Some major landmarks in the path from nuclein to human genome

Toxicology Mechanisms and Methods

Volumn 16, Issue 2-3, 2006, Pages 137-159

  Choudhuri, Supratim ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Genomics; Human Genome Sequencing; Nuclein

Indexed keywords

DNA; DNA POLYMERASE; MESSENGER RNA; NUCLEIC ACID; RNA; RNA DIRECTED DNA POLYMERASE; RNA POLYMERASE; TRANSCRIPTION FACTOR;

BACTERIAL GENE; BACTERIAL GENETICS; CHROMATIN STRUCTURE; CISTRON; CLINICAL RESEARCH; DIFFERENTIAL DISPLAY; DNA HYBRIDIZATION; DNA ISOLATION; DNA PURIFICATION; DNA RNA HYBRIDIZATION; DNA STRUCTURE; GENE CONTROL; GENE EXPRESSION REGULATION; GENE REPLICATION; GENETIC TRANSDUCTION; GENETIC VARIABILITY; GENOME ANALYSIS; HISTORY OF MEDICINE; HUMAN; HUMAN GENOME; LACTOSE OPERON; MESSENGER RNA SYNTHESIS; MOLECULAR CLONING; PATENT; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN PURIFICATION; PROTEIN SYNTHESIS; REGULATOR GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; RNA HYBRIDIZATION; SECOND MESSENGER; SERIAL ANALYSIS OF GENE EXPRESSION; TUMOR SUPPRESSOR GENE; VIRUS CARCINOGENESIS;

BACTERIA (MICROORGANISMS);

EID: 33644995652     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.1080/15376520600558606     Document Type: Review

References (135)

1. Adams, M. D., Kelley, J. M., Gocayne, J. D., Dubnick, M., Polymeropoulos, M. H., Xiao, H., Merril, C. R., Wu, A., Olde, B., Moreno, R. F., et al. 1991. Complementary DNA sequencing: Expressed sequence tags and human genome project. Science 252:1651-1656.
2. Adams, M. D., Dubnick, M., Kerlavage, A. R., Moreno, R., Kelley, J. M., Utterback, T. R., Nagle, J. W., Fields, C., and Venter, J. C. 1992. Sequence identification of 2,375 human brain genes. Nature 355:632-634.
3. Alwine, J. C., Kemp, D. J., and Stark, G. R. 1977. Method for detection of specific RNAs in agarose gels by transfer to diazobenzyloxymethyl-paper and hybridization with DNA probes. Proc. Natl. Acad. Sci. U.S.A. 74:5350-5354.
4. Avery, O. T., MacLeod, C. M., and McCarty, M. 1944. Studies on the chemical nature of the substance inducing transformation of pneumococcal types. Inductions of transformation by a desoxyribonucleic acid fraction isolated from pneumococcus type III. J. Exp. Med. 79:137-158.
5. Baltimore, D. 1970. RNA-dependent DNA polymerase in virions of RNA tumour viruses. Nature 226:1209-1211.
6. Benoist, C., and Chambon, P. 1981. In vivo sequence requirements of the SV40 early promoter region. Nature 290:304-310.
7. Berget, S. M., Moore, C., and Sharp, P. A. 1977. Spliced segments at the 5′ terminus of adenovirus 2 late mRNA. Proc. Natl. Acad. Sci. USA. 74:3171-3175.
8. Berk, A. J., and Sharp, P. A. 1977. Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids. Cell 12:721-732.
9. Bessman, M. J., Lehman, I. R., Simms, E. S., and Kornberg, A. 1958. Enzymatic synthesis of deoxyribonucleic acid. II. General properties of the reaction. J. Biol. Chem. 233:171-177.
10. Blattner, F. R., Williams, B. G., Blechl, A. E., Denniston-Thompson, K., Faber, H. E., Furlong, L., Grunwald, D. J., Kiefer, D. O., Moore, D. D., Schumm, J. W., Sheldon, E.L., and Smithies, O. 1977. Charon phages: Safer derivatives of bacteriophage lambda for DNA cloning. Science 196:161-169.
11. Bolivar, E. Rodriguez, R. L., Betlach, M. C., and Boyer, H. W. 1977a. Construction and characterization of new cloning vehicles. I. Ampicillin-resistant derivatives of the plasmid pMB9. Gene 2:75-93.
