In vitro metabolism studies of 18F-labeled 1-phenylpiperazine using mouse liver S9 fraction

Nuclear Medicine and Biology

Volumn 33, Issue 2, 2006, Pages 165-172

  Ryu, Eun Kyoung ^a   Choe, Yearn Seong ^a   Kim, Dong Hyun ^a   Ko, Bong Ho ^a   Choi, Yong ^a   Lee, Kyung Han ^a   Kim, Byung Tae ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

18F; In vitro method; Liver S9 fraction; Metabolism; Radiotracers

Indexed keywords

1 (4 FLUOROBENZYL) 4 PHENYLPIPERAZINE; 1 (4 FLUOROMETHYLBENZYL) 4 PHENYLPIPERAZINE; 1 PHENYLPIPERAZINE DERIVATIVE; FLUORIDE; FLUORINE 18; TRACER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD; BONE; CONTROLLED STUDY; DEFLUORINATION; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; LIVER; LIVER MICROSOME; MALE; MASS SPECTROMETRY; METABOLITE; MOUSE; MOUSE STRAIN; NONHUMAN; OXIDATION; THIN LAYER CHROMATOGRAPHY;

ANIMALS; FLUORINE RADIOISOTOPES; ISOTOPE LABELING; MALE; METABOLIC CLEARANCE RATE; MICE; MICE, INBRED ICR; MICROSOMES, LIVER; PIPERAZINES; RADIOPHARMACEUTICALS;

EID: 33644963369     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2005.12.002     Document Type: Article

References (18)

1. M. Delaforge Importance of metabolism in pharmacological studies: possible in vitro predictability Nucl Med Biol 25 1998 705 709
2. P. Mazel General principles and procedures for drug metabolism in vitro B.N. La Du H.G. Mandel E.L. Way Fundamentals of drug metabolism and drug deposition 1971 The Williams & Wilkins Company Baltimore 527 545
3. B. Mazière, R. Cantineau, H.H. Coenen, M. Guillaume, C. Halldin, and A. Luxen PET radiopharmaceutical metabolism - plasma metabolite analysis G. Stöcklin V.W. Pike Radiopharmaceuticals for positron emission tomography. Methodological aspects 1993 Kluwer Academic Publishers Dordrecht 151 178
4. 18F]PNBS) in rats Nucl Med Biol 20 1993 269 278
5. 18F labeled spiperone analog for positron emission tomographic studies of the dopamine receptor Nucl Med Biol 15 1988 83 97
6. 18F]altanserin in human and rodent Nucl Med Biol 26 1999 601 608
7. S.-Y. Lee, Y.S. Choe, D.H. Kim, B.-N. Park, S.E. Kim, and Y. Choi A simple and efficient in vitro method for metabolism studies of radiotracers Nucl Med Biol 28 2001 391 395
8. B.N. Ames, J. McCann, and E. Yamasaki Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test Mutat Res 31 1975 347 364
9. K. Liu, P. Guengerich, and S.K. Yang Enantioselective hydrolysis of lorazepam 3-acetate by esterases in human and rat liver microsome and rat brain S9 fraction Drug Metab Dispos 19 1991 609 613
10. A.P. Li, N.R. Hartman, C. Lu, J.M. Collins, and J.M. Strong Effects of cytochrome P450 inducers on 17α-ethynyloestradiol (EE2) conjugation by primary human hepatocytes Br J Clin Pharmacol 48 1999 733 742
11. S. Yoshihara, M. Makishima, N. Suzuki, and S. Ohta Metabolic activation of bisphenol A by rat liver S9 fraction Toxicol Sci 62 2001 221 227
12. F.P. Guengerich, M.V. Martin, P.H. Beaune, P. Kremers, T. Wolff, and D.J. Waxman Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism J Biol Chem 261 1986 5051 5060
13. 18F]GBR-13119 J Labelled Compd Radiopharm 27 1989 823 833
14. M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of dye-binding Anal Biochem 72 1976 248 254
15. 18F-labeled 3-(1-benzyl-piperidin-4-yl)- 1-(1-methyl-1H-indol-3-yl)propan-1-ones for in vivo mapping of acetylcholinesterase Nucl Med Biol 27 2000 263 267
16. 1A antagonists, N-{2-[4-(2-methoxyphenyl)piperazino]ethyl}-N- (2-pyridyl) trans- and cis-4-fluorocyclohexanecarboxamide, produced by human and rat hepatocytes J Chromatogr B 755 2001 47 56
17. 18F]fluoroalkylbiphenyls Bull Korean Chem Soc 25 2004 1225 1230
18. 18F]-labeled benzylfluoride derivatives Nucl Med Biol 27 2000 163 168