Increased urinary excretion of 8-iso-prostaglandin F2α in patients with HFE-related hemochromatosis: A case-control study

Free Radical Biology and Medicine

Volumn 40, Issue 7, 2006, Pages 1194-1200

  Kom, G D ^a   Schwedhelm, E ^a   Nielsen, P ^a   Boger R H ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

8 iso prostaglandin F2 ; Cardiovascular diseases; Free radicals; Haemochromatosis; Iron overload; Oxidative stress; Vitamin A; Vitamin E

Indexed keywords

8 ISO PROSTAGLANDIN F2 ALPHA; ALPHA TOCOPHEROL; FERRITIN; HFE PROTEIN; IRON; PROSTAGLANDIN F2 ALPHA DERIVATIVE; RETINOL; TRANSFERRIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CASE CONTROL STUDY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FOLLOW UP; GENE MUTATION; HEMOCHROMATOSIS; HOMOZYGOSITY; HUMAN; IRON OVERLOAD; MALE; OXIDATIVE STRESS; PHLEBOTOMY; PRIORITY JOURNAL; RETINOL DEFICIENCY; URINARY EXCRETION; VITAMIN BLOOD LEVEL;

ADULT; CASE-CONTROL STUDIES; DINOPROST; FEMALE; FERRITINS; HEMOCHROMATOSIS; HOMOZYGOTE; HUMANS; IRON; LIVER; MALE; MIDDLE AGED; OXIDATIVE STRESS; TRANSFERRIN; VITAMIN A;

EID: 33644918847     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2005.11.004     Document Type: Article

References (51)