12. Bolivar, F., Rodriguez, R. L., Greene, P. J., Betlach, M. C., Heyneker, H. L., and Boyer, H. W. 1977b. Construction and characterization of new cloning vehicles. II. A multipurpose cloning system. Gene 2:95-113.
13. Burgess, R. R., Travers, A. A., Dunn, J. J., and Bautz, E. K. 1969. Factor stimulating transcription by RNA polymerase. Nature 221:43-46.
14. Burke, D. T., Carle, G. F., Olson, M. V. 1987. Cloning of large segments of exogenous DNA into yeast by means of artificial chromosome vectors. Science 236:806-812.
15. Chang, A. C., Nunberg, J. H., Kaufman, R. J., Erlich, H. A., Schimke, R. T., and Cohen, S. N. 1978. Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase. Nature 275:617-624.
16. Chien, Y. H., Gascoigne, N. R., Kavaler, J., Lee, N. E., and Davis, M. M. 1984. Somatic recombination in a murine T-cell receptor gene. Nature 309:322-326.
17. Choudhuri, S. 2003. The path from nuclein to human genome: A brief history of DNA with a note on human genome sequencing and its impact on future research in biology. Bull Sci. Technol. Soc. 23:360-367.
18. Choudhuri, S. 2005. Gene regulation and molecular toxicology. Toxicol. Mechan. Methods 15:1-23.
19. Chow, L. T., Gelinas, R. E., Broker, T. R., and Roberts, R. J. 1977. An amazing sequence arrangement at the 5′ ends of adenovirus 2 messenger RNA. Cell 12:1-8.
20. Cohen, S. N., Chang, A. C., Boyer, H. W., and Helling, R. B. 1973. Construction of biologically functional bacterial plasmids in vitro. Proc. Natl. Acad. Sci. U.S.A. 70:3240-3204.
21. Collins, J., and Hohn, B. 1978. Cosmids: A type of plasmid gene-cloning vector that is packageable in vitro in bacteriophage lambda heads. Proc. Natl. Acad. Sci. U.S.A. 75:4242-4246.
22. Collins, F., Morgan, M., and Patrinos, A. 2003. The Human Genome Project: Lessons from large-scale biology. Science 300:286-290.
23. Cook-Deegan, R. 1994. The Gene Wars: Science, Politics, and the Human Genome. New York: Norton
24. Cowley, A. W., Jr. 2003. Physiological Genomics: The next three years. Physiol. Genomics 14:169-170.
25. Crawford, I. P., and Yanofsky, C. 1958. On the separation of the tryptophan synthetase of Escherichia coli into two protein components. Proc. Natl. Acad. Sci. USA. 44:1161-1170.
26. Crick, F. H. 1958. On protein synthesis. Symp. Soc. Exp. Biol. 12:138-163.
27. Crick, F. H. C. 1988. What mad pursuit: A Personal View of Scientific Discovery. New York: Basic Books.
28. Crick, F. H., Barnett, L., Brenner, S., and Watts-Tobin, R. J. 1961. General nature of the genetic code for proteins. Nature 192:1227-1232.
29. Czernilofsky, A. P., Levinson, A. D., Varmus, H. E., Bishop, J. M., Tischer, F., and Goodman, H. M. 1980. Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product.Nature 287:198-203.
30. Danna, K., and Nathans, D. 1971. Specific cleavage of simian virus 40 DNA by restriction endonuclease of Hemophilus influenzae. Proc. Natl. Acad. Sci. U.S.A. 68:2913-2917.
31. Danna, K. J., Sack, G. H. Jr., and Nathans, D. 1973. Studies of simian virus 40 DNA. VII. A cleavage map of the SV40 genome. J. Mol. Biol. 78:363-376.
32. Davies, K. 2001. Cracking the Genome. New York: Free Press.
33. Davis, M. M., Cohen, D. I., Nielsen, E. A., Steinmetz, M., Paul, W. E., and Hood, L. 1984. Cell-type-specific cDNA probes and the murine I region: The localization and orientation of Ad alpha. Proc. Natl. Acad. Sci. USA 81:2194-2198.
34. Dhar, R., Ellis, R. W., Shih, T. Y., Oroszlan, S., Shapiro, B., Maizel, J., Lowy, D., and Scolnick, E. 1982. Nucleotide sequence of the p21 transforming protein of Harvey murine sarcoma virus. Science 217:934-936.
