. Radiol. 62, 679-694 (1989).
23. P. Hahnfeldt and L. Hlatky, " Resensitization due to redistribution of cells in the phases of the cell cycle during arbitrary radiation protocols, " Radiat. Res. 145, 134-143 (1996).
24. D. J. Brenner, L. R. Hlatky, P. J. Hahnfeldt, E. J. Hall, and R. K. Sachs, " A convenient extension of the linear-quadratic model to include redistribution and reoxygenation, " Int. J. Radiat. Oncol., Biol., Phys. 32, 379-390 (1995).
25. D. J. Brenner, " Dose, volume, and tumor-control predictions in radiotherapy, " Int. J. Radiat. Oncol., Biol., Phys. 26, 171-179 (1993).
26. S. M. Crooks and L. Xing, " Application of constrained least-squares techniques to IMRT treatment planning, " Int. J. Radiat. Oncol., Biol., Phys. 54, 1217-1224 (2002).
27. G. Starkschall, " A constrained least-squares optimization method for external beam radiation therapy treatment planning, " Med. Phys. 11, 659-665 (1984).
28. S. Webb, " Optimization of conformal radiotherapy dose distributions by simulated annealing, " Phys. Med. Biol. 34, 1349-1370 (1989).
29. A. Pugachev, J. G. Li, A. L. Boyer, S. L. Hancock, Q. T. Le, S. S. Donaldson, and L. Xing, " Role of beam orientation optimization in intensity-modulated radiation therapy, " Int. J. Radiat. Oncol., Biol., Phys. 50, 551-560 (2001).
30. I. Turesson and H. D. Thames, " Repair capacity and kinetics of human skin during fractionated radiotherapy: erythema, desquamation, and telangiectasia after 3 and 5 year's follow-up, " Radiother. Oncol. 15, 169-188 (1989).
31. G. D. Wilson, S. Dische, and M. I. Saunders, " Studies with bromodeoxyuridine in head and neck cancer and accelerated radiotherapy, " Radiother. Oncol. 36, 189-197 (1995).
32. J. F. Fowler and R. Chappell, " Non-small cell lung tumors repopulate rapidly during radiation therapy, " Int. J. Radiat. Oncol., Biol., Phys. 46, 516-517 (2000).
33. S. A. Roberts and J. H. Hendry, " Time factors in larynx tumor radiotherapy: lag times and intertumor heterogeneity in clinical datasets from four centers, " Int. J. Radiat. Oncol., Biol., Phys. 45, 1247-1257 (1999).
34. D. J. Brenner, A. A. Martinez, G. K. Edmundson, C. Mitchell, H. D. Thames, and E. P. Armour, " Direct evidence that prostate tumors show high sensitivity to fractionation (low alpha/beta ratio), similar to late-responding normal tissue, " Int. J. Radiat. Oncol., Biol., Phys. 52, 6-13 (2002).
35. J. F. Fowler, M. A. Ritter, R. J. Chappell, and D. J. Brenner, " What hypofractionated protocols should be tested for prostate cancer?, " Int. J. Radiat. Oncol., Biol., Phys. 56, 1093-1104 (2003).
36. K. M. Haustermans, I. Hofland, H. Van Poppel, R. Oyen, W. Van de Voorde, A. C. Begg, and J. F. Fowler, " Cell kinetic measurements in prostate cancer, " Int. J. Radiat. Oncol., Biol., Phys. 37, 1067-1070 (1997).
37. S. L. Scott, P. H. Gumerlock, L. Beckett, Y. Li, and Z. Goldberg, " Survival and cell cycle kinetics of human prostate cancer cell lines after single- and multifraction exposures to ionizing radiation, " Int. J. Radiat. Oncol., Biol., Phys. 59, 219-227 (2004).
38. A. C. Begg, I. Hofland, M. Van Glabbeke, H. Bartelink, and H. J. C., " Predictive value of potential doubling time for radiotherapy of head and neck tumor patients: Results from the European Cooperative Trial 22851, " Semin. Radiat. Oncol. 2, 22-25 (1992).
39. J. D. Cox, T. F. Pajak, V. A. Marcial, L. Coia, M. Mohiuddin, K. K. Fu, H. Selim, P. Rubin, and H. Ortiz, " ASTRO plenary: interfraction interval is a major determinant of late effects, with hyperfractionated radiation therapy of carcinomas of upper respiratory and digestive tracts: results from Radiation Therapy Oncology Group protocol 8313, " Int. J. Radiat. Oncol., Biol., Phys. 20, 1191-1195 (1991).
40. D. J. Brenner, " Fractionation and late rectal toxicity, " Int. J. Radiat. Oncol., Biol., Phys. 60, 1013-1015 (2004).
41. R. W. Lloyd-Davies, C. D. Collins, and A. V. Swan, " Carcinoma of prostate treated by radical external beam radiotherapy using hypofractionation. Twenty-two years' experience (1962-1984), " Urology 36, 107-111 (1990).
42. I. Turesson and M. C. Joiner, " Clinical evidence of hypersensitivity to low doses in radiotherapy, " Radiother. Oncol. 40, 1-3 (1996).
43. B. K. Lind, L. M. Persson, M. R. Edgren, I. Hedlof, and A. Brahme, " Repairable-conditionally repairable damage model based on dual Poisson processes, " Radiat. Res. 160, 366-375 (2003).