1. J.N. Feder, A. Gnirke, W. Thomas, Z. Tsuchihashi, D.A. Ruddy, A. Basava, F. Dormishian, R. Domingo Jr., M.C. Ellis, A. Fullan, L.M. Hinton, N.L. Jones, B.E. Kimmel, G.S. Kronmal, P. Lauer, V.K. Lee, D.B. Loeb, F.A. Mapa, E. McClelland, N.C. Meyer, G.A. Mintier, N. Moeller, T. Moore, E. Morikang, and R.K. Wolff A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis Nat. Genet. 13 1996 399 408
2. J.L. Sullivan Iron and the sex difference in heart disease risk Lancet 1 1981 1293 1294
3. C. Niederau, R. Fischer, A. Sonnenberg, W. Stremmel, H.J. Trampisch, and G. Strohmeyer Survival and causes of death in cirrhotic and in noncirrhotic patients with primary hemochromatosis N. Engl. J. Med. 313 1985 1256 1262
4. C. Niederau, R. Fischer, A. Purschel, W. Stremmel, D. Haussinger, and G. Strohmeyer Long-term survival in patients with hereditary hemochromatosis Gastroenterology 110 1996 1107 1119
5. L. Bathum, L. Christiansen, H. Nybo, K.A. Ranberg, D. Gaist, B. Jeune, N.E. Petersen, J. Vaupel, and K. Christensen Association of mutations in the hemochromatosis gene with shorter life expectancy Arch. Intern. Med. 161 2001 2441 2444
6. N. Milman, P. Pedersen, T. Steig, K.E. Byg, N. Graudal, and K. Fenger Clinically overt hereditary hemochromatosis in Denmark 1948-1985: epidemiology, factors of significance for long-term survival, and causes of death in 179 patients Ann. Hematol. 80 2001 737 744
7. M.O. van Aken, A.J. De Craen, J. Gussekloo, P.H. Moghaddam, J.P. Vandenbroucke, B.T. Heijmans, P.E. Slagboom, and R.G. Westendorp No increase in mortality and morbidity among carriers of the C282Y mutation of the hereditary haemochromatosis gene in the oldest old: the Leiden 85-plus study Eur. J. Clin. Invest. 32 2002 750 754
8. J.P. Wojcik, M.R. Speechley, A.E. Kertesz, S. Chakrabarti, and P.C. Adams Natural history of C282Y homozygotes for hemochromatosis Can. J. Gastroenterol. 16 2002 297 302
9. P.C. Adams Nonexpressing homozygotes for C282Y hemochromatosis: minority or majority of cases? Mol. Genet. Metab. 71 2000 81 86
10. A.J. Dabbagh, T. Mannion, S.M. Lynch, and B. Frei The effect of iron overload on rat plasma and liver oxidant status in vivo Biochem. J. 300 1994 799 803
11. G. Davi, G. Ciabattoni, A. Consoli, A. Mezzetti, A. Falco, S. Santarone, E. Pennese, E. Vitacolonna, T. Bucciarelli, F. Costantini, F. Capani, and C. Patrono In vivo formation of 8-iso-prostaglandin f2alpha and platelet activation in diabetes mellitus: effects of improved metabolic control and vitamin E supplementation Circulation 99 1999 224 229
12. M.B. Kadiiska, B.C. Gladen, D.D. Baird, D. Germolec, L.B. Graham, C.E. Parker, A. Nyska, J.T. Wachsman, B.N. Ames, S. Basu, N. Brot, G.A. Fitzgerald, R.A. Floyd, M. George, J.W. Heinecke, G.E. Hatch, K. Hensley, J.A. Lawson, L.J. Marnett, J.D. Morrow, D.M. Murray, J. Plastaras, L.J. Roberts II, J. Rokach, M.K. Shigenaga, R.S. Sohal, J. Sun, R.R. Tice, D.H. Van Thiel, D. Wellner, P.B. Walter, K.B. Tomer, R.P. Mason, and J.C. Barrett Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning? Free Radic. Biol. Med. 38 2005 698 710
13. C. Vassalle, N. Botto, M.G. Andreassi, S. Berti, and A. Biagini Evidence for enhanced 8-isoprostane plasma levels, as index of oxidative stress in vivo, in patients with coronary artery disease Coron. Artery Dis. 14 2003 213 218
14. 2α as a risk marker in patients with coronary heart disease; a matched case-control study Circulation 109 2004 843 848
15. E. Schwedhelm, and R.H. Böger Application of gas chromatography-mass spectrometry for analysis of isoprostanes: their role in cardiovascular disease Clin. Chem. Lab. Med. 41 2003 1552 1561
16. J.L. Cracowski, T. Durand, and G. Bessard Isoprostanes as a biomarker of lipid peroxidation in humans: physiology, pharmacology and clinical implications Trends Pharmacol. Sci. 23 2002 360 366