35. Doenecke, D., and Karlson, P. 1984. Albrecht Kossel and the discovery of histones. Trends Biochem. Sci. 9:404-405.
36. Doudna, J. A., and Szostak, J. W. 1989. RNA-catalysed synthesis of: complementary-strand RNA. Nature 339:519-522.
37. Dulbecco, R. 1986. A turning point in cancer research: Sequencing the human genome. Science 231:1055-1056.
38. Dryja, T. P., Rapaport, J. M., Joyce, J. M., and Petersen, R. A. 1986. Molecular detection of deletions involving band q14 of chromosome 13 in retinoblastomas. Proc. Natl. Acad. Sci. USA. 83:7391-7394.
39. DuPraw, E. J. 1965. Macromolecular organization of nuclei and chromosomes: A folded fibre model based on whole-mount electron microscopy. Nature 206:338-343.
40. DuPraw, E. J. 1966. Evidence for a 'folded-fibre' organization in human chromosomes. Nature 209:577-581.
41. Durnam, D. M., and Palmiter, R. D. 1983. A practical approach for quantitating specific mRNAs by solution hybridization. Anal. Biochem. 131:385-393.
42. Echols, H. 2001. Operators and Promoters: The Story of Molecular Biology and Its Creators. Berkley, CA: University of California Press.
43. Ekins, R., and Chu, F. W. 1999. Microarrays: Their origins and applications. Trends Biotechnol. 17:217-218.
44. Ekins, R. Chu, F., and Micallef, J. 1989. High specific activity chemiluminescent and fluorescent markers: Their potential application to high sensitivity and "multi-analyt" immunoassays. J. Biolumin. Chemilumin. 4:59-78.
45. Fodor, S. P., Read, J. L., Pirrung, M. C., Stryer, L., Lu, A. T., and Solas, D. 1991. Light-directed, spatially addressable parallel chemical synthesis. Science 251:767-773.
46. Friend, S. H., Bernards, R., Rogelj, S., Weinberg, R. A., Rapaport, J. M., Albert, D. M., and Dryja, T. P. 1986. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature 323:643-646.
47. Gall, J. G., and Pardue, M. L. 1969. Formation and detection of RNA-DNA hybrid molecules in cytological preparations. Proc. Natl. Acad. Sci. U.S.A. 63:378-383.
48. Gefter, M. L., Becker, A., and Hurwitz, J. 1967 The enzymatic repair of DNA. I. Formation of circular lambda-DNA. Proc. Natl. Acad. Sci. USA. 58:240-247.
49. Gellert, M. 1967. Formation of covalent circles of lambda DNA by E. coli extracts. Proc. Natl. Acad. Sci. USA. 57:148-155.
50. Gilbert, W., and Muller-Hill, B. 1966. Isolation of the lac repressor. Proc. Natl. Acad. Sci. USA. 56:1891-1898.
51. Gilbert, W., and Maxam, A. 1973. The nucleotide sequence of the lac operator. Proc. Natl. Acad. Sci. USA. 70:3581-3584.
52. Gilbert, W. 1978. Why genes in pieces? Nature 271:501.
53. Gillespie, D., and Spiegelman, S. 1965. A quantitative assay for DNA-RNA hybrids with DNA immobilized on a membrane. J. Mol. Biol. 12:829-842.
54. Green, E. (2002). Sequencing the human genome. In The Genomic Revolution. ed. M. Yudell and R. DeSalle, 35-47. Washington, DC: Joseph Henry Press.
55. Greider, C. W., and Blackburn, E. H. 1985. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43:405-413.
56. Guerrier-Takada, C., Gardiner, K., Marsh, T., Pace, N., and Altman, S. 1983. The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme. Cell. 35:849-857.
57. Hall, B. D., and Spiegelman, S. 1961. Sequence complementarity of T2-DNA and T2-specific RNA. Proc. Natl. Acad. Sci. U.S.A. 47:137-163.
58. Hedrick, S. M., Cohen, D. I., Nielsen, E. A., and Davis, M. M. 1984. Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. Nature 308:149-153.
59. Hershey, A. D., and Chase, M. 1952. Independent functions of viral protein and nucleic acid in growth of bacteriophage. J. Gen. Physiol. 36:39-56.
60. Holley, R. W. 1965. Structure of an alanine transfer ribonucleic acid. JAMA 194:868-871.
61. Hozumi, N., and Tonegawa, S. 1976 Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions. Proc. Natl. Acad. Sci. USA. 73:3628-3632.
62. Huebner, R. J., and Todaro, G. J. 1969. Oncogenes of RNA tumor viruses as determinants of cancer. Proc. Natl. Acad. Sci. USA. 64:1087-1094.
