Short-term dehydroepiandrosterone treatment increases platelet cGMP production in elderly male subjects

Clinical Endocrinology

Volumn 64, Issue 3, 2006, Pages 260-264

  Martina, Valentino ^a,b   Benso, Andrea ^a   Gigliardi, Valentina Ramella ^a   Masha, Andi ^a   Origlia, Carla ^a   Granata, Riccarda ^a   Ghigo, Ezio ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b MOLINETTE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN B; CYCLIC GMP; ESTRADIOL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HOMOCYSTEINE; INSULIN; LIPID; LOW DENSITY LIPOPROTEIN; MARKER; NITRIC OXIDE; PLACEBO; PLASMINOGEN ACTIVATOR INHIBITOR 1; PRASTERONE; PRASTERONE SULFATE; SOMATOMEDIN C; TESTOSTERONE; TRIACYLGLYCEROL;

ADULT; AGED; ARTICLE; ATHEROGENESIS; ATHEROMA; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ESTRADIOL BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; LIPID BLOOD LEVEL; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TESTOSTERONE BLOOD LEVEL; THROMBOCYTE; THROMBOCYTOPOIESIS; TRIACYLGLYCEROL BLOOD LEVEL;

AGED; ATHEROSCLEROSIS; BIOLOGICAL MARKERS; BLOOD CHEMICAL ANALYSIS; BLOOD PLATELETS; CYCLIC GMP; DEHYDROEPIANDROSTERONE; DEHYDROEPIANDROSTERONE SULFATE; DRUG ADMINISTRATION SCHEDULE; HUMANS; MALE; MIDDLE AGED; NITRIC OXIDE; VASODILATOR AGENTS;

EID: 33644936778     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2006.02454.x     Document Type: Article

References (40)

