Cu(I)-Catalyzed cycloaddition of constrained azido-alkynes: Access to 12- to 17-membered monomeric triazolophanes incorporating furanoside rings

Tetrahedron Letters

Volumn 47, Issue 16, 2006, Pages 2775-2778

  Ray, Ankur ^a   Manoj, K ^b   Bhadbhade, Mohan M ^b   Mukhopadhyay, Ranjan ^a   Bhattacharjya, Anup ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

^b NATIONAL CHEMICAL LABORATORY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYNE DERIVATIVE; CUPROUS ION; ESTER; TRIAZOLE DERIVATIVE; TRIAZOLOPHANE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; CYCLOADDITION; SYNTHESIS;

EID: 33644980640     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.02.068     Document Type: Article

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27. 1H NMR spectrum (500 or 600 MHz) of 20 exhibited the crucial 16-H and 6-H protons as overlapping signals with little difference in chemical shifts. The observed NOE of the triazole proton with any one or both of these protons can only be explained by the structure 20. In the alternative 1,5-substituted isomer these protons would be far apart, and no NOE would be expected.