63. International Human Genome Sequencing Consortium. 2001. Initial sequencing and analysis of the human genome. Nature 409:860-921.
64. Itano, H. A., and Robinson, E. A. 1960. Genetic control of the α- and β-chains of hemoglobin. Proc. Natl. Acad. Sci. USA. 46:1492-1501.
65. Jackson, D. A., Symons, R. H., and Berg, P. 1972. Biochemical method for inserting new genetic information into DNA of Simian Virus 40: Circular SV40 DNA molecules containing lambda phage genes and the galactose operon of Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 69:2904-2909.
66. Judson, H. F. 1996. The Eighth Day of Creation: Makers of the Revolution in Biology. New York: Cold Spring Harbor Laboratory Press.
67. Kafatos, F. C., Jones, C. W., and Efstratiadis, A. 1979. Determination of nucleic acid sequence homologies and relative concentrations by a dot hybridization procedure. Nucl. Acids Res. 7:1541-1552.
68. Kelly, T. J. Jr., and Smith, H. O. 1970. A restriction enzyme from Hemophilus influence. II. J. Mol. Biol. 51:393-409.
69. Kevles, D. J. 1992. Out of eugenics: The historical politics of the human genome. In Code of Codes. ed. D. J. Kevles and L. Hood, 3-36. Cambridge, MA: Harvard University Press.
70. Kornberg, R. D. 1974. Chromatin structure: A repeating unit of histones and DNA. Science 184:868-871.
71. Kornberg, R. D., and Thomas, J. O. 1974. Chromatin structure; oligomers of the histones. Science 184:865-868.
72. Kruger, K., Grabowski, P. J., Zaug, A. J., Sands, J., Gottschling, D. E., and Cech, T. R. 1982. Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena. Cell. 31:147-157.
73. Kuska, B. 1998. Beer, Bethesda, and biology: How "genomics" came into being. J. Natl. Cancer Inst. 90:93.
74. Leder, P., Tiemeier, D., and Enquist, L. 1977. EK2 derivatives of bacteriophage lambda useful in the cloning of DNA from higher organisms: The λgt WES. system. Science 196:175-177.
75. Lehman, I. R., Bessman, M. J., Simms, E. S., and Kornberg, A. 1958. Enzymatic synthesis of deoxyribonucleic acid. I. Preparation of substrates and partial purification of an enzyme from Escherichia coli. J. Biol. Chem. 233:163-170.
76. Levine, M., and Tjian, R. 2003. Transcriptional regulation and animal diversity. Nature 424:147-151.
77. Liang, P., and Pardee, A. B. 1992. Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science 257:967-971.
78. Linn, S., and Arber, W. 1968. Host specificity of DNA produced by Escherichia coli, X. In vitro restriction of phage fd replicative form. Proc. Natl. Acad. Sci. U.S.A. 59:1300-1306.
79. Matsui, T., Segall, J., Weil, P. A., and Roeder, R. G. 1980. Multiple factors required for accurate initiation of transcription by purified RNA polymerase II. J. Biol. Chem. 255:11992-11996.
80. Maxam, A. M., and Gilbert, W. 1977 A new method for sequencing DNA. Proc. Natl. Acad. Sci. USA. 74:560-564.
81. Mayr, E. 1982. The Growth of Biological Thought. Cambridge, MA: Belknap.
82. McGinnis, W., Levine, M. S., Hafen, E., Kuroiwa, A., and Gehring, W. J. 1984a. A conserved DNA sequence in homoeotic genes of the Drosophila Antenna-pedia and Bithorax complexes. Nature 308:428-433.
83. McGinnis, W., Garber, R. L., Wirz, J., Kuroiwa, A., and Gehring, W. J. 1984b. A homologous protein-coding sequence in Drosophila homeotic genes and its conservation in other metazoans. Cell. 37:403-408.
84. Mertz, J. E., and Davis, R. W. 1972. Cleavage of DNA by R1 restriction endonuclease generates cohesive ends. Proc. Natl. Acad. Sci. U.S.A. 69:3370-3304.
85. Meselson, M., and Stahl, F. W. 1958. The Replication of DNA in Escherichia coli. Proc. Natl. Acad. Sci. USA. 44:671-682.
86. Moody, G. 2004. Digital Code of Life: How Bioinformatics is Revolutionizing Science, Medicine, and Business. New Jersey: John Wiley.
