Identification of cytotoxic, T-cell-selective 1,4-benzodiazepine-2,5-diones

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 9, 2006, Pages 2423-2427

  Francis, Tasha M ^a   Sundberg, Thomas B ^a   Cleary, Joanne ^a   Groendyke, Todd ^a   Opipari Jr , Anthony W ^b   Glick, Gary D ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Apoptosis; Autoimmunity benzodiazepine; Cancer; Mitochondria

Indexed keywords

1,4 BENZODIAZEPINE 2,5 DIONE; BENZODIAZEPINE DERIVATIVE; BZ 423; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG INHIBITION; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; T LYMPHOCYTE;

B-LYMPHOCYTES; BENZODIAZEPINES; CELL DEATH; DRUG EVALUATION, PRECLINICAL; HUMANS; JURKAT CELLS; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES;

ANIMALIA;

EID: 33644975104     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.01.113     Document Type: Article

References (14)

1. V.S. Marsden, and A. Strasser Annu. Rev. Immunol. 21 2003 71
2. S. Neidle, and D.E. Thurston Nat. Rev. Cancer 5 2005 285
3. J.J. Bednarski, R.E. Warner, T. Rao, F. Leonetti, R. Yung, B.C. Richardson, K.J. Johnson, J.A. Ellman, A.W. Opipari Jr., and G.D. Glick Arthritis Rheum. 48 2003 757
4. N.B. Blatt, J.J. Bednarski, R.E. Warner, F. Leonetti, K.M. Johnson, A. Boitano, R. Yung, B.C. Richardson, K.J. Johnson, J.A. Ellman, A.W. Opipari Jr., and G.D. Glick J. Clin. Invest. 110 2002 1123
5. K.M. Johnson, X. Chen, A. Boitano, L. Swenson, A.W. Opipari Jr., and G.D. Glick Chem. Biol. 12 2005 485
6. A. Boitano, C.D. Emal, F. Leonetti, N.B. Blatt, T.A. Dineen, J.A. Ellman, W.R. Roush, A.W. Opipari, and G.D. Glick Bioorg. Med. Chem. Lett. 13 2003 3327
7. All compounds were purified by preparatory TLC or flash chromatography to >95% purity and were soluble in all in vitro and cell-based assays.
8. Y. Gong, and W. He Org. Lett. 4 2002 3803
9. M.F. Cheng, and J.M. Fang J. Comb. Chem. 6 2004 99
10. R.S.B.B.K. McDowell, T.R. Gadek, L.R. McGee, T. Rawson, M.E. Reynolds, K.D. Robarge, T.C. Somers, E.D. Thorsett, M. Tischler, R.R. Webb, and M.C. Venuti J. Am. Chem. Soc. 116 1994 5077
11. D.J. Parks, L.V. Lafrance, R.R. Calvo, K.L. Milkiewicz, V. Gupta, J. Lattanze, K. Ramachandren, T.E. Carver, E.C. Petrella, M.D. Cummings, D. Maguire, B.L. Grasberger, and T. Lu Bioorg. Med. Chem. Lett. 15 2005 765
12. M.J. Allday, G.J. Inman, D.H. Crawford, and P.J. Farrell EMBO J. 14 1995 4994
13. I.H. Heijink, and A.J. Van Oosterhout Curr. Opin. Pharmacol. 5 2005 227
14. V.L. Schramm Biochim. Biophys. Acta 1587 2002 107