1. Orentreich N. Brind J.L. Rizer R.L. Vogelman J.H. 1984 Age changes and sex differences in serum dehydroepiandrosterone sulphate concentrations throughout adulthood Journal of Clinical Endocrinology and Metabolism 59 551 555
2. Hobkirk R. 1985 Steroid sulfotransferases and steroid sulfate sulfatases: characteristics and biological roles Canadian Journal of Biochemistry and Cell Biology 63 1127 1144
3. Rao L.G.S. 1970 Urinary steroid-excretion patterns after acute myocardial infarction Lancet 22 390 391
4. Barrett-Connor E. Goodman-Gruen D. 1995 The epidemiology of DHEAS and cardiovascular disease Annals of the New York Academy of Sciences 774 259 270
5. Trivedi D.P. Khaw K.T. 2001 Dehydroepiandrosterone sulphate and mortality in elderly men and women Journal of Clinical Endocrinology and Metabolism 86 4171 4177
6. Williams M.R.I. Dawood T. Sudhir K. Komesaroff P. 2001 Dehydroepiandrosterone improves cardiovascular function via mechanisms independent of androgen and estrogen receptors: in vitro and in vivo studies 83rd Annual Meeting of the Endocrine Society Denver, CO, USA
7. Dworkin C.R. Gorman S.D. Pashko L.L. Cristofalo V.J. Schwartz A.G. 1986 Inhibition of growth of HeLa and WI-38 cells by dehydroepiandrosterone and its reversal by ribo- and deoxyribonucleosides Life Sciences 38 1451 1457
8. Beer N.A. Jakubiwitz D.J. Matt D.W. Beer R.M. Nestler J.E. 1996 Dehydroepiandrosterone reduces plasma plasminogen activator inhibitor type 1 and tissue plasminogen activator antigen in men American Journal of Medical Science 311 205 210
9. Jesse R.L. Loesser K. Eich D.M. Qian Y.Z. Hess M.L. Nestler J.E. 1995 Dehydroepiandrosterone inhibits human platelet aggregation in vitro and in vivo Annals of the New York Academy of Sciences 774 281 290
10. Nestler J.E. Barlascini C.O. Clore J.N. Blackard W.G. 1988 Dehydroepiandrosterone reduces serum low density lipoprotein levels and body fat but does not alter insulin sensitivity in normal man Journal of Clinical Endocrinology and Metabolism 66 57 61
11. Lasco A. Frisina N. Morabito N. Gaudio A. Morini E. Trifiletti A. Basile G. Nicita-Mauro V. Cucinotta D. 2001 Metabolic effects od dehydroepiandrosterone replacement therapy in postmenopausal women European Journal of Endocrinology 145 457 461
12. Gordon G.B. Bush D.E. Weisman H.F. 1988 Reduction of atherosclerosis by administration of dehydroepiandrosterone. A study in the hypercholesterolemic New Zealand white rabbit with aortic intimal injury Journal of Clinical Investigation 82 712 720
13. Palmer R.M. Rees D.D. Ashton D.S. 1988 l -arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation Biochemical and Biophysical Research Communication 153 1251 1256
14. Palmer R.M. Moncada S. 1989 A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells Biochemical and Biophysical Research Communication 158 348 352
15. Radomski M.W. Palmer R.M. Moncada S. 1987 Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium Lancet 2 1057 1058
16. Moncada S. Radomski M.W. Palmer R.M. 1988 Endothelium derived relaxing factor: identification as nitric oxide and role in the control of vascular tone and platelet function Biochemical Pharmacology 37 2495 2501
17. Martina V. Bruno G.A. Trucco F. Zumpano E. Tagliabue M. DiBisceglie C. Pescarmona G.P. 1998 Platelet cNOS activity is reduced in patients with IDDM and NIDDM Thrombosis and Haemostasis 79 520 522
18. Napoli C. Ignarro L.J. 2001 Nitric oxide and atherosclerosis Nitric Oxide 5 88 97
19. Taddei S. Virdis A. Ghiadoni L. Sudano I. Salvetti A. 2001 Endothelial disfunction in hypertension Journal of Cardiovascular Pharmacology 38 S11 S14
20. Stamler J. Vaccaro O. Neaton J.D. 1993 The Multiple Risk Factor Intervention Trial Research Group Diabetes, other risk factors and 12-year cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial Diabetes 16 433 444
21. Hayashi T. Esaki T. Muto E. Kano H. Asai Y. Thakur N.K. Sumi D. Jayachandran M. Iguchi A. 2000 Dehydroepiandrosterone retards atherosclerosis formation through its conversion to estrogen. The possible role of nitric oxide Arteriosclerosis, Thrombosis and Vascular Biology 20 782 792
22. Liu D. Dillon J.S. 2002 Dehydroepiandrosterone activates endothelial cell nitric oxide synthase by a specific membrane receptor coupled to Galpha(i2,3) Journal of Biological Chemistry 277 21379 21388
23. Simoncini T. Mannella P. Fornari L. Varone G. Caruso A. Genazzani A.R. 2003 Dehydroepiandrosterone modulates endothelial nitric oxide synthesis via direct genomic and nongenomic mechanisms Endocrinology 144 3449 3455
24. Liu D. Dillon J.S. 2004 Dehydroepiandrosterone stimulates nitric oxide release in vascular endothelial cells: evidence for a cell surface receptor Steroids 69 279 289
25. Ignarro L.J. 1992 Haem-dependent activation of cytosolic guanylate cyclase by nitric oxide: a widespresd signal transduction mechanism Biochemical Society Transaction 20 465 469
26. Origlia C. Pescarmona G.P. Capizzi A. Cogotti S. Gambino R. Cassader M. Benso A. Granata R. Martina V. 2004 Platelet cGMP inversely correlates with age in healthy subjects Journal of Endocrinological Investigation 27 RC1 4
27. Legrain S. Massien C. Lahlou N. Roger M. Dbuire B. Diquet B. Chatellier B. Azizi M. Faucounau V. Porchet H. Baulieu E.E. 2000 Dehydroepiandrosterone replacement administration: pharmacokinetic administration and pharmacodynamic studies in healthy elderly Journal of Clinical Endocrinology and Metabolism 85 3208 3217
28. Malinow M.R. Kang S.S. Taylor L.M. Wong P.W. Coull B. Inahara T. Mukerjee D. Sexton G. Upson B. 1989 Prevalence of Hyperhomocysteinemia in patients with peripheral arterial occlusive disease Circulation 79 1180 1188
29. Albareda M. Rodriguez-Espinosa J. Murugo M. de Leiva A. Corcoy R. 2000 Assessment of insulin sensitivity and beta-cell function from measurements in the fasting state end during an oral glucose tolerance test Diabetologia 43 1507 1511
30. Morales A.J. Nolan J.J. Nelson J.C. Yen S.S.C. 1994 Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age Journal of Clinical Endocrinology and Metabolism 78 1360 1367
31. Jedrzejuk D. Medras M. Milewicz A. Demissie M. 2003 Dehydroepiandrosterone replacement in healthy men with age-related decline of DHEA-S: effects on fat distribution, insulin sensitivity and lipid metabolism Aging Male 6 151 156
32. Sulcovà J. Hill M. Hampl R. Masek Z. Novacek A. Ceska R. Starka L. 2000 Effects of transdermal application of DHEA on the levels of steroids, gonadotropins and lipids in men Physiological Research 49 685 693
33. Williams M.R.I. Dawood T. Ling S. Dai A. Lew R. Myles K. Funder J.W. Sudhir K. Komesaroff P. 2004 Dehydroepiandrosterone increases endothelial cell proliferation in vitro and improves endothelial function in vivo by mechanisms independent of androgen and estrogen receptors Journal of Clinical Endocrinology and Metabolism 89 4708 4715
34. Korbut R. Marcinkiewicz E. Cieslik K. Gryglewski R.J. 1995 The effect of nitric oxide donors on the release of plasminogen activator inhibitor (PAI) from rabbit platelets in vitro Journal of Physiology and Pharmacology 46 37 44
35. Hunt P.J. Gurnell E.M. Huppert F.A. Richards C. Prevost A.T. Wass J.A. Herbert J. Chatterjee V.K. 2000 Improvement in mood and fatigue after dehydroepiandrosterone replacement in Addison's disease in a randomized, double blind trial Journal of Clinical Endocrinology and Metabolism 85 4650 4656
36. Boger R.H. Sydow K. Borlak J. Thum T. Lenzen H. Schubert B. Tsikas D. Bode-Boger S.M. 2000 LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: involvement of S- adenosylmethionine-dependent methyltransferases Circulation Research 87 99 105
37. Baulieu E.E. Thomas G. Legrain S. Lahlou N. Roger M. Debuire B. Faucounau V. Girard L. Hervy M.P. Latour F. Leaud M.C. Mokrane A. Pitti-Ferrandi H. 2000 Dehydroepiandrosterone (DHEA), DHEA sulphate, and aging: contribution of the DHEAge Study to a sociobiomedical issue Proceeding of the National Academy of Science of the USA 97 4279 4282
38. Mortola J.F. Yen S.S.C. 1990 The effects of oral dehydroepiandrosterone on endocrine-metabolic parameters in postmenopausal women Journal of Clinical Endocrinology and Metabolism 71 696 704
39. Simoncini T. Hafezi-Moghadam A. Brazil D. Ley K. Chin W.W. Liao J.K. 2000 Interaction of estrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase Nature 407 538 541
40. Morales A.J. Haubrich R.H. Hwang J.Y. Asakura H. Yen S.S. 1998 The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroid, body composition and muscle strength in age advanced men and women Clinical Endocrinology 49 421 432