87. Morange, M. 1998. A History of Molecular Biology. Cambridge, MA: Harvard University Press.
88. Nirenberg, M. W., and Matthaei, J. H. 1961. The dependence of cell-free protein synthesis in E. coli upon naturally occurring or synthetic polyribonucleotides. Proc. Natl. Acad. Sci. USA. 47:1588-1602.
89. Noller, H. F., Hoffarth, V., and Zimniak, L. 1992. Unusual resistance of peptidyl transferase to protein extraction procedures. Science 256:1416-1419.
90. Nüsslein-Volhard, C., and Wieschaus, E. 1980. Mutations affecting segment number and polarity in Drosophila. Nature 287:795-801.
91. Olby, R. 1974. The Path to Double Helix (Reprint Edition with a foreword by Francis Crick, 1994). New York: Dover.
92. Olivera, B. M., and Lehman, I. R. 1967. Linkage of polynucleotides through phosphodiester bonds by an enzyme from Escherichia coli. Proc. Natl. Acad. Sci. USA. 57:1426-1433.
93. Orgel, L. E., and Crick, F. H. 1993. Anticipating an RNA world. Some past speculations on the origin of life: Where are they today? FASEB J. 7:238-239.
94. Pachl, C., Todd, J. A., Kern, D. G., Sheridan, P. J., Fong, S. J., Stempien, M., Hoo, B., Besemer, D., Yeghiazarian, T., Irvine, B., et al. 1995. Rapid and precise quantification of HIV-1 RNA in plasma using a branched DNA signal amplification assay. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 8:446-454.
95. Pease, A. C., Solas, D., Sullivan, E. J., Cronin, M. T., Holmes, C. P., and Fodor, S. P. 1994. Light-generated oligonucleotide arrays for rapid DNA sequence analysis. Proc. Natl. Acad. Sci. USA. 91:5022-5026.
96. Pennisi, E. 2003. Reaching their goals early, sequencing labs celebrate. Science 300:409.
97. Portin, P. 1993. The concept of the gene: Short history and present status. Quart. Rev. Biol. 68:173-223.
98. Roberts, L. 1988. Academy backs genome project. Science 239:725-726.
99. Roberts, T. M., Kacich, R., and Ptashne, M. 1979. A general method for maximizing the expression of a cloned gene. Proc. Natl. Acad. Sci. USA. 76:760-764.
100. Roberts, L., Davenport, R. J., Pennisi, E., and Marshall, E. 2001. A history of the human genome project. Science 291:1195-1200.
101. Roeder, R. G., and Rutter, W. J. 1969. Multiple forms of DNA-dependent RNA polymerase in eukaryotic organisms. Nature 224:234-237.
102. Saiki, R. K., Scharf, S., Faloona, F., Mullis, K. B., Horn, G. T., Erlich, H. A., and Arnheim, N. 1985. Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science 230:1350-1354.
103. Sanger, F., and Coulson, A. R. 1975. A rapid method for determining sequences in DNA by primed synthesis with DNA polymerase. J. Mol. Biol. 94:441-448.
104. Sanger, F., Nicklen, S., and Coulson, A. R. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA. 74:5463-5467.
105. Sargent, T. D., and Dawid, I. B. 1983. Differential gene expression in the gastrula of Xenopus laevis. Science 222:135-139.
106. Schena, M., Shalon, D., Davis, R. W., and Brown, P. O. 1995. Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 270:467-470.
107. Schildkraut, C. L., Marmur, J., Fresco, J. R., and Doty, P. 1961. Formation and properties of polyribonucleotide-polydeoxy-ribonucleotide helical complexes. J. Biol. Chem. 236:C2-PC4.
108. Schlenk, F. 1988. Early nucleic acid chemistry. Trends Biochem. Sci. 13:67-69.
109. Scott, M. P., and Weiner, A. J. 1984. Structural relationships among genes that control development: Sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila. Proc. Natl. Acad. Sci. USA. 81:4115-4119.
110. Segall, J., Matsui, T., and Roeder, R. G. 1980. Multiple factors are required for the accurate transcription of purified genes by RNA polymerase III. J. Biol. Chem. 255:11986-11991.
111. Shizuya, H., Birren, B., Kim, U. J., Mancino, V., Slepak, T., Tachiiri, Y., and Simon, M. 1992. Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector. Proc. Natl. Acad. Sci. U.S.A. 89:8794-8797.
112. Smith, H. O., and Wilcox, K. W. 1970. A restriction enzyme from Hemophilus influenzae. I. Purification and general properties. J. Mol. Biol. 51:379-391.