17. R. Fischer, R. Engelhardt, P. Nielsen, E.E. Gabbe, H.C. Heinrich, W.H. Schmiegel, and D. Wurbs Liver iron quantification in the diagnosis and therapy control of iron overload patients M. Hoke Advances in biomagnetism: clinical aspects 1992 Elsevier Amsterdam 585 588
18. P. Nielsen, R. Fischer, T. Engelhardt, and J. Düllman Diagnosis of hereditary haemochromatosis using non-invasive methods Tranfus. Med. Hemother. 30 2003 27 36
19. E.E. Gabbe, H.C. Heinrich, and F. Icagic Proposal for the standardization of the serum unsaturated iron binding capacity assay, and results in groups of subjects with normal iron stores and with prelatent, latent and manifest iron deficiency Clin. Chim. Acta 119 1982 51 63
20. M. Dürken, P. Nielsen, S. Knobel, B. Finckh, C. Herrnring, B. Dresow, B. Kohlschütter, M. Stockschlader, W.H. Kruger, A. Kohlschütter, and A.R. Zander Nontransferrin-bound iron in serum of patients receiving bone marrow transplantation Free Radic. Biol. Med. 22 1997 1159 1163
21. M. Dürken, C. Herrnring, B. Finckh, S. Nagel, P. Nielsen, R. Fischer, H.M. Berger, R.M. Moison, U. Pichlmeier, B. Kohlschütter, A.R. Zander, and A. Kohlschütter Impaired plasma antioxidative defence and increased non transferrin-bound iron during high-dose chemotherapy and radiochemotherapy preceding bone marrow transplantation Free Radic. Biol. Med. 28 2000 887 894
22. D. Tsikas, E. Schwedhelm, M.T. Suchy, J. Niemann, F.M. Gutzki, V.J. Erpenbeck, J.M. Hohlfeld, A. Surdacki, and J.C. Frölich Divergence in urinary 8-iso-PGF(2alpha) (iPF(2alpha)-III, 15-F(2t)-IsoP) levels from gas chromatography-tandem mass spectrometry quantification after thin-layer chromatography and immunoaffinity column chromatography reveals heterogeneity of 8-iso-PGF(2alpha). Possible methodological, mechanistic and clinical implications J. Chromatogr. B. Anal. Technol. Biomed. Life Sci. 794 2003 237 255
23. C. Hershko, G. Link, and I. Cabantchik Pathophysiology of iron overload Ann. N.Y. Acad. Sci. 850 1998 191 201
24. T.P. Tuomainen, K. Kontula, K. Nyyssonen, T.A. Lakka, T. Helio, and J.T. Salonen Increased risk of acute myocardial infarction in carriers of the hemochromatosis gene Cys282Tyr mutation; a prospective cohort study in men in Eastern Finland Circulation 100 1999 1274 1279
25. R. Jiang, J.E. Manson, J.B. Meigs, J. Ma, N. Rifai, and F.B. Hu Body iron stores in relation to risk of type 2 diabetes mellitus in apparently healthy women JAMA 291 2004 711 717
26. A. Piperno, P. Trombini, M. Gelosa, V. Mauri, V. Pecci, A. Vergani, A. Salvioni, R. Mariani, and G. Mancia Increased serum ferritin is common in men with essential hypertension J. Hypertens. 20 2002 1513 1518
27. C. Bozzini, D. Girelli, E. Tinazzi, O. Olivieri, C. Stranieri, A. Bassi, E. Trabetti, G. Faccini, P.F. Pignatti, and R. Corrocher Biochemical and genetic markers of iron status and the risk of coronary artery disease; an angiography-based study Clin. Chem. 48 2002 622 628
28. C.T. Sempos, A.C. Looker, R.F. Gillum, and D.M. Makuc Body iron stores and the risk of coronary heart disease N. Engl. J. Med. 330 1994 1119 1124
29. Y. Liao, R.S. Cooper, and D.L. McGee Iron status and coronary heart disease; negative findings from the NHANES I epidemiologic follow-up study Am. J. Epidemiol. 139 1994 704 712
30. A. Bachi, E. Zuccato, M. Baraldi, R. Fanelli, and C. Chiabrando Measurement of urinary 8-Epi-prostaglandin F2alpha, a novel index of lipid peroxidation in vivo, by immunoaffinity extraction/gas chromatography-mass spectrometry. Basal levels in smokers and nonsmokers Free Radic. Biol. Med. 20 1996 619 624
31. I.S. Young, T.G. Trouton, J.J. Torney, D. McMaster, M.E. Callender, and E.R. Trimble Antioxidant status and lipid peroxidation in hereditary haemochromatosis Free Radic. Biol. Med. 16 1994 393 397
32. H. Gaenzer, P. Marschang, W. Sturm, G. Neumayr, W. Vogel, J. Patsch, and G. Weiss Association between increased iron stores and impaired endothelial function in patients with hereditary hemochromatosis J. Am. Coll. Cardiol. 40 2002 2189 2194
33. J.F. Pulliam, C.D. Jennings, R.J. Kryscio, D.G. Davis, D. Wilson, T.J. Montine, F.A. Schmitt, and W.R. Markesbery Association of HFE mutations with neurodegeneration and oxidative stress in Alzheimer's disease and correlation with APOE Am. J. Med. Genet. 119B 2003 48 53
34. A.K. Salahudeen, B. Oliver, J.D. Bower, and L.J. Roberts II Increase in plasma esterified F2-isoprostanes following intravenous iron infusion in patients on hemodialysis Kidney Int. 60 2001 1525 1531
35. S. Yeoh-Ellerton, and M.C. Stacey Iron and 8-isoprostane levels in acute and chronic wounds J. Invest. Dermatol. 121 2003 918 925
36. S.J. Duffy, E.S. Biegelsen, M. Holbrook, J.D. Russell, N. Gokce, J.F. Keaney Jr., and J.A. Vita Iron chelation improves endothelial function in patients with coronary artery disease Circulation 103 2001 2799 2804
37. W. Ong, and B. Halliwell Iron, Atherosclerosis and neurodegeneration. A key role for cholesterol in promoting iron-dependent oxidative damage? Ann. N. Y. Acad. Sci. 1012 2004 51 64
38. W. Breuer, E. Greenberg, and Z.I. Cabantchik Newly delivered transferrin iron and oxidative cell injury FEBS Lett. 403 1997 213 219
39. C. Patrono, and G.A. FitzGerald Isoprostanes: potential markers of oxidant stress in atherothrombotic disease Arterioscler. Thromb. Vasc. Biol. 17 1997 2309 2315
40. P. Montuschi, P.J. Barnes, and L.J. Roberts II Isoprostanes: markers and mediators of oxidative stress FASEB J. 18 2004 1791 1800
41. N. Leitinger, J. Huber, C. Rizza, D. Mechtcheriakova, V. Bochkov, Y. Koshelnick, J.A. Berliner, and B.R. Binder The isoprostane 8-iso-PGF(2alpha) stimulates endothelial cells to bind monocytes: differences from thromboxane-mediated endothelial activation FASEB J. 15 2001 1254 1256
42. P. Brissot, A. Le Treut, G. Dien, M. Cottencin, M. Simon, and M. Bourel Hypovitaminemia A in idiopathic hemochromatosis and hepatic cirrhosis. Role of retinol-binding protein and zinc Digestion 17 1978 469 478
43. Y.Z. Fang, S. Yang, and G. Wu Free radicals, antioxidants, and nutrition Nutrition 18 2002 872 879
44. S. Urayama, T.W. Lissoos, G.A. Fishman, S. Grover, T.D. Schiano, H. Conjeevaram, and A.L. Baker Night blindness secondary to vitamin A deficiency in a patient with bile duct strictures after liver transplantation Transplantation 66 1998 537 539
45. A. Nyberg, B. Berne, H. Nordlinder, C. Busch, U. Eriksson, L. Loof, and A. Vahlquist Impaired release of vitamin A from liver in primary biliary cirrhosis Hepatology 8 1988 136 141
46. A. von Herbay, H. de Groot, U. Hegi, W. Stremmel, G. Strohmeyer, and H. Sies Low vitamin E content in plasma of patients with alcoholic liver disease, hemochromatosis and Wilson's disease J. Hepatol. 20 1994 41 46
47. H. Kumar Repeated blood donation effective in treating hyperlipidemia J. Assoc. Physicians India 42 1994 468 469
48. F.S. Facchini, and K.L. Saylor Effect of iron depletion on cardiovascular risk factors: studies in carbohydrate-intolerant patients Ann. N. Y. Acad. Sci. 967 2002 342 351
49. J.D. Morrow, B. Frei, A.W. Longmire, J.M. Gaziano, S.M. Lynch, Y. Shyr, W.E. Strauss, J.A. Oates, and L.J. Roberts II Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers. Smoking as a cause of oxidative damage N. Engl. J. Med. 332 1995 1198 1203
50. G. Strohmeyer, C. Niederau, and W. Stremmel Survival and causes of death in hemochromatosis. Observations in 163 patients Ann. N. Y. Acad. Sci. 526 1988 245 257
51. P. Nielsen, R. Fischer, R. Engelhardt, B. Dresow, and E.E. Gabbe Neue Möglichkeiten in der Diagnose der hereditären Hämochromatose. HFE-Mutations-Diagnostik und nichtinvasive Leber-Eisen-Quantifizierung mit einem SQUID-Biosusceptometer Deutsches Ärzteblatt 95 1998 A2915 A2921