113. Southern, E. M. 1975. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98:503-517.
114. Spector, D. H., Varmus, H. E., and Bishop, J. M. 1978. Nucleotide sequences related to the transforming gene of avian sarcoma virus are present in DNA of uninfected vertebrates. Proc. Natl. Acad. Sci. USA. 75:4102-4106.
115. Stehelin, D., Guntaka, R. V., Varmus, H. E., and Bishop, J. M. 1976a. Purification of DNA complementary to nucleotide sequences required for neoplastic transformation of fibroblasts by avian sarcoma viruses. J. Mol. Biol. 101:349-365.
116. Stehelin, D., Varmus, H. E., Bishop, J. M., Vogt, P. K. 1976b. DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA.Nature 260:170-173.
117. Sulston, J., and Ferry, G. 2002. The Common Thread: A Story of the Science, Politics, Ethics, and the Human Genome. Washington DC: The Joseph Henry Press.
118. Takeya, T., and Hanafusa, H. 1983. Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus. Cell 32:881-890.
119. Temin, H. M., and Mizutani, S. 1970. RNA-dependent DNA polymerase in virions of Rous sarcoma virus. Nature 226:1211-1213.
120. Tsuchida, N., Ryder, T., and Ohtsubo, E. 1982. Nucleotide sequence of the oncogene encoding the p21 transforming protein of Kirsten murine sarcoma virus. Science 217:937-939.
121. Velculescu, V. E., Zhang, L., Vogelstein, B., and Kinzler, K. W. 1995. Serial analysis of gene expression. Science 270:484-487.
122. Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., et al. 2001. The sequence of the human genome. Science 291:1304-1351.
123. Villa-Komaroff, L., Efstratiadis, A., Broome, S., Lomedico, P., Tizard, R., Naber, S. P., Chick, W. L., and Gilbert, W. 1978. A bacterial clone synthesizing proinsulin. Proc. Natl. Acad. Sci. USA. 75:3727-3731.
124. Volkin, E., and Astrachan L. 1956. Phosphorus incorporation in Escherichia coli ribo-nucleic acid after infection with bacteriophage T2. Virology 2:149-161.
125. Watson, J. D. 1968. The Double Helix: A Personal Account of the Discovery of the Structure of DNA (A Norton Critical Edition, 1980). New York: Norton.
126. Watson, J. D. 2003. DNA: The Secret of Life. New York: Knopf.
127. Witkowski, J. A. 1988. The discovery of "split genes": a scientific revolution. Trends Biochem. Sci. 13:110-113.
128. Weil, P. A., Luse, D. S., Segall, J., and Roeder, R. G. 1979a. Selective and accurate initiation of transcription at the Ad2 major late promotor in a soluble system dependent on purified RNA polymerase II and DNA. Cell. 18:469-484.
129. Weil, P. A., Segall, J., Harris, B., Ng, S. Y., and Roeder, R. G. 1979b. Faithful transcription of eukaryotic genes by RNA polymerase III in systems reconstituted with purified DNA templates. J. Biol. Chem. 254:6163-6173.
130. Weinmann, R., and Roeder, R. G. 1974. Role of DNA-dependent RNA polymerase 3 in the transcription of the tRNA and 5S RNA genes. Proc. Natl. Acad. Sci. USA. 71:1790-1794.
131. Weinmann, R., Raskas, H. J., and Roeder, R. G. 1974. Role of DNA-dependent RNA polymerases II and III in transcription of the adenovirus genome late in productive infection. Proc. Natl. Acad. Sci. USA. 71:3426-3439.
132. Weiss, B., and Richardson, C. C. 1967. Enzymatic breakage and joining of deoxyribonucleic acid, I. Repair of single-strand breaks in DNA by an enzyme system from Escherichia coli infected with T4 bacteriophage. Proc. Natl. Acad. Sci. USA. 57:1021-1028.
133. Yanofsky, C., and Crawford, I.P. 1959. The Effects of deletions, point mutations, reversions and suppressor mutations on the two components of the tryptophan synthetase of Escherichia Coli. Proc. Natl. Acad. Sci. USA. 45:1016-1026.
134. Yudell, M., and DeSalle, R. 2002. The Genomic Revolution: Unveiling the Unity of Life. Washington DC: Joseph Henry Press.
135. Zinn, K., DiMaio, D., and Maniatis, T. 1983. Identification of two distinct regulatory regions adjacent to the human beta-interferon gene. Cell 34:865-879.